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Yizhou Dong

  • Assistant Professor, Pharm CBO/Coll
  • Assistant Professor, Radiation Oncology
  • Room #434
    496 West 12th Ave
    Columbus, OH 43210
  • 614-292-3771

Honors

  • 20160801-20210701

    NIGMS-Maximizing Investigators' Research Award (MIRA).

  • 20160701-20170601

    New Investigator Grant.

  • 20150701-20170601

    Early Career Investigator Award.

  • 20160301-20170201

    Research Project Award.

  • 20150101-20160101

    ResearchReward.

  • 20130901-20140901

    Ruth L. Kirschstein NRSA Postdoctoral Fellowship.

  • 20140901

    Postdoctoral Fellow Awards.

  • 20130301-20130901

    Postdoctoral Fellowship.

  • 20091101

    Graduate Student Award in Drug Design and Discovery.

  • 20090501

    The Rho Chi Pharmacy Honor Society.

  • 20090301

    Graduate Travel Award.

  • 19980801-20020801

    Fellowship of Peking University.

  • 20020701

    Beijing Outstanding Graduates.

  • 19990801

    Beijing Outstanding Undergraduate Students.

Chapters

  • "Preparation and Optimization of Lipid-like Nanoparticles for mRNA Delivery." In RNA Nanostructures: Methods and Protocols,
  • Journal Articles

    2017

    • Li, B.; Zhao, W.; Luo, X.; Zhang, X. et al., 2017, "Engineering CRISPR–Cpf1 crRNAs and mRNAs to maximize genome editing efficiency." Nature Biomedical Engineering 1, no. 5, 0066-0066 - 0066-0066.
    • Luo, X.; Li, B.; Zhang, X.; Zhao, W. et al., 2017, "Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents.." Nanoscale 9, no. 4, 1575-1579 - 1575-1579.
    • Zhang, X.; Li, B.; Luo, X.; Zhao, W. et al., 2017, "Biodegradable Amino-Ester Nanomaterials for Cas9 mRNA Delivery in Vitro and in Vivo." ACS Applied Materials & Interfaces 9, no. 30, 25481-25487 - 25481-25487.
    • Jiang, C.; Mei, M.; Li, B.; Zhu, X. et al., 2017, "A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and pcsk9 in vivo." Cell Research 27, no. 3, 440-443 - 440-443.
    • Zhang, X.; Chen, X.; Zhao, W.; Zeng, C. et al., 2017, "GlcNAc Conjugated Atorvastatin with Enhanced Water Solubility and Cellular Internalization." Bioconjugate Chemistry 28, no. 8, 2109-2113 - 2109-2113.
    • Guo, S.; Li, H.; Ma, M.; Fu, J. et al., 2017, "Size, Shape and Sequence-dependent Immunogenicity of RNA Nanoparticles." Molecular Therapy - Nucleic Acids

    2016

    2015

    2014

    • 2014, "Nucleic acid-mediated intracellular protein delivery by lipid-like nanoparticles." BIOMATERIALS 35, no. 24,
    • 2014, "Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111, no. 11,
    • 2014, "Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo." ADVANCED HEALTHCARE MATERIALS 3, no. 9,
    • 2014, "In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight." NATURE NANOTECHNOLOGY 9, no. 8,

    2013

    • 2013, "Glucose-Responsive Microgels Integrated with Enzyme Nanocapsules for Closed-Loop Insulin Delivery." ACS NANO 7, no. 8,
    • 2013, "Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery." ADVANCED MATERIALS 25, no. 33,

