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Mahmood Khan

  • Associate Professor, Emergency Medicine
  • 376 W 10th Ave
    760 Prior Hall
    Columbus, OH 43210
  • 614-688-7803

Honors

  • November, 2016

    Fellowship of American Heart Association (FAHA).

  • November, 2016

    Young Investigator Award for the Top Abstract.

  • November, 2016

    Best of Basic Science Poster Presenter.

  • January, 2014

    Young Investigator Award.

  • January, 2014

    Best Basic Science Presentation Award.

  • January, 2013

    Best Basic Science Presentation Award.

  • January, 2013

    First Place in Scientist Category.

  • October, 2011

    Innovative Research Award.

  • May, 2010

    Early Career Investigator Travel Award.

  • October, 2008

    Poster Winner.

  • June, 2008

    Excellence Award.

  • September, 2007

    James Warren Award.

  • April, 2007

    Poster Winner.

  • October, 2006

    Finalist, Stem Cell and Myocardial Regeneraton Session, Poster Presentation.

  • September, 2005

    Young Investigator Award.

Chapters

2013

  • 2013. "MicroRNAs in Mesenchymal Stem Cells." In Essentials of Mesenchymal Stem Cell Biology and Its Clinical Translation, edited by Zhao, R.C.,
  • 2013. "Considerations of Quality Control Issues for the Mesenchymal Stem Cells-Based Medicinal Products." In Essentials of Mesenchymal Stem Cell Biology and Its Clinical Translation, edited by Zhao, R.C.,

2012

  • 2012. "Measurement of reactive oxygen species." In Manual of Research Techniques in Cardiovscular Medicine,

2010

  • 2010. "Rizwan Ahmad, Mahmood Khan, Deepti S. Vikram, Anna Bratasz, and Periannan Kuppusamy." In Methods in redox signaling,

2008

  • 2008. "Recent Progress in Medicinal Plants." In Phytopharmacology and Therapeutics values IV,
  • 2008. "Drug-induced nephrotoxicity by Spirulina." In Spirulina in Human Nutrition and Health,

Journal Articles

2017

  • Dougherty, J.A.; Kilbane Myers, J.; Khan, M.; Angelos, M.G. et al., 2017, "Dual-Specificity Phosphatase 4 Overexpression in Cells Prevents Hypoxia/Reoxygenation-Induced Apoptosis via the Upregulation of eNOS.." Front Cardiovasc Med 4, 22-22 - 22-22.

2016

  • Dall, C.; Chen, C.A.; Angelos, M.G.; Khan, M., 2016, "Oxygen Cycling to Improve Survival of Stem Cells for Myocardial Repair." LIFE SCIENCES
  • Li, Z.; Fan, Z.; Xu, Y.; Lo, W. et al., 2016, "pH-Sensitive and Thermosensitive Hydrogels as Stem-Cell Carriers for Cardiac Therapy.." ACS Appl Mater Interfaces 8, no. 17, 10752-10760 - 10752-10760.

2013

2012

  • Hassan, F.; Meduru, S.; Mostafa, M.; Taguchi, K. et al., 2012, "Carvedilol enhances mesenchymal stem cell therapy for myocardial infarction via inhibition of caspase-3 expression." J PHARMACOL EXP THER 343, no. 1,
  • Elnaskish, M.; Hassona, M.; Alhaj, M.; Moldovan, L. et al., 2012, "Rac-Induced Left Ventricular Dilation and Systolic Dysfunction in Thyoxin-Treated ZmRaD Transgenic Mice: Role of Cardiomyocite Apoptosis and Myocardial Fibrosis." PLoS ONE

