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Yizhou Dong

  • Assistant Professor, Pharm CBO/Coll
  • Parks Hall, 500 West 12th Ave
    Columbus, OH 43210
  • 614-292-3771

Honors

  • 2016-2021

    NIGMS-Maximizing Investigators' Research Award (MIRA). .

  • 2016-2017

    Research Project Award. .

  • 2016-2017

    New Investigator Grant. .

  • 2015-2017

    Early Career Investigator Award. .

  • 2015-2016

    ResearchReward. .

  • 2014

    Postdoctoral Fellow Awards. .

  • 2013-2014

    Ruth L. Kirschstein NRSA Postdoctoral Fellowship. .

  • 2013

    Postdoctoral Fellowship. .

  • 2009

    Graduate Student Award in Drug Design and Discovery. .

  • 2009

    The Rho Chi Pharmacy Honor Society. .

  • 2009

    Graduate Travel Award. .

  • 2002

    Beijing Outstanding Graduates. .

  • 1998-2002

    Fellowship of Peking University. .

  • 1999

    Beijing Outstanding Undergraduate Students. .

Chapters

  • Li, B, Dong, Y.. "Preparation and Optimization of Lipid-like Nanoparticles for mRNA Delivery."
  • Journal Articles

    2016

    2015

    • Li, B., Luo, X., Deng, B., Wang, J., McComb, D. W., Shi, Y., Gaensler, K. M., Tan, X., Dunn, A. L., Kerlin, B. A., Dong, Y., 2015, An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo. Nano Lett 15, no. 12, 8099 - 107.
    • Khan,Omar,F; Zaia,Edmond,W; Jhunjhunwala,Siddharth; Xue,Wen; Cai,Wenxin; Yun,Dong,Soo; Barnes,Carmen,M; Dahlman,James,E; Dong,Yizhou; Pelet,Jeisa,M; Webber,Matthew,J; Tsosie,Jonathan,K; Jacks,Tyler,E; Langer,Robert; Anderson,Daniel,G, 2015, "Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature." NANO LETTERS 15, no. 5, 3008 - 3016.

    2014

    • Dahlman,James,E; Barnes,Carmen; Khan,Omar,F; Thiriot,Aude; Jhunjunwala,Siddharth; Shaw,Taylor,E; Xing,Yiping; Sager,Hendrik,B; Sahay,Gaurav; Speciner,Lauren; Bader,Andrew; Bogorad,Roman,L; Yin,Hao; Racie,Tim; Dong,Yizhou; Jiang,Shan; Seedorf,Danielle; Dave,Apeksha; Sandhu,Kamaljeet,Singh; Webber,Matthew,J; Novobrantseva,Tatiana; Ruda,Vera,M; Lytton-Jean,Abigail,KR; Levins,Christopher,G; Kalish,Brian; Mudge,Dayna,K; Perez,Mario; Abezgauz,Ludmila; Dutta,Partha; Smith,Lynelle; Charisse,Klaus; Kieran,Mark,W; Fitzgerald,Kevin; Nahrendorf,Matthias; Danino,Dganit; Tuder,Rubin,M; von Andrian,Ulrich,H; Akinc,Akin; Panigrahy,Dipak; Schroeder,Avi; Koteliansky,Victor; Langer,Robert; Anderson,Daniel,G, 2014, "In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight." NATURE NANOTECHNOLOGY 9, no. 8, 648 - 655.
    • Dong,Yizhou; Love,Kevin,T; Dorkin,J,Robert; Sirirungruang,Sasilada; Zhang,Yunlong; Chen,Delai; Bogorad,Roman,L; Yin,Hao; Chen,Yi; Vegas,Arturo,J; Alabi,Christopher,A; Sahay,Gaurav; Olejnik,Karsten,T; Wang,Weiheng; Schroeder,Avi; Lytton-Jean,Abigail,KR; Siegwart,Daniel,J; Akinc,Akin; Barnes,Carmen; Barros,Scott,A; Carioto,Mary; Fitzgerald,Kevin; Hettinger,Julia; Kumar,Varun; Novobrantseva,Tatiana,I; Qin,June; Querbes,William; Koteliansky,Victor; Langer,Robert; Anderson,Daniel,G, 2014, "Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111, no. 11, 3955 - 3960.
    • Eltoukhy,Ahmed,A; Chen,Delai; Veiseh,Omid; Pelet,Jeisa,M; Yin,Hao; Dong,Yizhou; Anderson,Daniel,G, 2014, "Nucleic acid-mediated intracellular protein delivery by lipid-like nanoparticles." BIOMATERIALS 35, no. 24, 6454 - 6461.
    • Dong,Yizhou; Eltoukhy,Ahmed,A; Alabi,Christopher,A; Khan,Omar,F; Veiseh,Omid; Dorkin,J,Robert; Sirirungruang,Sasilada; Yin,Hao; Tang,Benjamin,C; Pelet,Jeisa,M; Chen,Delai; Gu,Zhen; Xue,Yuan; Langer,Robert; Anderson,Daniel,G, 2014, "Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo." ADVANCED HEALTHCARE MATERIALS 3, no. 9, 1392 - 1397.

