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Thomas Hund

  • Associate Professor, Biomedical Engineering
  • 287 Bevis Hall
    1080 Carmack Road
    Columbus, OH 43210
  • 614-292-0755

Honors

  • 2014

    Herman R. Weed Excellence in Teaching Award. .

  • 2013

    Complex Systems Scholar. .

  • 2011

    Research Scholar in Cardiovascular Disease. .

  • 2009

    NIH Pathway to Independence Award (K99/R00). .

  • 2008

    Early-Career Authors Prize. .

  • 2006

    NIH Ruth L. Kirchstein National Research Service Award (F32). .

Chapters

2014

  • Hund TJ, Smith SA, Makara MA, and Mohler PJ. 2014. "Cellular and Molecular Pathobiology of the Cardiac Conduction System." In Cellular and Molecular Pathobiology of Cardiovascular Disease, edited by Willis MS, Homeister JW, and Stone JR, San Diego: Academic Press.
  • Hund TJ and Mohler PJ. 2014. "Biophysics of Normal and Abnormal Cardiac Sodium Channel Function." In Cardiac Electrophysiology: From Cell to Bedside. 6th Edition, edited by Zipes DP and Jalife J, Philadelphia: Elsevier.

2012

  • Hund TJ, Cunha SR, and Mohler PJ. 2012. "Principles of Cellular Architecture and Physiology with Applications in Electrophysiology." In Electrophysiological Disorders of the Heart. 2nd Edition, edited by Saksena and Camm, Philadelphia: Elsevier.

2011

  • Hund TJ. 2011. "Calmodulin kinase II regulation of heart rhythm and disase." In Heart Rate and Rhythm: Molecular Basis, Pharmacological Modulation, and Clinical Implications, edited by Tripathi ON, Ravens U, and Sanguinetti MC, Berlin: Springer-Verlag.

Journal Articles

2015

  • Chen-Izu,Ye; Shaw,Robin,M; Pitt,Geoffrey,S; Yarov-Yarovoy,Vladimir; Sack,Jon,T; Abriel,Hugues; Aldrich,Richard,W; Belardinelli,Luiz; Cannell,Mark,B; Catterall,William,A; Chazin,Walter,J; Chiamvimonvat,Nipavan; Deschenes,Isabelle; Grandi,Eleonora; Hund,Thomas,J; Izu,Leighton,T; Maier,Lars,S; Maltsev,Victor,A; Marionneau,Celine; Mohler,Peter,J; Rajamani,Sridharan; Rasmusson,Randall,L; Sobie,Eric,A; Clancy,Colleen,E; Bers,Donald,M, 2015, "Na+ channel function, regulation, structure, trafficking and sequestration." JOURNAL OF PHYSIOLOGY-LONDON 593, no. 6, 1347 - 1360.
  • Radwanski,Przemyslaw,B; Brunello,Lucia; Veeraraghavan,Rengasayee; Ho,Hsiang-Ting; Lou,Qing; Makara,Michael,A; Belevych,Andriy,E; Anghelescu,Mircea; Priori,Silvia,G; Volpe,Pompeo; Hund,Thomas,J; Janssen,Paul,ML; Mohler,Peter,J; Bridge,John,HB; Poelzing,Steven; Györke,Sándor, 2015, "Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release.." Cardiovascular research 106, no. 1, 143 - 152.
  • Smith,Sakima,A; Sturm,Amy,C; Curran,Jerry; Kline,Crystal,F; Little,Sean,C; Bonilla,Ingrid,M; Long,Victor,P; Makara,Michael; Polina,Iuliia; Hughes,Langston,D; Webb,Tyler,R; Wei,Zhiyi; Wright,Patrick; Voigt,Niels; Bhakta,Deepak; Spoonamore,Katherine,G; Zhang,Chuansheng; Weiss,Raul; Binkley,Philip,F; Janssen,Paul,M; Kilic,Ahmet; Higgins,Robert,S; Sun,Mingzhai; Ma,Jianjie; Dobrev,Dobromir; Zhang,Mingjie; Carnes,Cynthia,A; Vatta,Matteo; Rasband,Matthew,N; Hund,Thomas,J; Mohler,Peter,J, 2015, "Dysfunction in the beta II Spectrin-Dependent Cytoskeleton Underlies Human Arrhythmia." CIRCULATION 131, no. 8, 695 - U72.
  • Sturm,Amy,C; Kline,Crystal,F; Glynn,Patric; Johnson,Benjamin,L; Curran,Jerry; Kilic,Ahmet; Higgins,Robert,SD; Binkley,Philip,F; Janssen,Paul,ML; Weiss,Raul; Raman,Subha,V; Fowler,Steven,J; Priori,Silvia,G; Hund,Thomas,J; Carnes,Cynthia,A; Mohler,Peter,J, 2015, "Use of whole exome sequencing for the identification of ito-based arrhythmia mechanism and therapy.." Journal of the American Heart Association 4, no. 5, e001762 -
  • Curran,Jerry; Musa,Hassan; Kline,Crystal,F; Makara,Michael,A; Little,Sean,C; Higgins,John,D; Hund,Thomas,J; Band,Hamid; Mohler,Peter,J, 2015, "Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca2+ Channel Targeting and Function in the Atria." JOURNAL OF BIOLOGICAL CHEMISTRY 290, no. 19, 12210 - 12221.

