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Gunjan Agarwal

  • Professor, Biomedical Engineering
  • 296 Bevis Hall
    1080 Carmack Road
    Columbus, OH 43210
  • 614-292-4213

About

Education

· B.S. (Physics, Math, Computer Science), J. K. Institute of Applied Physics, University of Allahabad, India, 1991
· M.S. (Physics), Indian Institute of Technology, Delhi, India, 1993
· Ph.D. (Biophysics), Tata Institute of Fundamental Research, Mumbai, India, 1997
 

Key Honors and Distinctions

Elizabeth L. Gross Award for faculty excellence by the OSU Biophysics Graduate Program (2018)
Outstanding reviewer for the journal Nanomedicine: Nanotechnology, Biology, Medicine (2017)
CEOS-Connect award for professional networking from NSF-Advance program at OSU (2013)
Young Scientists award by the Davis Heart and Lung Research Institute, OSU (2005)
 

RESEARCH AREAS 

· Biomaterials (extracellular matrix); Biomechanics; Biomineralization; Collagen receptors; Vascular biology; Biomedical applications of atomic force microscopy
· Graduate student research opportunities are currently available
 
PUBLICATIONS
 
 
Professor Agarwal’s research focusses on extracellular matrix (ECM) remodeling via the collagen receptors discoidin domain receptors (DDRs). We seek to answer fundamental questions pertaining to collagen fibrillogenesis and receptor function at the cell-matrix interface. Our approach encompasses a variety of microscopy techniques to understand the structure and function of the ECM in vascular diseases such as aneurysms and thrombosis. Another parallel vector of our research is to develop novel biomedical applications of the AFM. We have developed many aspects of magnetic force microscopy to study nanoparticle behavior and tissue iron deposits in health and disease. Professor Agarwal has also established and directs a multi-user Bio-AFM core facility at OSU.
 

Honors

  • January, 2018

    Elizabeth L. Gross Award for Faculty Excellence.

  • January, 1992

    Junior Research Fellowship.

Chapters

2016

  • Agarwal, G.. 2016. "DDRs and collagen fibrillogenesis." In Discoidin Domain Receptors in Health and Disease,

2009

  • 2009. "Characterization of Magnetic Nanomaterials using Magnetic Force Microscopy." In Magnetic Nanomaterials for Life Sciences, edited by Challa Kumar,

2008

  • 2008. "Introduction to Biological Light Microscopy." In Microscopic Image Analysis for Life Science Applications, edited by Jens Rittscher, Stephen T.C. Wong, and Raghu Machiraju,

2001

  • Wright-Smith, C.; Smith, C.M.. 2001. "Atomic force microscopy."

Journal Articles

2020

  • Agarwal, G.; Jones, B.; Tonniges, J.; Debski, A. et al., 2020, "Collagen fibril abnormalities in mice and human abdominal aortic aneurysm." Acta Biomaterialia
  • Hans, C.P.; Sharma, N.; Dev, R.; Blain, J.M. et al., 2020, "DAPT, a potent Notch inhibitor regresses actively growing abdominal aortic aneurysm via divergent pathways.." Clin Sci (Lond) 134, no. 12, 1555-1572 - 1555-1572.

