The Department of Biomedical Engineering & the Department of Chemical & Biomolecular Engineering Present the Following Seminar
Despite revolutionary developments in precision engineering of nanoparticles, nanomedicine successes in the clinic have been rare. This is mainly attributable to poor delivery to disease sites. I will describe my path to address these issues, starting briefly with non-invasive imaging approaches and computational simulations that uncover the complexity of nanoparticle targeting to cancer. I will discuss how nanoparticle imaging in living subjects led me to develop a novel ‘immune nanomedicine’ approach. Exploiting the native advantages of the immune system to deliver nanoparticle cargoes to disease sites, the power of this approach lies in its simplicity and reliability. It circumvents previous delivery issues by avoiding key biobarriers to nanoparticle transport, and could provide unprecedented flexibility in reliably targeting payloads to disease sites. I will illustrate the potential of this immune-based approach for multi-modal imaging diagnostics and/or therapeutics through an oncology imaging application, and will discuss how I intend to clinically translate nanomedicines.
After receiving his Bachelor’s degree in Physics, Mathematics, and Biomedical Engineering at Tufts University, Bryan Smith completed his Ph.D. in Biomedical Engineering as an NSF IGERT Fellow at The Ohio State University working in cancer nanotechnology. He moved to Stanford University for his post-doctoral work, where he was awarded a Stanford Molecular Imaging Scholar NIH Fellowship as well as a Stanford Dean's Fellowship. He was granted K99/R00 NIH Pathway to Independence and AACR (American Association of Cancer Research) awards for his work in cancer nanomedicine.