2014

  • Hund,Thomas,J; Snyder,Jedidiah,S; Wu,Xiangqiong; Glynn,Patric; Koval,Olha,M; Onal,Birce; Leymaster,Nicholas,D; Unudurthi,Sathya,D; Curran,Jerry; Camardo,Celia; Wright,Patrick,J; Binkley,Philip,F; Anderson,Mark,E; Mohler,Peter,J, 2014, "ßIV-Spectrin regulates TREK-1 membrane targeting in the heart." CARDIOVASCULAR RESEARCH 102, no. 1, 166 - 175.
  • Vreeker,Arnold; Van Stuijvenberg,Leonie; Hund,Thomas,J; Mohler,Peter,J; Nikkels,Peter,GJ; van Veen,Toon,AB, 2014, "Assembly of the cardiac intercalated disk during pre- and postnatal development of the human heart." PLOS ONE 9, no. 4, e94722 -
  • Bonilla,Ingrid,M; Vargas-Pinto,Pedro; Nishijima,Yoshinori; Pedraza-Toscano,Adriana; Ho,Hsiang-Ting; Long,Victor,P; Belevych,Andriy,E; Glynn,Patric; Houmsse,Mahmoud; Rhodes,Troy; Weiss,Raul; Hund,Thomas,J; Hamlin,Robert,L; Györke,Sandor; Carnes,Cynthia,A, 2014, "Ibandronate and ventricular arrhythmia risk." JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 25, no. 3, 299 - 306.
  • Ho,Hsiang-Ting; Liu,Bin; Snyder,Jedidiah,S; Lou,Qing; Brundage,Elizabeth,A; Velez-Cortes,Florencia; Wang,Honglan; Ziolo,Mark,T; Anderson,Mark,E; Sen,Chandan,K; Wehrens,Xander,HT; Fedorov,Vadim,V; Biesiadecki,Brandon,J; Hund,Thomas,J; Gyorke,Sandor, 2014, "Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides." CARDIOVASCULAR RESEARCH 101, no. 1, 165 - 174.
  • Onal, Birce; Unudurthi, Sathya, D; Hund, Thomas, J, 2014, "Modeling in cardiac physiology: From molecule to tissue." FRONTIERS IN PHARMACOLOGY 5, 9 -
  • Kline,Crystal,F; Scott,John; Curran,Jerry; Hund,Thomas,J; Mohler,Peter,J, 2014, "Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting." JOURNAL OF BIOLOGICAL CHEMISTRY 289, no. 8, 5285 - 5295.
  • Glynn,Patric; Onal,Birce; Hund,Thomas,J, 2014, "Cycle length restitution in sinoatrial node cells: a theory for understanding spontaneous action potential dynamics." PLOS ONE 9, no. 2, e89049 -
  • Unudurthi,Sathya,D; Wolf,Roseanne,M; Hund,Thomas,J, 2014, "Role of sinoatrial node architecture in maintaining a balanced source-sink relationship and synchronous cardiac pacemaking." FRONTIERS IN PHYSIOLOGY 5, 446 -
  • Glynn, PJ; Unudurthi, SD; Hund, TJ, 2014, "Mathematical modeling of physiological systems: An essential tool for discovery." LIFE SCIENCES 111, no. 1-2, 1 - 5.
  • Hund, TJ; Mohler PJ, 2014, "Nav channel complex heterogeneity: New targets for the treatment of arrhythmia?." CIRCULATION 130, 132 - 134.
  • Makara,Michael,A; Curran,Jerry; Little,Sean,C; Musa,Hassan; Polina,Iuliia; Smith,Sakima,A; Wright,Patrick,J; Unudurthi,Sathya,D; Snyder,Jed; Bennett,Vann; Hund,Thomas,J; Mohler,Peter,J, 2014, "Ankyrin-G Coordinates Intercalated Disc Signaling Platform to Regulate Cardiac Excitability In Vivo." CIRCULATION RESEARCH 115, no. 11, 929 - ?.
  • Curran, J; Makara, MA; Little, SC; Wu, X; Polina, I; Alecusan, J; Wright, P; Li, J; Band, H; Hund, TJ; Mohler, PJ, 2014, "EHD3-dependent endosome trafficking pathway regulates cardiac membrane excitability and physiology." CIRCULATION RESEARCH 115, no. 1, 68 - 78.
  • Dybkova, N; Wagner, S; Backs, J; Hund, TJ; Mohler,PJ; Nikolaev, VO; Maier, LS, 2014, "Tubulin polymerization disrupts cardiac beta-adrenergic activation of late INa." CARDIOVASCULAR RESEARCH 103, no. 1, 168 - 77.

