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Jeffrey Chalmers

  • Professor, Chemical & Biomolecular Eng
  • 151 W. Woodruff Ave.
    483 Koffolt Lab
    Columbus, OH 43210
  • 614-292-2727

Honors

  • 20140501

    Cell Culture Engineering 2014.

  • 20110101

    Lumley Research Award.

  • 20060101

    Lumley Research Award.

  • 20050101

    15C plenary lecture.

  • 20050101

    AAAS Fellow.

  • 20030101

    Harrison Award.

  • 20010101

    Fellow.

  • 20010101

    Lumley Research Award.

  • 19980101

    Annual Research Accomplishment Award.

  • 19970101

    Lumley Research Award.

  • 19960101

    Distinguished Multidisciplinary Team Research Award.

  • 19930101

    Lumley Research Award.

  • 19920101

    National Young Investigator Award.

  • 19890101-19911201

    DuPont Young Faculty Development Award.

  • Member.

Chapters

2009

  • 2009. "Magnetic cell separation to enrich for rare cells." In Methods in Bioengineering (MIB), edited by Yarmush, M and Langer, R.S.,

2006

  • 2006. "Aeration, Mixing, and Hydrodynamics in Bioreactors." In Cell Culture Technology for Pharmaceutical and Cellular Therapies,

2001

  • 2001. "Magnetic FFF." In Encyclopedia of Chromatography,

2000

  • 2000. "Animal Cell Culture, Effects of Agitation and Aeration on Cell Adaptation." In Encyclopedia of Cell Technology, edited by R. Spier, J.B. Griffiths, A. H. Scragg,

1997

  • 1997. "Hydrodynamic Properties in Bioreactors." In Mammalian Cell Biotechnology in Protein Production, edited by Hansjorg Hauser, Roland Wagner,

1995

  • 1995. "The Effect of Hydrodynamic Forces on Insect Cells." In Insect Cell Culture: Production of Improved Biopesticides and Proteins From Recombinant DNA, edited by Michael Shuler,

1989

  • 1989. "On Bioprocess Considerations and the Use of Genetically Modified Escherichia coli- systems for excretion of plasmic-encoded proteins." In Bioprocess Engineering: 1st Generation, edited by Trarum Ghose,

Journal Articles

2015

  • Oliveira-Costa,Joao,Paulo; Carvalho,Alex,Fiorinide; Silveira,Giorgia,Gobbida; Amaya,Peter; Wu,Yongqi; Park,Kyoung-Joo,Jenny; Gigliola,Mabel,Pinilla; Lustberg,Maryam; Buim,Marcilei,ElizaCavicchioli; Ferreira,Elisa,Napolitano; Kowalski,Luiz,Paulo; Chalmers,Jeffrey,J; Soares,Fernando,Augusto; Carraro,Dirce,Maria; Ribeiro-Silva,Alfredo, 2015, "Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells.." Oncotarget 6, no. 25, 20902-20920 - 20902-20920.
  • Buck,Amy; Moore,Lee,R; Lane,Christopher,D; Kumar,Anil; Stroff,Clayton; White,Nicolas; Xue,Wei; Chalmers,Jeffrey,J; Zborowski,Maciej, 2015, "Magnetic separation of algae genetically modified for increased intracellular iron uptake." JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS 380, 201-204 - 201-204.
  • Oliveira-Costa,Joao,Paulo; Silveira,Giorgia; Soares,Fernando; Chalmers,Jeffrey; Carraro,Dirce; Silva,Alfredo,Ribeiro, 2015, "PD-L1 Expression in Oral Squamous Cell Carcinoma and Circulating Tumor Cells: Prognostic Significance." FASEB JOURNAL 29, 1 - 1.
  • Oliveira-Costa,Joao,Paulo; de Carvalho,Alex,Fiorini; da Silveira,Giorgia,Gobbi; Amaya,Peter; Wu,Yongqi; Park,Kyoung-Joo,Jenny; Gigliola,Mabel,Pinilla; Lustberg,Maryam; Cavicchioli Buim,Marcilei,Eliza; Ferreira,Elisa,Napolitano; Kowalski,Luiz,Paulo; Chalmers,Jeffrey,J; Soares,Fernando,Augusto; Carraro,Dirce,Maria; Ribeiro-Silva,Alfredo, 2015, "Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells." ONCOTARGET 6, no. 25, 20902-20920 - 20902-20920.

2014

  • 4. Moore, L., Williams, P. S., Nehl, F., Abe, K., Chalmers, J.J., Zborowski, M, 2014, "Feasibility study of red blood cell debulking by magnetic field-flow fractionation with step-programmed flow.." Analytical and Bioanalytical Chemistry, 406(6), 1661-70 - 1661-70.
  • Hooley,Joseph,M; Chalmers,Jeffrey,R, 2014, "Implementation of computerized cumulative acetaminophen dose tracking." AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY 71, no. 3, 188-189 - 188-189.
  • 6. Lustberg, M., Balasubramanian, P., Miller, B., Garcia-Villa, A., Deighan, C., Wu, Y., Carothers, S., Berger, M., Ramaswamy, B., Macrae, E., Wesolowski, R., Layman, R., Morzek, E., Pan, X., Summers, T., Shapiro, C., Chalmers, J.J., 2014, "7. Heterogeneous atypical cell populations are present in blood of metastatic triple negative breast cancer.." Breast Cancer Research 16(2), R23 - R23.
  • 8. Chalmers, J. J, Ma, N., 2014, "Hydrodynamic Damage to Animal Cells, Cell Engineering vol. 9: Animal Cell Culture." Animal Cell Culture 9, 1 - 1.
  • Lustberg,Maryam,B; Balasubramanian,Priya; Miller,Brandon; Garcia-Villa,Alejandra; Deighan,Clayton; Wu,Yongqi; Carothers,Sarah; Berger,Michael; Ramaswamy,Bhuvaneswari; Macrae,Erin,R; Wesolowski,Robert; Layman,Rachel,M; Mrozek,Ewa; Pan,Xueliang; Summers,Thomas,A; Shapiro,Charles,L; Chalmers,Jeffrey,J, 2014, "Heterogeneous atypical cell populations are present in blood of metastatic breast cancer patients." BREAST CANCER RESEARCH 16, no. 2, R23 - R23.

