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Joshua Englert

  • Assistant Professor, Pulmonary, Crit Care, & Sleep
  • Physician, FGP-Pulm, Crit Care, & Sleep
  • 473 W 12th Ave
    Columbus, OH 43210


  • January, 2018

    BAL Award.

  • January, 2017

    Outstanding Young Investigator Award.

  • January, 2016

    K Travel Award.

  • January, 2014

    Young Physician Scientist Award.

  • January, 2014

    Chair's Research Award.

  • January, 2012-
    January, 2014

    Loan Repayment Award.

  • January, 2014

    Grant Review and Support Program.

  • January, 2009-
    January, 2011

    Loan Repayment Award.

  • January, 2007

    Nominee, Best Resident Teacher Award.

  • January, 2005

    Brinton Prize.

  • January, 2004-
    December, 2004

    Alpha Omega Alpha.

  • January, 2004

    Academy of Achievement Summit.

  • January, 2001-
    January, 2003

    Robert and Gertrude Harris Foundation Scholarship.

  • January, 1999-
    December, 1999

    Ruth E. Duffy Scholarship.

  • January, 1999

    Research Experience for Undergraduates (REU) Fellow.

  • January, 1998

    Alpha Epsilon Delta.



  • 2017. "Sepsis Syndrome." In The Brigham Intensive Review of Internal Medicine,
  • 2017. "Mechanical Ventilation." In The Brigham Intensive Review,


  • Sing, A.J.; Loscalzo, J.. 2012. "Sepsis syndrome.." In The Brigham Intensive Review of Internal Medicine,


  • 2008. "Sepsis syndrome.." In Brigham Intensive Review of Internal Medicine,

Journal Articles


  • Chung, S.; Kim, J.Y.; Song, M-A.; Park, G.Y. et al., 2018, "FoxO1 is a critical regulator of M2-like macrophage activation in allergic asthma.." Allergy


  • Englert, J.A.; Rogers, A.J., 2016, "Metabolism, Metabolomics, and Nutritional Support of Patients with Sepsis." Clinics in Chest Medicine 37, no. 2, 321-331 - 321-331.
  • Hou, H.W.; Wu, L.; Amador-Munoz, D.P.; Vera, M.P. et al., 2016, "Broad spectrum immunomodulation using biomimetic blood cell margination for sepsis therapy." Lab on a Chip - Miniaturisation for Chemistry and Biology 16, no. 4, 688-699 - 688-699.


  • Englert,Joshua,A; Macias,Alvaro,A; Amador-Munoz,Diana; Vera,Miguel,Pinilla; Isabelle,Colleen; Guan,Jiazhen; Magaoay,Brady; Velandia,Margarita,Suarez; Coronata,Anna; Lee,Awapuhi; Fredenburgh,Laura,E; Culley,Deborah,J; Crosby,Gregory; Baron,Rebecca,M, 2015, "Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity." ANESTHESIOLOGY 123, no. 2, 377-388 - 377-388.


  • Haspel,Jeffrey,A; Chettimada,Sukrutha; Shaik,Rahamthulla,S; Chu,Jen-Hwa; Raby,Benjamin,A; Cernadas,Manuela; Carey,Vincent; Process,Vanessa; Hunninghake,G,Matthew; Ifedigbo,Emeka; Lederer,James,A; Englert,Joshua; Pelton,Ashley; Coronata,Anna; Fredenburgh,Laura,E; Choi,Augustine,MK, 2014, "Circadian rhythm reprogramming during lung inflammation." NATURE COMMUNICATIONS 5, 4753 - 4753.
  • Langley,Raymond,J; Tipper,Jennifer,L; Bruse,Shannon; Baron,Rebecca,M; Tsalik,Ephraim,L; Huntley,James; Rogers,Angela,J; Jaramillo,Richard,J; O'Donnell,Denise; Mega,William,M; Keaton,Mignon; Kensicki,Elizabeth; Gazourian,Lee; Fredenburgh,Laura,E; Massaro,Anthony,F; Otero,Ronny,M; Fowler,Vance,G; Rivers,Emanuel,P; Woods,Chris,W; Kingsmore,Stephen,F; Soporil,Mohan,L; Perrella,Mark,A; Choi,Augustine,MK; Harrod,Kevin,S, 2014, "Integrative "Omic" Analysis of Experimental Bacteremia Identifies a Metabolic Signature That Distinguishes Human Sepsis from Systemic Inflammatory Response Syndromes." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 190, no. 4, 445-455 - 445-455.
  • Rogers,Angela,J; McGeachie,Michael; Baron,Rebecca,M; Gazourian,Lee; Haspel,Jeffrey,A; Nakahira,Kiichi; Fredenburgh,Laura,E; Hunninghake,Gary,M; Raby,Benjamin,A; Matthay,Michael,A; Otero,Ronny,M; Fowler,Vance,G; Rivers,Emanuel,P; Woods,Christopher,W; Kingsmore,Stephen; Langley,Ray,J; Choi,Augustine,MK, 2014, "Metabolomic Derangements Are Associated with Mortality in Critically Ill Adult Patients." PLOS ONE 9, no. 1, e87538 - e87538.


