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Keith Gooch

  • Professor, Biomedical Engineering
  • 270 Bevis Hall
    1080 Carmack Road
    Columbus, OH 43210
  • 614-292-2665

About

Education

  • Ph.D., Pennsylvania State University

 

Key Honors and Distinctions

  • Herman Weed Excellence in Teaching Award, Department of Biomedical Engineering, OSU (2017, 2011)
  • Lumley Research Award, College of Engineering, OSU (2012)

 

RESEARCH AREAS – Gooch Lab

  • Biomaterials; Molecular, cell and tissue engineering; Mechanobiology

 

  • PUBLICATIONS 

https://scholar.google.com/citations?user=Jcrg1uIAAAAJ&hl=en

 

  • PATENTS
    • Clerin,Valerie; Gusic,Rebecca; Gooch,Keith. "Ex vivo remodeling of excised blood vessels for vascular grafts." Patent number: 7011623

Professor Gooch’s research focuses on tissue engineering as applied to the cardiovascular system, cartilage, and diabetes, with emphasis on the regulation of the differentiation, growth, and remodeling of cells and tissues. He has published a host of articles in this area and is co-author of Physical Forces: Their Effects on Cells and Tissues. Dr. Gooch’s work has been funded by the National Science Foundation, the National Institutes of Health, and the American Heart Association.

 

Honors

  • 20120101

    Lumley Research Award.

  • 20110501

    The Herman Weed Excellence in Teaching Award.

  • 19970101-19980101

    National Research Service Award.

  • 19920101-19950101

    Institutional National Research Service Award.

  • 19940101

    Award for Excellence in Chemical Engineering.

  • 19900101

    Allied Signal's scholarship for summer studies.

Books

1997

  • Keith J. Gooch and Christopher J. Tennant. 1997. "Physical Forces: Their Effects on Cells and Tissues." Springer Verlag.

Chapters

2011

  • 2011. "Scaffolds and Angiogenesis." In EXS Biomaterials,

1998

  • 1998. "Mechanical Forces and Growth Factors in Tissue Engineering." In Frontiers in Tissue Engineering, edited by Patrick C, Mikos A, and McIntire L,

Journal Articles

2015

  • Holfinger SJ, Reinhardt JW, Reen R, Schultz KM, Passino KM, Ackerman WE, Kniss DA, Sander LM, Gallego-Perez D, Gooch KJ, 2015, "Pancreatic Epithelial Cells Form Islet-Like Clusters in the Absence of Directed Migration." Cellular and Molecular Bioengineering 8, no. 3, 496-506 - 496-506.

2014

  • Gooch,Keith,J; Trask,Aaron,J, 2014, "Vascular mechanics in intact and decellularized micro-and macro-vessels from type 2 diabetic db/db mice." ANGIOGENESIS 17, no. 1, 288-288 - 288-288.

2013

  • Stevenson,M,D; Piristine,H; Hogrebe,N,J; Nocera,T,M; Boehm,M,W; Reen,R,K; Koelling,K,W; Agarwal,G; Sarang-Sieminski,A,L; Gooch,K,J, 2013, "A self-assembling peptide matrix used to control stiffness and binding site density supports the formation of microvascular networks in three dimensions." ACTA BIOMATERIALIA 9, no. 8, 7651-7661 - 7651-7661.
  • Ma,Xiaoyue; Schickel,Maureen,E; Stevenson,Mark,D; Sarang-Sieminski,Alisha,L; Gooch,Keith,J; Ghadiali,Samir,N; Hart,Richard,T, 2013, "Fibers in the Extracellular Matrix Enable Long-Range Stress Transmission between Cells." BIOPHYSICAL JOURNAL 104, no. 7, 1410-1418 - 1410-1418.

2012

  • Gallego-Perez,Daniel; Higuita-Castro,Natalia; Reen,Rashmeet,K; Palacio-Ochoa,Marcela; Sharma,Sadhana; Lee,L,James; Lannutti,John,J; Hansford,Derek,J; Gooch,Keith,J, 2012, "Micro/nanoscale technologies for the development of hormone-expressing islet-like cell clusters." BIOMEDICAL MICRODEVICES 14, no. 4, 779-789 - 779-789.

