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Samir Ghadiali

  • Professor, Pulmonary, Crit Care, & Sleep
  • Professor, Biomedical Engineering
  • 292 Bevis Hall
    1080 Carmack Road
    Columbus, OH 43210
  • 614-292-7742

Honors

  • 2014

    Lumley Research Award. .

  • 2008-2013

    NSF CAREER Award. .

  • 2006-2011

    NIH RO1 New Investigator Award. .

  • 2010

    Herman Weed Excellence in Teaching Award. .

  • 2005-2008

    Frank Hook Assistant Professorship in Bioengineering. .

  • 2005-2008

    Parker B. Francis Fellowship in Pulmonary Research. .

  • 2005

    US National Committee on Biomechanics New Faculty Award. .

  • 2001

    Children’s Hospital of Pittsburgh Post-doctoral Research Fellowship. .

  • 1994-1998

    Louisiana Board of Regents Graduate Study Scholarship. .

  • Chair of Respiratory Engineering Track at BMES Annual Meetings in 2009 and 2014. .

Chapters

2013

  • Huang, Y., Ghadiali, S.N., Nana-Sinkam, S.P.. 2013. "MicroRNAs and Inflammation." In Micro-RNAs in Toxicology and Medicine, edited by Saura Sahu,

2011

  • Ghadiali, S.N. and Dailey, H.L.. 2011. "Mechanobiology and finite element analysis of cellular injury during microbubble flows." In Cellular and Biomolecular Mechanics and Mechanobiology, edited by Amit Gefen,

2008

  • Ghadiali, SN. 2008. "Computer Modeling in Otitis Media: Perspectives and Limits." In Chronic Otitis Media, Pathology -guided, Pathogenesis-oriented Therapeutic Management, edited by Bernard Ars,

Journal Articles

2016

  • 2016, "Substrate stiffness modulates lung cancer cell migration but not epithelial to mesenchymal transition." JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 104, no. 5,
  • 2016, "Multi-scale finite element modeling of Eustachian tube function: influence of mucosal adhesion." INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING 32, no. 12,
  • 2016, "Simvastatin Treatment Modulates Mechanically-Induced Injury and Inflammation in Respiratory Epithelial Cells." ANNALS OF BIOMEDICAL ENGINEERING 44, no. 12,

2015

  • 2015, "Survival in Adult Lung Transplant Recipients Receiving Pediatric Versus Adult Donor Allografts." ANNALS OF THORACIC SURGERY 100, no. 4,
  • 2015, "Myoferlin depletion elevates focal adhesion kinase and paxillin phosphorylation and enhances cell-matrix adhesion in breast cancer cells." AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 308, no. 8,
  • 2015, "Influence of HLA Mismatching on Survival in Lung Transplantation." LUNG 193, no. 5,

2014

  • 2014, "Influence of airway wall compliance on epithelial cell injury and adhesion during interfacial flows." JOURNAL OF APPLIED PHYSIOLOGY 117, no. 11,
  • Volakis,Leonithas,I; Li,Ruth; Ackerman,William,E; Mihai,Cosmin; Bechel,Meagan; Summerfield,Taryn,L; Ahn,Christopher,S; Powell,Heather,M; Zielinski,Rachel; Rosol,Thomas,J; Ghadiali,Samir,N; Kniss,Douglas,A, 2014, "Loss of Myoferlin Redirects Breast Cancer Cell Motility towards Collective Migration.." PloS one 9, no. 2, e86110 - e86110.
  • 2014, "Computational Analysis of Microbubble Flows in Bifurcating Airways: Role of Gravity, Inertia, and Surface Tension." JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME 136, no. 10,
  • 2014, "TRIM72 is required for effective repair of alveolar epithelial cell wounding." AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 307, no. 6,

