BME Seminar
"Tissue Injury and Repair: An Interdisciplinary Journey Across Skin, Heart, and the Brain" by Chandan Sen, PhD
All dates for this event occur in the past.
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Room 145 Mount Hall
1050 Carmack Road
Columbus, OH 43210
United States
Biomedical Engineering Seminar
Tuesday 11/23/2010, 4-5PM
Mount Hall (West Campus), Room 145
"Tissue Injury and Repair:
An Interdisciplinary Journey Across Skin, Heart, and the Brain"
by
Chandan Sen, PhD
Professor and Vice Chair (Research), Department of Surgery, OSU
Abstract:
Our laboratory is interested in Tissue Injury and Repair and works across three major organs: the skin, heart and brain. In the brain, our work rests on the observation that a poorly known natural form of vitamin E, alpha-tocotrienol, is orders of magnitude more potent than its better known counterpart alpha-tocopherol in protecting neural cells against a range of insults. Our work (NINDS sponsored) has ranged from developing understanding of underlying molecular mechanisms, in vivo stroke studies in small and large animals as well as phase I studies in humans. In the heart, we have proposed a new paradigm (NHLBI sponsored) where the reoxygenation component of ischemia-reperfusion may trigger differentiation of fibroblasts to myofibroblasts and contribute to adverse cardiac remodeling. Key roles of hyperoxia-induced microRNAs have emerged. In both brain as well as heart, MRI studies have been critical in generating functional outcomes data. In the skin, our interest is in wound healing and the approach covers animal as well as patient studies including four current clinical trials. One NIGMS project focus on tissue oxygenation while the other focuses on microRNA. At this presentation, I plan to discuss our key findings in the brain and follow that up with a discussion on the significance of microRNA in the heart and skin. In addition to novel mechanisms which may be of interest to a few in the audience, my goal will be to share my experience in trying to develop an interdisciplinary research program only a part of which relies on my specific expertise – the rest depends on strengths of others with the overriding goal being to do what it takes to solve a problem.
Biographical Information: Chandan Sen
Dr. Chandan Sen is the Associate Dean for Translational and Applied Research at The Ohio State University Medical Center. He also directs the Medical Center's Technology Commercialization and Industry Partnership program. Dr. Sen is a Professor and Vice Chair (Research) of Surgery. His research program is housed in the Davis Heart and Lung Research Institute where he serves as a Deputy Director and Director of the Regenerative Medicine Program. He is the Director of the OSU Comprehensive Wound Center. Dr. Sen is the Program Director of two programs in the CCTS Pilot Studies and Novel Clinical and Translational Methodologies Programs. After completing his Masters of Science in Human Physiology from the University of Calcutta, Dr. Sen received his PhD in Physiology from the University of Kuopio in Finland. Dr. Sen trained as a postdoctoral fellow at the University of California at Berkeley's Molecular and Cell Biology department. His first faculty appointment was in the Lawrence Berkeley National Laboratory in California. In fall of 2000, Dr. Sen moved to The Ohio State University where established a program on tissue injury and repair. Dr. Sen is a widely recognized expert in redox and oxygen biology. He is the Editor-in-Chief of the #1 rated journal in redox biology Antioxidants & Redox Signaling. He is also an Associate Editor of the prestigious American Physiological Society journal Physiology Genomics. He is the Editor-in-Chief of the Wound Healing Society's yearbook Advances in Wound Care. Dr. Sen has published ten books and over 250 research publications, over 150 of which are from OSU during his 10 years. He is cited over 700 times a year in the literature.