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B. Rita Alevriadou

  • Associate Professor, Biomedical Engineering
  • Associate Professor, Cardiovascular Medicine
  • 1080 Carmack Road
    Columbus, OH 43210
  • 614-292-5160

About

Latest Works

You can view Dr. Alevriadou's latest published works (Scholarly Presentations, Chapters in Edited Books, Journal Articles) and other information in here: https://osu.researchinview.thomsonreuters.com/profile/the-ohio-state-university/b-rita-alevriadou-phd/94845

Education

PhD, Chemical Engineering, Rice University, Houston, TX, 1992

MS, Chemical Engineering, Rice University, Houston, TX, 1989

BS, Chemical Engineering, Aristotle University, Thessaloniki, Greece, 1986

 

Biographical Narrative

Dr. Alevriadou received her PhD in Chemical Engineering (Bioengineering & Biosciences Institute) from Rice University, Houston, TX in 1992. Following postdoctoral training in the Department of Molecu­lar & Ex­pe­ri­mental Medi­cine of the Scripps Research Institute, La Jolla, CA, she joined the BME Department of the Johns Hopkins University, Baltimore, MD, as Assistant Professor. In 2003, she joined the BME Center (since 2008, Department) and Davis Heart & Lung Research Institute at OSU, as As­sociate Pro­fes­sor of BME and Internal Medicine, Division of Cardiovascular Medicine. Dr. Alevriadou’s expertise lies in vas­cular bioengineering, vascular endothelial mechanotransduction, free radi­cals, mi­to­chon­drial biol­ogy; in gen­eral, un­derstanding the role of the mecha­nochemical environment on mo­lec­ular mecha­nisms of cardio­vas­cular dis­ease (atherosclerosis, ischemia/re­perfusion in­jury, inflammation, throm­bosis). Her research is/has been sup­ported by the NIH and American Heart Association (AHA). She is a member of the Bio­medical Sciences and Bio­physics Gradu­ate Pro­grams and the Center for Regenerative Medicine & Cell-Based Ther­apies. At the na­tional level, she is a mem­ber of the Biomedical Engineering Society (BMES; elected member of its Board of Di­rectors, and of its Student Affairs and Diversity Committees, 2014-17), Society for Free Radi­cal Biology & Medicine (SFRBM), North Amer­ican Vas­cular Biology Or­gani­za­tion (NAVBO) and AHA. She reg­ularly re­views for fed­eral and local funding agencies (NIH, AHA, NSF) and for biomed­i­cal jour­nals, and has been a member of the Editorial Board of the American Journal of Physi­ology-Cell Physiology since 2002.

 

Vascular Mechanotransduction & Oxidative Stress (VMOS) Laboratory

To read about some of the research in the VMOS lab, click on: RESEARCH IN VMOS LAB.pdf

Currently, the VMOS lab is working on 3 projects:

  • Autophagy in endothelial cells under (chemical and/or mechanical) oxidative stress
  • Experimental/mathematical study on calcium homeostasis in sheared endothelial cells (role of mitochondria/ER)
  • Hemolysis-driven endothelial dysfunction due to blood transfusion and ECMO

Prospective students and postdocs, please contact Dr. Alevriadou at: alevriadou.1@osu.edu or rita.alevriadou@osumc.edu

List of Dr. Alevriadou’s past graduate students and postdocs (with current positions); the list excludes undergraduate students, rotating graduate students, and summer MD students:

