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Nathan Doble

  • Associate Professor, Ophthalmology
  • Associate Professor, Optometry
  • 338 W 10th Ave
    435A
    Columbus, OH 43210
  • 614-688-2052

Honors

  • 20030401

    1st Place Purdue Life Sciences Business Plan Competition ($60,000).

  • 20020401

    1st Place Fourth Annual UC Berkeley Business Plan Competition ($50,000).

  • 20020401

    1st Place MBA Jungle Second Annual Business Plan Competition ($25,000).

Chapters

2012

  • 2012. "The Human Eye and Adaptive Optics." In Topics in Adaptive Optics, edited by Robert Tyson,
  • 2012. "MEMS Adaptive Optics." In Encylopedia of Nanotechnology, edited by B Bhushan,

2006

  • 2006. "Wavefront Correctors for Vision Science." In Adaptive optics for vision science: principles, practices, design, and applications,

Unknown

  • "Adaptive Optics and OCT." In Handbook of Visual Optics, edited by P Artal,

Journal Articles

2016

  • Wells-Gray, E.M.; Choi, S.S.; Bries, A.; Doble, N., 2016, "Variation in rod and cone density from the fovea to the mid-periphery in healthy human retinas using adaptive optics scanning laser ophthalmoscopy." EYE 30, no. 8, 1135-1143 - 1135-1143.

2015

  • Morris,Hugh,J; Blanco,Leonardo; Codona,Johanan,L; Li,Simone,L; Choi,Stacey,S; Doble,Nathan, 2015, "Directionality of individual cone photoreceptors in the parafoveal region." VISION RESEARCH 117, 67-80 - 67-80.
  • Walker,Maria,K; Blanco,Leonardo; Kivlin,Rebecca; Choi,Stacey,S; Doble,Nathan, 2015, "Measurement of the photoreceptor pointing in the living chick eye." VISION RESEARCH 109, 59-67 - 59-67.
  • JL Codona and N Doble, 2015, "JWST Segment Phasing using Differential Optical Transfer Functions." Journal of Astronomical Telescopes, Instruments, and Systems 1, no. 2, 029001 - 029001.

2011

  • Headington,Kenneth; Choi,Stacey,S; Nickla,Debora; Doble,Nathan, 2011, "Single Cell Imaging of the Chick Retina with Adaptive Optics." CURRENT EYE RESEARCH 36, no. 10, 947-957 - 947-957.
  • Doble,Nathan; Choi,Stacey,S; Codona,Johanan,L; Christou,Julian; Enoch,Jay,M; Williams,David,R, 2011, "In vivo imaging of the human rod photoreceptor mosaic." OPTICS LETTERS 36, no. 1, 31-33 - 31-33.
  • Choi,Stacey,S; Zawadzki,Robert,J; Lim,Michele,C; Brandt,James,D; Keltner,John,L; Doble,Nathan; Werner,John,S, 2011, "Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging." BRITISH JOURNAL OF OPHTHALMOLOGY 95, no. 1, 131-141 - 131-141.

2009

  • Elliott,Sarah,L; Choi,Stacey,S; Doble,Nathan; Hardy,Joseph,L; Evans,Julia,W; Werner,John,S, 2009, "Role of high-order aberrations in senescent changes in spatial vision." JOURNAL OF VISION 9, no. 2, 24 - 24.
  • Werner,John,S; Elliott,Sarah,L; Choi,Stacey,S; Doble,Nathan, 2009, "Spherical aberration yielding optimum visual performance: Evaluation of intraocular lenses using adaptive optics simulation." JOURNAL OF CATARACT AND REFRACTIVE SURGERY 35, no. 7, 1229-1233 - 1229-1233.

2007

  • Xue,Bai; Choi,Stacey,S; Doble,Nathan; Werner,John,S, 2007, "Photoreceptor counting and montaging of en-face retinal images from an adaptive optics fundus camera." JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION 24, no. 5, 1364-1372 - 1364-1372.

2006

  • Choi,Stacey,S; Doble,Nathan; Hardy,Joseph,L; Jones,Steven,M; Keltner,John,L; Olivier,Scot,S; Werner,John,S, 2006, "In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function." INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 47, no. 5, 2080-2092 - 2080-2092.

2005

  • Doble,N, 2005, "High-resolution, in vivo retinal imaging using adaptive optics and its future role in ophthalmology." EXPERT REVIEW OF MEDICAL DEVICES 2, no. 2, 205-216 - 205-216.
  • Choi,S,S; Doble,N; Lin,J; Christou,J; Williams,D,R, 2005, "Effect of wavelength on in vivo images of the human cone mosaic." JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION 22, no. 12, 2598-2605 - 2598-2605.