2013

  • Wolf,Roseanne,M; Glynn,Patric; Hashemi,Seyed; Zarei,Keyan; Mitchell,Colleen,C; Anderson,Mark,E; Mohler,Peter,J; Hund,Thomas,J, 2013, "Atrial fibrillation and sinus node dysfunction in human ankyrin-B syndrome: a computational analysis." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 304, no. 9, H1253 - H1266.
  • Luo,Min; Guan,Xiaoqun; Luczak,Elizabeth,D; Lang,Di; Kutschke,William; Gao,Zhan; Yang,Jinying; Glynn,Patric; Sossalla,Samuel; Swaminathan,Paari,D; Weiss,Robert,M; Yang,Baoli; Rokita,Adam,G; Maier,Lars,S; Efimov,Igor,R; Hund,Thomas,J; Anderson,Mark,A, 2013, "Diabetes increases mortality after myocardial infarction by oxidizing CaMKII." JOURNAL OF CLINICAL INVESTIGATION 123, no. 3, 1262 - 1274.
  • DeGrande,Sean,T; Little,Sean,C; Nixon,Derek,J; Wright,Patrick; Snyder,Jedidiah; Dun,Wen; Murphy,Nathaniel; Kilic,Ahmet; Higgins,Robert; Binkley,Philip,F; Boyden,Penelope,A; Carnes,Cynthia,A; Anderson,Mark,E; Hund,Thomas,J; Mohler,Peter,J, 2013, "Molecular Mechanisms Underlying Cardiac Protein Phosphatase 2A Regulation in Heart." JOURNAL OF BIOLOGICAL CHEMISTRY 288, no. 2, 1032 - 1046.
  • Gao,Zhan; Rasmussen,Tyler,P; Li,Yue; Kutschke,William; Koval,Olha,M; Wu,Yiming; Wu,Yuejin; Hall,Duane,D; Joiner,Mei-ling,A; Wu,Xiang-Qiong; Swaminathan,Paari,D; Purohit,Anil; Zimmerman,Kathy; Weiss,Robert,M; Philipson,Kenneth,D; Song,Long-Sheng; Hund,Thomas,J; Anderson,Mark,E, 2013, "Genetic Inhibition of Na+-Ca2+ Exchanger Current Disables Fight or Flight Sinoatrial Node Activity Without Affecting Resting Heart Rate." CIRCULATION RESEARCH 112, no. 2, 309 - ?.
  • Zhang,Wujie; Zhao,Shuting; Rao,Wei; Snyder,Jedidiah; Choi,Jung,K; Wang,Jifu; Khan,Iftheker,A; Saleh,Navid,B; Mohler,Peter,J; Yu,Jianhua; Hund,Thomas,J; Tang,Chuanbing; He,Xiaoming, 2013, "A novel core-shell microcapsule for encapsulation and 3D culture of embryonic stem cells." JOURNAL OF MATERIALS CHEMISTRY B 1, no. 7, 1002 - 1009.
  • Noorman,Maartje; Hakim,Sara; Kessler,Elise; Groeneweg,Judith,A; Cox,Moniek,GPJ; Asimaki,Angeliki; van Rijen,Harold,VM; Van Stuijvenberg,Leonie; Chkourko,Halina; Van der Heyden,Marcel,AG; Vos,Marc,A; de Jonge,Nicolaas; van der Smagt,Jasper,J; Dooijes,Dennis; Vink,Aryan; de Weger,Roel,A; Varro,Andras; de Bakker,Jacques,MT; Saffitz,Jeffrey,E; Hund,Thomas,J; Mohler,Peter,J; Delmar,Mario; Hauer,Richard,NW; van Veen,Toon,AB, 2013, "Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy." HEART RHYTHM 10, no. 3, 412 - 419.
  • Dun,Wen; Lowe,John,S; Wright,Patrick; Hund,Thomas,J; Mohler,Peter,J; Boyden,Penelope,A, 2013, "Ankyrin-G Participates in I-Na Remodeling in Myocytes from the Border Zones of Infarcted Canine Heart." PLOS ONE 8, no. 10, e78087 -
  • Kline,Crystal,F; Wright,Patrick,J; Koval,Olha,M; Zmuda,Erik,J; Johnson,Benjamin,L; Anderson,Mark,E; Hai,Tsonwin; Hund,Thomas,J; Mohler,Peter,J, 2013, "beta(IV)-Spectrin and CaMKII facilitate Kir6.2 regulation in pancreatic beta cells." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110, no. 43, 17576 - 17581.
  • Toischer,Karl; Hartmann,Nico; Wagner,Stefan; Fischer,Thomas,H; Herting,Jonas; Danner,Bernhard,C; Sag,Can,M; Hund,Thomas,J; Mohler,Peter,J; Belardinelli,Luiz; Hasenfuss,Gerd; Maier,Lars,S; Sossalla,Samuel, 2013, "Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease." JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 61, 111 - 122.