    2012

    • Dong,Yizhou; Nakagawa-Goto,Kyoko; Lai,Chin-Yu; Morris-Natschke,Susan,L; Bastow,Kenneth,F; Kim,Yoon; Lee,EvaY-H,P; Lee,Kuo-Hsiung, 2012, "Antitumor Agents. 289. Design, Synthesis, and Anti-Breast Cancer Activity in Vivo of 4-Amino-2H-benzo[h]chromen-2-one and 4-Amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one Analogues with Improved Water Solubility." JOURNAL OF NATURAL PRODUCTS 75, no. 3, 370-377 - 370-377.
    • Lee, K-H.; Morris-Natschke, S.L.; Yang, X.; Huang, R. et al., 2012, "Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine." Journal of Traditional and Complementary Medicine 2, no. 2, 1-12 - 1-12.
    • 2012, "DYZ-2-90, a Novel Neo-tanshinlactone Ring-Opened Compound, Induces ERK-Mediated Mitotic Arrest and Subsequent Apoptosis by Activating JNK in Human Colorectal Cancer Cells." CHEMBIOCHEM 13, no. 11,
    • 2012, "Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation." JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 134, no. 16,

    2011

    • Dong,Yizhou; Nakagawa-Goto,Kyoko; Lai,Chin-Yu; Kim,Yoon; Morris-Natschke,Susan,L; Lee,Eva,Y-HP; Bastow,Kenneth,F; Lee,Kuo-Hsiung, 2011, "Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents." BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21, no. 1, 52-57 - 52-57.
    • Dong,Yizhou; Nakagawa-Goto,Kyoko; Lai,Chin-Yu; Morris-Natschke,Susan,L; Bastow,Kenneth,F; Lee,Kuo-Hsiung, 2011, "Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents." BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21, no. 1, 546-549 - 546-549.
    • Dong,Yizhou; Nakagawa-Goto,Kyoko; Lai,Chin-Yu; Morris-Natschke,Susan,L; Bastow,Kenneth,F; Lee,Kuo-Hsiung, 2011, "Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity." BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21, no. 8, 2341-2344 - 2341-2344.
    • Dong,Yizhou; Morris-Natschke,Susan,L; Lee,Kuo-Hsiung, 2011, "Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents." NATURAL PRODUCT REPORTS 28, no. 3, 529-542 - 529-542.

    2010

    • 2010, "Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents." BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20, no. 14,
    • 2010, "Design, Synthesis, and Preclinical Evaluation of New 5,6- (or 6,7-) Disubstituted-2-(fluorophenyl)quinolin-4-one Derivatives as Potent Antitumor Agents." JOURNAL OF MEDICINAL CHEMISTRY 53, no. 22,
    • Dong,Yizhou; Shi,Qian; Pai,Huei-Chen; Peng,Chieh-Yu; Pan,Shiow-Lin; Teng,Che-Ming; Nakagawa-Goto,Kyoko; Yu,Donglei; Liu,Yi-Nan; Wu,Pei-Chi; Bastow,Kenneth,F; Morris-Natschke,Susan,L; Brossi,Arnold; Lang,Jing-Yu; Hsu,Jennifer,L; Hung,Mien-Chie; Lee,Eva,Y-HP; Lee,Kuo-Hsiung, 2010, "Antitumor Agents. 272. Structure-Activity Relationships and In Vivo Selective Anti-Breast Cancer Activity of Novel Neo-tanshinlactone Analogues." JOURNAL OF MEDICINAL CHEMISTRY 53, no. 5, 2299-2308 - 2299-2308.
    • Dong,Yizhou; Shi,Qian; Nakagawa-Goto,Kyoko; Wu,Pei-Chi; Morris-Natschke,Susan,L; Brossi,Arnold; Bastow,Kenneth,F; Lang,Jing-Yu; Hung,Mien-Chie; Lee,Kuo-Hsiung, 2010, "Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents." BIOORGANIC & MEDICINAL CHEMISTRY 18, no. 2, 803-808 - 803-808.

    2009

    • Dong,Yizhou; Shi,Qian; Nakagawa-Goto,Kyoko; Wu,Pei-Chi; Bastow,Kenneth,F; Morris-Natschke,Susan,L; Lee,Kuo-Hsiung, 2009, "Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents." BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19, no. 22, 6289-6292 - 6289-6292.
    • Dong,Yizhou; Shi,Qian; Liu,Yi-Nan; Wang,Xiang; Bastow,Kenneth,F; Lee,Kuo-Hsiung, 2009, "Antitumor Agents. 266. Design, Synthesis, and Biological Evaluation of Novel 2-(Furan-2-yl)naphthalen-1-ol Derivatives as Potent and Selective Antibreast Cancer Agents." JOURNAL OF MEDICINAL CHEMISTRY 52, no. 11, 3586-3590 - 3586-3590.

