Swindle-Reilly's research group featured on cover of Journal of Controlled Release

A team of researchers, led by Katelyn Swindle-Reilly, assistant professor, departments of Biomedical Engineering (BME), Chemical and Bimolecular Engineering (CBE), and Ophthalmology, had their research published in the Journal of Controlled Release, as well as on the journal cover. The research article, “Injectable biodegradable bi-layered capsule for sustained delivery of bevacizumab in treating wet age-related macular degeneration”, introduces a new mechanism for the long-term release of bevacizumab, a drug used to treat wet age-related macular degeneration. Previously, maintaining high concentrations of bevacizumab (anti-VEGF) in the body was difficult due to insufficient drug loading capacity and drug-device interactions. To overcome this, the team developed a polymeric based bi-layered capsule that could address these challenges by extending the release over one year, thereby providing an effective platform to enable treatment of chronic vascular diseases. By providing optimal physical trapping and electrostatic interaction, the capsule structure ensures the appropriate release of bevacizumab over time.

The research team consisted of Katelyn Swindle-Reilly, PhD, assistant professor (BME, CBE, and Ophthalmology), Pengfei Jiang, PhD student (CBE), Andre Palmer, PhD, professor (CBE), Matthew Ohr, MD, physician and associate professor (Ophthalmology), John Lannutti, PhD, professor (MSE), Francisco Chaparro, PhD graduate (MSE), and Clayton Cuddington, PhD student (CBE).

Congratulations Dr. Swindle-Reilly and Team!