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Samir Ghadiali

  • Professor, Pulmonary, Crit Care, & Sleep
  • Professor, Biomedical Engineering
  • Chair, Biomedical Engineering
  • 292 Bevis Hall
    1080 Carmack Road
    Columbus, OH 43210
  • 614-292-7742

About

Education

  • B.S., Chemical Eng., Cornell University, 1994
  • M.S., Biomedical Eng., Tulane University, 1998
  • Ph.D., Biomedical Eng., Tulane University, 2000

 

Key Honors and Distinctions

  • Lumley Interdisciplinary Research Award, College of Engineering, Ohio State University, 2015
  • Lumley Research Award, College of Engineering, Ohio State University, 2014
  • Herman Weed Excellence in Teaching Award, 2010
  • NSF CAREER Award, 2008-2013
  • NIH RO1 New Investigator Award, 2006-2011
  • Parker B. Francis Fellowship in Pulmonary Research, 2005-2008
  • Frank Hook Assistant Professorship in Bioengineering, 2005 – 2007
  • US National Committee on Biomechanics New Faculty Award, 2005
  • Children’s Hospital of Pittsburgh Post-doctoral Research Fellowship, 2001

 

RESEARCH AREAS – Ghadiali Respiratory Mechanobiology Laboratory

  • Cell Mechanics, Mechanobiology, Biofluid Mechanics, Fluid-Structure Interactions, Tissue Mechanics; Mechanobiology of Lung Injury and Inflammation; Multi-scale Modeling of Eustachian Tube Function; microRNA Biology and Cell/Tissue Engineering

 

  • PUBLICATIONS

http://www.researcherid.com/rid/C-5463-2012

 

  • PATENTS

Dr. Ghadiali’s laboratory uses a combination of engineering, mathematical and molecular biology tools to to identify the mechanobiological mechanisms responsible for various respiratory and pulmonary/critical care disorders. A major emphasis of the lab is the translation of basic scientific knowledge about how mechanical factors influence disease progression into novel therapeutic agents for several disorders including Otitis Media/Upper Respiratory Infections, Acute Lung Injury, Lung and Breast Cancer and Pulmonary Fibrosis. The laboratory conducts in-vitro, in-vivo and ex-vivo experiments and also develops multi-scale computational models of the respiratory system. Current focus areas for the lab included 1) Biomechanical Mechanisms of Upper Respiratory Disorders, 2) Mechanobiology of Cellular Injury and Inflammation during Mechanical Ventilation and 3) Biomechanical Mechanisms of Cancer Cell Metastasis. Dr. Ghadiali’s research has been/is supported by the National Institutes of Health, the National Science Foundation, the Pelotonia Cancer Research Program and the American Heart Association.

 

Honors

  • May, 2014

    Lumley Research Award.

  • February, 2008-
    February, 2013

    NSF CAREER Award.

  • June, 2006-
    June, 2011

    NIH RO1 New Investigator Award.

  • February, 2010

    Herman Weed Excellence in Teaching Award.

  • June, 2005-
    June, 2008

    Parker B. Francis Fellowship in Pulmonary Research.

  • January, 2005-
    January, 2008

    Frank Hook Assistant Professorship in Bioengineering.

  • January, 2005

    US National Committee on Biomechanics New Faculty Award.

  • January, 2001-
    December, 2001

    Children’s Hospital of Pittsburgh Post-doctoral Research Fellowship.

  • August, 1994-
    August, 1998

    Louisiana Board of Regents Graduate Study Scholarship.

  • Chair of Respiratory Engineering Track at BMES Annual Meetings in 2009 and 2014.

