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Lakshmi Dasi

  • Professor, Surgery
  • Professor, Biomedical Engineering
  • Dorothy Davis Heart and Lung Research Institute, Room 405A
    473 W 12th Avenue
    Columbus, OH 43210
  • 614-247-8313

About

Education

  • B.Tech., Indian Institute of Technology,1998
  • M.S., Georgia Institute of Technology, 2000
  • Ph.D., Georgia Institute of Technology, 2004

 

Key Honors and Distinctions

  • George T. Abell Outstanding Teaching & Service Faculty Award, College of Engineering, Colorado State University (2014)
  • George T. Abell Outstanding Early Career Faculty Award, College of Engineering, Colorado State University (2013)

 

RESEARCH AREAS – Cardiovascular and Biofluid Mechanics

  • Biomaterials; Biomechanics; Fluid dynamics; Micro/Nanotechnology devices; Heart valve prostheses; Heart development
  • PUBLICATIONS 

https://scholar.google.com/citations?user=CC7aZdcAAAAJ&hl=en

Professor Dasi’s lab develops new knowledge as it pertains to tackling complex problems in cardiovascular fluid mechanics.  Current research projects underway include: (1) Understanding the role of mechanical stresses on the morphogenesis of embryonic heart, (2) Development of novel heart valve technologies, (3) Energy loss characteristics of multiple heart valve disease, (4) Fluid-structure interaction modeling of the native aortic valve, (5) Lagrangian blood damage modeling and novel bileaflet mechanical heart valve designs, (6) Minimally invasive heart valve therapy, and (7) Understanding the small-scale structure of strongly anisotropic turbulence.

Journal Articles

2016

  • Hatoum, H.; Crestanello, J.A.; Dasi, L.P., 2016, "To the Editor." New England Journal of Medicine 374, no. 16, 1591 - 1591.

Unknown

  • Johnson, B.; Garrity, D.; Dasi, L.P., "The Brine Shrimp's Butterfly Stroke."

Presentations

Papers in Proceedings

2018

  • Azimian, A.; Lilly, S.; Dollery, J.; Crestanello, J. et al. "Accurate Model to Predict Coronary Obstruction during TAVR." (2 2018).
  • Azimian, A.; Lilly, S.; Dollery, J.; Crestanello, J. et al. "Predictive Method for Paravalvular Leakage After Transcatheter Aortic Valve Replacement (TAVR) Using Patient-Specific Computational Modeling." (2 2018).
  • Azimian, A.; Lilly, S.; Dollery, J.; Crestanello, J. et al. "Predictive Method for Paravalvular Leakage After Transcatheter Aortic Valve Replacement (TAVR) Using Patient-Specific Computational Modeling." (2 2018).
  • Azimian, A.; Lilly, S.; Dollery, J.; Crestanello, J. et al. "Accurate Model to Predict Coronary Obstruction during TAVR." (2 2018).

2017

  • Yousefi, A.; Vaesken, A.; Amri, A.; Dasi, L.P. et al. "A comparative study on the in vitro hemodynamics of polyester heart valves." (1 2017).

2016

  • Vaesken, A.; Bark, D.L.; Koupei, A.Y.; Forleo, M. et al. "Textile prosthetic heart valve designs to reduce Reynolds shear stress." (1 2016).
  • Dasi, L.P.; Hatoum, H.; Moore, B.; Maureira, P. et al. "Sinus Flow Stasis Occurs in Valve in Valve Transcatheter Aortic Valve Implantation." (1 2016).
  • Dasi, L.P.; Hatoum, H.; Moore, B.; Maureira, P. et al. "Sinus Flow Stasis Occurs in Valve in Valve Transcatheter Aortic Valve Implantation." (1 2016).

2014

  • Moore, B.L.; Dasi, L.P.; ASME, "AORTIC VALVE SINUS VORTICITY DYNAMICS AND THE POTENTIAL ROLE OF CORONARY FLOW." (1 2014).
  • Dasi, L.P.; Morshed, K.N.; Forleo, M.; ASME, "PHENOMENOLOGY OF HEMOLYSIS IN TURBULENT FLOWS." (1 2014).
  • Schroder, B.W.; Johnson, B.M.; Garrity, D.M.; Dasi, L.P. et al. "Force spectroscopy in the bloodstream of live embryonic zebrafish with optical tweezers." (10 2014).
  • Moore, B.L.; Dasi, L.P. "AORTIC VALVE SINUS VORTICITY DYNAMICS AND THE POTENTIAL ROLE OF CORONARY FLOW." in 15th American-Society-Mechanical-Engineering Summer Bioengineering Conference (SBC2013). (1 2014).
  • Dasi, L.P.; Morshed, K.N.; Forleo, M. "PHENOMENOLOGY OF HEMOLYSIS IN TURBULENT FLOWS." in 15th American-Society-Mechanical-Engineering Summer Bioengineering Conference (SBC2013). (1 2014).

