Department of Biomedical Engineering

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Ronald Xu

Associate ProfessorBiomedical Engineering
Associate ProfessorOphthalmology


Univ of Science and Technology of China (USTC)
Hefei, Anhui, China, 230026

614-688-3635

Biographical Narrative

Dr. Ronald Xu is Associate Professor of Biomedical Engineering at The Ohio State University. He earned his PhD degree in Mechanical Engineering from Massachusetts Institute of Technology, followed by a postdoctoral training at Stanford University. Before joining the Ohio State University, he had been Director of Technology Development in a medical device company for five years and led the company efforts in technology development, benchtop testing, animal validation studies, and filing FDA 510k applications. His teaching and research interests include medical device innovation, bioinstrumentation, multimodal imaging, and image-guided therapy. Major clinical applications include cancer imaging and therapy, wound healing, and ocular drug delivery. He has led the development and validation of multiple handheld medical devices and multifunctional contrast agents for cancer detection and intraoperative imaging. He has carried out 5 clinical trials, published 11 patents, and authored more than 50 peer reviewed publications in the field. In 2010, he was profiled as one of ten best and brightest Central Ohioans in the Columbus CEO Magazine and was honored as one of two Superstars in the category of Research and Development. In 2011, he earned the TechColumbus Inventor of the Year Award.

Honors

2010

  • R & D "Superstar", Columbus CEO Magzine

2009

  • Herman R. Weed Excellence in Teaching Award, Department of Biomedical Engineering

2006

  • National Eye Institute Travel Award, ARVO/NIH

Chapters in Books

2010

  • Ronald Xu, "Chapter 17: Selected topics in biomedical engineering" In Intelligent Energy Field Manufacturing. Edited by Wenwu Zhang. Boca Raton: CRC Press. 2010.


Journal Articles

2010

  • Jeff Xu, Jiwei Huang, Ruogu Qin, Stephen Povoski, Edward Martin, Ronald Xu*, "Synthesizing and binding dual-mode poly (lactic-co-glycolic acid) (PLGA) nanobubbles for cancer targeting and imaging." Biomaterials 7 31 1716-1722
  • Peng Zou, Stephen P. Povoski,*, Nathan C. Hall, Michelle M. Carlton, George H. Hinkle, Ronald X. Xu, Cathy M. Mojzisik, Morgan A. Johnson, Michael V. Knopp, Edward W. Martin, and Duxin Sun, "124I-HuCC49deltaCH2 for TAG-72 antigen-directed positron emission tomography (PET) imaging of LS174T colon adenocarcinoma tumor implants in xenograft mice: Preliminary results." World Journal of Surgical Oncology 8
  • Ronald Xu*, Stephen Povoski, Edward Martin, "Targeted delivery of microbubbles and nanobubbles for image-guided thermal ablation therapy of tumors." Expert Rev Med Devices 3 7 303-306
  • Jiwei Huang, Jeff S. Xu, Ronald X. Xu*, "Heat-sensitive microbubbles for intraoperative assessment of cancerablation margins." Biomaterials 6 31 1278-1286
  • Hamid El-Dahdah, Bei Wang, Guanglong He, Ronald X. Xu*, "An Automatic Occlusion Device for Remote Control of Tumor Tissue Ischemia." Technology in Cancer Research and Treatment 1 9 71-76
  • Leilei Zhang, Jeff Xu, Alan Letson, Virginia Sanders, Cynthia Roberts, and Ronald Xu*, "Multi-functional microbubbles for image-guided anti-VEGF therapy." Journal of Biomedical Optics 3 15
  • Chulhong Kim, Ruogu Qin, Jeff Xu, Lihong Wang *, and Ronald Xu*, "Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging." Journal of Biomedical Optics 15 1
  • Ronald X. Xu, Kun Huang, Ruogu Qin, Jiwei Huang, Jeff S. Xu, Liya Ding, Urmila S. Gnyawali, Gayle Gordillo, Surya C. Gnyawali, and Chandan K. Sen, "Dual-mode imaging of cutaneous tissue oxygenation and tissue vascular thermal reactivity." Journal of Visualized Experiments