Presentations

  • "High Resolution Retinal Imaging Using Adaptive Optics." 2016, Presented at OSU Department of Biomedical Engineering,
  • "High Resolution Retinal Imaging Using Adaptive Optics." 2015, Presented at Oxyopia Research Lecture Series,
  • "High Performance MEMS Deformable Mirrors for Adaptive Optics." 2004, Presented at Applied Physics 483 Optics and Electronics Seminar, Stanford University,
  • "Vision Testing and High Resolution Retinal Imaging Using Adaptive Optics." 2005, Presented at Grand Rounds Presentation, California Pacific Medical Center,
  • "High Stroke MEMS DM for Vision Science." 2005, Presented at National Eye Institute - BioEngineering Research Partnership Annual Meeting. University of California at Davis,
  • "Retinal Imaging with Adaptive Optics." 2006, Presented at Stanford University Photonics Research Center Symposium,
  • "Application of Adaptive Optics in Vision Science." 2009, Presented at Schnurmacher Institute for Vision Research Colloquium, State University of New York Optometry School, (SUNY),,
  • "MEMS Deformable Mirrors for Adaptive Optics." 2004, Presented at NSF Center for Adaptive Optics (CfAO) Thirty Meter Telescope MEMS DM Workshop,
  • "Current MEMS Status and Projects at Iris AO Inc." 2006, Presented at NSF Center for Adaptive Optics (CfAO) Fall Retreat,
  • "Design and performance of Rochester's 2nd generation adaptive optics system for the human eye." 2000, Presented at International Symposium: Adaptive Optics: From Telescopes to the Human Eye,
  • "High Resolution Imaging with a Microelectromechanical (MEMS) Mirror." 2002, Presented at NSF Center for Adaptive Optics (CfAO) Fall Retreat,
  • "Adaptive optical system design and optimization for the human eye." 2001, Presented at SPIE Opto-North East and Imaging,
  • "A MEMS Mirror for Adaptive Optics in the Human Eye." 2001, Presented at NSF Center for Adaptive Optics (CfAO) Fall Retreat,
  • "The Use of a MEMS Mirror for Adaptive Optics in the Human Eye." 2002, Presented at NSF Center for Adaptive Optics (CfAO) MEMS Workshop,
  • "Measurement and Correction of the Aberrations of the Human Eye." 2002, Presented at NSF Center for Adaptive Optics (CfAO) Summer School,
  • "High Resolution Retinal Imaging Using Adaptive Optics." 2004, Presented at Dept. of Ophthalmology, Stanford University,
  • "Application of Adaptive Optics to Retinal Imaging and Vision Testing." 2011, Presented at Massachusetts Society of Optometrists (MSO),
  • "High Resolution Retinal Imaging with a Microelectromechanical (MEMS) Mirror." 2002, Presented at University of Rochester, Center for Visual Science's 23rd Symposium “Engineering the Eyeâ€�,
  • "The Application of Adaptive Optics to Vision Science and Ophthalmology." 2009, Presented at U. Mass Medical Center – Worchester,
  • "Indirect Wavefront Sensing by Dithering." 1999, Presented at Wavefront Sensing and its Applications’, Institute of Physics,
  • "High Resolution The Use of Microelectromechanical (MEMS) and Liquid Crystal Technology for Adaptive Optics in the Human Eye." 2001, Presented at Opto-North East and Imaging,
  • "A MEMS Mirror for Adaptive Optics in the Human Eye." 2001, Presented at OSA Annual Meeting and Exhibit,
  • "Applications of Adaptive Optics to Vision Sciences." 2001, Presented at SPIE Opto-North East and Imaging,
  • "The Use of a MEMS Mirror for Adaptive Optics in the Human Eye." 2001, Presented at NSF Center for Adaptive Optics Summer School,
  • "The Application of Adaptive Optics to Vision Science." 2009, Presented at New England College of Optometry (NECO) Alumni Conference,
  • "Adaptive Optics Retinal Imaging." 2010, Presented at New England College of Optometry (NECO) Summer Residency Conference,
  • "The Application of Adaptive Optics to Vision Science." 2009, Presented at New England College of Optometry (NECO) Summer Residency Conference,
  • "Adaptive Optics Retinal Imaging." 2010, Presented at New England College of Optometry (NECO) Laboratory Survey Course,
  • "Adaptive Optics for Vision Science." 2008, Presented at New England College of Optometry (NECO) Research Seminar,
  • "Adaptive Optics Retinal Imaging." 2008, Presented at New England College of Optometry (NECO) Laboratory Survey Course,
  • "High Resolution Retinal Imaging." 2014, Presented at Optometric Educators Inc. (OEI) Annual Summer Continuing Education Conference,
  • "Adaptive Optics Retinal Imaging." 2011, Presented at New England College of Optometry (NECO) Laboratory Survey Course,
  • "Design and performance of an adaptive optical system for the human eye." 2001, Presented at Integrating Research and A Conference for the Graduate Students and Postdoctoral Researchers of the NSF Center for Adaptive Optics (CfAO),