Chapters

2013

  • 2013. "microRNAs and Inflammation, 2013." In MicroRNAs in Toxicology and Medicine, edited by Saura Sahu,
  • 2013. "MicroRNAs and Inflammation." In Micro-RNAs in Toxicology and Medicine, edited by Saura Sahu,

2011

  • 2011. "Mechanobiology and finite element analysis of cellular injury during microbubble flows." In Cellular and Biomolecular Mechanics and Mechanobiology, edited by Amit Gefen,

2008

  • 2008. "Computer Modeling in Otitis Media: Perspectives and Limits." In Chronic Otitis Media, Pathology -guided, Pathogenesis-oriented Therapeutic Management, edited by Bernard Ars,

Journal Articles

2015

  • Blackstone, B.N.; Li, R.; Ackerman, W.E.; Ghadiali, S.N. et al., 2015, "Myoferlin depletion elevates focal adhesion kinase and paxillin phosphorylation and enhances Cell-Matrix adhesion in breast cancer cells." American Journal of Physiology - Cell Physiology 308, no. 8, C642-C649 - C642-C649.

2014

  • Volakis, L.I.; Li, R.; Ackerman, W.E.; Mihai, C. et al., 2014, "Loss of myoferlin redirects breast cancer cell motility towards collective migration.." PloS one 9, no. 2, e86110 - e86110.
  • Volakis,Leonithas,I; Li,Ruth; Ackerman,William,E; Mihai,Cosmin; Bechel,Meagan; Summerfield,Taryn,L; Ahn,Christopher,S; Powell,Heather,M; Zielinski,Rachel; Rosol,Thomas,J; Ghadiali,Samir,N; Kniss,Douglas,A, 2014, "Loss of Myoferlin Redirects Breast Cancer Cell Motility towards Collective Migration.." PloS one 9, no. 2, e86110 - e86110.

2013

  • Ma,Xiaoyue; Schickel,Maureen,E; Stevenson,Mark,D; Sarang-Sieminski,Alisha,L; Gooch,Keith,J; Ghadiali,Samir,N; Hart,Richard,T, 2013, "Fibers in the Extracellular Matrix Enable Long-Range Stress Transmission between Cells." BIOPHYSICAL JOURNAL 104, no. 7, 1410-1418 - 1410-1418.

2012

  • Huang,Yan; Crawford,Melissa; Higuita-Castro,Natalia; Nana-Sinkam,Patrick; Ghadiali,Samir,N, 2012, "miR-146a regulates mechanotransduction and pressure-induced inflammation in small airway epithelium." FASEB JOURNAL 26, no. 8, 3351-3364 - 3351-3364.

2011

  • Mengistu, M., Brotzman, H., Ghadiali, S.N., Lowe-Krentz, L., 2011, "Fluid Shear Stress-Induced JNK Activity Leads to Actin Remodeling for Cell Alignment." Journal of Cell Physiology 1, no. 226, 110-121 - 110-121.

2010

  • Sheer, F.J, Swarts, J.D., Ghadiali, S.N., 2010, "Finite Element Analysis of Eustachian Tube Function in Cleft Palate Infants Based on Histological Reconstructions." Cleft Palate Craniofacial Journal 6, no. 47, 600-610 - 600-610.
  • Huang, Y., Haas, C., Ghadiali, S.N., 2010, "Influence of Transmural Pressure and Cytoskeletal Structure on NF-κB Activation in Respiratory Epithelial Cells." Cellular and Molecular Bioengineering 4, no. 3, 415-427 - 415-427.
  • Dailey, H.L., Ghadiali, S.N., 2010, "Influence of Power Law Rheology on Cell Injury During Microbubble Flows." Biomechanics and Modeling in Mechanobiology 3, no. 9, 263-279 - 263-279.
  • Ghadiali, S.N., Bell, E.D., Swarts, J.D., 2010, "Timing of Tensor and Levator Veli Palatini Force Applications Determines Eustachian Tube Active Resistance Patterns during the Forced Response Test." Auris Nasus Larynx 6, no. 37, 720-729 - 720-729.