2009

  • Peng Zou, Songbo Xu, Stephen P. Povoski, Anna Wang, Morgan A. Johnson, Edward W. Martin, Jr., Vish Subramaniam,| Ronald Xu,* and Duxin Sun*, "Near-Infrared Fluorescence Labeled Anti-TAG-72 Monoclonal Antibodies for Tumor Imaging in Colorectal Cancer Xenograft Mice." Molecular Pharmaceutics 6 2 428-440
  • Stephen P. Povoski*, Rafael E. Jimenez, Wenle P. Wang, Ronald X. Xu, "Standardized and reproducible methodology for the comprehensive and systematic assessment of surgical resection margins during breast-conserving surgery for invasive breast cancer." BMC Cancer 9 1
  • Ronald Xu*, Jiwei Huang, Jeff Xu, Duxin Sun, George Hinkle, Edward Martin and S. Povoski, "Fabrication of indocyanine green encapsulated biodegradable microbubbles for structural and functional imaging of cancer." Journal of Biomedical Optics 14 3

2008

  • Bei Wang, Stephen P. Povoski, Xianhua Cao, Duxin Sun, and Ronald X. Xu, "Dynamic schema for near infrared detection of pressure-induced changes in solid tumors." Applied Optics 47 16 3053-3063
  • Ronald Xu*, Emanuel Sachs, "Rapid Thermal Cycling with Low Thermal Inertia Tools." Polymer Engineering & Science 2 49 305-316
  • Ronald X. Xu*, Joseph Ewing, Hamid El-Dhadah, Bei Wang, Stephen P. Povoski, "Design and benchtop validation of a handheld integrated dynamic breast imaging system for noninvasive characterization of suspicious breast lesions." Technology in Cancer Research and Treatment 6 7 471-482

2007

  • Ronald X. Xu*, Bo Qiang, Jimmy J. Mao, and Stephen P. Povoski, "Development of a handheld near infrared imager for dynamic characterization of in vivo biological tissue systems." Applied Optics 46 30 7442-7451
  • Ronald X. Xu*, Doung Young, Jimmy Mao, Stephen P. Povoski, "A prospective pilot clinical trial evaluating the utility of a dynamic near infrared imaging device for characterizing suspicious breast lesions." Breast Cancer Research 9
  • Ronald X. Xu* and Stephen P. Povoski, "Diffuse optical imaging and spectroscopy for cancer." Expert Rev Med Devices 4 1 83-95

2004

  • Xuefeng Cheng*, Jimmy .M. Mao, Xiaorong Xu, Mohamed Elmandjra, Robin Bush, Linda Christenson, Bill OKeefe, and John Bry, "Post-occlusive reactive hyperemia in patients with peripheral vascular disease." Clinical hemorheology and microcirculation 1 31 11-21

2001

  • X. Xu, E. Sachs*, M. Cima, "The design of conformal cooling channels in injectionn molding tooling." Polymer Engineering & Science 31 41 1265-1279

1999

  • P. S. Huang and X. Xu, "Design of an optical probe for surface profile measurement." Optical Engineering 7 38 1223-1228

Papers in Proceedings

2010

  • Leilei Zhang, Jeff Xu, Jiwei Huang, Cynthia Roberts, Ronald Xu*, "Bevacizumab (Avastin) conjugated microbubbles for anti-VEGF treatment of neovascular age-related macular degeneration." Proc. SPIE 2010.
  • Ruogu Qin, Jiwei Huang, Jeff S. Xu, Liya Ding, Surya Gnyawali, Chandan K. Sen, Kun Huang, and Ronald X. Xu*, "Dual-mode quantitative imaging of wound tissue oxygenation and perfusion." Proc. SPIE 2010.
  • Ronald X. Xu*, Jeff Xu, Ruogu Qin, Jiwei Huang, "Developing multifunctional tissue simulating phantoms for quantitative biomedical optical imaging." Proc. SPIE. 2010.
  • R. Xu*, J.S. Xu, J. Huang, M.F. Tweedle, C. Schmidt, S.P. Povoski, and E.W. Martin, "Targeted delivery of cancer-specific multimodal contrast agents for intraoperative detection of tumor boundaries and therapeutic margins." Proc. SPIE. 2010.
  • R. Qin, J. Xu, R. Xu*, C. Kim, and L. Wang*, "Fabricating multifunctional microbubbles and nanobubbles for concurrent ultrasound and photoacoustic imaging." Proc. SPIE 2010.

