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Samir Ghadiali

  • Professor, Pulmonary, Crit Care, & Sleep
  • Professor, Biomedical Engineering
  • 292 Bevis Hall
    1080 Carmack Road
    Columbus, OH 43210
  • 614-292-7742

Honors

  • 2014

    Lumley Research Award. .

  • 2008-2013

    NSF CAREER Award. .

  • 2006-2011

    NIH RO1 New Investigator Award. .

  • 2010

    Herman Weed Excellence in Teaching Award. .

  • 2005-2008

    Frank Hook Assistant Professorship in Bioengineering. .

  • 2005-2008

    Parker B. Francis Fellowship in Pulmonary Research. .

  • 2005

    US National Committee on Biomechanics New Faculty Award. .

  • 2001

    Children’s Hospital of Pittsburgh Post-doctoral Research Fellowship. .

  • 1994-1998

    Louisiana Board of Regents Graduate Study Scholarship. .

  • Chair of Respiratory Engineering Track at BMES Annual Meetings in 2009 and 2014. .

Chapters

2013

  • Huang, Y., Ghadiali, S.N., Nana-Sinkam, S.P.. 2013. "MicroRNAs and Inflammation." In Micro-RNAs in Toxicology and Medicine, edited by Saura Sahu, New York: Wiley Publishing.

2011

  • Ghadiali, S.N. and Dailey, H.L.. 2011. "Mechanobiology and finite element analysis of cellular injury during microbubble flows." In Cellular and Biomolecular Mechanics and Mechanobiology, edited by Amit Gefen, Berlin: Springer-Verlag.

2008

  • Ghadiali, SN. 2008. "Computer Modeling in Otitis Media: Perspectives and Limits." In Chronic Otitis Media, Pathology -guided, Pathogenesis-oriented Therapeutic Management, edited by Bernard Ars, Amsterdam: Kugler Publishing.

Journal Articles

2014

  • Volakis,Leonithas,I; Li,Ruth; Ackerman,William,E; Mihai,Cosmin; Bechel,Meagan; Summerfield,Taryn,L; Ahn,Christopher,S; Powell,Heather,M; Zielinski,Rachel; Rosol,Thomas,J; Ghadiali,Samir,N; Kniss,Douglas,A, 2014, "Loss of Myoferlin Redirects Breast Cancer Cell Motility towards Collective Migration.." PloS one 9, no. 2, e86110 -

2013

  • Ma,Xiaoyue; Schickel,Maureen,E; Stevenson,Mark,D; Sarang-Sieminski,Alisha,L; Gooch,Keith,J; Ghadiali,Samir,N; Hart,Richard,T, 2013, "Fibers in the Extracellular Matrix Enable Long-Range Stress Transmission between Cells." BIOPHYSICAL JOURNAL 104, no. 7, 1410 - 1418.
  • Zielinski,Rachel; Mihai,Cosmin; Kniss,Douglas; Ghadiali,Samir,N, 2013, "Finite element analysis of traction force microscopy: influence of cell mechanics, adhesion, and morphology.." Journal of biomechanical engineering 135, no. 7, 71009 - ?.
  • Swarts,J,Douglas; Alper,Cuneyt,M; Luntz,Michal; Bluestone,Charles,D; Doyle,William,J; Ghadiali,Samir,N; Poe,Dennis,S; Takahashi,Haruo; Tideholm,Bo, 2013, "Panel 2: Eustachian Tube, Middle Ear, and Mastoid-Anatomy, Physiology, Pathophysiology, and Pathogenesis." OTOLARYNGOLOGY-HEAD AND NECK SURGERY 148, E26 - E36.