2011

  • Mundy-Bosse BL, Lesinski GB, Jaime-Ramirez AC, Benninger K, Khan M, Kuppusamy P, Guenterberg K, Kondadasula SV, Ray Chaudhury A, La Perle KM, Kreiner M, Young GS, Guttridge DC, Carson WE, 2011, "MDSC inhibition of the IFN response in tumor-bearing mice." Cancer Res
  • Elnakish MY, Awad MM, Khan M, Kuppusamy P, Goldschmidt-Clermont, P, Hassanain HH et al, 2011, "Overexpression of Corn Rac Gene Induces Cardiac Hypertrophy with age in Mammalian hearts via Profilin1-induced Signaling." Am J Physiol Heart Circ Physiol EPub, EPub - EPub.
  • Khan M, Meduru S, Pandian RP, Rivera BK, Kuppusamy P, 2011, "Effect of oxygenation on stem-cell therapy for myocardial infarction." Adv Exp Med Biol 701:175-81,
  • Mundy-Bosse, B.L.; Lesinki, G.B.; Jaime-Ramirez, A.C.; Benninger, K. et al., 2011, "Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice." Cancer Res 71, no. 15,
  • Nishijima Y, Sridhar A, Bonilla I, Velayutham M, Khan M Terentyeva R, Li C, Kuppusamy P, Elton TS, Terentyev D, Györke S, Zweier JL, Cardounel AJ, Carnes CA., 2011, "Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to atrial electrical remodeling during heart failure." Cardiovascular Research

2010

  • Khan, M.; Brauner, M.E.; Plewa, M.C.; Angelos, M. et al., 2010, "Effects of Pulmonary-Generated Reactive Oxygen Species On Left Ventricular Dysfunction Associated With Ischemia-Reperfusion." Cell Biochemistry and Biophysics
  • Mundy BL, Lesinski GB, Benninger K, Khan M, Kuppusamy P, Cason III, WE et al, 2010, "MDSC inhibition of IFN response in tumor-bearing mice." Cancer Research
  • Chacko, M.; Ahmed, S.; Selvendiran, K.; Kuppusamy, M.L. et al., 2010, "Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cells." Am J Physiol Cell Physiol 299, no. 6,

2009

  • Khan M, Meduru S, Rivera B, Pandian RP, Kuppusamy ML, Kuppusamy P, 2009, "Effect of oxygenation on stem-cell therapy for myocardial infarction." Adv Exp Med Biol
  • Fisher EM, Khan M, Kuppusamy P, 2009, "Challenges to intestinal pO2 monitoring using EPR." Adv Exp Med Biol
  • Khan M, Mohan IK, Kutala VK, Kuppusamy P, 2009, "Sulfaphenazole, a cytochrome P450 inhibiotor attenuates myocardial ischemia-reperfusion injury through involvement of NOS2, Akt and p38 MAPK in vivo." Antioxidants and Redox Signaling 11(4): 725- 738. doi:10.1089/ars.2008.2155,
  • Khan M, Mohan IK, Sheik W, Kuppusamy et al, 2009, "Cardioprotection by a Pro-nitroxyl Modification of Verapamil, HO-4038: A Bifunctional Strategy Targeting both ischemia and Reperfusion in a Rat Model of Acute Myocardial Infarction." Am J Physiol Heart Circ Physiol 296(1):H140-51,
  • Khan,Mahmood; Mohan,Iyyapu,K; Kutala,Vijay,K; Kotha,Sainath,R; Parinandi,Narasimham,L; Hamlin,Robert,L; Kuppusamy,Periannan, 2009, "Sulfaphenazole Protects Heart Against Ischemia-Reperfusion Injury and Cardiac Dysfunction by Overexpression of iNOS, Leading to Enhancement of Nitric Oxide Bioavailability and Tissue Oxygenation." ANTIOXIDANTS & REDOX SIGNALING 11, no. 4, 725-738 - 725-738.
  • Chacko M, Khan M, Kuppusamy et al, 2009, "Monitoring of tissue oxygenation and functional improvement in a rat model of acute myocardial infarction (AMI) treated with stem cells." Am J Physiol Heart Circ Physiol 296(5):H1263-73,
  • Ryan Roberts, Eubank T, Jennifer Curry, Khan M, Periannan Kuppusamy, Clay Marsh, 2009, "GM-CSF inhibits breast cancer and metastases in mice and induces hypoxia in the tumor proper via stimulation of the soluble VEGF receptor." Cancer Res 69(5):2133- 40,