2009

  • Yalcin, H.C., Hallow, K.M., Wang, J., Ou-Yang, H.D., Ghadiali, S.N., 2009, "Influence of Cytoskeletal Structure and Mechanics on Epithelial Cell Injury during Cyclic Airway Reopening." American Journal of Physiology: Lung Cell and Molecular Physiology 5, no. 297, L881-L891 - L881-L891.
  • Dailey, H.L., Ricles, L.M., Yalcin, H.C., Ghadiali, S.N., 2009, "Image-Based Finite Element Modeling of Alveolar Epithelial Cell Injury during Airway Reopening." Journal of Applied Physiology ?, no. 106, 221-232 - 221-232.
  • Ghadiali, S.N., 2009, "Invited Editorial: Making "Time" for Alveolar Recruitment." Journal of Applied Physiology no. 106, 751-752 - 751-752.

2008

  • Wei, M.T., Zaorski, A., Yalcin, H.C., Wang, J., Hallow, M., Ghadiali, S.N., Chiou, A., Ou-Yang, H.D., 2008, "A Comparative Study of Living Cell Micromechanical Properties by Oscillatory Optical Tweezers." Optics Express ?, no. 16, 8594-8603 - 8594-8603.
  • Ghadiali, S.N. & Gaver, D.P., 2008, "Biomechanics of Liquid-Epithelium Interactions in Pulmonary Airways." Respiratory Physiology and Neurobiology ?, no. 163, 232-243 - 232-243.

2007

  • Yalcin, H.C., Perry, S.F., Ghadiali, S.N., 2007, "Influence of Airway Diameter and Cell Confluence on Epithelial Cell Injury in an In-Vitro Model of Airway Reopening." Journal of Applied Physiology ?, no. 103, 1796-1807 - 1796-1807.
  • Dailey, H.L. & Ghadiali, S.N., 2007, "Fluid-Structure Analysis of Microparticle Transport in Deformable Pulmonary Alveoli." Journal of Aerosol Science ?, no. 38, 269-288 - 269-288.

2000

  • Ghadiali, S.; Gaver, D., 2000, "Experimental and computational investigations of surfactant physicochemical behavior during pulmonary airway opening." Annals of Biomedical Engineering 28, no. SUPPL. 1,

1997

  • Gaver, D.P.; Krueger, M.A.; Ghadiali, S.N., 1997, "The influence of surfactant physicochemical properties on pulmonary interfacial flow analogues." American Society of Mechanical Engineers, Bioengineering Division (Publication) BED 36, 41-42 - 41-42.

Presentations

  • "Using Alveolar Pneumocyte Self-Derived Exosomes to Modulate Lung Inflammatory Response." 2017, Presented at Biomedical Engineering Society Meeting,
  • "Guiding Tumor Cell Invasion using Non-soluble Cues in the Tumor Microenvironment." 2017, Presented at Biomedical Engineering Society Meeting,

Papers in Proceedings

2018

  • Bobba, C.; Ballinger, M.; Englert, J.; Ghadiali, S. "MECHANOTRANSDUCTION IN ALVEOLAR MACROPHAGES CONTRIBUTES TO LUNG INJURY BY MODULATING PRO-INFLAMMATORY CYTOKINE SECRETION AND MIR-146A EXPRESSION." (4 2018).
  • Cho, Y.; Bobba, C.; Shukla, V.; Englert, J. et al. "Cyclic Mechanical Strain and Myoferlin Modulates Lung Adenocarcinoma Cell Proliferation and Erlotinib Resistance." (10 2018).
  • Bobba, C.; Ballinger, M.; Englert, J.; Ghadiali, S. "MECHANOTRANSDUCTION IN ALVEOLAR MACROPHAGES CONTRIBUTES TO LUNG INJURY BY MODULATING PRO-INFLAMMATORY CYTOKINE SECRETION AND MIR-146A EXPRESSION." in Midwestern Regional Meeting of the American-Federation-for-Medical-Research (AFMR). (4 2018).
  • Cho, Y.; Bobba, C.; Shukla, V.; Englert, J. et al. "Cyclic Mechanical Strain and Myoferlin Modulates Lung Adenocarcinoma Cell Proliferation and Erlotinib Resistance." (10 2018).

