BME Seminar Series: Kyle Bodnyk & Ryan Oba
Kyle Bodnyk Abstract:
"The Long-Term Residual Effects of Low Intensity Vibration on Skeletal Health"
The mechanical environment of bone plays an important role in developing and maintaining a healthy skeletal system. Bone adapts to the loads it experiences. Moderate load activities such as walking induce an anabolic response, remodeling bone to keep up with the mechanical demands of walking. On the other hand, bone is minimally loaded during bedrest and in space, causing bone resorption. Bone resorption can also occur due to osteoporosis, a common degenerative bone disease that manifests in debilitating fractures. Current osteoporosis treatments are drugs that are minimally effective. As an alternative, low intensity vibration (LIV) may improve skeletal health without potential side effects from drugs. LIV mimics the muscle induced strains applied to bone during passive activity that keep the skeleton healthy. Previous studies have shown LIV increases bone mineral density (BMD) and morphometric parameters. Although benefits occur during LIV treatment, once treatment is over, we don’t know if the benefits are maintained over a long period of time. The objective of this study is to elucidate long-term bone heath, post LIV treatment, using a murine model.
Ryan Oba Abstract:
"Effect of Sinotubular Junction Size on Aortic Sinus Hemodynamics"
Ryan's research explores the biomechanical etiology of calcific aortic valve disease. The project he will be presenting focuses on changes to aortic sinus hemodynamics due to changes in size of the sinotubular junction, which is known to idiopathically dilate in the elderly. His project also explores other factors such as heart rate, blood pressure, and coronary flow. Flow visualization is assessed through particle image velocimetry, with streak plots, velocity and vorticity contours, and leaflet shear stress profiles providing additional insight into the changes in aortic sinus hemodynamics.