2013

  • Wu,Yongqi; Deighan,Clayton,J; Miller,Brandon,L; Balasubramanian,Priya; Lustberg,Maryam,B; Zborowski,Maciej; Chalmers,Jeffrey,J, 2013, "Isolation and analysis of rare cells in the blood of cancer patients using a negative depletion methodology." METHODS 64, no. 2, 169-182 - 169-182.

2012

  • Xu,Jie; Mahajan,Kalpesh; Xue,Wei; Winter,Jessica,O; Zborowski,Maciej; Chalmers,Jeffrey,J, 2012, "Simultaneous, single particle, magnetization and size measurements of micron sized, magnetic particles." JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS 324, no. 24, 4189-4199 - 4189-4199.
  • Mahajan,Kalpesh,D; Vieira,Gregory,B; Ruan,Gang; Miller,Brandon,L; Lustberg,Maryam,B; Chalmers,Jeffrey,J; Sooryakumar,Ratnasingham; Winter,Jessica,O, 2012, "A MagDot-Nanoconveyor Assay Detects and Isolates Molecular Biomarkers." CHEMICAL ENGINEERING PROGRESS 108, no. 12, 41-46 - 41-46.
  • Lustberg,Maryam; Jatana,Kris,R; Zborowski,Maciej; Chalmers,Jeffrey,J, 2012, "Emerging technologies for CTC detection based on depletion of normal cells.." Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 195, 97-110 - 97-110.
  • Balasubramanian,Priya; Lang,James,C; Jatana,Kris,R; Miller,Brandon; Ozer,Enver; Old,Mathew; Schuller,David,E; Agrawal,Amit; Teknos,Theodoros,N; Summers,Thomas,A; Lustberg,Maryam,B; Zborowski,Maciej; Chalmers,Jeffrey,J, 2012, "Multiparameter Analysis, including EMT Markers, on Negatively Enriched Blood Samples from Patients with Squamous Cell Carcinoma of the Head and Neck.." PloS one 7, no. 7, e42048 - e42048.
  • Garcia-Villa,Alejandra; Balasubramanian,Priya; Miller,Brandon,L; Lustberg,Maryam,B; Ramaswamy,Bhuvaneswari; Chalmers,Jeffrey,J, 2012, "Assessment of ?-H2AX levels in circulating tumor cells from patients receiving chemotherapy.." Frontiers in oncology 2, 128-? - 128-?.

2011

  • Hu, W.; Berdugo, C.; Chalmers, J.J., 2011, "The potential of hydrodynamic damage to animal cells of industrial relevance: current understanding." CYTOTECHNOLOGY 63, no. 5, 445-460 - 445-460.
  • Jatana, KR, Lang, JC, Chalmers, JJ., 2011, "Identification of circulating tumor cells: a prognostic maker in squamous cell carcinoma of the head and neck?." Future Oncol. 7, no. 4, 481-4 - 481-4.
  • Wu, Y. Chalmers JJ, Wyslouzil, B., Casnocha, S., McCormick, E., Ma, N., 2011, "Growth and productivity of NS0 cells with cholesterol nanoparticle supplementation." Biotechnol Progress 27, no. 3, 796-802 - 796-802.

2010

  • Henighan, T., Chen, A., Vieira, G., Hauser, A.J., Yang, F.Y., Chalmers, J.J., Sooryakumar, R., 2010, "Transporting Biological Cells via Programmable Mobile Magnetic Traps." Biophys J.. 98, no. 3, 412-417 - 412-417.
  • Hu, W., Gladue, R., Hansen, J., Wojnar, C., Chalmers, JJ., 2010, "-up of algae culture can be limited due to high oxygen demand: It was not shear sensitivity this time!." Biotechnol. Progress 26, no. 1, 79-87 - 79-87.
  • Jatana,Kris,R; Balasubramanian,Priya; Lang,Jas,C; Yang,Liying; Jatana,Courtney,A; White,Elisabeth; Agrawal,Amit; Ozer,Enver; Schuller,David,E; Teknos,Theodoros,N; Chalmers,Jeffrey,J, 2010, "Significance of Circulating Tumor Cells in Patients With Squamous Cell Carcinoma of the Head and Neck." ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY 136, no. 12, 1274-1279 - 1274-1279.
  • Jatana, KR, Balasubramian, P., Lang, JC, White, E., Agrwal, A., Ozer, E., Schuller, DE, Teknos, TN, Chalmers, JJ., 2010, "Significance of circulating tumor cells in patients with squamous cell carcinoma of the head and neck." Archives of Otolaryngology--Head and Neck Surgery 136, no. 12, 1274-1279 - 1274-1279.