2017

  • Ghadiali, S.; Cho, Y.; Englert, J.; Kniss, D. "Myoferlin Regulates Epithelial To Mesenchymal Transition, Cell Migration And Erlotinib Resistance In Lung Adenocarcinoma Cells." (1 2017).
  • Bobba, C.; Ghadiali, S.; Englert, J. "INFLUENCE OF ALVEOLAR EPITHELIAL CELL-ALVEOLAR MACROPHAGE INTERACTIONS ON MECHANICALLY-INDUCED LUNG INJURY/INFLAMMATION." (4 2017).
  • Bobba, C.; Ghadiali, S.; Englert, J. "INFLUENCE OF ALVEOLAR EPITHELIAL CELL-ALVEOLAR MACROPHAGE INTERACTIONS ON MECHANICALLY-INDUCED LUNG INJURY/INFLAMMATION." in Midwestern Regional Meeting of the American-Federation-for-Medical-Research. (4 2017).
  • Bobba, C.; Englert, J.; Ballinger, M.N.; Ghadiali, S. "Alveolar Epithelial Cell And Macrophage Co-Culture Regulates Mechanically-Induced Inflammation." (1 2017).
  • Weist, J.; Barnhouse, V.; Shukla, V.; Ghadiali, S.N. et al. "Myoferlin depletion reduces autocrine TGF-beta 1 production to regulate epithelial-mesenchymal transition in breast cancer cells.." in Annual Joint Meeting of the American-Society-for-Cell-Biology and the European-Molecular-Biology-Organization (ASCB/EMBO). (1 2017).
  • Ghadiali, S.; Cho, Y.; Englert, J.; Kniss, D. "Myoferlin Regulates Epithelial To Mesenchymal Transition, Cell Migration And Erlotinib Resistance In Lung Adenocarcinoma Cells." in International Conference of the American-Thoracic-Society (ATS). (1 2017).
  • Bobba, C.; Englert, J.; Ballinger, M.N.; Ghadiali, S. "Alveolar Epithelial Cell And Macrophage Co-Culture Regulates Mechanically-Induced Inflammation." in International Conference of the American-Thoracic-Society (ATS). (1 2017).

2015

  • Nelson, K.; Black, S.M.; Eren, E.; Hayes, D. et al. "Determination of Optimum Ventilation Strategy for Ex-Vivo Lung Perfusion: Comparing Negative and Positive Pressure Ventilation." (4 2015).
  • Mathur, A.; Sizemore, G.M.; Balakrishnan, S.; Shukla, V.C. et al. "Stromal PDGFR-alpha activation stalls mammary ductal development and increases tumorigenic potential of mammary epithelia." in 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR). (8 2015).
  • Mathur, A.; Sizemore, G.M.; Balakrishnan, S.; Shukla, V.C. et al. "Stromal PDGFR-alpha activation stalls mammary ductal development and increases tumorigenic potential of mammary epithelia." (8 2015).
  • Nelson, K.; Black, S.M.; Eren, E.; Hayes, D. et al. "Determination of Optimum Ventilation Strategy for Ex-Vivo Lung Perfusion: Comparing Negative and Positive Pressure Ventilation." in 35th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation. (4 2015).

2011

  • Higuita-Castro, N.; Mihai, C.; Hansford, D.J.; Ghadiali, S.N. "In-vitro model of the microscale alveolar environment." (12 2011).
  • Sheer, F.J.; Ghadiali, S.N. "Computational analysis of adhesion dynamics in the eustachian tube during inflammatory otitis media." (12 2011).
  • Chen, X.; Ghadiali, S. "Computational model of microbubble flows during the reopening of airways." (12 2011).
  • Zielinski, R.; Mihai, C.; Ghadiali, S. "Multi-scale modeling of cancer cell migration and adhesion during epithelial-to-mesenchymal transition." (12 2011).