  • Trevor C. Huang, PhD (Sr. Product Development Manager, Medtronic Inc., Minneapolis, MN)
  • Dionne A. Graham, MS (Assistant Professor, Pediatrics, Harvard Medical School, Boston, MA)
  • Young J. Park, MS (Attorney, Paul Hastings, New York, NY)
  • Monica T. Hinds, PhD (Associate Professor, BME, Oregon Health & Science University, Beaverton, OR)
  • Daniela K. Zablocki, MS (Staff, Cardiovascular Research Institute, UMDNJ, Newark, NJ)
  • Li-Hong (Paul) Yeh, PhD (Regulatory Affairs Specialist, Banner Pharmacaps Inc., Greensboro/Winston-Salem, NC)
  • David M. Wootton, PhD (Associate Professor, Mechanical Engineering and Center for BME, Cooper Union, New York, NY)
  • C.-K. Domingos Ng, MS (Principal Research Associate, Genentech, Inc., San Francisco, CA)
  • Jered B. Haun, MS (Assistant Professor, BME, UC Irvine, Irvine, CA)
  • Sergio F. Martin, PhD (Staff, Brain Dynamics SL, Malaga, Spain)
  • Charles I. Jones III, MS (Orthopedic Surgeon, Mercy Clinic, Rogers, AR)
  • Zhaosheng (John) Han, PhD (Staff, XiangXue Life Sciences Ltd., Guangzhou, China)
  • Valerie K. Galbraith, MS (Associate Clinical Project Manager, Vanda Pharmaceuticals, Washington, DC)
  • Arden C. Santoso, MS (Staff, Materialise US, Plymouth, MI)
  • Randy J. Giedt, PhD (Postdoctoral Fellow, Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School, Boston, MA)
  • Devi M. Nair, PhD (Postdoctoral Fellow, OSU James Comprehensive Cancer Center, Columbus, OH)
  • Christopher G. Scheitlin, PhD (Senior Test Engineer, Chemical, Biological, Radiological, Nuclear, and Explosives Defense Group at Battelle, Columbus, OH)

Honors

  • 2014-2017

    Elected Member, Board of Directors (also Member of the Student Affairs Committee and the Diversity Committee). .

  • 2016-2017

    Grant-In-Aid (GIA) Award. .

  • 2016

    Invited speaker, Klassen Research Day. .

  • 2016

    Certificate of Recognition for dedication and volunteerism. .

  • 2016

    STAR Reviewer, selected by the Editors of the American Physiological Society (APS) journals. .

  • 2015

    Invited speaker, Mathematical Biosciences Institute. .

  • 2014

    Invited speaker, Life Sciences Division. .

  • 2013-2014

    Chair, College of Engineering Committee on the Responsible Contact of Research. .

  • 2013

    Invited speaker, Center for Regenerative Medicine 2nd Annual Retreat. .

  • 2011-2013

    Exploratory/Developmental Research Grant Award (R21). .

  • 2011

    Invited speaker, Cardiovascular Research Center. .

  • 2011

    Invited Big 10 speaker, BME Department. .

  • 2011

    OSU Nominee for the Research Grant Award. .

  • 2006-2010

    Member of the College of Engineering Committee on Academic Affairs (and Chair of Course Subcommittee). .

  • 2008-2009

    Member of the Davis Heart & Lung Research Institute Director's Executive Cabinet. .

  • 2009

    Co-Chair of the Cardiovascular Track, Annual Meeting. .

  • 2008-2009

    Exploratory/Developmental Research Grant Award (R21). .

  • 2009

    Invited speaker, Physiology Department. .

  • 2008

    Invited speaker, Institute for Environmental Medicine. .

  • 2003-2007

    Member of NIH Study Section (Surgery and Bioengneering; renamed: Bioengineering, Biotechnology and Surgical Sciences). .

  • 2005-2006

    Member of the BME Chair Search Committee. .

  • 2001-2006

    Research Project Grant Award (R01). .

  • 2002

    Editorial Board Member, American Journal of Physiology-Cell Physiology. .

  • 1995-2000

    First Award (R29). .

  • 1998

    Invited speaker, The 5th Japan-USA-Singapore-China Conference on Biomechanics. .

  • 1986-1992

    Graduate Fellowship, Robert A. Welch Foundation. .

  • 1992

    1st Prize, Graduate Student Symposium. .

  • 1983-1986

    Award for Academic Excellence, Technical Chamber of Greece. .

Chapters

2010

  • Alevriadou BR, Jones CI 3rd, Giedt RJ. 2010. "Nitric oxide and endothelial mitochondrial function: Implications for ischemia/reperfusion." In Hemodynamics & Mechanobiology of Endothelium, edited by Hsiai TK, Blackman B, Jo H, 153 - 177. Singapore & USA: World Scientific Publishing Co.

1998

  • Ross JM, Alevriadou BR, McIntire LV. 1998. "Rheology." In Thrombosis and Hemorrhage, edited by Loscalzo J, Schafer AI, 405 - 421. Baltimore: Williams & Wilkins.

1994

  • Alevriadou BR, McIntire LV. 1994. "Rheology." In Thrombosis and Hemorrhage, edited by Loscalzo J, Schafer AI, 369 - 381. Boston: Blackwell Scientific Publications.