2009

  • Shenkman, R.M.; Godoy-Silva, R.; Papas, K.K.; Chalmers, J.J., 2009, "Effects of Energy Dissipation Rate on Islets of Langerhans: Implications for Isolation and Transplantation." BIOTECHNOLOGY AND BIOENGINEERING 103, no. 2, 413-423 - 413-423.
  • Balasubramanian,Priya; Yang,Liying; Lang,James,C; Jatana,Kris,R; Schuller,David; Agrawal,Amit; Zborowski,Maciej; Chalmers,Jeffrey,J, 2009, "Confocal Images of Circulating Tumor Cells Obtained Using a Methodology and Technology That Removes Normal Cells." MOLECULAR PHARMACEUTICS 6, no. 5, 1402-1408 - 1402-1408.
  • Godoy-Silva, R.; Chalmers, J.J.; Casnocha, S.A.; Bass, L.A. et al., 2009, "Physiological Responses of CHO Cells to Repetitive Hydrodynamic Stress." BIOTECHNOLOGY AND BIOENGINEERING 103, no. 6, 1103-1117 - 1103-1117.
  • Godoy-Silva, R., Chalmers, J.J., Casnocha, SA, Bass, L.A., Ma, N., 2009, "Physiological Responses of CHO Cells to Repetitive Hydrodynamic Stress." Biotechnol. Bioeng. 103, no. 6, 1103-1117 - 1103-1117.
  • Shenkman, RM, Chalmers, J.J., Hering, BJ, Kirchhof, N., Papas, K., 2009, "Quadrupole Magnetic Sorting (QMS) of Porcine Islets of Langerhans." Tissue Engineering Part C Methods 15, no. 2, 147-56 - 147-56.
  • Wu, Y., Chalmers, J.J., Wyslouzil, B., 2009, "The use of Electrohydrodynamic Spraying to Disperse Hydrophobic Compounds in Aqueous Media." Aerosol Science 43, no. 9, 902-910 - 902-910.
  • Godoy-Silva, R.; Mollet, M.; Chalmers, J.J., 2009, "Evaluation of the Effect of Chronic Hydrodynamical Stresses on Cultures of Suspensed CHO-6E6 Cells." BIOTECHNOLOGY AND BIOENGINEERING 102, no. 4, 1119-1130 - 1119-1130.
  • Yang,Liying; Lang,James,C; Balasubramanian,Priya; Jatana,Kris,R; Schuller,David; Agrawal,Amit; Zborowski,Maciej; Chalmers,Jeffrey,J, 2009, "Optimization of an Enrichment Process for Circulating Tumor Cells From the Blood of Head and Neck Cancer Patients Through Depletion of Normal Cells." BIOTECHNOLOGY AND BIOENGINEERING 102, no. 2, 521-534 - 521-534.
  • Balasubramanian, P., Yang, L., Lang, J.C., Jatana, K.R., Schuller, D., Agrawal, A., Zborowski, M., Chalmers, J.J., 2009, "Confocal images of circulating tumor cells obtained using a methodology and technology that removes normal cells." Molecular Pharmaceutics 6, no. 5, 1402-1408 - 1402-1408.

2008

  • Jing, Y.; Mal, N.; Williams, P.S.; Mayorga, M. et al., 2008, "Quantitative intracellular magnetic nanoparticle uptake measured by live cell magnetophoresis." FASEB JOURNAL 22, no. 12, 4239-4247 - 4239-4247.
  • Mollet, M.; Godoy-Silva, R.; Berdugo, C.; Chalmers, J.J., 2008, "Computer Simulations of the energy dissipation rate in a fluorescence-activated cell sorter: Implications to cells." BIOTECHNOLOGY AND BIOENGINEERING 100, no. 2, 260-272 - 260-272.
  • Jing, Y., Nal, Niladri, Williams, P.S., Mayorga, Maritza, Penn, Marc, Chalmers, J. J., 2008, "Quantitative Intracellular Magnetic Nanoparticle Uptake Measured by Live Cell Magnetophoresis." FASEB Journal 22, 4239-4247 - 4239-4247.

2007

  • Mehta, B., Holman, D., Chalmers, J.J., Grzybowsk, D. M., 2007, "Characterization of arachnoidal cells cultured on three-dimensional non-woven PET matrix." Tissue Engineering 13, no. 6, 1269-79 - 1269-79.
  • Tong, X. ,Yang, L., Lang, J. Zborowski, M., Chalmers, J., 2007, "Application of immunomagnetic cell enrichment in combination with RT-PCR for the detection of rare circulating head and neck tumor cells in human peripheral blood.." Cytometry B Clin. Cytom. 72, no. 5, 310-323 - 310-323.
  • Mollet, M.; Godoy-Silva, R.; Berdugo, C.; Chalmers, J.J., 2007, "Acute hydrodynamic forces and apoptosis: A complex question." BIOTECHNOLOGY AND BIOENGINEERING 98, no. 4, 772-788 - 772-788.
  • Jing, Ying, Chalmers, J.J., Zborowski, M., 2007, "48. Jing, Ying, Chalmers, J.J., Zborowski, M. Blood progenitor cell separation from clinical leukapheresis product by magnetic nanoparticle binding and magnetophoresis." Biotechnol. Bioeng. 96, no. 6, 1139-1154 - 1139-1154.
  • Hu, W.; Gladue, R.; Hansen, J.; Wojnar, C. et al., 2007, "The sensitivity of the dinoflagellate Crypthecodinium cohnii to transient hydrodynamic forces and cell-bubble interactions." BIOTECHNOLOGY PROGRESS 23, no. 6, 1355-1362 - 1355-1362.
  • Jing, Y., Moore, LR, Schneider, T., Williams, PS, Chalmers, JJ., Farag, SS, Bolwell, B., Zborowski, M., 2007, "Negative Selection of Hematopoietic Progenitor Cells by Continuous Magnetophoresis." Experimental Hematology 35, no. 4, 662-672 - 662-672.
  • Tong, X.; Yang, L.; Lang, J.C.; Zborowski, M. et al., 2007, "Application of immunomagnetic cell enrichment in combination with RT-PCR for the detection of rare circulating head and neck tumor cells in human peripheral blood." CYTOMETRY PART B-CLINICAL CYTOMETRY 72B, no. 5, 310-323 - 310-323.

2006

  • Moore, L.R., Fujioka, H., Williams, P.S., Chalmers, J.J., Grimberg, B., Zimmerman, P., Zborowski, M., 2006, "Hemoglobin degradation in malaria-infected erythrocytes determined from live cell magnetophoresis." FASEB J. 20, no. 6, 747-9 - 747-9.

2005

  • Carpino, F., Moore, L.R., Zborowski, M., Chalmers, J.J., Williams, P.S., 2005, "Analysis of magnetic nanoparticles using quadrupole magnetic field-flow fractionation." Journal of Magnetism and Magnetic Materials 293, 546-552 - 546-552.

