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Thomas Hund

  • Associate Professor, Biomedical Engineering
  • 287 Bevis Hall
    1080 Carmack Road
    Columbus, OH 43210
  • 614-292-0755

Honors

  • 2017

    Lumley Research Award. .

  • 2016

    Distinguished Undergraduate Research Mentor, Nominee. .

  • 2015

    Melissa G. Piper Distinguished Mentor Award. .

  • 2014

    Herman R. Weed Excellence in Teaching Award. .

  • 2013

    Complex Systems Scholar. .

  • 2011

    Research Scholar in Cardiovascular Disease. .

  • 2009

    NIH Pathway to Independence Award (K99/R00). .

  • 2008

    Early-Career Authors Prize. .

  • 2006

    NIH Ruth L. Kirchstein National Research Service Award (F32). .

Chapters

2014

  • Hund TJ, Smith SA, Makara MA, and Mohler PJ. 2014. "Cellular and Molecular Pathobiology of the Cardiac Conduction System." In Cellular and Molecular Pathobiology of Cardiovascular Disease, edited by Willis MS, Homeister JW, and Stone JR,
  • Hund TJ and Mohler PJ. 2014. "Biophysics of Normal and Abnormal Cardiac Sodium Channel Function." In Cardiac Electrophysiology: From Cell to Bedside. 6th Edition, edited by Zipes DP and Jalife J,

2012

  • Hund TJ, Cunha SR, and Mohler PJ. 2012. "Principles of Cellular Architecture and Physiology with Applications in Electrophysiology." In Electrophysiological Disorders of the Heart. 2nd Edition, edited by Saksena and Camm,

2011

  • Hund TJ. 2011. "Calmodulin kinase II regulation of heart rhythm and disase." In Heart Rate and Rhythm: Molecular Basis, Pharmacological Modulation, and Clinical Implications, edited by Tripathi ON, Ravens U, and Sanguinetti MC,

Journal Articles

2017

  • 2017, "Integrative approaches for prediction of cardiotoxic drug effects and mitigation strategies." JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 102,

2016

  • 2016, "Dysfunction of the beta(2)- spectrin-based pathway in human heart failure." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 310, no. 11,
  • Birce, Onal; Gratz, Daniel; Hund, Thomas, 2016, "LongQt: A cardiac electrophysiology simulation platform." MethodsX 3, 589-599 - 589-599.
  • 2016, "Common human ANK2 variant confers in vivo arrhythmia phenotypes." HEART RHYTHM 13, no. 9,
  • 2016, "Neuronal Na(+) Channels Are Integral Components of Pro-arrhythmic Na(+)/Ca(2+) Signaling Nanodomain That Promotes Cardiac Arrhythmias During β-adrenergic Stimulation.." JACC. Basic to translational science 1, no. 4,
  • Onal,Birce; Hund,Thomas,J, 2016, "Physiological variability and atrial fibrillation therapy: Insights from population-based mathematical modeling.." Heart rhythm 13, 2366-2367 - 2366-2367.
  • 2016, "Atrial-specific pathways for control of intracellular signaling and mocyte function." JOURNAL OF CLINICAL INVESTIGATION 126, no. 10,
  • 2016, "Physiological variability and atrial fibrillation therapy: Insights from population-based mathematical modeling." HEART RHYTHM 13, no. 12,
  • 2016, "Late sodium current dysregulation as a causal factor in arrhythmia.." Expert Rev Cardiovasc Ther 14, no. 5,
  • Smith, Sakima, A; Hughes, Langston; Kline, Crystal, F; Kempton, Amber; Dorn, Lisa; Curran, Jerry; Makara, Michael; Webb, Tyler; Wright, Patrick; Voigt, Niels; Binkley, Philip, F; Janssen, Paul,M,L;Kilic, Ahmet; Carnes, Cynthia, A; Dobrev, Dobromir; Rasband, Matthew; Hund, Thomas, J; Mohler, Peter, J, 2016, "Dysfunction of the betaII spectrin-based pathway in human heart failure." AMERICAN JOURNAL OF PHYSIOLOGY - HEART AND CIRCULATORY PHYSIOLOGY 310, H1583-91 - H1583-91.
  • 2016, "Two-Pore K+ Channel TREK-1 Regulates Sinoatrial Node Membrane Excitability." JOURNAL OF THE AMERICAN HEART ASSOCIATION 5, no. 4,

