BME Seminar

M.L. Raghavan: “Characterizing motion of the Human Lung”

All dates for this event occur in the past.

145 Mount Hall
1050 Carmack Rd
Columbus, OH 43210
United States

Biomedical Engineering Seminar
Thursday 2/1/2011, 4-5PM
Mount Hall (West Campus), Room 145
 
"Characterizing Motion of the Human Lung"
by
 
Madhavan L. Raghavan, PhD
Associate Professor
Department of Biomedical Engineering
University of Iowa
 
Abstract:
This talk will focus on an ongoing project in pulmonary biomechanics. Characterizing the regional deformation of the lung during breathing can help us better understand the underlying mechanics of lung function, diagnose presence and severity of localized disease states and assess effectiveness of interventions. Deformation may be characterized by principal strains, but they do not have direct physiological relevance. Alternatively, regional volume change is physiologically intuitive, but does not characterize all aspects of deformation. For instance, a region may undergo no volume change, but still have deformed significantly – say, when the lengthening in one direction is compensated by contraction along another direction. The deformation of the lung is captured using three indices: the Jacobian – volume change; an anisotropic deformation index – a measure of the level of directional preference during volume change; and a slab-rod index – a measure of the nature of directional preference in volume change. Further, the sliding across lobar and chest wall boundaries are also captured using a localized max shear-type index, allowing for a quantification of sliding in the lungs experienced during breathing. The utility of these indices are demonstrated on a healthy human study population.

Biographical Information: M.L. Raghavan Ph.D.

Dr. Madhavan L. Raghavan, Ph.D., is an Associate Professor of Biomedical Engineering and Director of the BioMechanics of Soft Tissues (BioMOST) Division, Center for Computer Aided Design at University of Iowa. He obtained his Ph.D. in Bioengineering from University of Pittsburgh. Dr. Raghavan’s research focus is in applying principles in engineering mechanics to understanding, diagnosing, and treating disease states in the cardiopulmonary system. A significant focus area in his lab is the biomechanics of natural history and treatment of arterial aneurysms. Research methods include: device development – prosthetic heart valves and stent grafts; experimentation – tissue and device testing; and computational modeling – geometric modeling, computational fluid dynamics, and finite element methods.