2013

  • Moore, B.L.; Dasi, L.P. "Aortic valve sinus vorticity dynamics and the potential role of coronary flow." (12 2013).
  • Dasi, L.P.; Morshed, K.N.; Forleo, M. "Phenomenology of hemolysis in turbulent flows." (12 2013).

2012

  • Yun, B.M.; Dasi, L.P.; Aidun, C.K.; Yoganathan, A.P. "Simulations of flow through bileaflet mechanical heart valves with asymmetric leaflet motion." (12 2012).
  • Forleo, M.H.; Johnson, B.M.; Dasi, L.P.; ASME, "EFFECT OF BLOOD PRESSURE ON CLOSING DYNAMICS OF BILEAFLET MECHANICAL HEART VALVES." (1 2012).
  • Gogarty, M.B.; Dasi, L.P. "In vitro beating heart simulator for minimally invasive heart valve therapy research." (12 2012).
  • Johnson, B.M.; Garrity, D.M.; Dasi, L.P.; ASME, "QUANTIFYING THE BIOMECHANICS OF THE EMBRYONIC ZEBRAFISH HEART." (1 2012).
  • Yun, B.M.; Dasi, L.P.; Aidun, C.K.; Yoganathan, A.P. et al. "SIMULATIONS OF FLOW THROUGH BILEAFLET MECHANICAL HEART VALVES WITH ASYMMETRIC LEAFLET MOTION." (1 2012).
  • Johnson, B.M.; Garrity, D.M.; Dasi, L.P. "Quantifying the biomechanics of the embryonic zebrafish heart." (12 2012).
  • Gogarty, M.B.; Dasi, L.P. "IN VITRO BEATING HEART SIMULATOR FOR MINIMALLY INVASIVE HEART VALVE THERAPY RESEARCH." in ASME Summer Bioengineering Conference (SBC). (1 2012).
  • Johnson, B.M.; Garrity, D.M.; Dasi, L.P. "QUANTIFYING THE BIOMECHANICS OF THE EMBRYONIC ZEBRAFISH HEART." in ASME Summer Bioengineering Conference (SBC). (1 2012).
  • Gogarty, M.B.; Dasi, L.P.; ASME, "IN VITRO BEATING HEART SIMULATOR FOR MINIMALLY INVASIVE HEART VALVE THERAPY RESEARCH." (1 2012).
  • Forleo, M.H.; Johnson, B.M.; Dasi, L.P. "Effect of blood pressure on closing dynamics of bileaflet mechanical heart valves." (12 2012).
  • Forleo, M.H.; Johnson, B.M.; Dasi, L.P. "EFFECT OF BLOOD PRESSURE ON CLOSING DYNAMICS OF BILEAFLET MECHANICAL HEART VALVES." in ASME Summer Bioengineering Conference (SBC). (1 2012).
  • Yun, B.M.; Dasi, L.P.; Aidun, C.K.; Yoganathan, A.P. "SIMULATIONS OF FLOW THROUGH BILEAFLET MECHANICAL HEART VALVES WITH ASYMMETRIC LEAFLET MOTION." in ASME Summer Bioengineering Conference (SBC). (1 2012).