2012

  • Huang,Yan; Crawford,Melissa; Higuita-Castro,Natalia; Nana-Sinkam,Patrick; Ghadiali,Samir,N, 2012, "miR-146a regulates mechanotransduction and pressure-induced inflammation in small airway epithelium." FASEB JOURNAL 26, no. 8, 3351 - 3364.
  • Li,Ruth; Ackerman,William,E; Mihai,Cosmin; Volakis,Leonithas,I; Ghadiali,Samir; Kniss,Douglas,A, 2012, "Myoferlin Depletion in Breast Cancer Cells Promotes Mesenchymal to Epithelial Shape Change and Stalls Invasion." PLOS ONE 7, no. 6, e39766 -
  • Sheer,F,J; Swarts,J,D; Ghadiali,S,N, 2012, "Three-dimensional finite element analysis of Eustachian tube function under normal and pathological conditions." MEDICAL ENGINEERING & PHYSICS 34, no. 5, 605 - 616.
  • Mihai,Cosmin; Bao,Shengying; Lai,Ju-Ping; Ghadiali,Samir,N; Knoell,Daren,L, 2012, "PTEN inhibition improves wound healing in lung epithelia through changes in cellular mechanics that enhance migration." AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 302, no. 3, L287 - L299.

2011

  • Ghadiali,Samir; Huang,Yan; Crawford,Melissa; Nana-Sinkam,Patrick, 2011, "Role of microRNA-146a in regulating mechanically induced inflammation in human lung epithelial cells." FASEB JOURNAL 25, unknown -
  • Mihai,Cosmin; Zielinski,Rachel; Bao,Shaoying; Knoell,Daren; Ghadiali,Samir, 2011, "PTEN signaling modulates lung epithelial cells migration and wound repair through changes in cellular mechanics." FASEB JOURNAL 25, unknown -
  • Higuita-Castro,Natalia; Mihai,Cosmin; Hansford,Derek,J; Ghadiali,Samir,N, 2011, "Influence of Airway Wall Compliance on Epithelial Cell Injury during Cyclic Airway Reopening." FASEB JOURNAL 25, unknown -
  • Ghadiali,Samir; Huang,Y, 2011, "Role of airway recruitment and derecruitment in lung injury.." Critical reviews in biomedical engineering 39, no. 4, 297 - 317.
  • Mengistu, M., Brotzman, H., Ghadiali, S.N., Lowe-Krentz, L., 2011, "Fluid Shear Stress-Induced JNK Activity Leads to Actin Remodeling for Cell Alignment." Journal of Cell Physiology 1, no. 226, 110 - 121.

2010

  • Dailey, H.L., Ghadiali, S.N., 2010, "Influence of Power Law Rheology on Cell Injury During Microbubble Flows." Biomechanics and Modeling in Mechanobiology 3, no. 9, 263 - 279.
  • Huang, Y., Haas, C., Ghadiali, S.N., 2010, "Influence of Transmural Pressure and Cytoskeletal Structure on NF-κB Activation in Respiratory Epithelial Cells." Cellular and Molecular Bioengineering 4, no. 3, 415 - 427.
  • Sheer, F.J, Swarts, J.D., Ghadiali, S.N., 2010, "Finite Element Analysis of Eustachian Tube Function in Cleft Palate Infants Based on Histological Reconstructions." Cleft Palate Craniofacial Journal 6, no. 47, 600 - 610.
  • Ghadiali, S.N., Bell, E.D., Swarts, J.D., 2010, "Timing of Tensor and Levator Veli Palatini Force Applications Determines Eustachian Tube Active Resistance Patterns during the Forced Response Test." Auris Nasus Larynx 6, no. 37, 720 - 729.