2015

  • Musa,Hassan; Kline,Crystal,F; Sturm,Amy,C; Murphy,Nathaniel; Adelman,Sara; Wang,Chaojian; Yan,Haidun; Johnson,Benjamin,L; Csepe,Thomas,A; Kilic,Ahmet; Higgins,Robert,SD; Janssen,Paul,ML; Fedorov,Vadim,V; Weiss,Raul; Salazar,Christina; Hund,Thomas,J; Pitt,Geoffrey,S; Mohler,Peter,J, 2015, "SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112, no. 40, 12528-12533 - 12528-12533.
  • 2015, "Protein phosphatase 2A regulatory subunit B56 alpha limits phosphatase activity in the heart." SCIENCE SIGNALING 8, no. 386,
  • 2015, "Na+ channel function, regulation, structure, trafficking and sequestration." JOURNAL OF PHYSIOLOGY-LONDON 593, no. 6,
  • 2015, "Dysfunction in the beta II Spectrin-Dependent Cytoskeleton Underlies Human Arrhythmia." CIRCULATION 131, no. 8,
  • 2015, "Role of CaMKII in cardiac arrhythmias." TRENDS IN CARDIOVASCULAR MEDICINE 25, no. 5,
  • 2015, "Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca2+ Channel Targeting and Function in the Atria." JOURNAL OF BIOLOGICAL CHEMISTRY 290, no. 19,
  • 2015, "Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT." CARDIOVASCULAR RESEARCH 108, no. 2,
  • 2015, "Use of Whole Exome Sequencing for the Identification of Ito Based Arrhythmia Mechanism and Therapy." CIRCULATION 132,
  • 2015, "Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release." CARDIOVASCULAR RESEARCH 106, no. 1,
  • 2015, "Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo." CIRCULATION 132, no. 7,
  • Smith,Sakima,A; Sturm,Amy,C; Curran,Jerry; Kline,Crystal,F; Little,Sean,C; Bonilla,Ingrid,M; Long,Victor,P; Makara,Michael; Polina,Iuliia; Hughes,Langston,D; Webb,Tyler,R; Wei,Zhiyi; Wright,Patrick; Voigt,Niels; Bhakta,Deepak; Spoonamore,Katherine,G; Zhang,Chuansheng; Weiss,Raul; Binkley,Philip,F; Janssen,Paul,M; Kilic,Ahmet; Higgins,Robert,S; Sun,Mingzhai; Ma,Jianjie; Dobrev,Dobromir; Zhang,Mingjie; Carnes,Cynthia,A; Vatta,Matteo; Rasband,Matthew,N; Hund,Thomas,J; Mohler,Peter,J, 2015, "Dysfunction in the beta II Spectrin-Dependent Cytoskeleton Underlies Human Arrhythmia." CIRCULATION 131, no. 8, 695-U72 - 695-U72.

2014

  • 2014, "Mathematical modeling of physiological systems: An essential tool for discovery." LIFE SCIENCES 111, no. 1-2,
  • 2014, "Ankyrin-B Regulates Ca(v)2.1 and Ca(v)2.2 Channel Expression and Targeting*." JOURNAL OF BIOLOGICAL CHEMISTRY 289, no. 8,
  • 2014, "Modeling CaMKII in cardiac physiology: from molecule to tissue." FRONTIERS IN PHARMACOLOGY 5,
  • 2014, "Role of sinoatrial node architecture in maintaining a balanced source-sink relationship and synchronous cardiac pacemaking." FRONTIERS IN PHYSIOLOGY 5,
  • 2014, "Assembly of the Cardiac Intercalated Disk during Pre- and Postnatal Development of the Human Heart." PLOS ONE 9, no. 4,
  • 2014, "Cycle Length Restitution in Sinoatrial Node Cells: A Theory for Understanding Spontaneous Action Potential Dynamics." PLOS ONE 9, no. 2,
  • 2014, "beta(IV)-Spectrin regulates TREK-1 membrane targeting in the heart." CARDIOVASCULAR RESEARCH 102, no. 1,
  • 2014, "Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides." CARDIOVASCULAR RESEARCH 101, no. 1,
  • 2014, "Ibandronate and Ventricular Arrhythmia Risk." JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 25, no. 3,
  • 2014, "Ankyrin-G Coordinates Intercalated Disc Signaling Platform to Regulate Cardiac Excitability In Vivo." CIRCULATION RESEARCH 115, no. 11,
  • 2014, "Na-v Channel Complex Heterogeneity New Targets for the Treatment of Arrhythmia?." CIRCULATION 130, no. 2,
  • 2014, "EHD3-Dependent Endosome Pathway Regulates Cardiac Membrane Excitability and Physiology." CIRCULATION RESEARCH 115, no. 1,
  • 2014, "Tubulin polymerization disrupts cardiac beta-adrenergic regulation of late I-Na." CARDIOVASCULAR RESEARCH 103, no. 1,