2011

  • Joddar B, Shaffer RJG, and Gooch KJ, 2011, "Arterial pO2 stimulates intimal hyperplasia and serum stimulates inward eutrophic remodeling in porcine saphenous veins cultured ex vivo. Biomech Model Mechanobiology." Biomech Model Mechanobiology 2, no. 10, 161-175 - 161-175.
  • Joddar B, Reen RK, Firstenberg MS, Varadharaj S, McCord JM, Zweier JL, Gooch KJ, 2011, "Protandim attenuates intimal hyperplasia in human saphenous veins cultured ex vivo via a catalase-dependent pathway." Free Radic Biol Med 6, no. 50, 700-709 - 700-709.

2010

  • Stevenson MD, Sieminski AL, McLeod CM, Byfield FJ, Baracos VH, Gooch KJ., 2010, "Pericellular Conditions Regulate Extent of Cell-Mediated Compaction of Collagen Gels." Biophys J 1, no. 99, 19-28 - 19-28.
  • Nicholas Ferrell, Daniel Gallego-Perez, Natalia Higuita-Castro, Randall T. Butler, Rashmeet K. Reen, Keith J. Gooch, Derek J, 2010, "Vacuum-Assisted Cell Isolation in a Microwell Cell Culture System." Anal Chem 82, no. 15, 2380-2386 - 2380-2386.
  • Gallego-Perez D, Higuita-Castro N, Sharma S, Reen RK, Palmer AF, Gooch KJ, Lee LJ, Lannutti JJ, Hansford DJ, 2010, "High throughput assembly of spatially controlled 3D cell clusters on a micro/nanoplatform." Lab Chip 10, no. 21, 775-782 - 775-782.
  • Tzu Pin Shentu, Igor Titushkin, Dev Singh, Gooch KJ, 2010, "oxLDL-induced fluidization of membrane domains in control of endothelial biomechanics and network formation." Am J Physiol Cell Physiol 2, no. 299, C218-C229 - C218-C229.

2009

  • Byfield FJ, Reen R, Levitan I, and Gooch KJ, 2009, "Endothelial actin and cell stiffness is modulated by substrate stiffness in 2D and 3D." Journal of Biomechanics 8, no. 42, 1114-1119 - 1114-1119.
  • Lawrence AR and Gooch KJ, 2009, "Transmural Pressure and Axial Loading Interactively regulate Arterial Remodeling Ex Vivo." Am J Physiol Heart Circ Physiol 1, no. 291, H475-H484 - H475-H484.
  • Lawrence AR and Gooch KJ, 2009, "Differences in Transmural Pressure and Axial Loading Ex Vivo Affect Arterial Remodeling and Material Properties." J Biomech Eng 10, no. 131, 1-8 - 1-8.

2008

  • Joddar,Binata; Reen,Rashmeet,K; Firstenberg,Michael; Gooch,Keith,J, 2008, "Role of Oxygen Tension and Oxidative Stress in Human Saphenous Vein Remodeling." CIRCULATION 118, no. 18, S1017-S1017 - S1017-S1017.
  • Nichol JW, Khan AR, Birbach M, Gaynor JW, Gooch KJ, 2008, "Hemodynamics and Axial Strain Additively Increase Matrix Remodeling and MMP-9, But Not MMP-2, Expression in Arteries Engineered by Directed Remodeling." Tissue Eng Part A. 6, no. 15, 1281-1290 - 1281-1290.
  • Boretti MI, Gooch KJ, 2008, "Effect of Extracellular Matrix and 3D Morphogenesis on Islet Hormone Gene Expression by Ngn3-Infected Mouse Pancreatic Ductal Epithelial Cells." Tissue Eng Part A 12, no. 14, 1927-1937 - 1927-1937.

