BME Seminar Series: Dr. Crystal M. Ripplinger, University of California Davis
"The Nervous Heart"
Cardiac function is fine-tuned by the autonomic nervous system. Emerging clinical evidence suggests that either too much or too little sympathetic nerve input to the heart can lead to lethal cardiac arrhythmias. This talk will cover sympathetic nerve remodeling following myocardial infarction and the role of sympathetic activity in leading to ventricular arrhythmias. Using animal models of myocardial infarction and novel in vivo neuro-modulatory approaches, we have probed the interplay between myocardial and nerve remodeling in contributing to cardiac arrhythmias.
Dr. Ripplinger is an Associate Professor and Vice Chair for Research in the Department of Pharmacology at UC Davis. She received her BS degree in Electrical Engineering from North Dakota State University. She subsequently earned her MS and PhD degrees in Biomedical Engineering from Washington University in St. Louis. After spending time as a postdoctoral fellow at Harvard University and Massachusetts General Hospital, she was appointed in 2010 as an Assistant Professor in the Department of Pharmacology at UC Davis. Dr. Ripplinger's research focusses on the role of the autonomic nervous system in influencing cardiac electrophysiology and contributing to ventricular arrhythmias. Her work uses state-of-the-art optical imaging and neuro-modulatory approaches to assess the impact of autonomic input to the heart in health and disease.