    2013

    • Gu,Zhen; Dang,Tram,T; Ma,Minglin; Tang,Benjamin,C; Cheng,Hao; Jiang,Shan; Dong,Yizhou; Zhang,Yunlong; Anderson,Daniel,G, 2013, "Glucose-Responsive Microgels Integrated with Enzyme Nanocapsules for Closed-Loop Insulin Delivery." ACS NANO 7, no. 8, 6758 - 6766.
    • Zhang,Yunlong; Pelet,Jeisa,M; Heller,Daniel,A; Dong,Yizhou; Chen,Delai; Gu,Zhen; Joseph,Brian,J; Wallas,Jasmine; Anderson,Daniel,G, 2013, "Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery." ADVANCED MATERIALS 25, no. 33, 4641 - 4645.

    2012

    • Chen,Delai; Love,Kevin,T; Chen,Yi; Eltoukhy,Ahmed,A; Kastrup,Christian; Sahay,Gaurav; Jeon,Alvin; Dong,Yizhou; Whitehead,Kathryn,A; Anderson,Daniel,G, 2012, "Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation." JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 134, no. 16, 6948 - 6951.
    • Wang,Li-Ting; Pan,Shiow-Lin; Chen,Tzu-Hsuan; Dong,Yizhou; Lee,Kuo-Hsiung; Teng,Che-Ming, 2012, "DYZ-2-90, a Novel Neo-tanshinlactone Ring-Opened Compound, Induces ERK-Mediated Mitotic Arrest and Subsequent Apoptosis by Activating JNK in Human Colorectal Cancer Cells." CHEMBIOCHEM 13, no. 11, 1663 - 1672.
    • Dong,Yizhou; Nakagawa-Goto,Kyoko; Lai,Chin-Yu; Morris-Natschke,Susan,L; Bastow,Kenneth,F; Kim,Yoon; Lee,EvaY-H,P; Lee,Kuo-Hsiung, 2012, "Antitumor Agents. 289. Design, Synthesis, and Anti-Breast Cancer Activity in Vivo of 4-Amino-2H-benzo[h]chromen-2-one and 4-Amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one Analogues with Improved Water Solubility." JOURNAL OF NATURAL PRODUCTS 75, no. 3, 370 - 377.

    2011

    • Dong,Yizhou; Nakagawa-Goto,Kyoko; Lai,Chin-Yu; Morris-Natschke,Susan,L; Bastow,Kenneth,F; Lee,Kuo-Hsiung, 2011, "Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents." BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21, no. 1, 546 - 549.
    • Dong,Yizhou; Nakagawa-Goto,Kyoko; Lai,Chin-Yu; Morris-Natschke,Susan,L; Bastow,Kenneth,F; Lee,Kuo-Hsiung, 2011, "Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity." BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21, no. 8, 2341 - 2344.
    • Dong,Yizhou; Morris-Natschke,Susan,L; Lee,Kuo-Hsiung, 2011, "Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents." NATURAL PRODUCT REPORTS 28, no. 3, 529 - 542.
    • Dong,Yizhou; Nakagawa-Goto,Kyoko; Lai,Chin-Yu; Kim,Yoon; Morris-Natschke,Susan,L; Lee,Eva,Y-HP; Bastow,Kenneth,F; Lee,Kuo-Hsiung, 2011, "Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents." BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21, no. 1, 52 - 57.

