BME Seminar Series: Dr. Tendy Chiang, Nationwide Children's Hospital

 

 

In the last decade, the lack of surgical options to treat long-segment tracheal defects had accelerated human implantation of tissue engineered tracheal grafts (TETG). Early outcomes in the use of decellularized scaffolds evolved into the use of synthetic polymers to spare the need for donor tissue. However, human outcomes with synthetic tracheal replacement has been fraught with complications including stenosis, delayed epithelialization, the need for explantation, and death. In addition, controversy in clinical reports have emphasized the need for further pre-clinical testing. The goal of this seminar is to review the recent history of tissue engineered tracheal replacement and to discuss strategies to advance the field of airway tissue engineering through team science.

 

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