2010

  • Chen, X.; Ghadiali, S.; ASME, "FLUID-STRUCTURE MODELING OF LUNG EPITHELIAL CELL DEFORMATION DURING THE REOPENING OF COMPLIANT AIRWAYS." (1 2010).
  • Chen, X.; Ghadiali, S. "Fluid-structure modeling of lung epithelial cell deformation during the reopening of compliant airways." (12 2010).
  • Sheer, F.J.; Ghadiali, S.N. "Parametric analysis of eustachian tube function using fully coupled fluid-structure interaction models." (12 2010).
  • Knoell, D.; Lai, J.; Bao, S.; Mihai, C. et al. "Inhibition Of Phosphatase And Tensin Homolog Deleted On Chromosome Ten (PTEN) Enhances Lung Epithelial Migratory Capacity." (1 2010).
  • Chen, X.; Ghadiali, S. "FLUID-STRUCTURE MODELING OF LUNG EPITHELIAL CELL DEFORMATION DURING THE REOPENING OF COMPLIANT AIRWAYS." in 12th ASME Summer Bioengineering Conference. (1 2010).
  • Knoell, D.; Lai, J.; Bao, S.; Mihai, C. et al. "Inhibition Of Phosphatase And Tensin Homolog Deleted On Chromosome Ten (PTEN) Enhances Lung Epithelial Migratory Capacity." (1 2010).
  • Higuita-Castro, N.; Huang, Y.; Mihai, C.; Hansford, D.J. et al. "Influence of wall compliance on epithelial cell structure and injury during airway reopening." (12 2010).
  • Sheer, F.J.; Ghadiali, S.N. "PARAMETRIC ANALYSIS OF EUSTACHIAN TUBE FUNCTION USING FULLY COUPLED FLUID-STRURCTURE INTERACTION MODELS." in 12th ASME Summer Bioengineering Conference. (1 2010).
  • Mihai, C.; Bao, S.; Knoell, D.; Ghadiali, S.N. "Influence Of PTEN Inhibition On The Biomechanical Mechanisms Responsible For Rapid Cell Migration And Wound Repair." (1 2010).
  • Huang, Y.; Mihai, C.; Ghadiali, S.N. "ROLE OF TIGHT JUNCTIONS AND CYTOSKELETAL STRUCTURE ON BARRIER INTEGRITY AND CELL INJURY DURING AIRWAY REOPENING." (1 2010).
  • Huang, Y.; Ghadiali, S.N. "Influence of Shear Stress and Microbubble Flows on NF-kB activation in Epithelial C." (1 2010).
  • Sheer, F.J.; Ghadiali, S.N.; ASME, "PARAMETRIC ANALYSIS OF EUSTACHIAN TUBE FUNCTION USING FULLY COUPLED FLUID-STRURCTURE INTERACTION MODELS." (1 2010).
  • Higuita-Castro, N.; Huang, Y.; Mihai, C.; Hansford, D.J. et al. "INFLUENCE OF WALL COMPLIANCE ON EPITHELIAL CELL STRUCTURE AND INJURY DURING AIRWAY REOPENING." (1 2010).
  • Huang, Y.; Mihai, C.; Ghadiali, S.N. "ROLE OF TIGHT JUNCTIONS AND CYTOSKELETAL STRUCTURE ON BARRIER INTEGRITY AND CELL INJURY DURING AIRWAY REOPENING." (1 2010).
  • Knoell, D.; Lai, J.; Bao, S.; Mihai, C. et al. "Inhibition Of Phosphatase And Tensin Homolog Deleted On Chromosome Ten (PTEN) Enhances Lung Epithelial Migratory Capacity." (1 2010).
  • Huang, Y.; Ghadiali, S.N. "Influence of Shear Stress and Microbubble Flows on NF-kB activation in Epithelial C." (1 2010).
  • Knoell, D.; Lai, J.; Bao, S.; Mihai, C. et al. "Inhibition Of Phosphatase And Tensin Homolog Deleted On Chromosome Ten (PTEN) Enhances Lung Epithelial Migratory Capacity." (1 2010).
  • Mihai, C.; Bao, S.; Knoell, D.; Ghadiali, S.N. "Influence Of PTEN Inhibition On The Biomechanical Mechanisms Responsible For Rapid Cell Migration And Wound Repair." (1 2010).
  • Higuita-Castro, N.; Huang, Y.; Mihai, C.; Hansford, D.J. et al. "INFLUENCE OF WALL COMPLIANCE ON EPITHELIAL CELL STRUCTURE AND INJURY DURING AIRWAY REOPENING." in 12th ASME Summer Bioengineering Conference. (1 2010).