2009

  • Hallow K.M. & Ghadiali S.N., 2009, "Effect of Cytoskeletal Structure and Mechanics on Epithelial Cell Adhesion During Airway Reopening." Proceeding of the ASME Summer Bioengineering Conference 941 -
  • Dailey H.L., Ricles L.M., Ghadiali S.N., 2009, "Role of Membrane and Cortex Mechanics in Microrheology Measurements and Flow-Induced Cell Injury." Proceeding of the ASME Summer Bioengineering Conference 491 -
  • Dailey, H.L., Ricles, L.M., Yalcin, H.C., Ghadiali, S.N., 2009, "Image-Based Finite Element Modeling of Alveolar Epithelial Cell Injury during Airway Reopening." Journal of Applied Physiology ?, no. 106, 221 - 232.
  • Ghadiali, S.N., 2009, "Invited Editorial: Making "Time" for Alveolar Recruitment." Journal of Applied Physiology no. 106, 751 - 752.
  • Sheer F.J. & Ghadiali S.N., 2009, "Fully Coupled Fluid-Structure Interaction Model of Active Eustachian Tube Function." Proceeding of the ASME Summer Bioengineering Conference 511 -
  • Ricles L.M., Dailey H.L., Ghadiali S.N., 2009, "Accuracy of Cell Mechanical Measurements using Oscillating Optical Tweezers: A Computational Study." Proceeding of the ASME Summer Bioengineering Conference 495 -
  • Yalcin, H.C., Hallow, K.M., Wang, J., Ou-Yang, H.D., Ghadiali, S.N., 2009, "Influence of Cytoskeletal Structure and Mechanics on Epithelial Cell Injury during Cyclic Airway Reopening." American Journal of Physiology: Lung Cell and Molecular Physiology 5, no. 297, L881 - L891.
  • Ghadiali,Samir,N, 2009, "Making "time" for alveolar recruitment." JOURNAL OF APPLIED PHYSIOLOGY 106, no. 3, 751 - 752.

2008

  • Ghadiali,S,N; Dailey,H,L; Hallow,K,M; Ou-Yang,H,D, 2008, "Influence of power-law rheology and membrane mechanics on cellular injury during microbubble flows." BIORHEOLOGY 45, no. 1-2, 139 - 140.
  • Ghadiali, S.N. & Gaver, D.P., 2008, "Biomechanics of Liquid-Epithelium Interactions in Pulmonary Airways." Respiratory Physiology and Neurobiology ?, no. 163, 232 - 243.
  • Wei, M.T., Zaorski, A., Yalcin, H.C., Wang, J., Hallow, M., Ghadiali, S.N., Chiou, A., Ou-Yang, H.D., 2008, "A Comparative Study of Living Cell Micromechanical Properties by Oscillatory Optical Tweezers." Optics Express ?, no. 16, 8594 - 8603.

2007

  • Ghadiali,Samir,N; Yalcin,Huseyin; Dailey,Hannah, 2007, "Effect of cytoskeletal structure on cellular necrosis during airway reopening." FASEB JOURNAL 21, no. 5, A555 - A556.
  • Warrick A.E., Swarts J.D., Ghadiali S.N., 2007, "Fluid-structure interactions in the Eustachian tube under normal and pathological conditions." Proceeding of the ASME Summer Bioengineering Conference 451 - 452.
  • Dailey, H.L., Yalcin, H.C., Ghadiali, S.N., 2007, "Fluid-Structure Modeling of Flow-Induced Alveolar Epithelial Cell Deformation." Computers and Structures no. 85, 1066 - 1071.
  • Bell E.D. & Ghadiali S.N., 2007, "Finite element analysis of clinical pressure-flow waveforms in a collapsed respiratory airway." Proceeding of the ASME Summer Bioengineering Conference 309 - 310.
  • Kent,Melodie,Jan Lynettee; Ghadiali,Samir; Marzillier,Jutta; Perry,Susan, 2007, "Effect of mechanical forces on surfactant protein expression in alveolar lung epithelial cells." FASEB JOURNAL 21, no. 5, A552 - A552.
  • Dailey H.L., Yalcin H.C., Ghadiali S.N., 2007, "Multi-scale models of epithelial cell injury and detachment during microbubble flows." Proceeding of the ASME Summer Bioengineering Conference 291 - 292.
  • Yalcin, H.C., Perry, S.F., Ghadiali, S.N., 2007, "Influence of Airway Diameter and Cell Confluence on Epithelial Cell Injury in an In-Vitro Model of Airway Reopening." Journal of Applied Physiology ?, no. 103, 1796 - 1807.
  • Dailey, H.L. & Ghadiali, S.N., 2007, "Fluid-Structure Analysis of Microparticle Transport in Deformable Pulmonary Alveoli." Journal of Aerosol Science ?, no. 38, 269 - 288.
  • Dailey,H,L; Ghadiali,S,N, 2007, "Corrigendurn to "Fluid-structure analysis of microparticle transport in deformable pulmonary alveoli" Journal of Aerosol Science 38 (2007) 269-288." JOURNAL OF AEROSOL SCIENCE 38, no. 5, 572 - 572.