2004

  • Lara, O.; Tong, X.D.; Zborowski, M.; Chalmers, J.J., 2004, "Enrichment of rare cancer cells through depletion of normal cells using density and flow-through, immunomagnetic cell separation." EXPERIMENTAL HEMATOLOGY 32, no. 10, 891-904 - 891-904.
  • Mollet,M; Ma,N,N; Zhao,Y; Brodkey,R; Taticek,R; Chalmers,J,J, 2004, "Bioprocess equipment: Characterization of energy dissipation rate and its potential to damage cells." BIOTECHNOLOGY PROGRESS 20, no. 5, 1437-1448 - 1437-1448.
  • Fife, J.P., Derksen, R.C., Ozkan, H.E., Grewal, P.S., Chalmers, J.J., 2004, "Evaluation of a Contraction Flow Field on Hydrodynamic Damage to Entompathogenic Nematodes- a Biological Pest Control Agent." Biotechnology and Bioengineering 86, no. 1, 96-107 - 96-107.
  • Ma, N., Chalmers, J.J., Aunins, J.G., Zhou, W., Xie, L, 2004, "Quantitative Studies of Cell Damage in Sparged Bioreactors Using A Bubble Collector to Segregate Bubble Rupture Events." Biotechnology Progress 20, no. 4, 1183 – 1191 - 1183 – 1191.

2003

  • McCloskey, K. Moore, L., Hoyos, M., Rodrigues, A., Chalmers, J.J., Zborowski, M., 2003, "Magnetic cell separation is a function of antibody binding capacity (ABC)." Biotechnology Progress 19, no. 3, 899-907 - 899-907.
  • Zborowski, M.; Ostera, G.R.; Moore, L.R.; Milliron, S. et al., 2003, "Red blood cell magnetophoresis." BIOPHYSICAL JOURNAL 84, no. 4, 2638-2645 - 2638-2645.
  • McCloskey, K.E.; Chalmers, J.J.; Zborowski, M., 2003, "Magnetic cell separation: Characterization of magnetophoretic mobility." ANALYTICAL CHEMISTRY 75, no. 24, 6868-6874 - 6868-6874.

2002

  • Ma,N,N; Koelling,K,W; Chalmers,J,J, 2002, "Fabrication and use of a transient contractional flow device to quantify the sensitivity of mammalian and insect cells to hydrodynamic forces." BIOTECHNOLOGY AND BIOENGINEERING 80, no. 4, 428-437 - 428-437.
  • Zborowski, M.; Moore, L.R.; Williams, P.S.; Chalmers, J.J., 2002, "Separations based on magnetophoretic mobility." SEPARATION SCIENCE AND TECHNOLOGY 37, no. 16, 3611-3633 - 3611-3633.

2001

  • Moore,L,R; Rodriguez,A,R; Williams,P,S; McCloskey,K; Bolwell,B,J; Nakamura,M; Chalmers,J,J; Zborowski,M, 2001, "Progenitor cell isolation with a high-capacity quadrupole magnetic flow sorter." JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS 225, no. 1-2, 277-284 - 277-284.
  • McCloskey, K.E.; Comella, K.; Chalmers, J.J.; Margel, S. et al., 2001, "Mobility measurements of immunomagnetically labeled cells allow quantitation of secondary antibody binding amplification." BIOTECHNOLOGY AND BIOENGINEERING 75, no. 6, 642-655 - 642-655.

2000

  • Hoyos, M.; Moore, L.R.; McCloskey, K.E.; Margel, S. et al., 2000, "Study of magnetic particles pulse-injected into an annular SPLITT-like channel inside a quadrupole magnetic field." JOURNAL OF CHROMATOGRAPHY A 903, no. 1-2, 99-116 - 99-116.
  • McCloskey, K. E., Zborowski, M., Chalmers, J.J., 2000, "etophoretic Mobilities Correlate to Antibody Binding Capacity." Erata, Cytometry 41, no. 2, 150-150 - 150-150.
  • Gregoriades,N; Clay,J; Ma,N; Koelling,K; Chalmers,J,J, 2000, "Cell damage of microcarrier cultures as a function of local energy dissipation created by a rapid extensional flow." BIOTECHNOLOGY AND BIOENGINEERING 69, no. 2, 171-182 - 171-182.
  • Hoyos, M., Moore, L.R., McCloskey, K.E., Margel S., Zuberi, M., Chalmers, J.J., Zborowski, M., 2000, "Study of magnetic particles pulsed-injected into an annular SPLITT-like channel inside a quadrupole magnetic field." J. Chromatogr. 903, no. 1-2, 99-116 - 99-116.
  • McCloskey,K,E; Chalmers,J,J; Zborowski,M, 2000, "Magnetophoretic mobilities correlate to antibody binding capacities." CYTOMETRY 40, no. 4, 307-315 - 307-315.

1999

  • Zborowski, M.; Sun, L.P.; Moore, L.R.; Williams, P.S. et al., 1999, "Continuous cell separation using novel magnetic quadrupole flow sorter." JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS 194, no. 1-3, 224-230 - 224-230.
  • Chalmers, J.J., Haam, S., Zhou, Y., McCloskey, K., Moore, L., Zborowski, M., Williams, P.S., 1999, "Quantification of Cellular Properties from External Fields and Resulting Induced Velocity: Cellular Hydrodynamic Diameter." Biotechnology and Bioengineering 64, 509-518 - 509-518.
  • Zborowski, M., Sun, L., Moore, L.R., Chalmers, J.J., 1999, "Rapid cell isolation by magnetic flow sorting for applications in tissue engineering." ASIO Journal 45, 127-130 - 127-130.
  • Chalmers, J.J., Zhao, Y., Nakamura, M., Melnik, K. Lasky, L., Moore, L., Zborowski, M., 1999, "An Instrument to determine the magnetophoretic mobility of paramagnetic particles and labeled, biological cells." J. of Magnetism and Magnetic Materials 194, 231-241 - 231-241.
  • Zborowski,M; Sun,L,P; Moore,L,R; Williams,P,S; Chalmers,J,J, 1999, "Continuous cell separation using novel magnetic quadrupole flow sorter." JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS 194, no. 1-3, 224-230 - 224-230.
  • Chalmers, J.J.; Haam, S.; Zhao, Y.; McCloskey, K. et al., 1999, "Quantification of cellular properties from external fields and resulting induced velocity: magnetic susceptibility.." Biotechnology and bioengineering 64, no. 5, 519-526 - 519-526.
  • Williams, P.S., Zborowski, M., Chalmers, J.J., 1999, "Flow Rate for the Quadrupole Magnetic Cell Sorter." Analytical Chemistry 71, 3799-3807 - 3799-3807.