  • Li,Yongsheng; Dalli,Jesmond; Chiang,Nan; Baron,Rebecca,M; Quintana,Carolina; Serhan,Charles,N, 2013, "Plasticity of Leukocytic Exudates in Resolving Acute Inflammation Is Regulated by MicroRNA and Proresolving Mediators." IMMUNITY 39, no. 5, 885-898 - 885-898.
  • Nakahira,Kiichi; Kyung,Sun-Young; Rogers,Angela,J; Gazourian,Lee; Youn,Sojung; Massaro,Anthony,F; Quintana,Carolina; Osorio,Juan,C; Wang,Zhaoxi; Zhao,Yang; Lawler,Laurie,A; Christie,Jason,D; Meyer,Nuala,J; Mc Causland,Finnian,R; Waikar,Sushrut,S; Waxman,Aaron,B; Chung,Raymond,T; Bueno,Raphael; Rosas,Ivan,O; Fredenburgh,Laura,E; Baron,Rebecca,M; Christiani,David,C; Hunninghake,Gary,M; Choi,Augustine,MK, 2013, "Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation." PLOS MEDICINE 10, no. 12, e1001577 - e1001577.


  • Dolinay,Tamas; Kim,Young,Sam; Howrylak,Judie; Hunninghake,Gary,M; An,Chang,Hyeok; Fredenburgh,Laura; Massaro,Anthony,F; Rogers,Angela; Gazourian,Lee; Nakahira,Kiichi; Haspel,Jeffrey,A; Landazury,Roberto; Eppanapally,Sabitha; Christie,Jason,D; Meyer,Nuala,J; Ware,Lorraine,B; Christiani,David,C; Ryter,Stefan,W; Baron,Rebecca,M; Choi,Augustine,MK, 2012, "Inflammasome-regulated Cytokines Are Critical Mediators of Acute Lung Injury." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 185, no. 11, 1225-1234 - 1225-1234.
  • Lai,Peggy,S; Fresco,Jennifer,M; Pinilla,Miguel,A; Macias,Alvaro,A; Brown,Ronald,D; Englert,Joshua,A; Hofmann,Oliver; Lederer,James,A; Hide,Winston; Christiani,David,C; Cernadas,Manuela; Baron,Rebecca,M, 2012, "Chronic Endotoxin Exposure Produces Airflow Obstruction and Lung Dendritic Cell Expansion." AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 47, no. 2, 209-217 - 209-217.


  • Haspel,Jeffrey; Shaik,Rahamthulla,S; Ifedigbo,Emeka; Nakahira,Kiichi; Dolinay,Tamas; Englert,Joshua,A; Choi,Augustine,MK, 2011, "Characterization of macroautophagic flux in vivo using a leupeptin-based assay." AUTOPHAGY 7, no. 6, 629-642 - 629-642.
  • Nakahira,Kiichi; Haspel,Jeffrey,Adam; Rathinam,Vijay,AK; Lee,Seon-Jin; Dolinay,Tamas; Lam,Hilaire,C; Englert,Joshua,A; Rabinovitch,Marlene; Cernadas,Manuela; Kim,Hong,Pyo; Fitzgerald,Katherine,A; Ryter,Stefan,W; Choi,Augustine,MK, 2011, "Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome." NATURE IMMUNOLOGY 12, no. 3, 222-U57 - 222-U57.
  • Fredenburgh,Laura,E; Velandia,Margarita,MSuarez; Ma,Jun; Olszak,Torsten; Cernadas,Manuela; Englert,Joshua,A; Chung,Su,Wol; Liu,Xiaoli; Begay,Cynthia; Padera,Robert,F; Blumberg,Richard,S; Walsh,Stephen,R; Baron,Rebecca,M; Perrella,Mark,A, 2011, "Cyclooxygenase-2 Deficiency Leads to Intestinal Barrier Dysfunction and Increased Mortality during Polymicrobial Sepsis." JOURNAL OF IMMUNOLOGY 187, no. 10, 5255-5267 - 5255-5267.