    2005

    • 2005, "A highly efficient and direct approach for synthesis of enantiopure beta-amino alcohols by reductive cross-coupling of chiral N-tert-butanesulfinyl imines with aldehydes." JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 127, no. 34,

    Presentations

    • "Emerging nanotechnology to eliminate Hepatitis B." 2017, Presented at Ohio State University Discovery Talks-Infectious Disease,
    • "Development of nanomaterials for mRNA therapeutics and genome editing." 2017, Presented at CAB Day: Seeking Convergence to Advance Biomaterials Science and Translation,
    • "Development of nanomaterials for RNA delivery." 2016, Presented at Hemophilia BOSS (Bench-to-Outcomes Seminar Series),
    • "Development of nanomaterials for RNA delivery." 2016, Presented at Ohio State University, Immunology Seminar Series,
    • "Development of nanomaterials for RNA delivery." 2015, Presented at Wayne State University, Department of Biochemistry,
    • "Development of nanomaterials for RNA delivery." 2015, Presented at Cleveland State University, Department of Chemistry,
    • "Development of nanomaterials for RNA delivery." 2015, Presented at Ohio State University, Division of Medicinal Chemistry,
    • "Development of nanomaterials for RNA delivery." 2014, Presented at Nationwide Children’s Hospital,
    • "Development of nanomaterials for highly efficient and selective delivery of nucleic acids." 2014, Presented at Ohio State University, College of Pharmacy,
    • "Development of nanomaterials for highly efficient and selective delivery of nucleic acids." 2014, Presented at University of Illinois at Chicago, Department of Biomedical engineering,
    • "Development of nanomaterials for highly efficient and selective delivery of nucleic acids." 2014, Presented at Purdue University, College of Pharmacy,
    • "Development of nanomaterials for highly efficient and selective delivery of nucleic acids." 2014, Presented at College of Pharmacy University of Nebraska Medical Center,
    • "Development of nanomaterials for highly efficient and selective delivery of nucleic acids." 2014, Presented at Sanford Children’s Health Research Center,

    Papers in Proceedings

    2017

    • Dong, Y. "10th annual Translational to Clinical (T2C) Regenerative Medicine Wound Care Conference." (3 2017).
    • Dong, Y. "First Conference on Biomotors, Virus Assembly, and Nanobiotechnology Applications." (8 2017).
    • Dong, Y.; Luo, X.; Li, B. "Development of Lipid-like Nanoparticles for mRNA Delivery." in The Ohio LSAMP Alliance Conference. (3 2017).

    2016

    • Dong, Y. "2016 Controlled Release Society Annual Meeting." (7 2016).
    • Dong, Y. "RNA nanotechnology Conference." (8 2016).

    2015

    • Dong, Y. "2015 Materials Research Society Spring Meeting." (4 2015).
    • Dong, Y. "3rd International mRNA Health Conference." (11 2015).
    • Dong, Y. "13th US-Japan Symposium on Drug Delivery Systems." (12 2015).

    2014

    • Dong, Y.; Langer, R.; ANderson, D. "2014 AAPS Annual Meeting and Exposition." (10 2014).

    2013

    • Dong, Y.; Langer, R.; Anderson, D. "12th US-Japan Symposium on Drug Delivery Systems." (12 2013).
    • Dong, Y.; Langer, R.; Anderson, D. "Cancer Nanotechnology Gordon Research Conference." (7 2013).
    • Dong, Y.; Langer, R.; Anderson, D. "2013 BMES annual meeting." (9 2013).
    • Dong, Y.; Langer, R.; Anderson, D. "2013 ASME Global Congress on NanoEngineering for Medicine and Biology." (2 2013).
    • Dong, Y.; Langer, R.; Anderson, D. "Boston Symposium on Organic & Bioorganic Chemistry." (10 2013).

