Department of Biomedical Engineering

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Yi Zhao

Associate ProfessorBiomedical Engineering
Associate ProfessorOphthalmology

294 Bevis Hall
1080 Carmack Road
Columbus, OH 43210

614-247-7424

Biographical Narrative

Dr. Yi Zhao received BS and MS degrees in Mechanical Engineering from Tsinghua University, Beijing, China, and PhD degree in Manufacturing Engineering from Boston University, Boston. He founded the Laboratory for Biomedical Microsystems in October 2006 and conducts research in development of micro/nano devices for investigating cellular mechanotransduction and miniaturized tools for point-of-care diagnostics. He is also interested in addressing mechanical, material, and fabrication challenges in development of biomedical microsystems. His current research activities include development of smart robotic devices for quantitative assessment of physical therapy; liquid state motion sensing system for patients with vestibular disorder; artificial compound eye for advanced laproscopic imaging; and programmable micropatterning solutions for functional tissue engineering.

Honors

2011

  • Lumley Research Award, The Ohio State University

2010

  • NSF CAREER Award, National Science Foundation

Journal Articles

2013

  • Wang,Qian; Zhang,Xu; Zhao,Yi, "Micromechanical stimulator for localized cell loading: fabrication and strain analysis." JOURNAL OF MICROMECHANICS AND MICROENGINEERING 23 1
  • Haas,Caroline; Butterfield,Timothy,A; Abshire,Sarah; Zhao,Yi; Zhang,Xiaoli; Jarjoura,David; Best,Thomas,M, "Massage Timing Affects Postexercise Muscle Recovery and Inflammation in a Rabbit Model." MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 45 6 1105-1112
  • Wei,Kang; Zeng,Hansong; Zhao,Yi, "Substrate material affects wettability of surfaces coated and sintered with silica nanoparticles." APPLIED SURFACE SCIENCE 273 32-38
  • Zhang,Xu; Wang,Qian; Gablaski,Brian; Zhang,Xiaojin; Lucchesi,Pamela; Zhao,Yi, "A microdevice for studying intercellular electromechanical transduction in adult cardiac myocytes." LAB ON A CHIP 13 15 3090-3097

2012

  • Haas, C., Butterfield, T. A., Zhao, Y., Zhang, X., Jarjoura, D., and Best, T. M., "Dose-Dependency of Massage-Like Compressive Loading on Recovery of Active Muscle Properties Following Eccentric Exercise: Rabbit Study with Clinical Relevance." British Journal of Sports Medicine 47 2 83-8
  • Hass, C., Best, T.M., Wang, Q. and Zhao, Y., "In Vivo Passive Mechanical Properties of Skeletal Muscle Improve With Massage-Like Loading Following Eccentric Exercise." JOURNAL OF BIOMECHANICS 45 15 2030-2036
  • Zhang,Xu; Zhao,Yi, "Programmable patterning of polymeric microparticles by floating electrodes-assisted electrospray." JOURNAL OF MICROMECHANICS AND MICROENGINEERING 22 4
  • Kim,Bongsu; Zhang,Xu; Borteh,Hassan; Li,Zhenqing; Guan,Jianjun; Zhao,Yi, "Fabrication of porous microtent structures toward an in vitro endothelium model." JOURNAL OF MICROMECHANICS AND MICROENGINEERING 22 8

2011

  • Zeng,Hansong; Zhao,Yi, "Liquid-state motion sensing." SENSORS AND ACTUATORS B-CHEMICAL 154 1 33-40
  • Xu S. and Zhao Y., "Monolithic fabrication of nanochannels using core-sheath nanofibers as sacrificial mold." Microfluidics and Nanofluidics 11 3 359-365
  • Zeng,Hansong; Zhao,Yi, "Sensing Movement: Microsensors for Body Motion Measurement." SENSORS 11 1 638-660
  • Zeng,H; Zhao,Y, "Rheological analysis of non-Newtonian blood flow using a microfluidic device." SENSORS AND ACTUATORS A-PHYSICAL 166 2 207-213
  • Zeng,H; Zhao,Y, "Microfabrication in electrospun nanofibers by electrical discharges." SENSORS AND ACTUATORS A-PHYSICAL 166 2 214-218