2009

  • Hallow, K.M.; Ghadiali, S.N. "Simvastatin Treatment Mitigates Epithelial Cell Injury during Cyclic Airway Reopening.." (1 2009).
  • Hallow, K.M.; Dailey, H.L.; Ghadiali, S.N. "Influence of Methyl-beta-Cyclodextrin on Epithelial Cell Injury and Mechanotransduction during Airway Reopening." (1 2009).
  • Hallow, K.M.; Dailey, H.L.; Ghadiali, S.N. "Influence of Methyl-beta-Cyclodextrin on Epithelial Cell Injury and Mechanotransduction during Airway Reopening." (1 2009).
  • Natalini, J.; Hallow, K.M.; Ghadiali, S.N. "Effect of Fluid Shear Stress and Microbubble Flows on Surfactant Secretion from Alveolar Epithelial Cells." (1 2009).
  • Natalini, J.; Hallow, K.M.; Ghadiali, S.N. "Effect of Fluid Shear Stress and Microbubble Flows on Surfactant Secretion from Alveolar Epithelial Cells." (1 2009).
  • Hallow, K.M.; Ghadiali, S.N. "Simvastatin Treatment Mitigates Epithelial Cell Injury during Cyclic Airway Reopening.." (1 2009).

2005

  • Dailey, H.L.; Ghadiali, S.N. "Fluid-structure analysis of convective and diffusive particle transport in pulmonary alveoli." (12 2005).
  • Bluestone, C.D.; Alper, C.M.; Buchman, C.A.; Felding, J.U. et al. "Eustachian tube, middle ear, and mastoid anatomy; Physiology, pathophysiology, and pathogenesis." in 8th Post Symposium Research Conference. (1 2005).
  • Bluestone, C.D.; Alper, C.M.; Buchman, C.A.; Felding, J.U. et al. "Eustachian tube, middle ear, and mastoid anatomy; physiology, pathophysiology, and pathogenesis." (1 2005).
  • Capozzi, M.T.; Swarts, J.D.; Ghadiali, S. "Influence of molecular adhesion on flow phenomena in a collapsed respiratory airway: A multi-scale analysis." (12 2005).
  • Bluestone, C.D.; Alper, C.M.; Buchman, C.A.; Felding, J.U. et al. "Eustachian tube, middle ear, and mastoid anatomy; Physiology, pathophysiology, and pathogenesis." (1 2005).

2001

  • Ghadiali, S.N.; Federspiel, W.J.; Douglas Swarts, J.; Doyle, W.J. "Measurement of Eustachian tube mechanical properties using a modified forced response test." (12 2001).
  • Gaver, D.P.; Ghadiali, S.N.; Williams, H.A.R.; Halpern, D. "Pulmonary surfactant transport in steady and unsteady flows." (12 2001).

1999

  • Ghadiali, S.N.; Gaver, D.P. "Influence of bulk surfactant transport on airway reopening." (12 1999).

Unknown

  • Hostnik, E.T.; Ham, K.; Ghadiali, S.; Habing, G. et al. "Quantification of Airflow Resistance by Computed Tomography in English Bulldogs Before and After Airway Surgery." in 2017 ACVS Surgery Summit.