2006

  • Nichol,Jason,W; Gaynor,J,William; Gooch,Keith,J, 2006, "Simultaneously reduced hemodynamics and increased axial strain in engineered arteries leads to additive increase in MMP-9 but not MMP-2 expression, mediated by NF-kappa B subunits p50 and p65." VASCULAR PHARMACOLOGY 45, no. 3, 186-187 - 186-187.

2005

  • Stachelek,S,J; Alferiev,I; Choi,H; Kronsteiner,A; Uttayarat,P; Gooch,K,J; COMPOSTO,R,J; Chen,I,W; Hebbel,R,P; Levy,R,J, 2005, "Cholesterol-derivatized polyurethane: Characterization and endothelial cell adhesion." JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 72A, no. 2, 200-212 - 200-212.
  • Gusic, R.J.; Myung, R.; Petko, M.; Gaynor, J.W. et al., 2005, "Shear stress and pressure modulate saphenous vein remodeling ex vivo.." Journal of biomechanics 38, no. 9, 1760-1769 - 1760-1769.
  • Stachelek, Stanley, J; Alferiev, Ivan; Choi, Hoon; Kronsteiner, Allyson; Uttayarat, Pimporn; Gooch, Keith, J; Composto, Russell, J; Chen, I-Wei; Hebbel, Robert, P; Levy, Robert J, 2005, "Cholesterol-derivatized polyurethane: characterization and endothelial cell adhesion.." Journal of biomedical materials research. Part A 72, no. 2, 200-12 - 200-12.

2004

  • Schreiber, F.S.; Deramaudt, T.B.; Brunner, T.B.; Boretti, M.I. et al., 2004, "Successful growth and characterization of mouse pancreatic ductal cells: functional properties of the Ki-RAS(G12V) oncogene.." Gastroenterology 127, no. 1, 250-260 - 250-260.

2002

  • Blunk, T.; Sieminski, A.L.; Gooch, K.J.; Courter, D.L. et al., 2002, "Differential effects of growth factors on tissue-engineered cartilage.." Tissue engineering 8, no. 1, 73-84 - 73-84.

2001

  • Gooch, K.J.; Blunk, T.; Courter, D.L.; Sieminski, A.L. et al., 2001, "IGF-I and mechanical environment interact to modulate engineered cartilage development.." Biochemical and biophysical research communications 286, no. 5, 909-915 - 909-915.

Unknown

  • Anghelescu M, Tonniges JR, Calomeni E, Shamhart PE, Agarwal G, Gooch KJ, Trask AJ, "Vascular Mechanics in Decellularized Aortas and Coronary Resistance Microvessels in Type 2 Diabetic db/db Mice." Ann Biomed Eng