2009

  • Murphy, D.W.; Dasi, L.P.; Glezer, A.; Yoganathan, A.P. "REDUCTION OF FLOW-INDUCED BLOOD DAMAGE IN BILEAFLET MECHANICAL HEART VALVES THROUGH PASSIVE FLOW CONTROL." in ASME Summer Bioengineering Conference. (1 2009).
  • Murphy, D.W.; Dasi, L.P.; Glezer, A.; Yoganathan, A.P. "Reduction of flow-induced blood damage in bileaflet mechanical heart valves through passive flow control." (12 2009).
  • Kim, H.S.; Yap, C.H.; Dasi, L.P.; Yoganathan, A.P. et al. "MULTISCALE STRUCTURAL ANALYSIS OF PORCINE AORTIC HEART VALVES USING A COLLAGEN FIBER NETWORK (CFN) MICROMODEL." (1 2009).
  • Yap, C.H.; Dasi, L.P.; Rusly, R.J.; Yoganathan, A.P. "DYNAMICS OF THE AORTIC VALVE UNDER NORMAL, FLOW RATE-VARIED AND HEART RATE-VARIED CONDITIONS: AN IN VITRO STUDY." in ASME Summer Bioengineering Conference. (1 2009).
  • Dasi, L.P.; Pekkan, K.; Sundareswaran, K.S.; de Zelicourt, D. et al. "HEMODYNAMIC ENERGY DISSIPATION IN THE CARDIOVASCULAR SYSTEM: GENERALIZED THEORETICAL ANALYSIS ON DISEASE STATES." (1 2009).
  • Yap, C.H.; Kim, H.S.; Dasi, L.P.; Weiler, M.J. et al. "STRUCTURAL DEFORMATION OF NATIVE AORTIC VALVE LEAFLET UNDER HYPERTENSION: AN IN VITRO STUDY." (1 2009).
  • Murphy, D.W.; Dasi, L.P.; Glezer, A.; Yoganathan, A.P. et al. "REDUCTION OF FLOW-INDUCED BLOOD DAMAGE IN BILEAFLET MECHANICAL HEART VALVES THROUGH PASSIVE FLOW CONTROL." (1 2009).
  • Dasi, L.P.; Pekkan, K.; Sundareswaran, K.S.; De Zelicourt, D. et al. "Hemodynamic energy dissipation in the cardiovascular system: Generalized theoretical analysis on disease states." (12 2009).
  • Haggerty, C.M.; Dasi, L.P.; Kanter, J.; Yoganathan, A.P. et al. "EFFECT OF FLOW PULSATILITY ON 2(ND) STAGE FONTAN HEMODYNAMICS: AN IN VITRO INVESTIGATION." (1 2009).
  • Yap, C.H.; Dasi, L.P.; Rusly, R.J.; Yoganathan, A.P. "Dynamics of the aortic valve under normal, flow rate-varied and heart rate-varied conditions: An in vitro study." (12 2009).
  • Yap, C.H.; Kim, H.S.; Dasi, L.P.; Weiler, M.J. et al. "STRUCTURAL DEFORMATION OF NATIVE AORTIC VALVE LEAFLET UNDER HYPERTENSION: AN IN VITRO STUDY." in ASME Summer Bioengineering Conference. (1 2009).
  • Haggerty, C.M.; Dasi, L.P.; Kanter, J.; Yoganathan, A.P. "Effect of flow pulsatility on 2nd stage Fontan hemodynamics: An in vitro investigation." (12 2009).
  • Dasi, L.P.; Pekkan, K.; Sundareswaran, K.S.; de Zelicourt, D. et al. "HEMODYNAMIC ENERGY DISSIPATION IN THE CARDIOVASCULAR SYSTEM: GENERALIZED THEORETICAL ANALYSIS ON DISEASE STATES." in ASME Summer Bioengineering Conference. (1 2009).
  • Haggerty, C.M.; Dasi, L.P.; Kanter, J.; Yoganathan, A.P. "EFFECT OF FLOW PULSATILITY ON 2(ND) STAGE FONTAN HEMODYNAMICS: AN IN VITRO INVESTIGATION." in ASME Summer Bioengineering Conference. (1 2009).
  • Yap, C.H.; Kim, H.S.; Dasi, L.P.; Weiler, M.J. et al. "Structural deformation of native aortic valve leaflet under hypertension: An in vitro study." (12 2009).
  • Kim, H.S.; Yap, C.H.; Dasi, L.P.; Yoganathan, A.P. et al. "MULTISCALE STRUCTURAL ANALYSIS OF PORCINE AORTIC HEART VALVES USING A COLLAGEN FIBER NETWORK (CFN) MICROMODEL." in ASME Summer Bioengineering Conference. (1 2009).
  • Kim, H.S.; Yap, C.H.; Dasi, L.P.; Yoganathan, A.P. et al. "Multiscale structural analysis of porcine aortic heart valves using a collagen fiber network (CFN) micromodel." (12 2009).
  • Yap, C.H.; Dasi, L.P.; Rusly, R.J.; Yoganathan, A.P. et al. "DYNAMICS OF THE AORTIC VALVE UNDER NORMAL, FLOW RATE-VARIED AND HEART RATE-VARIED CONDITIONS: AN IN VITRO STUDY." (1 2009).