2013

  • 2013, "Diabetes increases mortality after myocardial infarction by oxidizing CaMKII." JOURNAL OF CLINICAL INVESTIGATION 123, no. 3,
  • 2013, "Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease." JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 61,
  • 2013, "Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy." HEART RHYTHM 10, no. 3,
  • 2013, "A novel core-shell microcapsule for encapsulation and 3D culture of embryonic stem cells." JOURNAL OF MATERIALS CHEMISTRY B 1, no. 7,
  • 2013, "Ankyrin-G Participates in I-Na Remodeling in Myocytes from the Border Zones of Infarcted Canine Heart." PLOS ONE 8, no. 10,
  • 2013, "beta(IV)-Spectrin and CaMKII facilitate Kir6.2 regulation in pancreatic beta cells." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110, no. 43,
  • 2013, "Atrial fibrillation and sinus node dysfunction in human ankyrin-B syndrome: a computational analysis." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 304, no. 9,
  • DeGrande,Sean,T; Little,Sean,C; Nixon,Derek,J; Wright,Patrick; Snyder,Jedidiah; Dun,Wen; Murphy,Nathaniel; Kilic,Ahmet; Higgins,Robert; Binkley,Philip,F; Boyden,Penelope,A; Carnes,Cynthia,A; Anderson,Mark,E; Hund,Thomas,J; Mohler,Peter,J, 2013, "Molecular Mechanisms Underlying Cardiac Protein Phosphatase 2A Regulation in Heart." JOURNAL OF BIOLOGICAL CHEMISTRY 288, no. 2, 1032-1046 - 1032-1046.
  • 2013, "Molecular Mechanisms Underlying Cardiac Protein Phosphatase 2A Regulation in Heart." JOURNAL OF BIOLOGICAL CHEMISTRY 288, no. 2,
  • 2013, "Genetic Inhibition of Na+-Ca2+ Exchanger Current Disables Fight or Flight Sinoatrial Node Activity Without Affecting Resting Heart Rate." CIRCULATION RESEARCH 112, no. 2,

2012

  • Cerrone,Marina; Noorman,Maartje; Lin,Xianming; Chkourko,Halina; Liang,Feng-Xia; van der Nagel,Roel; Hund,Thomas; Birchmeier,Walter; Mohler,Peter; van Veen,Toon,A; van Rijen,Harold,V; Delmar,Mario, 2012, "Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency." CARDIOVASCULAR RESEARCH 95, no. 4, 460-468 - 460-468.
  • Koval,Olha,M; Snyder,Jedidiah,S; Wolf,Roseanne,M; Pavlovicz,Ryan,E; Glynn,Patric; Curran,Jerry; Leymaster,Nicholas,D; Dun,Wen; Wright,Patrick,J; Cardona,Natalia; Qian,Lan; Mitchell,Colleen,C; Boyden,Penelope,A; Binkley,Philip,F; Li,Chenglong; Anderson,Mark,E; Mohler,Peter,J; Hund,Thomas,J, 2012, "Ca2+/Calmodulin-Dependent Protein Kinase II-Based Regulation of Voltage-Gated Na+ Channel in Cardiac Disease.." Circulation 126, no. 17, 2084-2094 - 2084-2094.
  • 2012, "CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome." HEART RHYTHM 9, no. 12,
  • 2012, "Calmodulin-Dependent Protein Kinase II: Linking Heart Failure and Arrhythmias." CIRCULATION RESEARCH 110, no. 12,
  • 2012, "Differential regulation of EHD3 in human and mammalian heart failure." JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 52, no. 5,
  • 2012, "Ankyrin-B Protein in Heart Failure IDENTIFICATION OF A NEW COMPONENT OF METAZOAN CARDIOPROTECTION." JOURNAL OF BIOLOGICAL CHEMISTRY 287, no. 36,
  • 2012, "Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice." HEART RHYTHM 9, no. 4,
  • 2012, "Defects in cytoskeletal signaling pathways, arrhythmia, and sudden cardiac death." FRONTIERS IN PHYSIOLOGY 3,