2010

  • Zeng,H; Zhao,Y, "Dynamic behavior of a liquid marble based accelerometer." APPLIED PHYSICS LETTERS 96 11
  • Gu,Wenwen; Zhao,Yi, "Cellular electrical impedance spectroscopy: an emerging technology of microscale biosensors." EXPERT REVIEW OF MEDICAL DEVICES 7 6 767-779

2009

  • Zhao,Yi; Zeng,Hansong; Nam,Jin; Agarwal,Sudha, "Fabrication of Skeletal Muscle Constructs by Topographic Activation of Cell Alignment." BIOTECHNOLOGY AND BIOENGINEERING 102 2 624-631
  • Zhao,Yi; Zeng,Hansong, "Fabricating non-photodefinable polymer microstructures for micro-total-analysis." SENSORS AND ACTUATORS B-CHEMICAL 139 2 673-681
  • Zhao,Yi; Zeng,Hansong, "Rotational Maneuver of Ferromagnetic Nanowires for Cell Manipulation." IEEE TRANSACTIONS ON NANOBIOSCIENCE 8 3 226-236
  • Zhao,Yi, "Investigating electrical field-affected skeletal myogenesis using a microfabricated electrode array." SENSORS AND ACTUATORS A-PHYSICAL 154 2 281-287

2008

  • Butterfield,Timothy,A; Zhao,Yi; Agarwal,Sudha; Haq,Furqan; Best,Thomas,M, "Cyclic Compressive loading facilitates recovery after eccentric exercise." MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 40 7 1289-1296
  • Zeng,Hansong; Butterfield,Timothy,A; Agarwal,Sudha; Haq,Furqan; Best,Thomas,M; Zhao,Yi, "An Engineering Approach for Quantitative Analysis of the Lengthwise Strokes in Massage Therapies." JOURNAL OF MEDICAL DEVICES-TRANSACTIONS OF THE ASME 2 4
  • Zhao,Yi; Zhang,Xin, "Profile control in silicon nanostructures using fluorine-enhanced oxide passivation." IEEE TRANSACTIONS ON NANOTECHNOLOGY 7 1 40-47

2007

  • Zhao,Yi; Lim,Chee,Chew; Sawyer,Douglas,Brian; Liao,Ronglih; Zhang,Xin, "Simultaneous orientation and cellular force measurements in adult cardiac myocytes using three-dimensional polymeric microstructures." CELL MOTILITY AND THE CYTOSKELETON 64 9 718-725
  • Zhao,Yi; Zhang,Xin, "Adaptation of myofibrils to a microstructured polymeric substrate." SENSORS AND ACTUATORS A-PHYSICAL 136 2 491-495

2006

  • Zhao,Yi; Zhang,Xin, "Determination of the deformations in polymeric nanostructures using geometric moire techniques for biological applications." SENSORS AND ACTUATORS B-CHEMICAL 117 2 376-383
  • Zhao,Y; Zhang,X, "An approach for creating polymeric microstructures with various aspect ratios for cellular analysis applications." SENSORS AND ACTUATORS A-PHYSICAL 127 2 216-220
  • Zhao,Y; Lim,C,C; Sawyer,D,B; Liao,R,L; Zhang,X, "Microchip for subcellular mechanics study in living cells." SENSORS AND ACTUATORS B-CHEMICAL 114 2 1108-1115
  • Zhao,Y; Zhang,X, "Cellular mechanics study in cardiac myocytes using PDMS pillars array." SENSORS AND ACTUATORS A-PHYSICAL 125 2 398-404

2005

  • Zhao,Y; Zhang,X, "Adaptation of flexible polymer fabrication to cellular mechanics study." APPLIED PHYSICS LETTERS 87 14
  • Zhao,Y; Lim,C,C; Sawyer,D,B; Liao,R,L; Zhang,X, "Cellular force measurements using single-spaced polymeric microstructures: isolating cells from base substrate." JOURNAL OF MICROMECHANICS AND MICROENGINEERING 15 9 1649-1656

2004

  • Zhang,X; Zhao,Y; Li,B; Ludlow,D, "Pumping capacity and reliability of cryogenic micro-pump for micro-satellite applications." JOURNAL OF MICROMECHANICS AND MICROENGINEERING 14 10 1421-1429

Papers in Proceedings

2013

  • K. Wei and Y. Zhao, "A Three-Dimensional Deformable Liquid Lens Array For Directional and Wide angle Laparoscopic Imaging." Technical Digest of the 25th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2013) 2013.

