Ocular Aging and Trauma Laboratory
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Ocular Aging and Trauma Laboratory
By combining computational and experimental biomechanics, custom instrumentation, as well as biochemical and optical techniques, we develop mechanistic insights, diagnostics, and treatments for visual deficits arising from aging and trauma.
News
PhD Candidate Annie Ryan awarded Vision Research Fellowship grant
September 6, 2023
PhD Candidate Annie Ryan awarded Vision Research Fellowship grant
Former Student Honored
August 14, 2018
Former Student Honored
Graduate Student Honored
June 16, 2017
Graduate Student Honored
Former Student Honored
September 15, 2016
Former Student Honored
Research
The Ocular Aging and Trauma Laboratory studies the biomechanical mechanisms leading to age- and trauma-related problems with the eye and visual system. Experimental and computational approaches are used to examine length scales spanning from molecular- to organ-level. For example, cellular and/or biochemical events accumulating over a period of decades may contribute to macroscopic changes in the optical and mechanical properties of the ocular lens. During traumatic injury, mechanical insults to the eye lasting only milliseconds can have downstream biological effects over periods of weeks or months.
Accommodation, Presbyopia, and Cataract
Accommodation is the ability of the eye to increase its optical power to allow clear vision when vieweing nearby objects. Presbyopia is the progressive loss of accommodation ability with age. The biomechanical driving force(s) for presbyopia remain poorly understood. We use a combination of custom mechanical instrumentation, computational mechanics, and biochemical methods to simulate various aspects of aging on laboratory timescales to gain insights into the natural aging process.
Current Projects
- Biomechanical phenotyping of mouse lenses
- Biomolecular mechanisms of lens stiffening
- Lens epithelial cell mechanobiology
Trauma to the Eye and Optic Nerve
Ocular trauma is the fastest growing type of injury in both civilian and military settings. We use a combined experimental/computational approach to understand the mechanisms of trauma to the eye and optic nerve arising from blast exposure and blunt impact. These models are used to develop diagnostic criteria, evaluate potential therapeutics, and design new protective equipment.
Current Projects
- Pathophysiology of traumatic optic neuropathy
- Novel diagnostics and treatmet of traumatic optic neuropathy
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Accordions
Peer-Reviewed Journal Articles
2022
- Martin, J.B., Herman, K., Houssin, N.S., Rich, W., Reilly, M.A., Plageman, T.F., Arvcf dependent adherens junction stability is required to prevent age-related cortical cataracts. Frontiers in Cell and Developmental Biology, 2022;10:840129.
- Maxwell, C.J., Soltisz, A.M., Rich, W.W., Choi, A., Reilly, M.A., Swindle-Reilly, K.E., Alginate Hydrogels as Injectable Drug Delivery Vehicles for Optic Neuropathy Treatment. Journal of Biomedical Materials Research A, 2022;110:1621-1635.
- Yousefi, A., Roberts, C., Reilly, M.A., The Shape of Corneal Deformation Alters Air Puff-Induced Loading, Frontiers in Bioengineering and Biotechnology, 2022, 10:848060.42.
- Luo, R.H., Tram, N.K., Parekh, A.M., Puri, R,. Reilly, M.A., Swindle-Reilly, K.E., The Roles of Vitreous Biomechanics in Ocular Disease, Biomolecule Transport, and Pharmacokinetics, Current Eye Research, 2022, 18:1-13.
- Yousefi, A., Ma, Y., Roberts, C.J., Moroi, S.E., Reilly, M.A., Hydrodynamic Interaction Between Tear Film and Air Puff from Noncontact Tonometry. Translational Vision Science and Technology, 2022, 11(2):e2.
2021
- 40. Rodriguez, J., Reilly, M.A., Mecham, R.P., Bassnett, S., Biological Preparation and Mechanical Technique for Determining Viscoelastic Properties of Zonular Fibers. Journal of Visualized Experiments, 2021, 178:e63171.
- Shi, Y., Jones, W., Beatty, W., Tan, Q., Mecham, R., Reilly, M.A., Rodriguez, J., Bassnett, S., Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers. Matrix Biology, 2021,
- 95:15-31.
2020
- Kumar, B., Reilly, M.A., The Development, Growth, and Regeneration of the Crystalline Lens: A Review. Current Eye Research, 2020; 45(3):313-326.
- Nguyen, B.A., Reilly, M.A., Roberts, C.J., Biomechanical contribution of the sclera to dynamic corneal response in air-puff induced deformation in human donor eyes. Experimental Eye Research, 2020, 191:107904 (5 pages).
- Tram, N.K., Jiang, P., Jacobs, K.M., Ruzga, M.N., Allen, M.G., Prieto, R.P., Carus, S.A., Reilly, M.A., Swindle-Reilly, K.E., Biomechanical Influence of Accommodative Tissues on Corneal Morphogenesis. Journal of Biomechanics, 2020, 100:109582 (9 pages).
