BME Seminar Series: Dr. Sandor Gyorke - The Ohio State University
"Integration of calcium signaling mechanisms in cardiac myocytes and heart disease"
Calcium ions (Ca2+) play a central role in the operation of the heart, including activation of the heartbeat, and alterations in Ca2+ handling have been implicated in diseases, such as cardiac arrhythmia and heart. The seminar will review the principal types of Ca2+ signaling mechanisms in cardiac myocytes, including release of Ca2+ from the sarcoplasmic reticulum (SR) and store-operated Ca2+ entry (SOCE), their subcellular organization, molecular components and target effectors. The seminar will also discuss how spatially and temporally different Ca2+ signals are integrated within cardiac cells to regulate various functions and how alterations of Ca2+ handling result in arrhythmia and heart failure.
Dr. Sandor Gyorke is a Professor of Physiology and Cell Biology at the Ohio State University. He received his Ph.D. at the Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Sciences in St. Petersburg, and then completed postdoctoral training at the University of Texas Medical Branch at Galveston. Dr. Gyorke’s studies have focused on processes that control excitation-contraction coupling and calcium handling in cardiac myocytes and how alterations of calcium results in cardiac diseases such as arrhythmia and heart failure.