2011

  • Borteh,H; Kim,B; Zhao,Y, "POROUS MICROFLUIDICS: A UNIQUE PLATFORM FOR TRANSVASCULAR STUDY." 24th IEEE International Conference on Micro Electro Mechanical Systems (MEMS'11) 2011.
  • Q. Wang, and Y. Zhao, "Miniaturized Cell Mechanical Stimulator with Controlled Strain Gradient for Cellular Mechanobiological Study." Proceeding of 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS'11) 2011.
  • H. Zeng, and Y. Zhao, "A 3D Artificial Compound Eye with Focus-Tunable Single Lenses." Proceeding of 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS'11) 2011.

2009

  • H. Zeng, and Y. Zhao, "Electrical Discharge Based Microfabrication on Electrospun Nanofibers." 22nd IEEE International Conference on Micro Electro Mechanical Systems (MEMS '09) 2009.
  • H. Zeng, and Y. Zhao, "Cell Manipulation by Rotating Ferromagnetic Nanowires." Proceeding of the 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS'09) 2009.
  • B. Kim, D. M. Grzybowski, P. Weber, C. J. Roberts, and Y. Zhao, "Electrospun Micro/Nanofiber Assisted In Vitro Construction of Trabecular Meshwork for Glaucoma Investigation." Proceeding of the 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS'09) 2009.
  • H. Zeng, and Y. Zhao, "On-Chip Blood Viscometer Towards Point-of-Care Hematological Diagnosis." 22nd IEEE International Conference on Micro Electro Mechanical Systems (MEMS'09) 2009.

2008

  • S.W. Price, B. Kim, C.J. Roberts, D.M. Grzybowski and Y. Zhao, "Investigating the Porosity of Trabecular Meshwork Using Microfabricated Structures for Glaucoma Treatments." Proceeding of the 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS'08) 2008.
  • Zhao,Y, "Microchip for the regulation of skeletal muscle differentiation." 21st IEEE International Conference on Micro Electro Mechanical Systems (MEMS'08) 2008.
  • Zhao,Y, "Closely spaced polymer microstructures as a unique tool for characterization at the small scales." 21st IEEE International Conference on Micro Electro Mechanical Systems (MEMS'08) 2008.
  • Y. Zhao, "Investigation of Interstructural Collapse of PDMS Microstructures." Proceeding of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS'08) 2008.

2007

  • Y. Zhao, "Skeletal Myoblasts Proliferation and Fusion Regulated by Microelectrode Arrays." 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS'07) 2007.
  • Zhao,Yi; Zhang,Xin, "Adaptation of myofibrils to a microstructured polymeric substrate." Workshop on Solid-State Sensors, Actuators and Microsystems (Hilton Head'06) 2007.

2006

  • Y. Zhao and X. Zhang, "Directional Reassembly of Myofibrils in Cultured Cardiac Myocytes Using a Three-Dimensional Polymeric Substrate." Technical Digest of IEEE Solid-State Sensor and Actuator Workshop (Hilton Head '06) 2006.
  • Y. Zhao, D. Mabius, J. Regis, and X. Zhang, "Pressure-Assisted Micropatterning of Non-Photodefinable Polymers." Proceeding of the 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS'06) 2006.

