2022
26. Jones CE, Sharick JT, Sizemore ST, Cukierman E, Strohecker AM, Leight JL. A miniaturized screening platform to identify novel regulators of extracellular matrix alignment. Cancer Research Communications. Nov 2022. (Link)
25. Sharick JT, Atieh AJ, Gooch KJ, Leight JL. Click chemistry functionalization of self-assembling peptide hydrogels. Journal of Biomedical Materials Research Part A, Oct 10, 2022. (Link)
24. Nairon KG, DePalma TJ, Zent JM, Leight JL, Skardal A. Tumor cell-conditioned media drives collagen remodeling via fibroblast and pericyte activation in an in vitro premetastatic niche model. iScience 25 (7), 104645, 2022. (Link)
2021
23. Drain AP, Zahir N, Northey JJ, Zhang H, Huang P, Maller O, Lakins JN, Yu X, Leight JL, Alston-Mills BP, Hwang ES, Chen Y, Park CC, Weaver VM. Matrix compliance permits NF-kB activation to drive therapy resistance in breast cancer. J of Experimental Medicine, May 3, 2021. (Link)
22. Jones CE, Sharick JT, Colbert SE, Shukla VC, Zent JM, Ostrowski MC, Ghadiali SN, Sizemore ST, Leight JL. Pten regulates collagen fibrillogenesis by fibroblasts through SPARC. PLoS One, Feb 3; 16(2), 2021. (Link)
2020
21. Wormsbaecher C, Hindman AR, Avendano A, Cortes-Medina M, Jones CE, Bushman A, Onua L, Kovalchin CE, Murphy AR, Helber HL, Shapiro A, Voytovitch K, Kuang X, Aguilar-Valenzuela R, Leight JL, Song JW, Burd CJ. In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness. Breast Cancer Research, 2020. (Link)
2019
20. Casadei L, Calore F, Braggio DA, Zewdu A, Deshmukh AA, Fadda P, Lopez G, Wabitsch M, Song C, Leight JL, Grignol VP, Lev D, Croce CM, Pollock RE. MDM2 Derived from Dedifferentiated Liposarcoma Extracellular Vesicles Induces MMP2 Production from Preadipocytes. Cancer Research, 2019. (Link)
19. Campbell WA 4th, Deshmukh AA, Blum S, Todd L, Mendonca N, Weist JL, Zent J, Hoang TV, Blackshaw S, Leight JL, Fischer AJ. Matrix-metalloproteinase expression and gelatinase activity in the avian retina and their influence on Müller glia proliferation. Experimental Neurology, Jun 25; 320:112984, 2019. (Pubmed)
18. Fakhouri AS, Weist JL, Tomusko AR, Leight JL. High Throughput 3D Hydrogel Cell Encapsulation Assay for Measuring Matrix Metalloproteinase Activity. ASSAY and Drug Development Technologies, Apr 17(3): 100-115, 2019. (Link)
17. Fakhouri AS, Leight JL. Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels. Journal of Visualized Experiments, e59123, doi:10.3791/59123, 2019. (Link)
16. Jones CE, Hammer AM, Cho Y, Sizemore GM, Cukierman E, Yee LD, Ghadiali SN, Ostrowski MC, Leight JL. Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary Gland. Neoplasia. Jan 21(1): 132–145, 2019. (Link)
2018
15. Deshmukh AA, Weist JL, Leight JL. Detection of Protease Activity by Fluorescent Peptide Zymography. Journal of Visualized Experiments, e58938, doi:10.3791/58938, 2018. (Link)
14. Deshmukh AA, Weist JL, Leight JL. Detection of proteolytic activity by covalent tethering of fluorogenic substrates in zymogram gels. Biotechniques. 64(5):203-210, 2018. (Link)
13. Barnhouse VR*, Weist JL*, Shukla VC, Ghadiali SN, Kniss DA, Leight JL. Myoferlin Regulates Epithelial Cancer Cell Plasticity and Migration through Autocrine TGF-β1 Signaling. Oncotarget. 9 (27):19209–19222, 2018. (Link)
12. Shin DS, Tokuda EY, Leight JL, Miksch CE, Brown TE, Anseth KS. Synthesis of microgel sensors for spatial and temporal monitoring of protease activity. ACS Biomaterials Science and Engineering. 4(2):378-387, 2018. (Pubmed)
11. Shukla V, Barnhouse V, Ackerman WE, Summerfield TL, Powell HM, Leight JL, Kniss DA, Ghadiali SN. Cellular Mechanics of Primary Human Cervical Fibroblasts: Influence of Progesterone and a Pro-Inflammatory Cytokine. Annals of Biomedical Engineering. Jan;46(1):197-207, 2018. (Pubmed)
2017
10. Leight JL*, Drain AP*, Weaver VW. Extracellular Matrix Remodeling and Stiffening Modulate Tumor Phenotype and Treatment Response. Annu Rev Cancer Biol.1:313-334, 2017.
2015
9. Leight JL*, Tokuda EY*, Jones CE, Lin AJ, Anseth KS. Multifunctional bioscaffolds for 3D culture of melanoma cells reveal increased MMP activity and migration with BRAF kinase inhibition. Proc Natl Acad Sci U S A. 112(17):5366-71, 2015. (Pubmed)
8. Sridhar BV, Brock JL, Silver JS, Leight JL, Randolph MA, Anseth KS. Development of a Cellularly Degradable PEG Hydrogel to Promote Articular Cartilage Extracellular Matrix Deposition. Adv Healthc Mater. 4(5):702-13, 2015. (Pubmed)
2014
7. Tokuda EY, Leight JL, and Anseth KS. Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness. Biomaterials. 35(14):4310-8, 2014. (Pubmed)
2013
6. Leight JL, Alge DA, Maier AJ, and Anseth KS. Direct measurement of matrix metalloproteinase activity in 3D cellular microenvironments using a fluorogenic peptide substrate. Biomaterials. 34(30):7344-52, 2013. (Pubmed)
2012
5. Leight JL*, Liu WL*, Chaturvedi RR, Chen S, Yang MT, Raghavan S, and Chen CS. Manipulation of 3D cluster size and geometry by release from 2D micropatterns. Cellular and Molecular Bioengineering. 5(3):299-306, 2012. (Pubmed)
4. Leight JL, Wozniak MA, Chen S, Lynch ML, and Chen CS. Matrix rigidity regulates a switch between TGF-β1-induced apoptosis and epithelial-mesenchymal transition.Molecular Biology of the Cell. 23(5):781-91, 2012. (Pubmed) Highlighted by Faculty of 1000, March 2012
2009
3. Gehler S, Baldassarre M, Lad Y, Leight JL, Wozniak MA, Riching KM, Eliceiri KW, Weaver VM, Calderwood DA, and Keely PJ. Filamin A-{beta}1 Integrin Complex Tunes Epithelial Cell Response to Matrix Tension. Molecular Biology of the Cell. 20(14): p3224-3238, 2009. (Pubmed)
2007
2. Johnson KR, Leight JL, and Weaver VM. Demystifying the Effects of a Three-Dimensional Microenvironment in Tissue Morphogenesis. Methods in Cell Biology. 83: p539-575, 2007. (Pubmed)
1. Janmey PA, McCormick ME, Rammensee S, Leight JL, Georges PC, and Mackintosh FC. Negative normal stress in semiflexible biopolymer gels. Nature Materials. 6(1):p48-51, 2007. (Pubmed)
Bold highlights Leight lab members
*both authors contributed equally to this work
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