2019

  • Fridman, R.; Agarwal, G., 2019, "New Concepts on the Interactions of Discoidin Domain Receptors with Collagen." BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1866, no. 11,
  • Chavez, M.B.; Kolli, T.N.; Tan, M.H.; Zachariadou, C. et al., 2019, "Loss of Discoidin Domain Receptor 1 Predisposes Mice to Periodontal Breakdown.." J Dent Res 98, no. 13, 1521-1531 - 1521-1531.
  • Sifford, J.; Walsh, K.J.; Tong, S.; Bao, G. et al., 2019, "Indirect magnetic force microscopy.." Nanoscale Adv 1, no. 6, 2348-2355 - 2348-2355.
  • Yeung, D.A.; Shanker, N.; Sohail, A.; Weiss, B.A. et al., 2019, "Clustering, Spatial Distribution, and Phosphorylation of Discoidin Domain Receptors 1 and 2 in Response to Soluble Collagen I.." J Mol Biol 431, no. 2, 368-390 - 368-390.
  • Farzadi, A.; Renner, T.; Calomeni, E.; Presley, K. et al., 2019, "Modulation of biomimetic mineralization of collagen by soluble ectodomain of discoidin domain receptor 2." Materials Science & Engineering C-Materials for Biological Applications 104, 109905-109905 - 109905-109905.
  • Agarwal, G.; Smith, A.W.; Jones, B., 2019, "Discoidin domain receptors: Micro insights into macro assemblies.." Biochim Biophys Acta Mol Cell Res 1866, no. 11, 118496 - 118496.

2018

  • Blissett, A.R.; Deng, B.; Wei, P.; Walsh, K.J. et al., 2018, "Sub-cellular In-situ Characterization of Ferritin(iron) in a Rodent Model of Spinal Cord Injury.." Sci Rep 8, no. 1, 3567 - 3567.
  • Hogrebe, N.J.; Reinhardt, J.W.; Tram, N.K.; Debski, A.C. et al., 2018, "Independent control of matrix adhesiveness and stiffness within a 3D self-assembling peptide hydrogel." ACTA BIOMATERIALIA 70, 110-119 - 110-119.

2017

  • Blissett, A.R.; Ollander, B.; Penn, B.; McTigue, D.M. et al., 2017, "Magnetic mapping of iron in rodent spleen.." Nanomedicine 13, no. 3, 977-986 - 977-986.

2016

  • Metzler, K.M.; Roberts, C.J.; Mahmoud, A.M.; Agarwal, G. et al., 2016, "Ex Vivo Transepithelial Collagen Cross-linking in Porcine and Human Corneas Using Human Decorin Core Protein." JOURNAL OF REFRACTIVE SURGERY 32, no. 6, 410-+ - 410-+.
  • Tonniges, J.R.; Albert, B.; Calomeni, E.P.; Roy, S. et al., 2016, "Collagen Fibril Ultrastructure in Mice Lacking Discoidin Domain Receptor 1.." Microsc Microanal 22, no. 3, 599-611 - 599-611.
  • Mehta, N.; Chacko, P.; Jin, J.; Tran, T. et al., 2016, "Serum versus Imaging Biomarkers in Friedreich Ataxia to Indicate Left Ventricular Remodeling and Outcomes.." Tex Heart Inst J 43, no. 4, 305-310 - 305-310.

2015

  • Anghelescu, M.; Tonniges, J.R.; Calomeni, E.; Shamhart, P.E. et al., 2015, "Vascular Mechanics in Decellularized Aortas and Coronary Resistance Microvessels in Type 2 Diabetic db/db Mice.." Ann Biomed Eng 43, no. 11, 2760-2770 - 2760-2770.

2014

  • Nocera, T.M.; Zeng, Y.; Agarwal, G., 2014, "Distinguishing ferritin from apoferritin using magnetic force microscopy." Nanotechnology 25, no. 46,

2013

  • Fu, H-L.; Valiathan, R.R.; Arkwright, R.; Sohail, A. et al., 2013, "Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling.." J Biol Chem 288, no. 11, 7430-7437 - 7430-7437.
  • Yeung, D.; Chmielewski, D.; Mihai, C.; Agarwal, G., 2013, "Oligomerization of DDR1 ECD affects receptor-ligand binding.." J Struct Biol 183, no. 3, 495-500 - 495-500.
  • Stevenson, M.D.; Piristine, H.; Hogrebe, N.J.; Nocera, T.M. et al., 2013, "A self-assembling peptide matrix used to control stiffness and binding site density supports the formation of microvascular networks in three dimensions.." Acta Biomater 9, no. 8, 7651-7661 - 7651-7661.
  • Palko, J.R.; Iwabe, S.; Pan, X.; Agarwal, G. et al., 2013, "Biomechanical Properties and Correlation With Collagen Solubility Profile in the Posterior Sclera of Canine Eyes With an ADAMTS10 Mutation." INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54, no. 4, 2685-2695 - 2685-2695.