2005

  • Zhao,Y; Zhang,X, "In situ force probing for cardiac myocyte using PDMS pillar array." 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '04) 2005.
  • Zhao,Y; Yu,H; Zhang,X, "Creating polymer-based microstructures with various aspect ratios from a single template for cellular force measurements." 18th IEEE International Conference on Micro Electro Mechanical Systems (MEMS '05) 2005.
  • Zhao,Y; Li,F; Zhang,X, "Determination of deformations in polymeric nanostructures using geometric Moire techniques for biological applications." 13th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers '05) 2005.
  • Yu,H; Zhao,Y; Li,B; Zhang,X, "Three-dimensional microvalves based on single-layered SU-8 for Lab-on-Chip application." 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '04) 2005.
  • Y. Zhao, F. Li, and X. Zhang, "Determination of Deformations in Polymeric Nanostructures Using Geometric Moire Techniques for Biological Applications." Proceeding of the 13th International Conference on Solid-State Sensors and Actuators and Microsystems (Transducers '05) 2005.
  • Y. Zhao, and X. Zhang, "Contraction Force Measurements in Cardiac Myocytes Using PDMS Pillar Arrays." Proceeding of the 18th IEEE International Conference on Micro Electro Mechanical Systems (MEMS '05) 2005.
  • Zhao,Y; Zhang,X, "Contraction force measurements in cardiac myocytes using PDMS pillar arrays." 18th IEEE International Conference on Micro Electro Mechanical Systems (MEMS '05) 2005.

2004

  • Y. Zhao, and X. Zhang, "In Situ Force Probing for Cardic Myocyte Using Micro PDMS Pillar Array." Proceeding of the 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS '04) 2004.

2003

  • H. Yu, A. Gruntzig, Y. Zhao, A. Sharon, B. Li, and X. Zhang, "Rapid Prototyping 3D Microstructures on Soft and Rigid Templates Using a Scanning Laser System." Proceeding of the 7th International Conference on Miniaturized Chemical and BioChemical Analysis Systems (MicroTAS '03) 2003.

Unknown Year

  • Zhang, X. and Zhao, Y., "Microfabricated Particle Assemblies for Versatile Cell Patterning." Proceeding of 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences
  • Wang, Q., Zhao, Y., "Microdevice for Studying Intercellular Mechanical Interaction." Proceeding of 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences
  • Kang, W., and Zhao, Y., "Fast and Versatile Fabrication of PDMS Nanowrinkling Structures." Proceeding of 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences
  • Q. Wang and Y. Zhao, "A Microfluidic Device to Load Multiple Mechanical Stimulators with Differing Strain Magnitudes with A Single Pump." Proceeding of the 17th International Conference on Solid-State Sensors and Actuators and Microsystems (Transducers2013)
  • X. Zhang, and Y. Zhao, "Creating Particulate Microstructures For two- and Three- Dimensional Cell Patterning." Proceeding of the 17th International Conference on Solid-State Sensors and Actuators and Microsystems (Transducers2013)

Presentations

2013

  • "Transducers for Improving and Quantifying the Efficacy of┬áRehabilitation." Ohio University. Athens. 2013.

2011

  • "Electrospun Polymer Nanofibers for Tissue Biofabrication and Micro/Nanofluidics." University of Minnesota. 2011.
  • "Electrospun/electrosprayed Constructs for Microscale Cell/Tissue Engineering." Boston University. 2011.

2010

  • "MEMS Inertial Sensors Design &Applications." Peking University. 2010.

2009

  • "Microfabrication of Electrospun Polymer Fibrous Materialsfor Functional Tissue Engineering." Institute of Microelectronics, Peking University. Beijing. 2009.
  • "Microfabrication of Electrospun Polymer Fibrous Materials for Functional Tissue Engineering." Institute of Microelectronics, Tsinghua University. Beijing. 2009.
  • "Implantable Inertial Sensors for Vestibular Prosthesis." Nankai University. Nankai University. 2009.
  • "Implantable Inertial Sensors for Vestibular Prosthesis." Tianjin University. Tianjin. 2009.
  • "Bioinspired Motion Sensors for Vestibular Prosthesis." University of Science and Technology at Beijing. 2009.

2008

  • "Meeting with Small." STEM Leadership Summer Camp. 2008.

Patents

2011

  • Zhao, Y., and Zeng, H. Artificial Compound Eye with Adaptive Microlenses. Filed Dec 2011
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