2008

  • Paden, M.I.; Reid, C.; Wagoner, S.F.; Sucosky, P. et al. "Inaccuracy of concomitant CVVH in ECMO patients." (10 2008).
  • Sundareswaran, K.; Zelicourt, D.D.; Dasi, L.P.; Yoganathan, A.P. et al. "Wasted Energy and Right Ventricular Volumes in Patients after Tetralogy of Fallot Repair - A Key to Understanding Right Heart Function?." (10 2008).
  • Sundareswaran, K.; Zelicourt, D.D.; Dasi, L.P.; Yoganathan, A.P. et al. "Wasted Energy and Right Ventricular Volumes in Patients after Tetralogy of Fallot Repair - A Key to Understanding Right Heart Function?." in 81st Annual Scientific Session of the American-Heart-Association. (10 2008).
  • Paden, M.I.; Reid, C.; Wagoner, S.F.; Sucosky, P. et al. "Inaccuracy of concomitant CVVH in ECMO patients." (10 2008).

2007

  • Dasi, L.P.; Sucosky, P.; Goldman, S.; Paden, M. et al. "Development of a novel fluid management system for accurate continuous hemofiltration in extracorporeal membrane oxygenation." (11 2007).
  • Krishnankuttyrema, R.; Dasi, L.P.; Pekkan, K.; Sundareswaran, K. et al. "A skeletalized representation of the total cavopulmonary connection." (12 2007).
  • Borazjani, I.; Ge, L.; Sotiropoulos, F.; Dasi, L.P. et al. "Fluid-structure interaction in Bi-leaflet mechanical heart valves." (11 2007).
  • Sundareswaran, K.S.; Pekkan, K.; Dasi, L.P.; Kitajima, H.D. et al. "Significant impact of the total Cavopulmonary connection resistance on cardiac output and exercise performance in single ventricles." in 80th Annual Scientific Session of the American-Heart-Association. (10 2007).
  • Borazjani, I.; Ge, L.; Sotiropoulos, F.; Dasi, L.P. et al. "Fluid-structure interaction in bi-leaflet mechanical heart valves." (1 2007).
  • Krishnankuttyrema, R.; Dasi, L.P.; Pekkan, K.; Sundareswaran, K. et al. "A skeletalized representation of the total cavopulmonary connection." (1 2007).
  • Dasi, L.P.; Sucosky, P.; Goldman, S.; Paden, M. et al. "Development of a novel fluid management system for accurate continuous hemofiltration in extracorporeal membrane oxygenation." (1 2007).
  • Sundareswaran, K.S.; Pekkan, K.; Dasi, L.P.; Kitajima, H.D. et al. "Significant impact of the total Cavopulmonary connection resistance on cardiac output and exercise performance in single ventricles." (10 2007).
  • Borazjani, I.; Ge, L.; Sotiropoulos, F.; Dasi, L.P. et al. "Fluid-structure interaction in bi-leaflet mechanical heart valves." in Frontiers in Biomedical Devices Conference. (1 2007).
  • Krishnankuttyrema, R.; Dasi, L.P.; Pekkan, K.; Sundareswaran, K. et al. "A skeletalized representation of the total cavopulmonary connection." in ASME Summer Bioengineering Conference. (1 2007).
  • Dasi, L.P.; Sucosky, P.; Goldman, S.; Paden, M. et al. "Development of a novel fluid management system for accurate continuous hemofiltration in extracorporeal membrane oxygenation." in Frontiers in Biomedical Devices Conference. (1 2007).
  • Dasi, L.; Pekkan, K.; Whitehead, K.; Fogel, M. et al. "Hepatic venous blood flow distribution in the total cavopulmonary connection: Patient-specific anatomical models." (12 2007).

2005

  • Dasi, L.P.; Webster, D.R. "Geometric characteristics of passive scalar interfaces for plumes in turbulent boundary layers." (12 2005).
  • Leo, H.L.; Dasi, L.P.; Carberry, J.; Yoganathan, A. "Hemodynamics assessment of three polymeric heart valves using three-dimensional particle image velocimetry." (12 2005).

2004

  • Rahman, S.; Dasi, L.P.; Webster, D.R.; Roberts, P.J.W. "Characteristics of turbulent plumes using PLIF technique." (12 2004).