2012

  • Nocera, T.M.; Chen, J.; Murray, C.B.; Agarwal, G., 2012, "Magnetic anisotropy considerations in magnetic force microscopy studies of single superparamagnetic nanoparticles.." Nanotechnology 23, no. 49, 495704 - 495704.

2010

  • J. Xu, K.J. Kwak, L.J. Lee and G. Agarwal, 2010, "Lifting and Sorting of Charged Au Nanoparticles by Electrostatic Forces in Atomic Force Microscopy." Small 6, no. 19, 2105-2108 - 2105-2108.
  • Sivakumar, L.; Agarwal, G., 2010, "The influence of discoidin domain receptor 2 on the persistence length of collagen type I fibers.." Biomaterials 31, no. 18, 4802-4808 - 4802-4808.
  • Flynn, L.A.; Blissett, A.R.; Calomeni, E.P.; Agarwal, G., 2010, "Inhibition of collagen fibrillogenesis by cells expressing soluble extracellular domains of DDR1 and DDR2.." J Mol Biol 395, no. 3, 533-543 - 533-543.

2009

  • Mihai, C.; Chotani, M.; Elton, T.S.; Agarwal, G., 2009, "Mapping of DDR1 distribution and oligomerization on the cell surface by FRET microscopy.." J Mol Biol 385, no. 2, 432-445 - 432-445.
  • Blissett, A.R.; Garbellini, D.; Calomeni, E.P.; Mihai, C. et al., 2009, "Regulation of collagen fibrillogenesis by cell-surface expression of kinase dead DDR2.." J Mol Biol 385, no. 3, 902-911 - 902-911.

2008

  • Savla, M.; Pandian, R.P.; Kuppusamy, P.; Agarwal, G., 2008, "Magnetic Force Microscopy of an Oxygen-Sensing Spin-Probe." ISRAEL JOURNAL OF CHEMISTRY 48, no. 1, 33-38 - 33-38.
  • Iscru, D.F.; Anghelina, M.; Agarwal, S.; Agarwal, G., 2008, "Changes in surface topologies of chondrocytes subjected to mechanical forces: an AFM analysis.." J Struct Biol 162, no. 3, 397-403 - 397-403.
  • Schreiber, S.; Savla, M.; Pelekhov, D.V.; Iscru, D.F. et al., 2008, "Magnetic force microscopy of superparamagnetic nanoparticles.." Small 4, no. 2, 270-278 - 270-278.

2007

  • Agarwal, G.; Mihai, C.; Iscru, D.F., 2007, "Interaction of discoidin domain receptor 1 with collagen type 1.." J Mol Biol 367, no. 2, 443-455 - 443-455.

2006

  • Turner, M.S.; Agarwal, G.; Jones, C.W.; Wang, J.C. et al., 2006, "Fiber depolymerization.." Biophys J 91, no. 3, 1008-1013 - 1008-1013.
  • Mihai, C.; Iscru, D.F.; Druhan, L.J.; Elton, T.S. et al., 2006, "Discoidin domain receptor 2 inhibits fibrillogenesis of collagen type 1.." J Mol Biol 361, no. 5, 864-876 - 864-876.

2005

  • Dickerson, M.B.; Naik, R.R.; Sarosi, P.M.; Agarwal, G. et al., 2005, "Ceramic nanoparticle assemblies with tailored shapes and tailored chemistries via biosculpting and shape-preserving inorganic conversion.." J Nanosci Nanotechnol 5, no. 1, 63-67 - 63-67.