2013

  • 2013, "Panel 2: Eustachian Tube, Middle Ear, and Mastoid-Anatomy, Physiology, Pathophysiology, and Pathogenesis." OTOLARYNGOLOGY-HEAD AND NECK SURGERY 148,
  • 2013, "Finite Element Analysis of Traction Force Microscopy: Influence of Cell Mechanics, Adhesion, and Morphology." JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME 135, no. 7,
  • Ma,Xiaoyue; Schickel,Maureen,E; Stevenson,Mark,D; Sarang-Sieminski,Alisha,L; Gooch,Keith,J; Ghadiali,Samir,N; Hart,Richard,T, 2013, "Fibers in the Extracellular Matrix Enable Long-Range Stress Transmission between Cells." BIOPHYSICAL JOURNAL 104, no. 7, 1410-1418 - 1410-1418.

2012

  • Huang,Yan; Crawford,Melissa; Higuita-Castro,Natalia; Nana-Sinkam,Patrick; Ghadiali,Samir,N, 2012, "miR-146a regulates mechanotransduction and pressure-induced inflammation in small airway epithelium." FASEB JOURNAL 26, no. 8, 3351-3364 - 3351-3364.
  • 2012, "PTEN inhibition improves wound healing in lung epithelia through changes in cellular mechanics that enhance migration." AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 302, no. 3,
  • 2012, "Three-dimensional finite element analysis of Eustachian tube function under normal and pathological conditions." MEDICAL ENGINEERING & PHYSICS 34, no. 5,
  • 2012, "miR-146a regulates mechanotransduction and pressure-induced inflammation in small airway epithelium." FASEB JOURNAL 26, no. 8,
  • 2012, "Myoferlin Depletion in Breast Cancer Cells Promotes Mesenchymal to Epithelial Shape Change and Stalls Invasion." PLOS ONE 7, no. 6,

2011

  • Mengistu, M., Brotzman, H., Ghadiali, S.N., Lowe-Krentz, L., 2011, "Fluid Shear Stress-Induced JNK Activity Leads to Actin Remodeling for Cell Alignment." Journal of Cell Physiology 1, no. 226, 110-121 - 110-121.
  • 2011, "Role of airway recruitment and derecruitment in lung injury." Critical Reviews in Biomedical Engineering 39, no. 4,
  • Mihai,Cosmin; Zielinski,Rachel; Bao,Shaoying; Knoell,Daren; Ghadiali,Samir, 2011, "PTEN signaling modulates lung epithelial cells migration and wound repair through changes in cellular mechanics." FASEB JOURNAL 25, unknown - unknown.
  • 2011, "Role of microRNA-146a in regulating mechanically induced inflammation in human lung epithelial cells." FASEB JOURNAL 25,
  • 2011, "Influence of Airway Wall Compliance on Epithelial Cell Injury during Cyclic Airway Reopening." FASEB JOURNAL 25,

2010

  • 2010, "Timing of tensor and levator veli palatini force application determines eustachian tube resistance patterns during the forced-response test." AURIS NASUS LARYNX 37, no. 6,
  • 2010, "Influence of power-law rheology on cell injury during microbubble flows." BIOMECHANICS AND MODELING IN MECHANOBIOLOGY 9, no. 3,
  • 2010, "Finite element analysis of eustachian tube function in cleft palate infants based on histological reconstructions." Cleft Palate-Craniofacial Journal 47, no. 6,
  • 2010, "Influence of Transmural Pressure and Cytoskeletal Structure on NF-kappa B Activation in Respiratory Epithelial Cells." CELLULAR AND MOLECULAR BIOENGINEERING 3, no. 4,
  • Huang, Y., Haas, C., Ghadiali, S.N., 2010, "Influence of Transmural Pressure and Cytoskeletal Structure on NF-κB Activation in Respiratory Epithelial Cells." Cellular and Molecular Bioengineering 4, no. 3, 415-427 - 415-427.
  • Dailey, H.L., Ghadiali, S.N., 2010, "Influence of Power Law Rheology on Cell Injury During Microbubble Flows." Biomechanics and Modeling in Mechanobiology 3, no. 9, 263-279 - 263-279.
  • Sheer, F.J, Swarts, J.D., Ghadiali, S.N., 2010, "Finite Element Analysis of Eustachian Tube Function in Cleft Palate Infants Based on Histological Reconstructions." Cleft Palate Craniofacial Journal 6, no. 47, 600-610 - 600-610.
  • Ghadiali, S.N., Bell, E.D., Swarts, J.D., 2010, "Timing of Tensor and Levator Veli Palatini Force Applications Determines Eustachian Tube Active Resistance Patterns during the Forced Response Test." Auris Nasus Larynx 6, no. 37, 720-729 - 720-729.

