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Joshua Englert

  • Assistant Professor, Pulmonary, Crit Care, & Sleep
  • Physician, FGP-Pulm, Crit Care, & Sleep
  • 473 W 12th Ave
    Columbus, OH 43210

Honors

  • 2014

    Chair's Research Award. .

  • 2014

    Young Physician Scientist Award. .

  • 2007

    Nominee, Best Resident Teacher Award. .

  • 2005

    Brinton Prize. .

  • 2004

    Academy of Achievement Summit. .

  • 2004

    Alpha Omega Alpha. .

  • 2001-2003

    Robert and Gertrude Harris Foundation Scholarship. .

  • 1999

    Ruth E. Duffy Scholarship. .

  • 1999

    Research Experience for Undergraduates (REU) Fellow. .

  • 1998

    Alpha Epsilon Delta. .

Journal Articles

2015

  • Englert,Joshua,A; Macias,Alvaro,A; Amador-Munoz,Diana; Vera,Miguel,Pinilla; Isabelle,Colleen; Guan,Jiazhen; Magaoay,Brady; Velandia,Margarita,Suarez; Coronata,Anna; Lee,Awapuhi; Fredenburgh,Laura,E; Culley,Deborah,J; Crosby,Gregory; Baron,Rebecca,M, 2015, "Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity." ANESTHESIOLOGY 123, no. 2, 377 - 388.

2014

  • Langley,Raymond,J; Tipper,Jennifer,L; Bruse,Shannon; Baron,Rebecca,M; Tsalik,Ephraim,L; Huntley,James; Rogers,Angela,J; Jaramillo,Richard,J; O'Donnell,Denise; Mega,William,M; Keaton,Mignon; Kensicki,Elizabeth; Gazourian,Lee; Fredenburgh,Laura,E; Massaro,Anthony,F; Otero,Ronny,M; Fowler,Vance,G; Rivers,Emanuel,P; Woods,Chris,W; Kingsmore,Stephen,F; Soporil,Mohan,L; Perrella,Mark,A; Choi,Augustine,MK; Harrod,Kevin,S, 2014, "Integrative "Omic" Analysis of Experimental Bacteremia Identifies a Metabolic Signature That Distinguishes Human Sepsis from Systemic Inflammatory Response Syndromes." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 190, no. 4, 445 - 455.
  • Rogers,Angela,J; McGeachie,Michael; Baron,Rebecca,M; Gazourian,Lee; Haspel,Jeffrey,A; Nakahira,Kiichi; Fredenburgh,Laura,E; Hunninghake,Gary,M; Raby,Benjamin,A; Matthay,Michael,A; Otero,Ronny,M; Fowler,Vance,G; Rivers,Emanuel,P; Woods,Christopher,W; Kingsmore,Stephen; Langley,Ray,J; Choi,Augustine,MK, 2014, "Metabolomic Derangements Are Associated with Mortality in Critically Ill Adult Patients." PLOS ONE 9, no. 1, e87538 -
  • Haspel,Jeffrey,A; Chettimada,Sukrutha; Shaik,Rahamthulla,S; Chu,Jen-Hwa; Raby,Benjamin,A; Cernadas,Manuela; Carey,Vincent; Process,Vanessa; Hunninghake,G,Matthew; Ifedigbo,Emeka; Lederer,James,A; Englert,Joshua; Pelton,Ashley; Coronata,Anna; Fredenburgh,Laura,E; Choi,Augustine,MK, 2014, "Circadian rhythm reprogramming during lung inflammation." NATURE COMMUNICATIONS 5, 4753 -