2012

  • Koval,Olha,M; Snyder,Jedidiah,S; Wolf,Roseanne,M; Pavlovicz,Ryan,E; Curran,Jerry; Dun,Wen; Wright,Patrick,J; Cardona,Natalia; Qian,Lan; Mitchell,Colleen,C; Boyden,Penelope,A; Binkley,Philip,F; Li,Chenglong; Anderson,Mark,E; Mohler,Peter,J; Hund,Thomas,J, 2012, "Ca2+/Calmodulin-Dependent Protein Kinase II-Based Regulation of Voltage-Gated Na+ Channel in Cardiac Disease." CIRCULATION 126, no. 17, 2084 - 2094.
  • Smith,Sakima; Curran,Jerry; Hund,Thomas,J; Mohler,Peter,J, 2012, "Defects in cytoskeletal signaling pathways, arrhythmia, and sudden cardiac death." FRONTIERS IN PHYSIOLOGY 3, 122 -
  • Swaminathan,Paari,Dominic; Purohit,Anil; Hund,Thomas,J; Anderson,Mark,E, 2012, "Calmodulin-Dependent Protein Kinase II: Linking Heart Failure and Arrhythmias." CIRCULATION RESEARCH 110, no. 12, 1661 - 1677.
  • Kashef,Farshid; Li,Jingdong; Wright,Patrick; Snyder,Jedidiah; Suliman,Faroug; Kilic,Ahmet; Higgins,Robert,SD; Anderson,Mark,E; Binkley,Philip,F; Hund,Thomas,J; Mohler,Peter,J, 2012, "Ankyrin-B Protein in Heart Failure: Identification of a new component of metazoan cardioprotection." JOURNAL OF BIOLOGICAL CHEMISTRY 287, no. 36, 30268 - 30281.
  • Jansen,John,A; Noorman,Maartje; Musa,Hassan; Stein,Mera; de Jong,Sanne; van der Nagel,Roel; Hund,Thomas,J; Mohler,Peter,J; Vos,Marc,A; van Veen,Toon,A; de Bakker,Jacques,M; Delmar,Mario; van Rijen,Harold,V, 2012, "Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice." HEART RHYTHM 9, no. 4, 600 - 607.
  • Degrande,Sean; Nixon,Derek; Koval,Olha; Curran,Jerald,W; Wright,Patrick; Wang,Qiongling; Kashef,Farshid; Chiang,David; Li,Na; Wehrens,Xander,HT; Anderson,Mark,E; Hund,Thomas,J; Mohler,Peter,J, 2012, "CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome." HEART RHYTHM 9, no. 12, 2034 - 2041.
  • Cerrone,Marina; Noorman,Maartje; Lin,Xianming; Chkourko,Halina; Liang,Feng-Xia; van der Nagel,Roel; Hund,Thomas; Birchmeier,Walter; Mohler,Peter; van Veen,Toon,A; van Rijen,Harold,V; Delmar,Mario, 2012, "Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency." CARDIOVASCULAR RESEARCH 95, no. 4, 460 - 468.
  • Gudmundsson,Hjalti; Curran,Jerry; Kashef,Farshid; Snyder,Jedidiah,S; Smith,Sakima,A; Vargas-Pinto,Pedro; Bonilla,Ingrid,M; Weiss,Robert,M; Anderson,Mark,E; Binkley,Philip; Felder,Robert,B; Carnes,Cynthia,A; Band,Hamid; Hund,Thomas,J; Mohler,Peter,J, 2012, "Differential regulation of EHD3 in human and mammalian heart failure." JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 52, no. 5, 1183 - 1190.