2009

  • Ghadiali, S.N., 2009, "Invited Editorial: Making "Time" for Alveolar Recruitment." Journal of Applied Physiology no. 106, 751-752 - 751-752.
  • Yalcin, H.C., Hallow, K.M., Wang, J., Ou-Yang, H.D., Ghadiali, S.N., 2009, "Influence of Cytoskeletal Structure and Mechanics on Epithelial Cell Injury during Cyclic Airway Reopening." American Journal of Physiology: Lung Cell and Molecular Physiology 5, no. 297, L881-L891 - L881-L891.
  • Dailey, H.L., Ricles, L.M., Yalcin, H.C., Ghadiali, S.N., 2009, "Image-Based Finite Element Modeling of Alveolar Epithelial Cell Injury during Airway Reopening." Journal of Applied Physiology ?, no. 106, 221-232 - 221-232.
  • 2009, "ACCURACY OF CELL MECHANICAL MEASUREMENTS USING OSCILLATING OPTICAL TWEEZERS: A COMPUTATIONAL STUDY." PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE 2008, PTS A AND B
  • 2009, "FULLY COUPLED FLUID-STRUCTURE INTERACTION MODEL OF ACTIVE EUSTACHIAN TUBE FUNCTION." PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE 2008, PTS A AND B
  • 2009, "Making "time" for alveolar recruitment." JOURNAL OF APPLIED PHYSIOLOGY 106, no. 3,
  • 2009, "EFFECT OF CYTOSKELETAL STRUCTURE AND MECHANICS ON EPITHELIAL CELL ADHESION DURING AIRWAY REOPENING." PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE 2008, PTS A AND B
  • 2009, "Image-based finite element modeling of alveolar epithelial cell injury during airway reopening." JOURNAL OF APPLIED PHYSIOLOGY 106, no. 1,
  • 2009, "ROLE OF MEMBRANE AND CORTEX MECHANICS IN MICRORHEOLOGY MEASUREMENTS AND FLOW-INDUCED CELL INJURY." PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE 2008, PTS A AND B
  • 2009, "Influence of cytoskeletal structure and mechanics on epithelial cell injury during cyclic airway reopening." AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 297, no. 5,

2008

  • 2008, "A comparative study of living cell micromechanical properties by oscillatory optical tweezers." OPTICS EXPRESS 16, no. 12,
  • 2008, "Biomechanics of liquid-epithelium interactions in pulmonary airways." RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY 163, no. 1-3,
  • Ghadiali, S.N. & Gaver, D.P., 2008, "Biomechanics of Liquid-Epithelium Interactions in Pulmonary Airways." Respiratory Physiology and Neurobiology ?, no. 163, 232-243 - 232-243.
  • 2008, "Influence of power-law rheology and membrane mechanics on cellular injury during microbubble flows." BIORHEOLOGY 45, no. 1-2,
  • Wei, M.T., Zaorski, A., Yalcin, H.C., Wang, J., Hallow, M., Ghadiali, S.N., Chiou, A., Ou-Yang, H.D., 2008, "A Comparative Study of Living Cell Micromechanical Properties by Oscillatory Optical Tweezers." Optics Express ?, no. 16, 8594-8603 - 8594-8603.