    2012

    • Dong, Y.; Love, K.; Dorkin, J.; Sirirungruang, S. et al. "Drug Carriers in Medicine & Biology Gordon Research Conference." (8 2012).

    2009

    • Dong, Y.; Shi, Q.; Liu, Y.N.; Morris-Natschke, S. et al. "Fourth Annual Chapel Hill Drug Conference." (5 2009).
    • Dong, Y.; Shi, Q.; Liu, Y.N.; Wang, X. et al. "238th ACS National Meeting." (8 2009).
    • Dong, Y.; Shi, Q.; Nakagawa-Goto, K.; Wu, P.C. et al. "2009 AAPS Annual Meeting and Exposition." (11 2009).

    Unknown

    • Dong, Y.; Qian, S.; Liu, Y.N.; Morris-Natschke, S. et al. "237th ACS National Meeting."
    • Dong, Y. "Lipid-like Nanoparticles for mRNA Delivery in vivo." in The Second Annual Inhibitors to Factor VIII: Translating the Bench to the Bedside.

    Patents

    • Dong, Y, Love, KT, Chen, D, Chen, Y, Zhang, Y, Vegas, A, Alabi, CA, Langer, R, Anderson, DG.. "Amino acid-, Peptide- and Polypeptide-Lipids, Isomers, Compositions, and Uses Thereof." Patent number: 9512073
    • Dong, Y, Eltoukhy, AA, Alabi, CA, Yin, H, Dorkin, RJ, Chen, D, Langer, R, Anderson, DG.. "1,3,5-triazinane-2,4,6-trione (TNT) Derivatives and Uses Thereof." Patent number: 9315472
    • Dong, Y, Dorkin, RJ, Langer, R, Anderson, DG.. "BRUSH-POLY (GLYCOAMIDOAMINE)-LIPIDS AND USES THEREOF." Patent number: 20160067346
    • Xu, MH, Lin, GQ, Zhong, YW, Dong, Y.. "Process for Preparation of Chiral Amino Alcohols and Derivatives via Cross-coupling Reaction." Patent number: CN1709865
    • Dong, Y, Li, B.. "NA."
    • Dong, Y, Zhang, X.. "NA."
    • Dong, Y, Byrd, J, Jordan, C, Li, B, Wang, J.. "NA."
    • Dong, Y, Li, B.. "Lipid-Like Nanoparticles (LLN) and Uses Thereof."
    • Dong, Y, Wang, W, Appel, EA, Veiseh, O, Webber, MJ, Tang, BC, Xue, K, Langer, R, Anderson, DG.. "POLYMERS, HYDROGELS, AND USES THEREOF."
    • Dong, Y, Chakravarti, A, Li, B, Wang, J, Wesolowski, R, White, J..
    • Lee, KH, Dong, Y, Bastow, K, Nakagawa-Goto,K., Lee, EYH.. "4-Amino-2H-pyran-2-one Analogs as Anticancer Agents."
    • Lee, KH, Dong, Y, Shi, Q, Bastow, K.. "Substituted FNO (2-(Furan-2-yl) naphthalen-1-ol) Derivatives as Anti-cancer Agents."
    • Lee, KH, Dong, Y, Nakagawa-Goto,K, Bastow, K.. "Novel 4-amino-2H-benzo[h]chromen-2-one Analogs as Anti-Cancer agents."
    • Lee, KH, Dong, Y, Shi, Q, Bastow, K, Wu, PC.. "Substituted AFPO (6-aryl-4H-furo [3,2-c]pyran-4-one) Derivatives as Anti-cancer Agents."
    • Lee, KH, Dong, Y, Shi, Q, Bastow, K.. "Neo-tanshinlactone Analogs as Potent and Selective Anti-breast Cancer Agents."