2011

  • Swaminathan,Paari,Dominic; Purohit,Anil; Soni,Siddarth; Voigt,Niels; Singh,Madhu,V; Glukhov,Alexey,V; Gao,Zhan; He,B,Julie; Luczak,Elizabeth,D; Joiner,Mei-ling,A; Kutschke,William; Yang,Jinying; Donahue,J,Kevin; Weiss,Robert,M; Grumbach,Isabella,M; Ogawa,Masahiro; Chen,Peng-Sheng; Efimov,Igor; Dobrev,Dobromir; Mohler,Peter,J; Hund,Thomas,J; Anderson,Mark,E, 2011, "Oxidized CaMKII causes cardiac sinus node dysfunction in mice." JOURNAL OF CLINICAL INVESTIGATION 121, no. 8, 3277 - 3288.
  • Gao,Zhan; Singh,Madhu,V; Hall,Duane,D; Koval,Olha,M; Luczak,Elizabeth,D; Joiner,Mei-ling,A; Chen,Biyi; Wu,Yuejin; Chaudhary,Ashok,K; Martins,James,B; Hund,Thomas,J; Mohler,Peter,J; Song,Long-Sheng; Anderson,Mark,E, 2011, "Catecholamine-Independent Heart Rate Increases Require Ca2+/Calmodulin-Dependent Protein Kinase II." CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY 4, no. 3, 379 - U194.
  • Hund,Thomas,J; Mohler,Peter,J, 2011, "Differential roles for SUR subunits in K-ATP channel membrane targeting and regulation." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 300, no. 1, H33 - H35.
  • Mohler,Peter,J; Hund,Thomas,J, 2011, "Role of CaMKII in cardiovascular health, disease, and arrhythmia." HEART RHYTHM 8, no. 1, 142 - 144.
  • Besse,Ian,M; Mitchell,Colleen,C; Hund,Thomas,J; Shibata,Erwin,F, 2011, "A computational investigation of cardiac caveolae as a source of persistent sodium current." FRONTIERS IN PHYSIOLOGY 2, 87 -
  • Cunha,Shane,R; Hund,Thomas,J; Hashemi,Seyed; Voigt,Niels; Li,Na; Wright,Patrick; Koval,Olha; Li,Jingdong; Gudmundsson,Hjalti; Gumina,Richard,J; Karck,Matthias; Schott,Jean-Jacques; Probst,Vincent; Le Marec,Herve; Anderson,Mark,E; Dobrev,Dobromir; Wehrens,Xander,HT; Mohler,Peter,J, 2011, "Defects in Ankyrin-Based Membrane Protein Targeting Pathways Underlie Atrial Fibrillation." CIRCULATION 124, no. 11, 1212 - 1222.
  • Mohler,Peter,J; Hund,Thomas,J, 2011, "Membrane-select regulation of cardiac Na-v channel isoforms." HEART RHYTHM 8, no. 12, 1931 - 1932.