2003

  • Agarwal, G.; Sowards, L.A.; Naik, R.R.; Stone, M.O., 2003, "Dip-pen nanolithography in tapping mode.." J Am Chem Soc 125, no. 2, 580-583 - 580-583.
  • Naik, R.R.; Brott, L.L.; Rodriguez, F.; Agarwal, G. et al., 2003, "Bio-inspired approaches and biologically derived materials for coatings." PROGRESS IN ORGANIC COATINGS 47, no. 3-4, 249-255 - 249-255.
  • Agarwal, G.; Naik, R.R.; Stone, M.O., 2003, "Immobilization of histidine-tagged proteins on nickel by electrochemical dip pen nanolithography.." J Am Chem Soc 125, no. 24, 7408-7412 - 7408-7412.

2002

  • Agarwal, G.; Kovac, L.; Radziejewski, C.; Samuelsson, S.J., 2002, "Binding of discoidin domain receptor 2 to collagen I: an atomic force microscopy investigation.." Biochemistry 41, no. 37, 11091-11098 - 11091-11098.
  • Agarwal, G.; Wang, J.C.; Kwong, S.; Cohen, S.M. et al., 2002, "Sickle hemoglobin fibers: mechanisms of depolymerization.." J Mol Biol 322, no. 2, 395-412 - 395-412.
  • Naik, R.R.; Stringer, S.J.; Agarwal, G.; Jones, S.E. et al., 2002, "Biomimetic synthesis and patterning of silver nanoparticles.." Nat Mater 1, no. 3, 169-172 - 169-172.
  • Wang, J.C.; Turner, M.S.; Agarwal, G.; Kwong, S. et al., 2002, "Micromechanics of isolated sickle cell hemoglobin fibers: bending moduli and persistence lengths.." J Mol Biol 315, no. 4, 601-612 - 601-612.

1999

  • Agarwal, G.; Phadke, R.S., 1999, "Laser-assisted deposition of bacteriorhodhopsin assemblies." NANOTECHNOLOGY 10, no. 3, 336-339 - 336-339.
  • Phadke, R.S.; Agarwal, G., 1999, "Methods of deposition and characterization of thin films of amphiphiles." MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS 8-9, 113-118 - 113-118.
  • Agarwal, G.; Phadke, R.S., 1999, "Correlations between morphology and conductivity properties of films of polyaniline." ADVANCED MATERIALS FOR OPTICS AND ELECTRONICS 9, no. 4, 151-156 - 151-156.

1998

  • Phadke, R.S.; Agarwal, G., 1998, "Laser-assisted deposition of preformed mesoscopic systems." MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC MATERIALS SENSORS AND SYSTEMS 5, no. 3-4, 237-241 - 237-241.
  • Agarwal, G.; Phadke, R.S., 1998, "Deposition of Langmuir monolayers using conical trough." THIN SOLID FILMS 327, 9-13 - 9-13.
  • Agarwal, G.; Phadke, R.S., 1998, "Laser assisted deposition of supramolecular organizates on solid surfaces." MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS 6, no. 1, 13-17 - 13-17.

1996

  • Agarwal, G.; Phadke, R.S., 1996, "Novel method for monolayer deposition: Water seepage method." Supramolecular Science 3, no. 4, 183-187 - 183-187.
  • Phadke, R.S.; Agarwal, G., 1996, "Self assembled organizations of thermotropic amphiphiles in molecular electronics (synthesis, characterization and utility)." MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS 288, 119-128 - 119-128.

1995

  • Agarwal, G.; Patel, A.B.; Apte, P.R.; Phadke, R.S., 1995, "Elucidation of self-assembling properties of RBF and its derivative when interfaced with solid supports." MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC MATERIALS SENSORS AND SYSTEMS 3, no. 3-4, 263-266 - 263-266.