Papers in Proceedings

2015

  • B Vohnsen, SS Choi, N Doble, E Wells-Gray, H Xu, AW Stitt "Modeling High-Resolution SLO and OCT Retinal Imaging using Backscattering of Light from Elementary Sources." (10 2015).
  • Wells-Gray,Elaine,M; Zawadzki,Robert,J; Finn,Susanna,C; Greiner,Cherry; Werner,John,S; Choi,Stacey,S; Doble,Nathan "Performance of a combined optical coherence tomography and scanning laser ophthalmoscope with adaptive optics for human retinal imaging applications." in Conference on Adaptive Optics and Wavefront Control for Biological Systems. (1 2015).

2014

  • J. Codona, L. Blanco, M. Lloyd-Hart, N. Doble "In-vivo, Imaging of Human Cone Photoreceptors without the Use of Adaptive Optics." in Investigative Ophthalmology & Visual Science. (5 2014).
  • L. Blanco, J. Codona,, N. Doble "Rapid Measurement of Cone Photoreceptor Pointing using Focus Diversity." (5 2014).

2013

  • Finn,S,C; Greiner,C;Doble,N;Zawadzki,R,J;Werner,J,S;Choi,S,S; "AO-OCT Retinal Imaging with a 163-Segment Deformable Mirror." in Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology. (1 2013).
  • Doble,N; Kivlin,R; Codona,J,L; Li,S; Choi,S,S; "Photoreceptor Pointing as a Function of Retinal Eccentricity in Normal Human Eyes." in Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology. (1 2013).
  • L Wetherby, E Harb, N Doble, SS Choi "Cone Density and Packing Characteristics in Treated Amblyopic Eyes." in Optom & Vis Sci. (10 2013).
  • Codona,JL; Doble,N "Volumetric imaging of the intraocular propagation medium using differential OTF wavefront sensing." in Conference on Ophthalmic Technologies XXIII as a part of the SPIE Photonics West BiOS Meeting. (1 2013).
  • L Blanco, R Kivlin, JL Codona, S Li, SS Choi, N Doble "Optical Waveguide Properties of Individual Cone Photoreceptors at Various Retinal Eccentricities." in Optom & Vis Sci. (10 2013).
  • Greiner,C; Finn,SC; Choi,S; Doble,N "Characterization of a MEMS deformable mirror by far field intensity evaluation." in Conference on MEMS Adaptive Optics VII. (1 2013).

2012

  • Codona,Johanan,L; Doble,Nathan "Experimental Evaluation of Differential OTF (dOTF) Wavefront Sensing." in Conference on Adaptive Optics Systems III. (1 2012).
  • LA Wetherby, E Harb, SS Choi, N Doble, E Weissberg "Inner Retinal Characteristics in Treated Amblyopic Eyes." in Optom & Vis Sci. (10 2012).

2011

  • Wetherby,L,A;Harb,E;Choi,S,S;Doble,N;Weissberg,E; "Investigation of Outer Retinal Differences in Amblyopic Eye." in Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology. (1 2011).

2009

  • N Doble, SS Choi "Widefield Imaging of the Human Retina using Adaptive Optics." in Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology. (5 2009).

2008

  • MV Subbaram, IG Cox, N Doble "Dynamics of the IRIS AO deformable mirror in a wavefront aberrometer system." in Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology. (1 2008).
  • N Doble, C Kempf, MA Helmbrecht "An AO Previewer with a Segmented Piston, Tip Tilt MEMS DM." in Wavefront Congress Meeting on Wavefront Sensing & Presbyopic Refractive Corrections. (2 2008).

2007

  • SL Elliott, SS Choi, JL Hardy, N Doble, JS Werner "Role of Higher-Order Aberrations in Spatial Vision of Aging Eyes." in Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology. (1 2007).
  • N Doble, C Kempf, B Xue, MA.Helmbrecht SS Choi "The Design and Construction of an Adaptive Optics Confocal Scanning Laser Ophthalmoscope for Focused Delivery of Laser Energy to the Eye." in Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology. (1 2007).
  • C Kempf, N Doble, MA Helmbrecht "Control of a MEMS Based Segmented Deformable Mirror for an Vision Science Instrumentation." in Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology. (1 2007).
  • MA Helmbrecht, N Doble, C Kempf, M He "Latest Mems DM Developments and the Path Ahead at IRIS AO, Inc.." in ADAPTIVE OPTICS FOR INDUSTRY AND MEDICINE: Proceedings of the Sixth International Workshop. (9 2007).