2010

  • Gudmundsson,Hjalti; Hund,Thomas,J; Wright,Patrick,J; Kline,Crystal,F; Snyder,Jedidiah,S; Qian,Lan; Koval,Olha,M; Cunha,Shane,R; George,Manju; Rainey,Mark,A; Kashef,Farshid,E; Dun,Wen; Boyden,Penelope,A; Anderson,Mark,E; Band,Hamid; Mohler,Peter,J, 2010, "EH Domain Proteins Regulate Cardiac Membrane Protein Targeting." CIRCULATION RESEARCH 107, no. 1, 84 - U175.
  • Hund,Thomas,J; Mohler,Peter,J, 2010, "Cardiac spectrins: Alternative splicing encodes functional diversity." JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 48, no. 6, 1031 - 1032.
  • Li,Jingdong; Kline,Crystal,F; Hund,Thomas,J; Anderson,Mark,E; Mohler,Peter,J, 2010, "Ankyrin-B Regulates Kir6.2 Membrane Expression and Function in Heart." JOURNAL OF BIOLOGICAL CHEMISTRY 285, no. 37, 28723 - 28730.
  • Koval,Olha,M; Guan,Xiaoquan; Wu,Yuejin; Joiner,Mei-Ling; Gao,Zhan; Chen,Biyi; Grumbach,Isabella,M; Luczak,Elizabeth,D; Colbran,Roger,J; Song,Long-Sheng; Hund,Thomas,J; Mohler,Peter,J; Anderson,Mark,E, 2010, "Ca-V 1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107, no. 11, 4996 - 5000.
  • Hund,Thomas,J; Koval,Olha,M; Li,Jingdong; Wright,Patrick,J; Dian,Lan; Snyder,Jedidiah,S; Gudmundsson,Hjalti; Kline,Crystal,F; Davidson,Nathan,P; Cardona,Natalia; Rasband,Matthew,N; Anderson,Mark,E; Mohler,Peter,J, 2010, "A beta(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice." JOURNAL OF CLINICAL INVESTIGATION 120, no. 10, 3508 - 3519.
  • Kline,Crystal,F; Hund,Thomas,J; Mohler,Peter,J, 2010, "Ankyrin regulates K-ATP channel membrane trafficking and gating in excitable cells." CHANNELS 4, no. 1, 55 - 57.
  • Wolf,Roseanne,M; Mitchell,Colleen,C; Christensen,Matthew,D; Mohler,Peter,J; Hund,Thomas,J, 2010, "Defining new insight into atypical arrhythmia: a computational model of ankyrin-B syndrome." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 299, no. 5, H1505 - H1514.

2009

  • Wu,Yuejin; Gao,Zhan; Chen,Biyi; Koval,Olha,M; Singh,Madhu,V; Guan,Xiaoqun; Hund,Thomas,J; Kutschke,William; Sarma,Satyam; Grumbach,Isabella,M; Wehrens,Xander,HT; Mohler,Peter,J; Song,Long-Sheng; Anderson,Mark,E, 2009, "Calmodulin kinase II is required for fight or flight sinoatrial node physiology." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106, no. 14, 5972 - 5977.
  • Christensen,Matthew,D; Dun,Wen; Boyden,Penelope,A; Anderson,Mark,E; Mohler,Peter,J; Hund,Thomas,J, 2009, "Oxidized Calmodulin Kinase II Regulates Conduction Following Myocardial Infarction: A Computational Analysis." PLOS COMPUTATIONAL BIOLOGY 5, no. 12, e1000583 -
  • Decker,Keith,F; Heijman,Jordi; Silva,Jonathan,R; Hund,Thomas,J; Rudy,Yoram, 2009, "Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 296, no. 4, H1017 - H1026.
  • Hund,Thomas,J; Wright,Patrick,J; Dun,Wen; Snyder,Jedidiah,S; Boyden,Penelope,A; Mohler,Peter,J, 2009, "Regulation of the ankyrin-B-based targeting pathway following myocardial infarction." CARDIOVASCULAR RESEARCH 81, no. 4, 742 - 749.
  • Kline,Crystal,F; Kurata,Harley,T; Hund,Thomas,J; Cunha,Shane,R; Koval,Olha,M; Wright,Patrick,J; Christensen,Matthew; Anderson,Mark,E; Nichols,Colin,G; Mohler,Peter,J, 2009, "Dual role of K-ATP channel C-terminal motif in membrane targeting and metabolic regulation." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106, no. 39, 16669 - 16674.
  • Hashemi,Seyed,M; Hund,Thomas,J; Mohler,Peter,J, 2009, "Cardiac ankyrins in health and disease." JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 47, no. 2, 203 - 209.