Journal Articles

2016

  • Scheitlin,Christopher,G; Julian,Justin,A; Shanmughapriya,Santhanam; Madesh,Muniswamy; Tsoukias,Nikolaos,M; Alevriadou,B,Rita, 2016, "Endothelial mitochondria regulate the intracellular Ca2+ response to fluid shear stress." AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 310, no. 6, C479 - C490.

2014

  • Scheitlin,Christopher,G; Nair,Devi,M; Crestanello,Juan,A; Zweier,Jay,L; Alevriadou,B,Rita, 2014, "Fluid Mechanical Forces and Endothelial Mitochondria: A Bioengineering Perspective." CELLULAR AND MOLECULAR BIOENGINEERING 7, no. 4, 483 - 496.

2012

  • Giedt,Randy,J; Pfeiffer,Douglas,R; Matzavinos,Anastasios; Kao,Chiu-Yen; Alevriadou,B,Rita, 2012, "Mitochondrial Dynamics and Motility Inside Living Vascular Endothelial Cells: Role of Bioenergetics." ANNALS OF BIOMEDICAL ENGINEERING 40, no. 9, 1903 - 1916.
  • Wootton DM, Alevriadou BR, 2012, "The shear stress of busting blood clots." N Engl J Med 367, no. 14, 1361 - 3.
  • Wootton,David,M; Alevriadou,B,Rita, 2012, "The Shear Stress of Busting Blood Clots." NEW ENGLAND JOURNAL OF MEDICINE 367, no. 14, 1361 - 1363.
  • Giedt RJ, Yang C, Zweier JL, Matzavinos A, Alevriadou BR, 2012, "Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: Role of nitric oxide and reactive oxygen species." Free Radic Biol Med 52, no. 2, 348 - 56.

2011

  • Chen J, Chen CL, Alevriadou BR, Zweier JL, Chen YR, 2011, "Excess NO predisposes mitochondrial succinate-cytochrome c reductase to produce hydroxyl radical." Biochim Biophys Acta 1807, no. 5, 491 - 502.

2009

  • Lyczkowski RW, Alevriadou BR, Horner M, Panchal CB, Shroff SG, 2009, "Application of multiphase computational fluid dynamics to analyze monocyte adhesion." Annals Biomed Eng 37, no. 8, 1516 - 1533.
  • Han Z, Varadharaj S, Giedt RJ, Zweier JL, Szeto HH, Alevriadou BR., 2009, "Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells.." J Pharmacol Exp Ther 329, no. 1, 94 - 101.

2008

  • Jones CI 3rd, Han Z, Presley T, Varadharaj S, Zweier JL, Ilangovan G, Alevriadou BR, 2008, "Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite.." American Journal of Physiology - Cell Physiology 295, no. 1, C180 - 91.

2007

  • Jones CI 3rd, Zhu H, Martin SF, Han Z, Li Y, Alevriadou BR, 2007, "Regulation of antioxidants and phase 2 enzymes by shear-induced reactive oxygen species in endothelial cells.." Annals of Biomedical Engineering 35, no. 5, 683 - 693.
  • Han Z, Chen Y-R, Jones CI 3rd, Meenakshisundaram G, Zweier JL, Alevriadou BR, 2007, "Shear-induced reactive nitrogen species inhibit mitochondrial respiratory complex activities in cultured vascular endothelial cells.." American Journal of Physiology - Cell Physiology 292, no. 3, C1103 - 12.
  • Jones CI 3rd, Han Z, Szeto HH, Alevriadou BR., 2007, "Expression of heme oxygenase-1 in sheared vascular endothelial cells is regulated by mitochondrial H2O2 formation." Free Radical Biology & Medicine 43, no. Suppl. 1, S151 -

2006

  • Han Z, Jones CI 3rd, Alevriadou BR., 2006, "Mitochondrial electron transport is required for the induction of heme oxygenase-1 protein in vascular endothelial cells exposed to shear stress." Free Radical Biology & Medicine 41, no. Suppl. 1, S37 -

2005

  • Haun JB, Baldwin WM 3rd, Alevriadou BR, 2005, "Clearance of complement by human vascular endothelial cells: effects of hypoxia/reoxygenation and IL-1beta activation.." Transplant International 18, no. 4, 475 - 82.
  • Martin SF, Chatterjee S, Parinandi N, Alevriadou BR, 2005, "Rac1 inhibition protects against hypoxia/reoxygenation-induced lipid peroxidation in human vascular endothelial cells.." Vascular Pharmacology 43, no. 3, 148 - 56.