2008

  • Khan M, Kutala VK, Wisel S, Chacko SM, Kuppusamy ML, Kwiatkowski P and Kuppusamy P, 2008, "Measurement of myocardial tissue pO2 after stem cell therapy using oxygen sensing probe by EPR spectroscopy." Adv Exp Med Biol 614:45-52,

2007

  • Kutala, V.K.; Khan, M.; Angelos, M.G.; Kuppusamy, P., 2007, "Role of Oxygen in Post-ischemic Myocardial Injury." Antioxi Red Signal 9, no. 8, 1193-1206 - 1193-1206.
  • Khan M, Kutala VK, Kuppusamy P et al, 2007, "Skeletal myoblasts transplanted in the ischemic myocardium enhances in situ tissue oxygenation." Am J Physiol Heart Circ Physiol 293(4):H2129-39,

2006

  • 30. Khan M, Kutala VK, Vikram D, Wisel S, Pawel Kwiatkowski, Simi M Chacko, Kuppusamy ML, Jay L Zweier and Kuppusamy P, 2006, "Non-invasive Tracking of Cells and Monitoring of In Situ pO2 during Engraftment of Skeletal Myoblasts in Infarct Mouse Heart." Circulation. Vol 114, No 18,
  • Kumar KV, Khan M, Rajarsi Mandal, Latha P. Ganesan, Susheela Tridandapani, Tamas Kalai, Kalman Hideg, and Periannan Kuppusamy, 2006, "Attenuation of Myocardial Ischemia-reperfusion Injury by Trimetazidine Derivatives Functionalized with Antioxidant Properties." Journal of Pharmacology and Experimental Therapeutics 317, no. 3, 921-928 - 921-928.

2004

  • Khan, M. Patil, P. A. Shobha, J. C., 2004, "Influence of Bryophyllum pinnatum (Lam.) leaf extract on wound healing in albino rats." Journal of natural remedies l 4: 41-46,

Presentations

  • "Hyperbaric oxygenation enhances the stem cell graft and improves the functional recovery in the infarct heart." 2008, Presented at 3rd Annual DHLRI retreat,
  • "Role of Oxygenation and Stem Cells for Myocardial Regeneration." 2011, Presented at Seminar for Students and Faculty,
  • "Sulfaphenazoland Cardioprotection: Modulation of Myocardial Oxygenation, iNOS and Akt in Rat Model Acute of Myocardial Infarction." 2008, Presented at US-JSPS Core-to-ore EPR Symposium,
  • "Stem-cell Therapy for Cardiac Repair: Challenges and Approaches." 2009, Presented at Fourth Annual Research Day, Davis Heart and Lung Research Institute,
  • "Reprogramming of Stem Cells by miRNAs." 2012, Presented at International Conference on Stem Cells and Regenerative Medicine,
  • "Antioxidant activity of Spirulina extract in-vitro." 2002, Presented at Thirty-Fifth Annual Conference of the Indian Pharmacological Society,
  • "Influence of Bryophyllum Pinnatum Lam on wound healing in albino rats." 2002, Presented at Thirty-Fourth Annual Conference of the Indian Pharmacological Society,
  • "Non-Invasive Measuerment of Myocardial Oxygenation in the Infarct Heart After Stem Cell Therpy." 2007, Presented at Society for Free Radical Research,
  • "Effect of spirulina on cyclosporine–induced nephrotoxicity in rats.." 2004, Presented at International Symposium on Recent Advances in Pharmacology,
  • "Hyperbaric oxygen enhances the Engraftment and survival of Mesenchymal stem cells in the infarct heart." 2008, Presented at 3rd Annual DHLRI retreat,
  • "Hyperbaric oxygenation enhances the stem cell graft and improves the functional recovery in the infarct heart." 2009, Presented at International Society on Oxygen Transport to Tissue Meeting,
  • "Trimetazidne (Vastarel) Protects Mesenchymal Stem Cell against Oxidative Stress and Enhances Cell Therapy in Infarct Rat Heart by Activation of Akt and Bcl-2 Expression." 2008, Presented at 3rd Annual DHLRI retreat,
  • "Sulfaphenazole, a cytochrome P450 inhibitor attenuates ischemia-reperfusion injury through involvement of iNOS, AKT and p38 MAPK in a rat model of myocardial infarction." 2007, Presented at American Heart Association,
  • "Non-invasive Tracking of Cells and Monitoring of In Situ pO2 during Engraftment of Skeletal Myoblasts in Infarct Mouse Heart.." Presented at American Heart Association,
  • "Mir-133 Transfection in MSCs Downregulates Critical Pro- Apoptotic Genes in the Infarct Heart and Improves Cardiac Function." 2011, Presented at American Heart Association Scientific Sessions,
  • "Stem Cell Therapy for Cardiac Repair." 2010, Presented at SFRR Meeting,
  • "Novel cell-based therapies for mending broken hearts." 2017, Presented at Wright State University,
  • "Stem cells for myocardial repair: Challenges and approaches." 2015, Presented at University of Cincinatti,
  • "Stem cells in myocardial regeneration." 2012, Presented at University of Minnesota,
  • "Stem Cell Therapy for Cardiac Repair." 2010, Presented at Society for Free Radical Research,
  • "Bioengineering of Nanofiber Cardiac Patch for Myocardial Repair." 2015, Presented at H3C Health Science and Innovation Conference,
  • "Regenerative Medicine." 2015, Presented at H3C Health Science and Innovation Conference,
  • "Stem Cell and Regenerative Medicine: Research to Business." 2012, Presented at Stem Cells in Cardiac Disease, International School of Business,
  • "Morning Session." 2008, Presented at US-JSPS EPR Core-to-Core Symposium,