2008

  • Le Scouarnec,Solena; Bhasin,Naina; Vieyres,Claude; Hund,Thomas,J; Cunha,Shane,R; Koval,Olha; Marionneau,Celine; Chen,Biyi; Wu,Yuejin; Demolombe,Sophie; Song,Long-Sheng; Le Marec,Herve; Probst,Vincent; Schott,Jean-Jacques; Anderson,Mark,E; Mohler,Peter,J, 2008, "Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105, no. 40, 15617 - 15622.
  • Lowe,John,S; Palygin,Oleg; Bhasin,Naina; Hund,Thomas,J; Boyden,Penelope,A; Shibata,Erwin; Anderson,Mark,E; Mohler,Peter,J, 2008, "Voltage-gated Na-v channel targeting in the heart requires an ankyrin-G-dependent cellular pathway." JOURNAL OF CELL BIOLOGY 180, no. 1, 173 - 186.
  • Thiel,William,H; Chen,Biyi; Hund,Thomas,J; Koval,Olha,M; Purohit,Anil; Song,Long-Sheng; Mohler,Peter,J; Anderson,Mark,E, 2008, "Proarrhythmic Defects in Timothy Syndrome Require Calmodulin Kinase II." CIRCULATION 118, no. 22, 2225 - U38.
  • Kline,Crystal,F; Cunha,Shane,R; Lowe,John,S; Hund,Thomas,J; Mohler,Peter,J, 2008, "Revisiting ankyrin-InsP(3) receptor interactions: Ankyrin-B associates with the cytoplasmic N-terminus of the InsP(3) receptor." JOURNAL OF CELLULAR BIOCHEMISTRY 104, no. 4, 1244 - 1253.
  • Hund,Thomas,J; Decker,Keith,F; Kanter,Evelyn; Mohler,Peter,J; Boyden,Penelope,A; Schuessler,Richard,B; Yamada,Kathryn,A; Rudy,Yoram, 2008, "Role of activated CaMKII in abnormal calcium homeostasis and I-Na remodeling after myocardial infarction: Insights from mathematical modeling." JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 45, no. 3, 420 - 428.
  • Hund,Thomas,J; Mohler,Peter,J; Ziman,Andrew,P; Lederer,W,J, 2008, "The cardiac IP3 receptor: Uncovering the role of "the other" calcium-release channel." JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 45, no. 2, 159 - 161.

2007

  • Hund,Thomas,J; Lerner,Deborah,L; Yamada,Kathryn,A; Schuessler,Richard,B; Saffitz,Jeffrey,E, 2007, "Protein kinase C epsilon mediates salutary effects on electrical coupling induced by ischemic preconditioning." HEART RHYTHM 4, no. 9, 1183 - 1193.

2006

  • Hund,T,J; Rudy,Y, 2006, "A role for calcium/calmodulin-dependent protein kinase II in cardiac disease and arrhythmia.." HANDBOOK OF EXPERIMENTAL PHARMACOLOGY 171, 201 - 220.

2005

  • Hund,T,J; Saffitz,J,E, 2005, "Is CaMKII a therapeutic target for ventricular rate control?." HEART RHYTHM 2, no. 6, 641 - 642.

2004

  • Hund,T,J; Rudy,Y, 2004, "Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model." CIRCULATION 110, no. 20, 3168 - 3174.

2001

  • Hund,T,J; Kucera,J,P; Otani,N,F; Rudy,Y, 2001, "Ionic charge conservation and long-term steady state in the Luo-Rudy dynamic cell model." BIOPHYSICAL JOURNAL 81, no. 6, 3324 - 3331.

2000

  • Hund,T,J; Rudy,Y, 2000, "Determinants of excitability in cardiac myocytes: Mechanistic investigation of memory effect." BIOPHYSICAL JOURNAL 79, no. 6, 3095 - 3104.
  • Hund,T,J; Otani,N,F; Rudy,Y, 2000, "Dynamics of action potential head-tail interaction during reentry in cardiac tissue: ionic mechanisms." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 279, no. 4, H1869 - H1879.

Presentations

  • "Cycle length restitution and spontaneous action potential dynamics in sinoatrial node disease." 2014, Presented at Biomedical Engineering Society 2014 Annual Meeting, San Antonio, US|USA