2007

  • Nasser Kashou*, Ronald Xu, Cynthia Roberts, Larwence Leguire, "Using FMRI and FNIRS for localization and monitoring of visual cortex activities." 29th International Conference of the IEEE Engineering in Medicine and Biology Society 2007.

2006

  • R. Xu*, B. Qiang and C. Roberts, "Retinal Tissue Oxygen Imaging by Near Infrared Lightand White Light Interferometry." Proc. SPIE 2006.
  • Ronald Xu*, Bo Qiang, John Olsen, Stephen Povoski, Lisa Yee, Jimmy Mao, "Near Infrared/ Ultrasound Dual Modal Imaging for Breast Cancer Detection." Proc. SPIE 2006.
  • Ronald X. Xu*, Abdul Rana, Robert Lee, and Bo Qiang, "Dynamic near infrared imaging with ultrasound guidance (dNIRUS): analytical model and benchtop validation on multilayer tissue simulating phantoms." Proc. SPIE 2006.

2005

  • Ronald Xu*, Bo Qiang, and Jun Liu, "Ultrasound-guided near-infrared spectroscopy for brain functional study: feasibility analysis and preliminary work." Proc. SPIE 2005.
  • R. Xu*, B. Qiang, J. Olsen, S. Povoski, L. Yee, and J. Mao, "Localization and functional parameter reconstruction of suspicious breast lesions by near infrared/ultrasound dualmodal imaging." Conf Proc IEEE Eng Med Biol Soc 2005.
  • R. Xu*, B. Qiang, and J. Mao, "Near infrared imaging of tissue heterogeneity: probe designand sensitivity analysis." Conf Proc IEEE Eng Med Biol Soc 2005.
  • B. Qiang, A. Rana, and R. Xu*, "Reconstruction of tissue heterogeneity by near infraredimaging: a novel algorithm and benchtop validation." Conf Proc IEEE Eng Med Biol Soc 2005.

Presentations

2010

  • "Gold nanoparticle assisted light activation of heat-sensitive nanobubbles for photothermal therapy." Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in PhotodynamicTherapy XIX. SPIE Photonics West 2010. San Francisco. 2010.
  • "Innovations in Wound Imaging." Advances in Wound Care and HBO Update 2010. Columbus. 2010.
  • "Optical imaging of cutaneous tissue oxygen and vascular function." OSU Biophysics Seminar Day. Columbus. 2010.
  • "Multifunctional active agents for image-guided cancer therapy." Engineering and Medicine Symposium on Translational Research. Columbus. 2010.
  • "Multimodal Imaging and Image-guided Therapy in Cancer." Department of Radiology Seminar. Ann Arbor. 2010.

Patents

2010

2009

  • Ronald Xu, Jeff Xu, Jiwei Huang. Targeted delivery of heat-sensitive nanobubbles and microbubbles for the assessment of thermal ablation margins in bresat cancer and other malignancies. Filed Jan 2009
  • Ronald Xu, Cynthia Roberts, Leilei Zhang. Targeted delivery of biodegradable multifunctional nanoparticles for integrated imaging and therapy of age-related macular degeneration. Filed Sep 2009
  • Michael Tweedle, Ronald Xu. Tumor Therapy with Heat Burst Micro Capsules. Filed Oct 2009

2008

  • Edward Martin, Ronald Xu, Duxin Sun, Stephen Povoski, Joseph Heremans, Robert Lee, Vish Subramaniam. Fluorescence Detection System. Filed Dec 2008 and Issued Jun 2009.
  • Edward Martin, Ronald Xu, Duxin Sun, Stephen Povoski, Joseph Heremans, Robert Lee, Vish Subramaniam. Fluorescence Detection System. Filed Dec 2008 and Issued Aug 2009.
  • Chandan Sen, Ronald Xu. Wound goggles. Filed Dec 2008 and Issued Apr 2010.

2007

  • Ronald Xu, Joseph Heremans, Robert Lee, Edward Martin, Stephen Povoski, Vish Subramanian, and Duxin Sun. Fluorescence Detection System 60020345 Filed Dec 2007

2005

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