2006

  • Helmbrecht,Michael,A; Juneau,Thor; Hart,Matthew; Doble,Nathan "Performance of a high-stroke, segmented MEMS deformable-mirror technology." in Conference on MEMS/MOEMS Components and Their Applications III. (1 2006).
  • Helmbrecht,Michael,A; Juneau,Thor; Hart,Matthew; Doble,Nathan "Segmented MEMS deformable-mirror technology for space applications." in Conference on Micro (MEMS) and Nanotechnologies for Space Applications. (1 2006).
  • Helmbrecht,Michael,A; He,Min; Juneau,Thor; Hart,Matthew; Doble,Nathan "Segmented MEMS deformable-mirror for wavefront correction." in Conference on Optomechatronic Micro/Nano Devices and Components II. (1 2006).

2005

  • Doble,N; Helmbrecht,M; Hart,M; Juneau,T "Advanced wavefront correction technology for the next generation of adaptive optics equipped ophthalmic instrumentation." in 15th Conference on Ophthalmic Technologies. (1 2005).

2004

  • N Doble "Current and Future Technology for Adaptive Optics in the Human Eye." in Frontiers in Optics 2004/Laser Science XXII/Diffractive Optics and Micro-Optics/Optical Fabrication and Testing, OSA Technical Digest Series (Optical Society of America, 2004). (10 2004).
  • Doble,N; Choi,S; Williams,D "Implications of infrared images of the living human cone mosaic for models of fundus reflectance." in Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology. (4 2004).

2003

  • RM Myers, AJ Longmore, CR Benn, DF Buscher, P Clark, NA Dipper, N Doble, AP Doel, CN Dunlop, X Gao, T Gregory, RA Humphreys, D Ives, R Ostensen, PT Peacocke, RG M. Rutten, C J Tierney, AJA Vick, MR Wells, RW.Wilson, SP Worswick, A Zadrozny "The NAOMI Adaptive Optics System for the 4.2m William Herschel Telescope." (6 2003).

2002

  • Doble,N; Yoon,G,Y; Chen,L; Singer,B; Bierden,P; Olivier,S; Williams,D "Low cost. Compact wavefront correctors for ophthalmic instrumentation equipped with adaptive optics." in Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology. (5 2002).
  • N Doble, L Chen, GY Yoon, P Bierden, S Olivier, DR Williams "The Use of a MEMS Mirror for Closed Loop Adaptive Optics in the Human Eye." (6 2002).

2001

  • N Doble, GY Yoon, L Chen, DR Williams "Alternative Wavefront Correctors for Adaptive Optics in the Human Eye." in ADAPTIVE OPTICS FOR INDUSTRY AND MEDICINE: Proceedings of the Third International Workshop. (9 2001).
  • L Chen, G Yoon, H Hofer, B Singer, Y Yamauchi, N Doble, J Porter, DR Williams "A real time adaptive optics system for the human eye." in ADAPTIVE OPTICS FOR INDUSTRY AND MEDICINE: Proceedings of the Third International Workshop. (9 2001).

1999

  • N Doble, G Love, DF Buscher, RM Myers, A Purvis "The Use of Image Quality Metrics for Correction of Non-Common Path Errors in the ELECTRA Adaptive Optics System." (12 1999).
  • N Doble, D Buscher, G Love, R Myers "Correction of Non-Common Path Errors in an Adaptive Optics System." in Proceedings of the Second International Workshop on Adaptive Optics for Industry and Medicine. (10 1999).

Unknown

  • N Doble, MK Walker, L Blanco, R Kivlin, SS Choi "Retinal Imaging and Cone Pointing Measurements in the Living Chick Eye, OSA Frontiers in Optics APS/DLS."
  • B Vohnsen, SS Choi, N Doble, E Wells-Gray, H Xu, AW Stitt "Modeling High-Resolution SLO and OCT Retinal Imaging using Backscattering of Light from Elementary Sources, OSA Frontiers in Optics APS/DLS."

Patents

  • HG Morris, L Blanco, JL Codona, N Doble. "RAPID MEASUREMENT OF INDIVIDUAL CONE PHOTORECEPTOR POINTING FOR EVALUATION OF EYE HEALTH USING FOCUS DIVERSITY."