2019
- Gu, S., Biswas, S., Rodriguez, L., Li, Z., Li, Y., Riquelme, M.A., Shi, W., Wang, K., White, T.W., Reilly, M.A., Lo, W.-K., Jiang, J.X., Connexin 50 and AQP0 are Essential in Maintaining Organization and Integrity of Lens Fibers. Investigative Ophthalmology and Visual Science, 2019, 60:4021-4032.
- Kumar, B., Chandler, H., Plageman, T., Reilly, M.A., Lens Stretching Modulates Lens Epithelial Cell Proliferation via YAP Regulation. Investigative Ophthalmology and Visual Science, 2019, 60:3920–3929.
- Rios, J.D., Choi, J.H., McDaniel, J., Becera, S., Bice, L., Johnson, P., Cleland, J.M., Glickman, R.D., Reilly, M.A., Gray, W., Sponsel, W.E., Lund, B.J., Altered Expression of Aquaporin 1 and Aquaporin 5 in the Cornea After Primary Blast Exposure. Molecular Vision, 2019, 25:283-294.
- Nguyen, B.A., Roberts, C.J., Reilly, M.A., Biomechanical impact of the sclera on corneal deformation response to an air-puff: a finite element study. Frontiers in Bioengineering and Biotechnology, 2019, 6:210 (8 pages).
2018
- Hogrebe, N., Reinhardt, J.W., Tram, N., Reilly, M.A., Gooch, K.J., Independent control of matrix adhesiveness and stiffness within a 3D self-assembling peptide hydrogel. Acta Biomateriala, 2018;70:110-119.
2017
- Sponsel, W.E., Johnson, S.L., Trevino, R., Gonzalez, A., Groth, S.L., Majcher, C., Fulton, D.C., Reilly, M.A., Pattern Electroretinography and Visual Evoked Potentials Provide Clinical Evidence of CNS Modulation of High- and Low-Contrast VEP Latency in Glaucoma. Translational Vision Science and Technology, 2017;6(6.6):1-11.
- Reilly, M.A., Cleaver, A., Inverse Elastographic Method for Analyzing the Ocular Lens Compression Test. Journal of Innovative Optical Health Sciences, 2017;10(6):1742009
- Balikov, D.A., Crowder, S.W., Boire, T.C., Lee, J.B., Gupta, M.K., Fenix, A.M., Lewis, N.L., Ambrose, C.M., Short, P.A., Kim, C.S., Burnette, D.T., Reilly, M.A., Murthy, S., Kang, M.L., Kim, W.S., Sung, H.-K., Tunable Surface Repellency Maintains Stemness and Redox Capacity of Human Mesenchymal Stem Cells. ACS Applied Material Interfaces, 2017;9(27):22994-23006.
- Bonugli, E., Cormier, J., Reinhart, L.H., Reilly, M.A., Replicating Real-World Friction of Motorcycle Helmet Impacts and its Effects on Head Injury Metrics. SAE Technical Papers, 2017 1:1433.
- Kotzur, T., Benavides-Garcia, R., Mecklenburg, J., Sanchez, J.R., Reilly, M.A., Hermann, B.P., Granulocyte Colony-Stimulating Factor (G-CSF) Promotes Spermatogenic Regeneration From Surviving Spermatogonia After High-Dose Alkylating Chemotherapy. Reproductive Biology and Endocrinology, 2017; 15(1):7.
2016
- Jones, K.R., Choi, J.H., Sponsel, W.E., Gray, W., Groth, S.L., Glickman, R.D., Lund, B.J., Reilly, M.A., Low-Level Primary Blast Causes Significant Ocular Injuries in Rabbits. Journal of Neurotrauma, 2016, 33(13):1194-1201.
- Reilly, M.A., Martius, P., Kumar, S., Burd, H.J., Stachs, O., The Mechanical Response of the Young Porcine Lens to a Spinning Test. Zeitschrift für Medizinische Physik, 2016, 26(2):127-135.
- Marinkovic, M., Block, T.J., Rakian, R., Li, Q., Wang, E., Reilly, M.A., Dean, D.D., Chen, X.D., One size does not fit all: Developing a cell-specific niche for in vitro study of cell behavior. Matrix Biology, 2016, 44-45:426-441.
- Wilkes, R.P., Reilly, M.A., A pre-tensioned finite element model of ocular accommodation and presbyopia. International Journal of Advances in Engineering Sciences and Applied Mathematics, 2016, 8(1):25–38.
2015
- Rex, T., Reilly, M.A., Sponsel, W.E., Elucidating the effects of primary blast on the eye. Clinical and Experimental Ophthalmology, 2015;43(3):197–199.
- Watson, R., Gray, W., Sponsel, W.E., Lund, B.J., Glickman, R.D., Reilly, M.A., Simulations of Porcine Eye Exposure to Primary Blast Insult. Translational Vision Research and Technology, 2015, 4(4):1-11.
- Reilly, M.A., Villareal, A., Maddess, T., Sponsel, W.E., Refined Frequency Doubling Perimetry Analysis Affirms Central Nervous System Control of Chronic Glaucomatous Neurodegeneration. Translational Vision Science and Technology, 2015, 4(3):1-12.