2011

  • 2011, "Defects in Ankyrin-Based Membrane Protein Targeting Pathways Underlie Atrial Fibrillation." CIRCULATION 124, no. 11,
  • 2011, "Membrane-select regulation of cardiac Na-v channel isoforms." HEART RHYTHM 8, no. 12,
  • 2011, "Catecholamine-Independent Heart Rate Increases Require Ca2+/Calmodulin-Dependent Protein Kinase II." CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY 4, no. 3,
  • 2011, "A computational investigation of cardiac caveolae as a source of persistent sodium current." FRONTIERS IN PHYSIOLOGY 2,
  • 2011, "Role of CaMKII in cardiovascular health, disease, and arrhythmia." HEART RHYTHM 8, no. 1,
  • 2011, "Differential roles for SUR subunits in K-ATP channel membrane targeting and regulation." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 300, no. 1,
  • 2011, "Oxidized CaMKII causes cardiac sinus node dysfunction in mice." JOURNAL OF CLINICAL INVESTIGATION 121, no. 8,

2010

  • 2010, "Defining new insight into atypical arrhythmia: a computational model of ankyrin-B syndrome." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 299, no. 5,
  • 2010, "Cardiac spectrins: Alternative splicing encodes functional diversity." JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 48, no. 6,
  • 2010, "Ca-V 1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107, no. 11,
  • 2010, "Ankyrin regulates K-ATP channel membrane trafficking and gating in excitable cells." CHANNELS 4, no. 1,
  • 2010, "Ankyrin-B Regulates Kir6.2 Membrane Expression and Function in Heart." JOURNAL OF BIOLOGICAL CHEMISTRY 285, no. 37,
  • 2010, "EH Domain Proteins Regulate Cardiac Membrane Protein Targeting." CIRCULATION RESEARCH 107, no. 1,
  • 2010, "A beta(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice." JOURNAL OF CLINICAL INVESTIGATION 120, no. 10,

2009

  • 2009, "Calmodulin kinase II is required for fight or flight sinoatrial node physiology." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106, no. 14,
  • 2009, "Regulation of the ankyrin-B-based targeting pathway following myocardial infarction." CARDIOVASCULAR RESEARCH 81, no. 4,
  • 2009, "Oxidized Calmodulin Kinase II Regulates Conduction Following Myocardial Infarction: A Computational Analysis." PLOS COMPUTATIONAL BIOLOGY 5, no. 12,
  • 2009, "Dual role of K-ATP channel C-terminal motif in membrane targeting and metabolic regulation." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106, no. 39,
  • 2009, "Cardiac ankyrins in health and disease." JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 47, no. 2,
  • 2009, "Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 296, no. 4,

2008

  • 2008, "Proarrhythmic Defects in Timothy Syndrome Require Calmodulin Kinase II." CIRCULATION 118, no. 22,
  • 2008, "The cardiac IP3 receptor: Uncovering the role of "the other" calcium-release channel." JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 45, no. 2,
  • 2008, "Revisiting ankyrin-InsP(3) receptor interactions: Ankyrin-B associates with the cytoplasmic N-terminus of the InsP(3) receptor." JOURNAL OF CELLULAR BIOCHEMISTRY 104, no. 4,
  • 2008, "Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105, no. 40,
  • 2008, "Role of activated CaMKII in abnormal calcium homeostasis and I-Na remodeling after myocardial infarction: Insights from mathematical modeling." JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 45, no. 3,
  • 2008, "Voltage-gated Na-v channel targeting in the heart requires an ankyrin-G-dependent cellular pathway." JOURNAL OF CELL BIOLOGY 180, no. 1,

2007

  • 2007, "Protein kinase C epsilon mediates salutary effects on electrical coupling induced by ischemic preconditioning." HEART RHYTHM 4, no. 9,