2013

  • Nakahira,Kiichi; Kyung,Sun-Young; Rogers,Angela,J; Gazourian,Lee; Youn,Sojung; Massaro,Anthony,F; Quintana,Carolina; Osorio,Juan,C; Wang,Zhaoxi; Zhao,Yang; Lawler,Laurie,A; Christie,Jason,D; Meyer,Nuala,J; Mc Causland,Finnian,R; Waikar,Sushrut,S; Waxman,Aaron,B; Chung,Raymond,T; Bueno,Raphael; Rosas,Ivan,O; Fredenburgh,Laura,E; Baron,Rebecca,M; Christiani,David,C; Hunninghake,Gary,M; Choi,Augustine,MK, 2013, "Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation." PLOS MEDICINE 10, no. 12, e1001577 -
  • Langley,Raymond,Jg; Tsalik,Ephraim,L; van Velkinburgh,Jennifer,C; Glickman,Seth,W; Rice,Brandon,J; Wang,Chunping; Chen,Bo; Carin,Lawrence; Suarez,Arturo; Mohney,Robert,P; Freeman,Debra,H; Wang,Mu; You,Jinsam; Wulff,Jacob; Thompson,J,Will; Moseley,M,Arthur; Reisinger,Stephanie; Edmonds,Brian,T; Grinnell,Brian; Nelson,David,R; Dinwiddie,Darrell,L; Miller,Neil,A; Saunders,Carol,J; Soden,Sarah,S; Rogers,Angela,J; Gazourian,Lee; Fredenburgh,Laura,E; Massaro,Anthony,F; Baron,Rebecca,M; Choi,Augustine,MK; Corey,G,Ralph; Ginsburg,Geoffrey,S; Cairns,Charles,B; Otero,Ronny,M; Fowler,Vance,G; Rivers,Emanuel,P; Woods,Christopher,W; Kingsmore,Stephen,F, 2013, "An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis." SCIENCE TRANSLATIONAL MEDICINE 5, no. 195, 195ra95 -
  • Li,Yongsheng; Dalli,Jesmond; Chiang,Nan; Baron,Rebecca,M; Quintana,Carolina; Serhan,Charles,N, 2013, "Plasticity of Leukocytic Exudates in Resolving Acute Inflammation Is Regulated by MicroRNA and Proresolving Mediators." IMMUNITY 39, no. 5, 885 - 898.

2012

  • Lai,Peggy,S; Fresco,Jennifer,M; Pinilla,Miguel,A; Macias,Alvaro,A; Brown,Ronald,D; Englert,Joshua,A; Hofmann,Oliver; Lederer,James,A; Hide,Winston; Christiani,David,C; Cernadas,Manuela; Baron,Rebecca,M, 2012, "Chronic Endotoxin Exposure Produces Airflow Obstruction and Lung Dendritic Cell Expansion." AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 47, no. 2, 209 - 217.
  • Dolinay,Tamas; Kim,Young,Sam; Howrylak,Judie; Hunninghake,Gary,M; An,Chang,Hyeok; Fredenburgh,Laura; Massaro,Anthony,F; Rogers,Angela; Gazourian,Lee; Nakahira,Kiichi; Haspel,Jeffrey,A; Landazury,Roberto; Eppanapally,Sabitha; Christie,Jason,D; Meyer,Nuala,J; Ware,Lorraine,B; Christiani,David,C; Ryter,Stefan,W; Baron,Rebecca,M; Choi,Augustine,MK, 2012, "Inflammasome-regulated Cytokines Are Critical Mediators of Acute Lung Injury." AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 185, no. 11, 1225 - 1234.