  • Yang,Runkuan; Harada,Tomoyuki; Mollen,Kevin,P; Prince,Jose,M; Levy,Ryan,M; Englert,Joshua,A; Gallowitsch-Puerta,Margot; Yang,LiHong; Yang,Huan; Tracey,Kevin,J; Harbrecht,Brian,G; Billiar,Timothy,R; Fink,Mitchell,P, 2006, "Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock." MOLECULAR MEDICINE 12, no. 4-6, 105-114 - 105-114.
  • Killeen,M,E; Englert,J,A; Stolz,D,B; Song,M,C; Han,Y,S; Delude,R,L; Kellum,J,A; Fink,M,P, 2006, "The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 316, no. 3, 1070-1079 - 1070-1079.


  • Yang,R,K; Harada,T; Li,J,Y; Uchiyama,T; Han,Y,S; Englert,J,A; Fink,M,P, 2005, "Bile modulates intestinal epithelial barrier function via an extracellular signal related kinase 1/2 dependent mechanism." INTENSIVE CARE MEDICINE 31, no. 5, 709-717 - 709-717.
  • Han,Y,S; Englert,J,A; Yang,R,K; Delude,R,L; Fink,M,P, 2005, "Ethyl pyruvate inhibits nuclear factor-kappa B-dependent signaling by directly targeting p65." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 312, no. 3, 1097-1105 - 1097-1105.
  • Han,Y,S; Englert,J,A; Delude,R,L; Fink,M,P, 2005, "Ethacrynic acid inhibits multiple steps in the NF-kappa B signaling pathway." SHOCK 23, no. 1, 45-53 - 45-53.
  • Sappington,P,L; Cruz,R,J; Harada,T; Yang,R,K; Han,Y,S; Englert,J,A; Ajami,A,A; Killeen,M,E; Delude,R,L; Fink,M,P, 2005, "The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro." BIOCHEMICAL PHARMACOLOGY 70, no. 11, 1579-1592 - 1579-1592.
  • Englert, J., 2005, "The multiple organ dysfunction syndrome and late-phase mortality in sepsis.." Current infectious disease reports 7, no. 5,


  • "Role of NOS-2 in a mouse model of sepsis induced ARDS." 2009, Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital,
  • "Role of mechanical mTORC1 activation in ventilator induced lung injury." 2015, Presented at Invited Research Seminar,
  • "Role of mTORC1 activation in the pathogenesis of stretch induced lung injury." 2011, Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital,
  • "Role of surfactant protein D in polymicrobial sepsis." 2013, Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital,
  • "Zinc deficiency primes the lung for ventilator induced lung injury." Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital,
  • "mTORC1 activation and impaired autophagy in ventilator induced lung injury." 2010, Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital,
  • "Zinc, mechanical ventilation, and ARDS." 2016, Presented at Pulmonary Research Conference,
  • "ARDS, From clinical observations to translational studies." 2017, Presented at Pulmonary Research Conference,
  • "Targeting mechanotransduction in the lung to develop novel ARDs therapies." 2018, Presented at Center for Perinatal Research Seminar,
  • "Role of mTORC1 activation in ventilator induced lung injury and the acute respiratory distress syndrome." 2017, Presented at Central Society for Clinical and Translational Research Annual Meeting,
  • "Navigating Early Career Funding." 2017, Presented at American Thoracic Society International Conference,

Papers in Proceedings


  • Lai, P.S.; Austin, J.M.; Brown, R.D.; Macias, A.A. et al. "Airway Reactivity And Persistent Inflammation Is Associated With Antigen Presenting Cell Population Shifts In A Murine Model Of Chronic Inhalational Endotoxin Exposure." (1 2011).