1998

  • Agarwal,M; Koelling,K,W; Chalmers,J,J, 1998, "Characterization of the degradation of polylactic acid polymer in a solid substrate environment." BIOTECHNOLOGY PROGRESS 14, no. 3, 517-526 - 517-526.
  • Sun, L.P.; Zborowski, M.; Moore, L.R.; Chalmers, J.J., 1998, "Continuous, flow-through immunomagnetic cell sorting in a quadrupole field." CYTOMETRY 33, no. 4, 469-475 - 469-475.
  • Chalmers, J., Zborowski, M., Sun, L., Moore, L., 1998, "Flow Through, Immunomagnetic Cell Separation." Biotechnology Progress 14, 141-148 - 141-148.
  • Wheeler, G., Chalmers, J.J., Tomasko, D., 1998, "A Linked Supercritical Extraction-Biodegradation System to Extract and Degrade Phenol." Chemical Engineering Science 53, 189-201 - 189-201.
  • Sun,L,P; Zborowski,M; Moore,L,R; Chalmers,J,J, 1998, "Continuous, flow-through immunomagnetic cell sorting in a quadrupole field." CYTOMETRY 33, no. 4, 469-475 - 469-475.

1997

  • Vir, R., Chalmers, J.J., 1997, "A Confocal Microscopic Observation of Non-Submerged Biofilms." Biotechnology Progress 13, 727-732 - 727-732.

1996

  • Chalmers, Jeffrey J.J., 1996, "Shear sensitivity of insect cells." Cytotechnology 20, 163-171 - 163-171.

1995

  • Chattopadhyay, D., Rathman, J., Chalmers, J.J.,, 1995, "A Thermodynamic Explanation for Cell Adhesion to Gas-Liquid Interfaces." Biotechnology and Bioengineering 48, 649-658 - 649-658.

1994

  • Trinh, K., Garcia-Briones, M., Hink, F., Chalmers, J.J., 1994, "Quantification of Suspended Cell Damage as a Result of Bubble Rupture." Biotechnology and Bioengineering 43, 37-45 - 37-45.
  • Garcia-Briones, M.A., Brodkey, R.S., Chalmers, J.J., 1994, "Computer Simulations of the Rupture of a Gas Bubble at a Gas-Liquid Interface and its Implications in Animal Cell Damage." Chemical Engineering Science 49, 2301-2320 - 2301-2320.

1991

  • BAVARIAN,F; Fan,L,S; Chalmers,J,J, 1991, "MICROSCOPIC VISUALIZATION OF INSECT CELL BUBBLE INTERACTIONS .1. RISING BUBBLES, AIR MEDIUM INTERFACE, AND THE FOAM LAYER." BIOTECHNOLOGY PROGRESS 7, no. 2, 140-150 - 140-150.
  • 106. Kleman, G., Chalmers, J.J., Strohl, W., 1991, "Glucose-stat: A Predictive and Feedback Controlled Continuous Culture." Applied and Environmental Microbiology 57, 918-923 - 918-923.

1990

  • Chalmers, J.J., Shuler, M.L., Wilson, D.B., 1990, "A Simple Membrane Reactor to Obtain High Cell Density and Plasmid Encoded Protein Production." Escherichia coli, Biotechnology Techniques 4, 73-78 - 73-78.
  • Goldblum, S.D., Bae, Y.K., Hink, W., Chalmers, J.J., 1990, "The Protective Effect of Methylcellulose on Suspended Insect Cells Subjected to Laminar Shear Stress." Biotechnology Progress 6, 383-390 - 383-390.

1985

  • Georgiou, G.; Chalmers, J.J.; Shuler, M.L.; Wilson, D.B., 1985, "Continuous Immobilized Recombinant Protein Production from E. coli Capable of Selective Protein Excretion: A Feasibility Study.." Biotechnology progress 1, no. 1, 75-79 - 75-79.

Unknown

  • Balasubramanian, P., Lang, J.C., Jatana, K., Miller, B., Schuller, D., Agrawal, A., Lustberg, M., Zborowski, M., Chalmers, J.J., "Multiparameter analysis, including EMT markers, on negatively enriched blood samples from patients with squamous cell carcinoma of the head and neck." PLOS one
  • 2. Mathsyaraja, H., Thies, K., Taffany, D.A., Deighan, C., Liu, T., Pecot, T., Yu, L., Fernandez, S.A., Shapiro, C., Otero, J., Timmers, C., Lustberg, M.B., Chalmers, J.J., Leone, G., Ostrowski, M.C., "CSF1 Induces Oncogenic microRNAs in Macrophages to Drive Metastatic Tumor Growth.." Oncogene
  • Jin, X., Poenicke, K., Grunewald, S., Agarwal, A., Sharma, R., Glander, H., Chalmers, J., Zborowski, M., Paasch, U., "Label-free magnetic separation of human spermatozoa." Androgenoy
  • Shenkman, R., Wu, Y., Wyslouzil, B., Chalmers, J.J., "Micron-Sized Magnetic Polymer Labels via High-Pressure Nebulization." J. of Magnetism and Magnetic Materials