2011

  • Haspel,Jeffrey; Shaik,Rahamthulla,S; Ifedigbo,Emeka; Nakahira,Kiichi; Dolinay,Tamas; Englert,Joshua,A; Choi,Augustine,MK, 2011, "Characterization of macroautophagic flux in vivo using a leupeptin-based assay." AUTOPHAGY 7, no. 6, 629 - 642.
  • Fredenburgh,Laura,E; Velandia,Margarita,MSuarez; Ma,Jun; Olszak,Torsten; Cernadas,Manuela; Englert,Joshua,A; Chung,Su,Wol; Liu,Xiaoli; Begay,Cynthia; Padera,Robert,F; Blumberg,Richard,S; Walsh,Stephen,R; Baron,Rebecca,M; Perrella,Mark,A, 2011, "Cyclooxygenase-2 Deficiency Leads to Intestinal Barrier Dysfunction and Increased Mortality during Polymicrobial Sepsis." JOURNAL OF IMMUNOLOGY 187, no. 10, 5255 - 5267.
  • Nakahira,Kiichi; Haspel,Jeffrey,Adam; Rathinam,Vijay,AK; Lee,Seon-Jin; Dolinay,Tamas; Lam,Hilaire,C; Englert,Joshua,A; Rabinovitch,Marlene; Cernadas,Manuela; Kim,Hong,Pyo; Fitzgerald,Katherine,A; Ryter,Stefan,W; Choi,Augustine,MK, 2011, "Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome." NATURE IMMUNOLOGY 12, no. 3, 222 - U57.

2008

  • Englert JA and Baron RM, 2008, "Sepsis syndrome.." The Brigham Intensive Review of Internal Medicine. 1, 380 - 385.
  • Englert JA and Baron RM, 2008, "Sepsis syndrome.." The Brigham Intensive Review of Internal Medicine. 2, 308 - 385.

2006

  • Killeen,M,E; Englert,J,A; Stolz,D,B; Song,M,C; Han,Y,S; Delude,R,L; Kellum,J,A; Fink,M,P, 2006, "The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 316, no. 3, 1070 - 1079.
  • Yang,Runkuan; Harada,Tomoyuki; Mollen,Kevin,P; Prince,Jose,M; Levy,Ryan,M; Englert,Joshua,A; Gallowitsch-Puerta,Margot; Yang,LiHong; Yang,Huan; Tracey,Kevin,J; Harbrecht,Brian,G; Billiar,Timothy,R; Fink,Mitchell,P, 2006, "Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock." MOLECULAR MEDICINE 12, no. 4-6, 105 - 114.

2005

  • Yang,R,K; Harada,T; Li,J,Y; Uchiyama,T; Han,Y,S; Englert,J,A; Fink,M,P, 2005, "Bile modulates intestinal epithelial barrier function via an extracellular signal related kinase 1/2 dependent mechanism." INTENSIVE CARE MEDICINE 31, no. 5, 709 - 717.
  • Englert,Joshua,A; Fink,Mitchell,P, 2005, "The multiple organ dysfunction syndrome and late-phase mortality in sepsis.." Current infectious disease reports 7, no. 5, 335 - 341.
  • Sappington,P,L; Cruz,R,J; Harada,T; Yang,R,K; Han,Y,S; Englert,J,A; Ajami,A,A; Killeen,M,E; Delude,R,L; Fink,M,P, 2005, "The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro." BIOCHEMICAL PHARMACOLOGY 70, no. 11, 1579 - 1592.
  • Han,Y,S; Englert,J,A; Delude,R,L; Fink,M,P, 2005, "Ethacrynic acid inhibits multiple steps in the NF-kappa B signaling pathway." SHOCK 23, no. 1, 45 - 53.
  • Han,Y,S; Englert,J,A; Yang,R,K; Delude,R,L; Fink,M,P, 2005, "Ethyl pyruvate inhibits nuclear factor-kappa B-dependent signaling by directly targeting p65." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 312, no. 3, 1097 - 1105.

Presentations

  • "Role of NOS-2 in a mouse model of sepsis induced ARDS." 2009, Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital,
  • "Role of mTORC1 activation in the pathogenesis of stretch induced lung injury." 2011, Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital,
  • "Role of surfactant protein D in polymicrobial sepsis." 2013, Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital,
  • "Zinc deficiency primes the lung for ventilator induced lung injury." 2014, Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital,
  • "Role of mechanical mTORC1 activation in ventilator induced lung injury." 2015, Presented at Invited Research Seminar, Columbus,
  • "mTORC1 activation and impaired autophagy in ventilator induced lung injury." 2010, Presented at Work-in-Progress, Pulmonary Division, Brigham and Women’s Hospital,