2005

  • Bluestone,Charles,D; Hebda,Patricia,A; Alper,Cuneyt,M; Sando,Isamu; Buchman,Craig,A; Stangerup,Sven-Eric; Felding,Jens,U; Swarts,J,Douglas; Ghadiali,Samir,N; Takahashi,Haruo, 2005, "Recent advances in otitis media. 2. Eustachian tube, middle ear, and mastoid anatomy; physiology, pathophysiology, and pathogenesis.." The Annals of otology, rhinology & laryngology. Supplement 194, 16 - 30.
  • Kanick,S,C; Doyle,W,J; Ghadiali,S,N; Federspiel,W,J, 2005, "On morphometric measurement of oxygen diffusing capacity in middle ear gas exchange." JOURNAL OF APPLIED PHYSIOLOGY 98, no. 1, 114 - 119.

2004

  • Ghadiali,S,N; Banks,J; Swarts,J,D, 2004, "Finite element analysis of active Eustachian tube function." JOURNAL OF APPLIED PHYSIOLOGY 97, no. 2, 648 - 654.

2003

  • Ghadiali,S,N; Swarts,J,D; Doyle,W,J, 2003, "Effect of tensor veli palatini muscle paralysis on eustachian tube mechanics." ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 112, no. 8, 704 - 711.
  • Ghadiali,S,N; Gaver,D,P, 2003, "The influence of non-equilibrium surfactant dynamics on the flow of a semi-infinite bubble in a rigid cylindrical capillary tube." JOURNAL OF FLUID MECHANICS 478, 165 - 196.

2002

  • Ghadiali,S,N; Swarts,J,D; Federspiel,W,J, 2002, "Model-based evaluation of eustachian tube mechanical properties using continuous pressure-flow rate data." ANNALS OF BIOMEDICAL ENGINEERING 30, no. 8, 1064 - 1076.
  • Ghadiali,S,N; Federspiel,W,J; Swarts,J,D; Doyle,W,J, 2002, "Measurement of the viscoelastic compliance of the eustachian tube using a modified forced-response test." AURIS NASUS LARYNX 29, no. 1, 1 - 5.
  • Ghadiali,S; Swarts,J,D; Banks,J; Doyle,W,J, 2002, "Influence of lung surfactant on Eustachain tube mechanics." FASEB JOURNAL 16, no. 5, A1151 - A1151.
  • Ghadiali,S,N; Banks,J; Swarts,J,D, 2002, "Effect of surface tension and surfactant administration on Eustachian tube mechanics." JOURNAL OF APPLIED PHYSIOLOGY 93, no. 3, 1007 - 1014.

2001

  • Ghadiali,S,N; HALPERN,D; Gaver,D,P, 2001, "A dual-reciprocity boundary element method for evaluating bulk convective transport of surfactant in free-surface flows." JOURNAL OF COMPUTATIONAL PHYSICS 171, no. 2, 534 - 559.

2000

  • Ghadiali,S,N; Gaver,D,P, 2000, "An investigation of pulmonary surfactant physicochemical behavior under airway reopening conditions." JOURNAL OF APPLIED PHYSIOLOGY 88, no. 2, 493 - 506.

1998

  • Ghadiali,S; Gaver,D,P, 1998, "Exogenous replacement surfactants reduce airway reopening stresses by interfacial remobilization." FASEB JOURNAL 12, no. 4, A171 - A171.