2006

  • 2006, "A role for calcium/calmodulin-dependent protein kinase II in cardiac disease and arrhythmia.." Handb Exp Pharmacol no. 171,

2005

  • 2005, "Is CaMKII a therapeutic target for ventricular rate control?." HEART RHYTHM 2, no. 6,

2004

  • 2004, "Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model." CIRCULATION 110, no. 20,

2001

  • 2001, "Ionic charge conservation and long-term steady state in the Luo-Rudy dynamic cell model." BIOPHYSICAL JOURNAL 81, no. 6,

2000

  • 2000, "Dynamics of action potential head-tail interaction during reentry in cardiac tissue: ionic mechanisms." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 279, no. 4,
  • 2000, "Determinants of excitability in cardiac myocytes: Mechanistic investigation of memory effect." BIOPHYSICAL JOURNAL 79, no. 6,

Presentations

  • "Defining novel mechanisms for regulation of cardiac excitability and function." 2016,
  • "Regulation of the late sodium current by CaMKII." 2016,
  • "Automaticity and cardiac pacemaking: A computational analysis." 2013,
  • "CaMKII-dependent regulation of cardiac excitability in health and disease." 2012,
  • "Integrating in vivo, in vitro, and in silico approaches to define excitable cell disease." 2011,
  • "The role of calcium in ischemia and heart failure." 2007,
  • "Excitable cell disease from in silico to in vivo." 2013,
  • "CaMKII-dependent regulation of cardiac excitability in health and disease." 2011,
  • "Ankyrin-B dysfunction and arrhythmias." 2012,
  • "CaMKII-dependent Na+ channel regulation: Modeling studies." 2014,
  • "Mathematical modeling of mitochondria." 2014,
  • "Modeling for non-modelers." 2014,
  • "Modeling intercellular coupling in post-MI arrhythmias." 2010,
  • "Cycle length restitution and spontaneous action potential dynamics in sinoatrial node disease." 2014,
  • "Defining novel mechanisms underlying atrial arrhythmias: Insights from computational studies." 2016,
  • "Defining novel mechanisms for regulation of cardiac excitability." 2016,
  • "Sodium channel scaffolds." 2015,
  • "Protein phosphatae post-translational regulation in heart disease." 2015,

Papers in Proceedings

2014

  • "EHD3 Mediates Integral Membrane Protein Trafficking and Maintain Electrical Excitability and Adrenergic Responsiveness in the Heart." in 58th Annual Meeting of the Biophysical-Society. (1 2014).

2013

  • "Atrial Fibrillation and Sinus Node Dysfunction in Human Ankyrin-B Syndrome: A Computational Analysis." in 57th Annual Meeting of the Biophysical-Society. (1 2013).

2012

  • Dybkova,N; Wagner,S; Backs,J; Mohler,P; Hund,T; Maier,L "CaMKII-dependent late INa and cardiac Na channel phosphorylation are disturbed by tubulin polymerization." JOURNAL: "EUROPEAN HEART JOURNAL." in Congress of the European-Society-of-Cardiology (ESC). (8 2012). 1046-1046 - 1046-1046.

2010

  • "Ankyrin-b-Based Protein Complex Regulates the Ischemic Response in Heart." (11 2010).

2003

  • "Calcium regulation and cellular electrophysiology." in 25th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society. (1 2003).

2002

  • "Ca2+/calmodulin-dependent protein kinase underlies rate dependence of Ca2+ transient in a dynamic model of the ventricular action potential." in American-Heart-Association Abstracts From Scientific Sessions. (11 2002).

2000

  • "Dynamics of action potential head-tail interaction during reentry in cardiac tissue theoretical study of ionic mechanisms.." (1 2000).

1999

  • "Restitution of excitability and action potential duration in cardiac myocytes: Mechanistic investigation of memory effect.." (1 1999).

Patents

  • Carnes, Cynthia; Hund, Thomas; Li, Pui-Kai "Tom; Li, Chenglong; Mohler, Peter. "PP2A Regulatory Subunit Modification in Disease."
  • Hund, Thomas and Mohler, Peter. "SCN5A mouse model."
  • Hund, Thomas and Mohler, Peter. "SCN5E mouse model."