2007

  • Kent,Melodie,Jan Lynettee; Ghadiali,Samir; Marzillier,Jutta; Perry,Susan, 2007, "Effect of mechanical forces on surfactant protein expression in alveolar lung epithelial cells." FASEB JOURNAL 21, no. 5, A552-A552 - A552-A552.
  • 2007, "Finite element analysis of clinical pressure-flow waveforms in a collapsed respiratory airway." PROCEEDING OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2007
  • 2007, "Corrigendurn to "Fluid-structure analysis of microparticle transport in deformable pulmonary alveoli" Journal of Aerosol Science 38 (2007) 269-288." JOURNAL OF AEROSOL SCIENCE 38, no. 5,
  • Yalcin, H.C., Perry, S.F., Ghadiali, S.N., 2007, "Influence of Airway Diameter and Cell Confluence on Epithelial Cell Injury in an In-Vitro Model of Airway Reopening." Journal of Applied Physiology ?, no. 103, 1796-1807 - 1796-1807.
  • 2007, "Effect of cytoskeletal structure on cellular necrosis during airway reopening." FASEB JOURNAL 21, no. 5,
  • 2007, "Fluid-structure interactions in the eustachain tube under normal and pathological conditions." PROCEEDING OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2007
  • 2007, "Multi-scale models of epithelial cell injury and detachment during microbubble flows." PROCEEDING OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2007
  • Dailey, H.L. & Ghadiali, S.N., 2007, "Fluid-Structure Analysis of Microparticle Transport in Deformable Pulmonary Alveoli." Journal of Aerosol Science ?, no. 38, 269-288 - 269-288.
  • 2007, "Fluid-structure modeling of flow-induced alveolar epithelial cell deformation." COMPUTERS & STRUCTURES 85, no. 11-14,
  • 2007, "Influence of airway diameter and cell confluence on epithelial cell injury in an in vitro model of airway reopening." JOURNAL OF APPLIED PHYSIOLOGY 103, no. 5,

2005

  • 2005, "Recent advances in otitis media. 2. Eustachian tube, middle ear, and mastoid anatomy; physiology, pathophysiology, and pathogenesis.." The Annals of otology, rhinology & laryngology. Supplement 194,
  • 2005, "On morphometric measurement of oxygen diffusing capacity in middle ear gas exchange." JOURNAL OF APPLIED PHYSIOLOGY 98, no. 1,

2004

  • 2004, "Finite element analysis of active Eustachian tube function." JOURNAL OF APPLIED PHYSIOLOGY 97, no. 2,

2003

  • 2003, "Effect of tensor veli palatini muscle paralysis on eustachian tube mechanics." ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 112, no. 8,
  • 2003, "The influence of non-equilibrium surfactant dynamics on the flow of a semi-infinite bubble in a rigid cylindrical capillary tube." JOURNAL OF FLUID MECHANICS 478,

2002

  • 2002, "Model-based evaluation of eustachian tube mechanical properties using continuous pressure-flow rate data." ANNALS OF BIOMEDICAL ENGINEERING 30, no. 8,
  • 2002, "Measurement of the viscoelastic compliance of the eustachian tube using a modified forced-response test." AURIS NASUS LARYNX 29, no. 1,
  • 2002, "Effect of surface tension and surfactant administration on Eustachian tube mechanics." JOURNAL OF APPLIED PHYSIOLOGY 93, no. 3,
  • Ghadiali,S; Swarts,J,D; Banks,J; Doyle,W,J, 2002, "Influence of lung surfactant on Eustachain tube mechanics." FASEB JOURNAL 16, no. 5, A1151-A1151 - A1151-A1151.

2001

  • 2001, "A dual-reciprocity boundary element method for evaluating bulk convective transport of surfactant in free-surface flows." JOURNAL OF COMPUTATIONAL PHYSICS 171, no. 2,

2000

  • 2000, "An investigation of pulmonary surfactant physicochemical behavior under airway reopening conditions." JOURNAL OF APPLIED PHYSIOLOGY 88, no. 2,

1998

  • Ghadiali,S; Gaver,D,P, 1998, "Exogenous replacement surfactants reduce airway reopening stresses by interfacial remobilization." FASEB JOURNAL 12, no. 4, A171-A171 - A171-A171.