- Benavides-Garcia, R., Joachim, R.C., Pina, N.A., Mutoji, K.N., Reilly, M.A., Her-mann, B.P. Granulocyte colony-stimulating factor prevents loss of spermatogenesis after sterilizing busulfan chemotherapy. Fertility and Sterility, 2015, 103(1):270–280.
2014
- Reilly, M.A., A Quantitative Geometric Mechanics Lens Model: Insights into the Mechanisms of Accommodation and Presbyopia. Vision Research, 2014, 113:20–31.
- Sponsel, W.E., Groth, S.L., Satsangi, N., Maddess, T., Reilly, M.A., Refined Data Analysis Provides Clinical Evidence for Central Nervous System Control of Chronic Glaucomatous Neurodegeneration. Translational Vision Science and Technology, 2014, 3(3):1–13.
- Sherwood, D., Sponsel, W.E., Lund, B.J., Gray, W.M., Watson, R., Groth, S., Thoe, K., Glickman, R.D., Reilly, M.A., Anatomical Manifestations of Primary Blast Ocular Trauma Observed in a Postmortem Porcine Model. Investigative Ophthalmology and Visual Science, 2014, 55(2):1124–1132.
2012
- Du, H., Hamilton, P., Reilly, M.A., Ravi, N., Injectable in situ Physically and Chemically Crosslinkable Gellan Hydrogel. Macromolecular Biosciences, 2012, 12(7):952–961.
2010
- Reilly, M.A., Andley, U.P., Quantitative Biometric Phenotype Analysis in Mouse Lenses. Molecular Vision, 2010, 16:1041–1046.
- Andley, U.P., Reilly, M.A., In Vivo Lens Deficiency of the R49C αA-Crystallin Mutant. Experimental Eye Research, 2010, 90(6):699–702.
- Reilly, M.A., Ravi, N., A Geometric Model of Ocular Accommodation. Vision Research, 2010, 50:330–336.
2009
- Du, H., Hamilton, P.D., Reilly, M.A., d’Avignon, A., Ravi, N., A Facile Synthesis of Highly Water-Soluble, Core-Shell Organo-Silica Nanoparticles with Controllable Size via Sol-Gel Process. Journal of Colloid and Interface Science, 2009, 340:202–208.
- Reilly, M.A., Hamilton P.D., Perry G., Ravi N., Comparison of the Behavior of Natural and Refilled Porcine Lenses in a Robotic Lens Stretcher. Experimental Eye Research, 2009, 88(3):483–494.
- Reilly, M.A., Ravi N., Microindentation of the Young Porcine Ocular Lens. Journal of Biomechanical Engineering, 2009, 131(4):044502.
- Reilly, M.A., Perry G., Ravi N., A Dynamic Microindentation Device with Electrical Contact Detection. Review of Scientific Instruments, 2009, 80(1):015105.
2008
- Reilly, M.A., Rapp B., Hamilton P.D., Shen A.Q., Ravi N., Material Characterization of Porcine Lenticular Soluble Proteins. Biomacromolecules, 2008, 9(6):1519–1526.
- Reilly, M.A., Hamilton P.D., Ravi N., Dynamic Multi-Arm Radial Lens Stretcher: A Machine Analog of the Ciliary Body. Experimental Eye Research, 2008, 86(1):157–164.
Book Chapters
- Reilly, M.A., Accommodation and Presbyopia, in: Biomechanics of the eye. C.J. Roberts, W.J. Dupps, and J.C. Downs, ed., Kugler Publications, Amsterdam, The Netherlands, 2018.
- Swindle-Reilly, K.E., Reilly, M.A., Ravi, N., Current Concepts in the Design of Hydrogels as Vitreous Substitutes, in: Biomaterials and regenerative medicine in ophthalmology, 2nd edition; T.V. Chirila, ed., Woodhead Publishing Ltd., Cambridge, UK, 2016.
- Reilly, M.A., Swindle-Reilly, K.E., Ravi, N., Hydrogels for Intraocular Lenses and Other Ophthalmic Prostheses, in: Biomedical hydrogels: Biochemistry, manufacture, and medical applications. S. Rimmer, ed., Woodhead Publishing Ltd., Cambridge, UK, 118-148, 2011.
NLM MyBibliography
http://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/47545033
Current Federal Grant Support
DOD CDMRP Vision Research Program
- W81XWH-15-1-0074: Torsion-Induced Traumatic Optic Neuropathy (TITON): Animal Model for Diagnostics, Drug Delivery, and Therapeutics for Injuries to the Central Nervous System
- W81XWH-22-1-0989: Therapeutic Screening for Traumatic Optic Neuropathy
National Eye Institute
- 1R01EY033815-01: Elucidation of Arvcf-dependent mechanisms required for lens function
Information
Department of Biomedical Engineering
Ocular Aging and Trauma Laboratory
4120 Fontana Laboratories
140 W. 19th Avenue
Columbus, OH 43210