Presentations

  • "The potential, and currently practical uses of immunomagnetic labels for detection." 1999, Presented at First NASA & NCI Workshop on Sensors for Bio-Molecular Signatures,
  • "Scale-up of Animal Cell Bioprocesses Equipment: Overview and Current Unknowns." 2004, Presented at Pfizer,
  • "Exploitation of Magnetic Nano-particles in Cell Analysis and Separation: Theoretical, Experimental and Clinical Considerations." 2005, Presented at UMBC,
  • "Blood Pharming: Infinite Supply of fresh RBCs?." 2010, Presented at Cell Culture Engineering XII,
  • "Enrichment of CTCs in clinical samples using purely negative selection: Current status and potential." 2010, Presented at ADAPT 2010,
  • "Cell-Bubble Interactions: Proposed Mechanisms of Cell death in Sparged Bioreactors." 1991, Presented at Amgen,
  • "Where is the Engineering in Biochemical Engineering." 1993, Presented at Engineering Foundation Conference,
  • "Fluids Engineering of Bioprocess Equipment." 1997, Presented at ASME Bioprocess Equipment Seminar,
  • "Fluids Engineering of Bioprocess Equipment." 2000, Presented at ASME Bioprocess Equipment Seminar,
  • "Scale-up of Animal Cell Bioreactors." 2000, Presented at MERCK,
  • "Quantification of the field interaction parameter and the binding constants of several antibody-magnetic nanoparticle conjugates." 2005, Presented at Pacific Polymer Federation IX Conference,
  • "Relationship of Hydrodynamic Forces to Suspended Cells and Application of Magnetic Cell Separation Technology." 2005, Presented at Pfizer,
  • "Enrichment of CTCs in clinical samples using purely negative selection: Current status and potential." 2010, Presented at Biomarker Assay Development Conference,
  • "Circulating Tumor Cells: Clinical Potential and Bioprocess considerations to develop a commercially viable process." 2010, Presented at University of Oklahoma,
  • "The Impact of Interfaces on Cells and Proteins." 1994, Presented at ASME Bioprocess Equipment Seminar,
  • "Determination of Cell Surface Marker Density Using Particle Tracking Velocity." 1997, Presented at Cleveland Clinic Foundation,
  • "Exploitation of Immunomagnetic Labeling: Rapid Cell Sorting and Fractionation." 2000, Presented at Department of Chemical Engineering,
  • "Characterization of the Magnetophoretic Mobility of cells Labeled with Paramagnetic Nanoparticels." 2001, Presented at Particles 2001,
  • "Scale-up of Mammalian Cell Bioreactors." 2002, Presented at American Association of Pharmaceutical Scientists National Biotechnology Conference,
  • "Development of a Reliable, Routine Process to Isolate/Enrich Cancer Cells from Bone and Peripheral Blood Samples." 2002, Presented at 2nd International NCI-EORTC Meeting on Cancer Diagnostics,
  • "Fluids Engineering of Bioprocess Equipment." 2002, Presented at ASME Bioprocess Equipment Seminar,
  • "Process Scale-up Considerations for Therapeutic Antibody Production." 2010, Presented at Beijing International Healthcare Industry Forum,
  • "Expanding the definition of traditional CTCs: Detection and characterization of cells associated with cancer in the blood of patients with solid tumors." 2011, Presented at Lorentz Center workshop: Circulating tumor cell isolation and diagnostics,
  • "bius Sensor Ready Technology: A Novel Approach to Monitoring Single-Use Bioreactors." 2011, Presented at ESCAT,
  • "Immunomagnetic Cell Separation." 1997, Presented at Biochemical Engineering X, Engineering Foundation Conferences,
  • "Issues Surrounding the Scale-up of Animal Cell Culture." 1998, Presented at Biogen Inc.,
  • "Mutliparameter Analysis of circulating tumor cells, CTC, in clinical samples using purely negative selection." 2010, Presented at AICHE Annual Meeting,
  • "Process Scale-up Considerations for Therapeutic Antibody Production." 2011, Presented at Centocor R&D,
  • "Investigations into the Mechanisms of Cell Damage/Death in Sparged Bioreactors." 1990, Presented at DuPont,
  • "Cell-Bubble Interactions: Proposed Mechanisms of Cell death in Sparged Bioreactors." 1991, Presented at Engineering Foundation Conference,
  • "Local Energy Dissipation and Shear Sensitive Cells in Bioreactors, and Interfacial Phenomena in Bioprocessing." 1996, Presented at Genentech,
  • "Fluids Engineering of Bioprocess Equipment." 1996, Presented at ASME Bioprocess Equipment Seminar,
  • "Characterization and Quantification of Microbial Activity During the Composting Process." 1996, Presented at World Environmental Congress (World '96),
  • "High Throughput Separation based on Cell Surface Marker Density or Surface Marker Affinity." Presented at 213th ACS National Meeting,
  • "Magnetic Flow Sorting." 1998, Presented at Scientific and Clinical Applications of Magnetic Carriers,
  • "Cell Tracking Velocity." 1998, Presented at Scientific and Clinical Applications of Magnetic Carriers,
  • "Cell Separation Case Studies: Fundamental and Scale-Up." 2000, Presented at ASME Bioprocess Equipment Seminar,
  • "A Proposed Methodology for the Scale-up/down of Animal Cell Bioreactors." 2000, Presented at Biogen,
  • "Performance of Continuous Magnetic Cell Separation is a Function of Cellular Antibody Binding Capacity." Presented at 221st ACS National Meeting,
  • "Surfactants in Animal Cell Culture." 2001, Presented at MERCK,
  • "Cell Separation." 2001, Presented at Genomic Sample Preparation conference,
  • "Magnetic Cell Separation: Biomedical, Bioprocess, or Biochemical? Its all Chemical Engineering to me!,." 2005, Presented at Department of Chemical Engineering,
  • "The Use of Energy Dissipation Rate as a Parameter to assist in the evaluation, scale-up, and scale-down of Bioprocesses." 2006, Presented at Cell Culture Engineering X,
  • "Mammalian Cell Fluid Mechanics and Scale-up Considerations Application and Design of Bioprocessing Equipment." 2006, Presented at Society of Bioprocessing Professionals 2006 Bioprocessing Institute,
  • "Magnetic separation methods for detection and analysis of circulating tumor cells. Enrichment of CTCs in clinical samples using purely negative selection: Current status and potential." 2009, Presented at Circulating Tumor Cells: Emerging Technologies for Detection, Diagnosis, Prognosis, and Treatment,
  • "Enrichment of CTCs in clinical samples using purely negative selection: Current status and potential." 2009, Presented at Circulating Tumor Cells: Emerging Technologies for Detection, Diagnosis, Prognosis, and Treatment,
  • "Overview of Posters." 2010, Presented at 2010 ASCO-NCI-EORTC Annual Meeting on Molecular Markers in Cancer,
  • "Hydrodynamics Within Bioreactors." 1993, Presented at Merck, Sharp, & Dohme Research Laboratories,