Presentations

  • "Collagen fibril abnormalities in human and mice abdominal aortic aneurysm." 2019, Presented at Gordon Research Conference on Collagen,
  • "Indirect Magnetic Force Microscopy of Superparamagnetic Nanoparticles." 2019, Presented at Frontiers in BioMagnetic Particles Meeting,
  • "Abnormal Collagen Fibril Ultrastructure in Abdominal Aortic Aneurysms." 2018, Presented at Biennial Meeting of the American Society for Matrix Biology,
  • "Mineralization of collagen by soluble ectodomain of discoidin domain receptor 2." 2018, Presented at Gordon Research Seminar and Gordon Research Conference on Biomineralization,
  • "DDR1 deficiency in the murine aorta alters collagen fiber structure and platelet adhesion." 2015, Presented at Gordon Research Seminar and Gordon Research Conference (Collagen),
  • "Modification of collagen ultrastructure by DDR1 impacts matrix mineralization." 2014, Presented at Biennial Meeting of the American Society for Matrix Biology,
  • "Discoidin Domain Receptors as a drug target-pilot study." 2012, Presented at Biomedical Engineering Society Annual Meeting,
  • "Regulation of Platelet-Collagen Interactions by the Collagen Receptor DDR1." 2012, Presented at Biomedical Engineering Society Annual Meeting,
  • "DDRs inhibit platelet collagen interactions." 2011, Presented at Gordon Research Conference on Collagen,
  • "Role of DDR1 in Bone Remodeling." 2011, Presented at Gordon Research Conference on Collagen,
  • "Effect of DDR Receptors on Mechanical Properties of Extracellular Matrix." 2010, Presented at Biomedical Engineering Society Annual Meeting,
  • "DDR1 and DDR2 Affect Platelet-Collagen Interactions." 2009, Presented at Annual Meeting of the American Society of Cell Biology,
  • "Magnetic Force microscopy of Magnetic Nanoparticles in Cells." 2009, Presented at Biomedical Engineering Society Annual Meeting,

Papers in Proceedings

2018

  • Agarwal, G.; Ollander, B.; Sifford, J.; Walsh, K.J. et al. "Direct and Indirect Magnetic Force Microscopy in Histology." in 62nd Annual Meeting of the Biophysical-Society. (2 2018).

2016

  • Wang, C.; Yeung, D.; Wellerming, J.; Herr, A. et al. "Role of DDR2 ECD Oligomerization in Binding to Collagen." in Annual Meeting of the Microscopy Society of America. (7 2016).
  • Tonniges, J.; Albert, B.; Calomeni, E.; Agarwal, G. "Ultrastructural Imaging of Collagen Fibrils in Mouse Model of Abdominal Aortic Aneurysm." in Annual Meeting of the Microscopy Society of America. (7 2016).

2013

  • Tonniges, J.; Chen, S.; Lee, J.; Calomeni, E. et al. "Changes in Collagen Ultrastructure due to the Collagen-Binding Protein DDR1 Impacts GPVI and VWF Binding." in Annual Meeting of the Microscopy Society of America. (10 2013).
  • Yeung, D.; Chen, S.; Tonniges, J.; Lee, J. et al. "Collagen Ultrastructure and Skin Mechanics in DDR1 KO Mice." in Annual meeting of the Microscopy Society of America. (5 2013).

2012

  • Chacko, P.; Jin, J.; Tran, T.; Prior, T.W. et al. "Procollagen I Carboxyterminal Propeptide Levels in Friedreich Ataxia and Its Relation to Subclinical Myocardial Disease." in Basic Cardiovascular Sciences Scientific Session. (8 2012).

2009

  • Agarwal, G. "Oligomerization And Interaction Of DDR1 With Collagen: An AFM And FRET Microscopy Study." (2 2009).

2008

  • Yang, J.; Liu, C.; Lee, L.J.; Iscru, D. et al. "Comparison of AFM nanoindentation and gold nanoparticle embedding technique for measuring elastic modulus of polymer thin films." (9 2008).