2004

  • J.B. Haun, W.M. Baldwin III and B.R. Alevriadou, 2004, "Clearance of complement by human vascular endothelial cells: Effects of hypoxia/reoxygenation and IL-1." The FASEB Journal

2003

  • Vijayan KV, Huang TC, Liu Y, Bernando A, Dong JF, Goldschmidt-Clermont PJ, Alevriadou BR, Bray PF., 2003, "Shear stress augments the enhanced adhesive phenotype of cells expressing the Pro33 isoform of integrin beta3.." FEBS Letters 540, 41 - 6.
  • Alevriadou BR, 2003, "CAMs and Rho small GTPases: gatekeepers for leukocyte transendothelial migration. Focus on "VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration".." American Journal of Physiology - Cell Physiology 285, no. 2, C250 - 2.

2002

  • Martin,S,F; Alevriadou,B,R, 2002, "Oxidative stress and lipid peroxidation due to endothelial cell exposure to fluid shear stress." SECOND JOINT EMBS-BMES CONFERENCE 2002, VOLS 1-3, CONFERENCE PROCEEDINGS 1-3, 636 - 637.
  • Wootton DM, Popel AS, Alevriadou BR, 2002, "An experimental and theoretical study on the dissolution of mural fibrin clots by tissue-type plasminogen activator.." Biotechnology and Bioengineering 77, no. 4, 405 - 19.
  • Ng CKD, Deshpande SS, Irani K, Alevriadou BR, 2002, "Adhesion of flowing monocytes to hypoxia-reoxygenation-exposed endothelial cells: role of Rac1, ROS, and VCAM-1.." American Journal of Physiology - Cell Physiology 283, no. 1, C93 - 102.

2001

  • Hinds MT, Park YJ, Jones SA, Giddens DP, Alevriadou BR, 2001, "Local hemodynamics affect monocytic cell adhesion to a three-dimensional flow model coated with E-selectin.." Journal of Biomechanics 34, no. 1, 95 - 103.
  • Huang TC, Jordan RE, Hantgan RR, Alevriadou BR, 2001, "Differential effects of c7E3 Fab on thrombus formation and rt-PA-Mediated thrombolysis under flow conditions.." Thrombosis Research 102, no. 5, 411 - 25.
  • Yeh LH, Kinsey AM, Chatterjee S, Alevriadou BR, 2001, "Lactosylceramide mediates shear-induced endothelial superoxide production and intercellular adhesion molecule-1 expression.." Journal of Vascular Research 38, no. 6, 551 - 9.

2000

  • Zablocki DK, Rade JJ, Alevriadou BR, 2000, "Adenovirus-mediated expression of tissue plasminogen activator does not alter endothelial cell proliferation and invasion.." In Vitro Cellular & Developmental Biology-Animal 36, no. 10, 625 - 8.

1999

  • Yeh LH, Park YJ, Hansalia RJ, Ahmed IS, Deshpande SS, Goldschmidt-Clermont PJ, Irani K, Alevriadou BR., 1999, "Shear-induced tyrosine phosphorylation in endothelial cells requires Rac1-dependent production of reactive oxygen species.." American Journal of Physiology - Cell Physiology 276, C838 - 47.

1998

  • Huang TC, Graham DA, Nelson LD, Alevriadou BR, 1998, "Fibrinolytic agents inhibit platelet adhesion onto collagen type I-coated surfaces at high blood flow conditions.." Blood Coagulation & Fibrinolysis 9, no. 3, 213 - 26.
  • Graham DA, Huang TC, Keyt BA, Alevriadou BR, 1998, "Real-time measurement of lysis of mural platelet deposits by fibrinolytic agents under arterial flow.." Annals of Biomedical Engineering 26, no. 4, 712 - 24.

1993

  • Alevriadou BR, Eskin SG, McIntire LV, Schilling WP, 1993, "Effect of shear stress on 86Rb+ efflux from calf pulmonary artery endothelial cells.." Annals of Biomedical Engineering 21, no. 1, 1 - 7.
  • Alevriadou BR, Moake JL, Turner NA, Ruggeri ZM, Folie BJ, Phillips MD, Schreiber AB, Hrinda ME, McIntire LV, 1993, "Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets.." Blood 81, no. 5, 1263 - 76.