  • "What every Cell Culturist Needs to Know About Bubbles." 1994, Presented at Cell Culture Engineering IV, Engineering Foundation Conference,
  • "Fluids Engineering of Bioprocess Equipment." 1998, Presented at ASME Bioprocess Equipment Seminar,
  • "Novel methods of cell separation using molecular and nanometer-scale magnetic reagents." 1999, Presented at First NASA & NCI Workshop on Sensors for Bio-Molecular Signatures,
  • "Exploitation of Immunomagnetic Labeling: Rapid Cell Sorting and Fractionation." 2000, Presented at Department of Bioengineering,
  • "Fluids Engineering of Bioprocess Equipment." 2000, Presented at MERIAL,
  • "Fluids Engineering of Bioprocess Equipment." 2000, Presented at MERCK,
  • "Immunomagnetic Cell Separation for Rare Cancer Cell Detection in Blood: Current Applications and Future Potential." 2000, Presented at INNOVATIVE MOLECULAR ANALYSIS TECHNOLOGIES PI MEETING,
  • "Immunomagnetic Cell Separation for Rare Cancer Cell Detection in Blood: Current Applications and Future Potential." 2001, Presented at INNOVATIVE MOLECULAR ANALYSIS TECHNOLOGIES PI MEETING,
  • "Exploitation of Magnetic Nano-particles in Cell Analysis and Separation: Theoretical, Experimental and Clinical Considerations. Department of Material Science, Stanford University, May 23, 2005.." 2004, Presented at RPI,
  • "Mammalian Cell Fluid Mechanics and Scale-up Considerations Application and Design of Bioprocessing Equipment." 2004, Presented at Society of Bioprocessing Professionals 2004 Bioprocessing Institute,
  • "Optimization of Tissue Disaggregation." Presented at AIChE Annual meeting,
  • "Mammalian Cell Fluid Mechanics and Scale-up Considerations Application and Design of Bioprocessing Equipment." 2007, Presented at Society of Bioprocessing Professionals 2006 Bioprocessing Institute,
  • "Shear Sensitivity: What’s all the Fuss?." 2004, Presented at Eli Lilly and Company,
  • "Characterization of the Hydrodynamics in Different Types and Sizes of Bioreactors." 1996, Presented at Genentech Inc,
  • "Panel Discussion on Gas-Liquid Interfaces and Cells." 1996, Presented at 42nd Annual Conference of American Society of Artificial Internal Organs,
  • "Local Energy Dissipation and Shear Sensitive Cells in Bioreactors, and Interfacial Phenomena in Bioprocessing." 1996, Presented at 10th International Biotechnology Symposium,
  • "Development of a Reliable, Routine Process to Isolate/Enrich Cancer Cells from Bone and Peripheral Blood Samples." 2002, Presented at INNOVATIVE MOLECULAR ANALYSIS TECHNOLOGIES PI MEETING,
  • "Scale-up of Mammalian Cell Bioreactor and Bioprocess Equipment." 2003, Presented at Wythe Pharmaceuticals,
  • "Mammalian Cell Fluids Mechanics and Scale-up Considerations." 2003, Presented at SBP Institute,
  • "Exploitation of Magnetic Nano-particles in Cell Analysis and Separation: Theoretical, Experimental and Clinical Considerations. Department of Material Science, Stanford University, May 23, 2005.." 2005, Presented at Department of Material Science,
  • "Quantification of the field interaction parameter and the binding constants of several antibody-magnetic nanoparticle conjugates." 2005, Presented at 3rd International Meeting on the Diagnostic and Biotechnology Applications of SuperParaMagnetic Microspheres,
  • "The Use of Energy Dissipation Rate as a Parameter to assist in the evaluation, scale-up, and scale-down of Bioprocesses." 2006, Presented at AMGEN,
  • "The Use of Energy Dissipation Rate as a Parameter to assist in the evaluation, scale-up, and scale-down of Bioprocesses." 2008, Presented at Genzyme,
  • "Multparameter Analysis of potential CTC’s." 2010, Presented at World Circulating Tumor Cell Summit,
  • "Fluids Engineering of Bioprocess Equipment." 2001, Presented at ASME Bioprocess Equipment Seminar,
  • "Cell-Bubble Interactions: Proposed Mechanisms of Cell death in Sparged Bioreactors." 1990, Presented at Eli Lilly and Company,
  • "Local Energy Dissipation and Shear Sensitive Cells in Bioreactors." 1997, Presented at Merck Inc,
  • "Scale-up of Animal Cell Bioprocesses Equipment: Overview and Current Unknowns." 2004, Presented at Martek Biotechnology,
  • "Immunomagnetic Cell Separation: Fundamentals, Current Issues, and Future Potentials." 2007, Presented at AICHE Annual Meeting,
  • "The Use of Magnetic Nanoparticles to Enrich for Rare, Circulating Tumor Cells in Head and Neck Cancer." 2008, Presented at Nanomedicine Summit,
  • "Mammalian Cell Culture Fluid Mechanics: Scale-up Considerations." 2005, Presented at Society for Industrial Microbiology annual meeting,
  • "Quantification of the field interaction parameter and the binding constants of several antibody-magnetic nanoparticle conjugates." 2005, Presented at 79th ACS Colloid and Surface Science Symposium,
  • "Enrichment of CTCs in clinical samples using purely negative selection: Current status and potential." 2009, Presented at ADAPT 2009,
  • "Insect Cell Interactions with Gas Bubbles." 1992, Presented at Baculoviruses and Recombinant Protein Production Processes Workshop,
  • "Fluids Engineering of Bioprocess Equipment." 1995, Presented at ASME Bioprocess Equipment Seminar,
  • "Characterization of the Hydrodynamics in Different Types and Sizes of Bioreactors." 1995, Presented at 8th Annual Meeting of Japanese Association for Animal Cell Technology,
  • "Fluids Engineering of Bioprocess Equipment." 1999, Presented at ASME Bioprocess Equipment Seminar,
  • "Magnetic-based Technologies." 2002, Presented at Detection and Measurement of Occult Disease for the Prognosis of Solid Tumors,
  • "Exploitation of Magnetic Nano-particles in Cell Analysis and Separation: Theoretical, Experimental and Clinical Considerations." 2003, Presented at Tufts University,
  • "Exploitation of Magnetic Nano-particles in Cell Analysis and Separation: Theoretical, Experimental and Clinical Considerations." 2004, Presented at FABE,
  • "Magnetic Cell Separation: Biomedical, Bioprocess, or Biochemical? Its all Chemical Engineering to me!,." 2005, Presented at AIChE meeting,
  • "Enrichment of CTCs in clinical samples using purely negative selection: Current status and potential." 2010, Presented at Genitourinary Oncology Service,
  • "Separating Magnetically labeled and Unlabeled Biological Cells within microfluidic channels using magnetic traps created with nanowires and disks." 2011, Presented at Biochemical and Molecular Engineering XVII: Emerging Frontiers,
  • "Performance of continuous magnetic cell separation is a function of cellular antibody binding capacity.."
  • "High through-put separation based on cell surface marker density or surface marker affinity.."
  • "Optimization of tissue disaggregation."

