Struckman’s paper published in Microscopy & Microanalysis journal

BME graduate student Heather Struckman’s paper "Super-Resolution Imaging Using a Novel High-Fidelity Antibody Reveals Close Association of the Neuronal Sodium Channel NaV1.6 with Ryanodine Receptors in Cardiac Muscle" was recently published in the February 2020 issue of Microscopy & Microanalysis with images from the article featured on the journal cover. Struckman has earned a cover with her very first paper as primary author.

The manuscript is the product of a collaboration between BME assistant professor Rengasayee (Sai) Veeraraghavan’s lab and Dr. Przemyslaw (Prez) Radwanski (OSU college of Pharmacy). They generated and rigorously validated a novel antibody against a brain-type sodium channel protein, named because it was first recognized in the brain, and used to investigate three presence of this protein in the heart.  Using multiple microscopy approaches they found that it is expressed in the transverse tubules of cardiac muscle cells, in close proximity (<50 nanometers) to ryanodine receptor calcium release channels.  This has major implications for a variety of heart diseases where abnormal sodium influx near ryanodine receptors dysregulates sodium-calcium dynamics and leads to life-threatening irregular heartbeats.

Cover photo credit of Microscopy society of America/ Cambridge University Press