Presentations

  • "Cardiovascular Tissue Engineering." 2000, Presented at Department of Biomedical Engineering, University of Virginia Seminar Series,
  • "Control of Cell and Tissue growth and Differentiation." 2000, Presented at Coriell Institute for Medical Research Camden Seminar Series,
  • "Tissue Engineering of Microvascular Networks and Conduit Vessels." 2001, Presented at Department of Bioengineering UCSD Seminar Series,
  • "Tissue Engineering of Microvascular Networks and Conduit Vessels." 2001, Presented at Duke University Program in Cellular and Biosurface Engineering Seminar Series,
  • "Tissue Engineering of Conduit Vessels and Microvascular Networks." 2002, Presented at Department of Biomedical Engineering University of Virginia Seminar Series,
  • "Vascular Tissue Engineering." 2005, Presented at Center for Biomedical Engineering OSU Seminar Series,
  • "Nontraditional Regulators of Vascular Structure and Function." 2010, Presented at Department of Biology University of Dayton Seminar Series,
  • "Mechanical regulation of cardiovascular remodeling." 2012, Presented at Department of Biomedical Engineering Unviresity of Virgina,
  • "Mechanical Regulation of Cardiovascular Remodeling." 2014, Presented at Center for Cardiovascular and Pulmunary Research Nationwide Childrens Hospital Work in Progress Seminar Series,
  • "Formation and Remodeling of Blood Vessels: Computational and Experimental Studies." 2015, Presented at Department of Biomedical Engineering University of Akron Seminar Series,
  • "Tissue Engineering for Gene Therapy and Structural Tissue Repair." 1997, Presented at University of Pennsylvania Department of Bioengieering Seminar Series,
  • "Tissue Engineering of Microvascular Networks and Conduit Vessels." 2001, Presented at Department of Biomedical Engineering Rice University Seminar Series,
  • "Tissue Engineering of Microvascular Networks and Conduit Vessels." 2001, Presented at Department of Biomedical Engineering Johns Hopkins University Seminar Series,
  • "Nontraditional Regulators of Vascular Structure and Function." 2006, Presented at Division of Pulmonary, Critical Care & Sleep Medicine UIC School of Medicine Seminar Series,
  • "Differential Adhesion and Engineered Tissues." 2006, Presented at Department of Pharmaceutical Science University of Regensburg Seminar Series,
  • "Cardiovascular Tissue Engineering." 2011, Presented at Department of Chemical Engineering Drexel Seminar Series,
  • "Tissue Engineering for Gene Therapy and Structural Tissue Repair." 1997, Presented at University of Regensburg Department of Pharmacuetical Science Seminar Series,
  • "Tissue Engineering for Gene Therapy and Structural Tissue Repair." 1997, Presented at Johns Hopkins University Department of Biomedical Engineering Seminar Series,
  • "Cardiovascular Tissue Engineering." 2000, Presented at Department of Physiology, Thomas Jefferson University Seminar Series,
  • "Tissue Engineering of Microvascular Networks and Conduit Vessels." 2001, Presented at Department of Chemical Engineering Drexel Seminar Series,
  • "Cardiovascular Tissue Engineering." 2002, Presented at Department of Chemical Engineering Florida State University Seminar Series,
  • "Nontraditional Regulators of Vascular Structure and Function." 2008, Presented at 20. University of Minnesota, Department of Biomedical Engineering Seminar Series,
  • "Tissue Engineering of Microvascular Networks and Conduit Vessels." 2011, Presented at Department of Biomedical Engineering University of Minnesota Seminar Series,
  • "Matrix Microarchitecture is a Potent Regulator of Cellular Response." 2014, Presented at OSU Materials Week 2014,
  • "Agent-based modeling of cell-matrix interactions." 2015, Presented at Interagency Modeling and Analysis Group Cell-to-Macroscale Working Group Webinar Series,
  • "In Vitro Evaluation of Engineered Tissues." 2007, Presented at FDA/NIST sponsored workshop on in vitro evaluation of cell/scaffold products,
  • "Role of oxygen Tension and Oxidative Stress in Human Saphenous Vein Remodeling." 2010, Presented at School of Biomedical Engineering of Purdue,
  • "Mathematical and computational modeling of cell-matrix interactions." 2012, Presented at MBI Workshop: Tissue Engineering and Regenerative Medicine,

Papers in Proceedings

2014

  • Gooch KJ, Trask AJ "Vascular mechanics in intact and decellularized micro-and macro-vessels from type 2 diabetic db/db mice." in Vascular Biology 2013 NAVBO. (1 2014).

2009

  • Ma X, Green JEF, Gooch KJ, Jansen RM and Hart RT "FINITE ELEMENT MODELING OF ENTANGLED COLLAGEN FIBER GELS WITH RANDOMLY ORIENTED FIBERS." PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE." in ASME SUMMER BIOENGINEERING CONFERENCE - 200. (1 2009).

Patents

  • Valerie Clerin; Rebecca Gusic; Keith Gooch. "Ex Vivo Remodeling of Excised Blood Vessels for Vascular Grafts."
  • Clerin,Valerie; Gusic,Rebecca; Gooch,Keith. "Ex vivo remodeling of excised blood vessels for vascular grafts." Patent number: 7011623
  • Venkatram P Shastri; Keith J Gooch; Jason W Nichol. "Retention of endothelial cells on vascular grafts."
  • Lisa E Freed; Keith J Gooch; Donald L Courter; Torsten Blunk; Alisha L Sieminski; Gordana V Vunjak-Novakovic. "Effect of bone morphogenetic proteins on engineered cartilage."