Papers in Proceedings

2009

  • Chalmers,Jeffrey,J; Lang,James; Balasubramanian,P; Jatana,K; Schuller,D; Agrawal,A; Zborowski,Maciej "BIOT 22-Are circulating tumor cells present in the peripheral blood of cancer patients' cancer stem cells?." in ACS Meeting. (8 2009).

2005

  • Carpino F, Moore LR, Chalmers JJ, Zborowski M, Williams PS. "Quadrupole magnetic field-flow fractionation for the analysis of magnetic nanoparticles." in ICFPM Proceedings in Journal of Physics: Conference Series. (1 2005).

2004

  • Chalmers, J.J., Garcia-Briones, M., Bavarian, F., Hink, F. "Insect Cell Interactions with Gas Bubbles." (1 2004).

1999

  • Moore, L.R., Zborowski, M., Sun, Liping, Chalmers, J.J. "Lymphocyte Fractionation in a Magnetic Flow Cell Sorter." (1 1999).

1996

  • Zborowski, M., Moore, L.R., Reddy, S., Chen, G.H., Sun, L., Chalmers, J. "netic Flow Sorting Using a Model System of Human Lymphocytes and a colloidal magnetic label." in Unspecified. (1 1996).

1993

  • Venkat, R.V., Brodkey, R.S., Guezennec, Y.G., Chalmers, J.J. "Experimental determination of local hydrodynamic information in microcarrier culture spinner flasks." (9 1993).
  • Garcia-Briones, M.A., Chalmers, J.J. "Analysis of Hydrodynamic Information Obtained from Computer Simulations of the Rupture of a Gas Bubble in Relation to Animal Cell Damage in Sparged Bioreactors." in 3rd International Conference on Bioreactor & Bioprocess Fluid Dynamics. (9 1993).

1985

  • Arnold, F.H., Chalmers, J.J., Saunders, M.S., Croughan, M.S., Blanch, H.W., Wilke, C.R., "A Rational Approach to the Scale-up of Affinity Chromatography." (1 1985).

Patents

  • Zborowski, M., Chalmers, J.J. Moore, L.. "Method for magnetically separating cells into fractionated flow streams." Patent number: U.S. Patent 5,968,820
  • Zborowski, M., Chalmers, J.J., Moore, L.. "System and Device for determining particle characteristics." Patent number: U.S. Patent 6,412,359
  • Zborowski M, Chalmers PS, Moore LR.. "Continuous particle and molecule separation with an annular flow channel." Patent number: U.S. Patent 6,467,630
  • Zborowski, M., Chalmers, J.J., Moore, L.. "System and device for determining particle characteristics." Patent number: U.S. Patent 6,557,430
  • Fleischman, A., Roy, S., Chalmers, J., Zborowski, M.. "MEMS-BASED Integrated Magnetic Particle Identification System." Patent number: U. S. Patent 6,623,984
  • Zborowski, M., Chalmers, J.J. Moore, L.. "Fractional cell sorter." Patent number: U.S. Patent 6,120,735
  • Zborowski, M., Chalmers, J.J. Moore, L.. "Method for determining particle characteristics." Patent number: U.S. Patent 6,142,025
  • Zborowski, M., Chalmers, J.J. Moore, L.. "Method for Determining Particle Characteristics." Patent number: U.S. Patent 5,974,901
  • Zborowski, M., Chalmers, J.J., Moore, L.. "System and Device for Determining Particle Characteristics." Patent number: U.S. Patent 6,082,205; 2000
  • Sooryakumar,Ratnasingham; Henighan,Thomas,Charles; Vieira,Gregory,B; Chalmers,Jeffrey,J; Sooryakumar,Ratnasingham; Henighan,Thomas,Charles; Vieira,Gregory,B; Chalmers,Jeffrey,J. "Magnetic platforms for biomolecule trappings, manipulations, and sorting." Patent number: 8691557
  • Sooryakumar,Ratnasingham; Sooryakumar,Dhriti; Vieira,Gregory; Chalmers,Jeffrey,J; Sooryakumar,Ratnasingham; Sooryakumar,Dhriti; Vieira,Gregory; Chalmers,Jeffrey,J. "Mobile magnetic traps and platforms for micro/nano particle manipulation." Patent number: 8399229
  • Sooryakumar,Ratnasingham; Henighan,Thomas,Charles; Vieira,Gregory,B; Chalmers,Jeffrey,J; Sooryakumar,Ratnasingham; Henighan,Thomas,Charles; Vieira,Gregory,B; Chalmers,Jeffrey,J. "Magnetic platforms for biomolecule trappings, manipulations, and sorting." Patent number: 8906691
  • Chalmers,Jeffrey,J; Rathman,James,F; Hu,Weiwei; Chalmers,Jeffrey,J; Rathman,James,F; Hu,Weiwei. "Compositions for reducing cell adhesion to bubbles." Patent number: 8440800