1992

  • Alevriadou BR, McIntire LV, Lasslo A, 1992, "Inhibition of platelet adhesion and thrombus formation on a collagen-coated surface by novel carbamoylpiperidine antiplatelet agents.." Biochimica et Biophysica Acta 1137, no. 3, 279 - 86.

Presentations

  • "Image analysis of dynamic changes in mitochondrial motion and shape inside living vascular endothelial cells: Role of bioenergetics." 2011, Presented at OSU BME Conference, Columbus,
  • "Application of multiphase computational fluid dynamics to analyze monocyte adhesion." 2006, Presented at BMES Annual Meeting, Chicago,
  • "Endothelial cell respiration is affected by the oxygen tension during shear exposure." 2007, Presented at BMES Annual Meeting, Los Angeles,
  • "Analysis of mitochondrial morphology in postischemic vascular endothelial cells." 2010, Presented at American Heart Association (AHA) Young Researchers Reception, Columbus,
  • "Mitochondrial DNA damage in vascular endothelial cells exposed to shear stress." 2009, Presented at Experimental Biology Annual Meeting, New Orleans,
  • "Image analysis of dynamic changes in mitochondrial motion and shape inside living vascular endothelial cells: Role of bioenergetics." 2011, Presented at DHLRI Research Day, Columbus,
  • "Mitochondrial changes in endothelial cells due to mechanochemical stimuli." 2011, Presented at BMES Annual Meeting, Hartford,
  • "Shear stress regulates the respiration of cultured vascular endothelial cells." 2006, Presented at BMES Annual Meeting, Chicago,
  • "Reactive nitrogen species inhibit mitochondrial respiratory complexes in sheared endothelial cells." 2006, Presented at BMES Annual Meeting, Chicago,
  • "Analysis of mitochondrial morphology in cells experiencing a heart attack." 2010, Presented at Edward F. Hayes Graduate Research Forum, Columbus,
  • "Mitochondrial network morphology changes, mechanisms and consequences in postischemic vascular endothelial cells." 2010, Presented at OSU BME Conference, Columbus,
  • "H/RO and I/RP induce mitochondrial removal by autophagy in endothelial cells." 2011, Presented at BMES Annual Meeting, Hartford,
  • "Mitochondrial superoxide levels in endothelial cells exposed to changes in flow and oxygen tension." 2008, Presented at BMES Annual Meeting, St. Louis,
  • "Mitochondria, NO and endothelial mechanosignaling." 2008, Presented at Experimental Biology Annual Meeting, San Diego,
  • "Mitochondrial superoxide radical generation in endothelial cells exposed to hemodynamic forces." 2009, Presented at BMES Annual Meeting, Pittsburgh,
  • "Mitochondrial network morphology in postischemic vascular endothelial cells." 2010, Presented at AHA Scientific Sessions, Chicago,
  • "Mitochondrial network morphology in postischemic vascular endothelial cells." 2010, Presented at BMES Annual Meeting, Austin,
  • "Mitochondrial network morphology changes, mechanisms and consequences in postischemic vascular endothelial cells." 2010, Presented at DHLRI Research Day, Columbus,
  • "Autophagy in vascular endothelial cells exposed to hypoxia/reoxygenation." 2012, Presented at BMES Annual Meeting, Atlanta,
  • "Calcium changes in endothelial cells exposed to mechanochemical stimuli." 2012, Presented at BMES Annual Meeting, Atlanta,
  • "Endogenous nitric oxide regulates Ca2+ homeostasis in sheared vascular endothelial cells." 2013, Presented at BMES Annual Meeting, Seattle,
  • "Analysis of shear-induced calcium oscillations in vascular endothelium." 2014, Presented at BMES Annual Meeting, San Antonio,
  • "Emerging determinants of cytosolic Ca2+ homeostasis in sheared endothelium." 2014, Presented at BMES Annual Meeting, San Antonio,
  • "Modeling the mitochondrial control of shear-induced calcium dynamics in vascular endothelial cells." 2015, Presented at BMES Annual Meeting, Tampa,
  • "Endothelial mitochondria are required for cytosolic calcium transients induced by fluid shear stress." 2015, Presented at BMES Annual Meeting, Tampa,
  • "Endothelial mitochondria are required for cytosolic calcium transients induced by fluid shear stress.." Tempa,