    2010

    • Dong,Yizhou; Shi,Qian; Pai,Huei-Chen; Peng,Chieh-Yu; Pan,Shiow-Lin; Teng,Che-Ming; Nakagawa-Goto,Kyoko; Yu,Donglei; Liu,Yi-Nan; Wu,Pei-Chi; Bastow,Kenneth,F; Morris-Natschke,Susan,L; Brossi,Arnold; Lang,Jing-Yu; Hsu,Jennifer,L; Hung,Mien-Chie; Lee,Eva,Y-HP; Lee,Kuo-Hsiung, 2010, "Antitumor Agents. 272. Structure-Activity Relationships and In Vivo Selective Anti-Breast Cancer Activity of Novel Neo-tanshinlactone Analogues." JOURNAL OF MEDICINAL CHEMISTRY 53, no. 5, 2299 - 2308.
    • Dong,Yizhou; Shi,Qian; Nakagawa-Goto,Kyoko; Wu,Pei-Chi; Morris-Natschke,Susan,L; Brossi,Arnold; Bastow,Kenneth,F; Lang,Jing-Yu; Hung,Mien-Chie; Lee,Kuo-Hsiung, 2010, "Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents." BIOORGANIC & MEDICINAL CHEMISTRY 18, no. 2, 803 - 808.
    • Dong,Yizhou; Nakagawa-Goto,Kyoko; Lai,Chin-Yu; Morris-Natschke,Susan,L; Bastow,Kenneth,F; Lee,Kuo-Hsiung, 2010, "Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents." BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20, no. 14, 4085 - 4087.
    • Chou,Li-Chen; Tsai,Meng-Tung; Hsu,Mei-Hua; Wang,Sheng-Hung; Way,Tzong-Der; Huang,Chi-Hung; Lin,Hui-Yi; Qian,Keduo; Dong,Yizhou; Lee,Kuo-Hsiung; Huang,Li-Jiau; Kuo,Sheng-Chu, 2010, "Design, Synthesis, and Preclinical Evaluation of New 5,6- (or 6,7-) Disubstituted-2-(fluorophenyl)quinolin-4-one Derivatives as Potent Antitumor Agents." JOURNAL OF MEDICINAL CHEMISTRY 53, no. 22, 8047 - 8058.

    2009

    • Dong,Yizhou; Shi,Qian; Liu,Yi-Nan; Wang,Xiang; Bastow,Kenneth,F; Lee,Kuo-Hsiung, 2009, "Antitumor Agents. 266. Design, Synthesis, and Biological Evaluation of Novel 2-(Furan-2-yl)naphthalen-1-ol Derivatives as Potent and Selective Antibreast Cancer Agents." JOURNAL OF MEDICINAL CHEMISTRY 52, no. 11, 3586 - 3590.
    • Dong,Yizhou; Shi,Qian; Nakagawa-Goto,Kyoko; Wu,Pei-Chi; Bastow,Kenneth,F; Morris-Natschke,Susan,L; Lee,Kuo-Hsiung, 2009, "Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents." BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19, no. 22, 6289 - 6292.

    2005

    • Zhong,Y,W; Dong,Y,Z; Fang,K; Izumi,K; Xu,M,H; Lin,G,Q, 2005, "A highly efficient and direct approach for synthesis of enantiopure beta-amino alcohols by reductive cross-coupling of chiral N-tert-butanesulfinyl imines with aldehydes." JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 127, no. 34, 11956 - 11957.

    Patents

    • Lee, KH, Dong, Y, Shi, Q, Bastow, K, Wu, PC.. "Substituted AFPO (6-aryl-4H-furo [3,2-c]pyran-4-one) Derivatives as Anti-cancer Agents."
    • Lee, KH, Dong, Y, Nakagawa-Goto,K, Bastow, K.. "Novel 4-amino-2H-benzo[h]chromen-2-one Analogs as Anti-Cancer agents."
    • Lee, KH, Dong, Y, Bastow, K, Nakagawa-Goto,K., Lee, EYH.. "4-Amino-2H-pyran-2-one Analogs as Anticancer Agents."
    • Dong, Y, Dorkin, RJ, Langer, R, Anderson, DG.. "BRUSH-POLY (GLYCOAMIDOAMINE)-LIPIDS AND USES THEREOF." Patent number: 20160067346
    • Dong, Y, Love, KT, Chen, D, Chen, Y, Zhang, Y, Vegas, A, Alabi, CA, Langer, R, Anderson, DG.. "Amino acid-, Peptide- and Polypeptide-Lipids, Isomers, Compositions, and Uses Thereof." Patent number: 9512073
    • Lee, KH, Dong, Y, Shi, Q, Bastow, K.. "Neo-tanshinlactone Analogs as Potent and Selective Anti-breast Cancer Agents."
    • Dong, Y, Wang, W, Appel, EA, Veiseh, O, Webber, MJ, Tang, BC, Xue, K, Langer, R, Anderson, DG.. "POLYMERS, HYDROGELS, AND USES THEREOF."
    • Xu, MH, Lin, GQ, Zhong, YW, Dong, Y.. "Process for Preparation of Chiral Amino Alcohols and Derivatives via Cross-coupling Reaction." Patent number: CN1709865
    • Lee, KH, Dong, Y, Shi, Q, Bastow, K.. "Substituted FNO (2-(Furan-2-yl) naphthalen-1-ol) Derivatives as Anti-cancer Agents."
    • Dong, Y, Eltoukhy, AA, Alabi, CA, Yin, H, Dorkin, RJ, Chen, D, Langer, R, Anderson, DG.. "1,3,5-triazinane-2,4,6-trione (TNT) Derivatives and Uses Thereof." Patent number: 9315472