Papers in Proceedings

2016

  • Khan, M.; Johnson, J.; Angelos, M.G. "Biodegradable Multilayered Aligned Nanofiber Cardiac Patch Composed of Human Inducible Pluripotent Stem Cell Derived Cardiomyocytes (hiPSC-CMs) Enhances Cardiac Function and Cell Survival In Vivo." (11 2016).
  • Khan, M.; Johnson, J.; Angelos, M.G. "Biodegradable Multilayered Aligned Nanofiber Cardiac Patch Composed of Human Inducible Pluripotent Stem Cell Derived Cardiomyocytes (hiPSC-CMs) Enhances Cardiac Function and Cell Survival In Vivo." in Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium. (11 2016).

2012

  • Elnakish, M.T.; Hassona, M.D.H.; Alhaj, M.A.; Moldovan, L. et al. "Physiologic Cardiac Hypertrophy and Cardiac Dilation: A Comparative Study Using ZmRacD Transgenic Mouse Model." in Experimental Biology Meeting. (4 2012).
  • Elnakish, M.T.; Hassona, M.D.H.; Alhaj, M.A.; Moldovan, L. et al. "Physiologic Cardiac Hypertrophy and Cardiac Dilation: A Comparative Study Using ZmRacD Transgenic Mouse Model." (4 2012).

2011

  • Khan, M.; Meduru, S.; Pandian, R.P.; Rivera, B.K. et al. "Effect of oxygenation on stem-cell therapy for myocardial infarction.." (1 2011).
  • Khan,Mahmood; Meduru,Sarath; Pandian,Ramasamy,P; Rivera,Brian,K; Kuppusamy,Periannan "Effect of Oxygenation on Stem-Cell Therapy for Myocardial Infarction." in 37th Annual Meeting of the International-Society-on-Oxygen-Transport-to-Tissue. (1 2011).
  • Khan, M.; Meduru, S.; Pandian, R.P.; Rivera, B.K. et al. "Effect of oxygenation on stem-cell therapy for myocardial infarction.." (1 2011).
  • Khan, M.; Meduru, S.; Bryant, A.; Martin, M. et al. "Mir-133 Transfection in Mscs Downregulates Critical Pro-Apoptotic Genes in the Infarct Heart and Improves Cardiac Function." (11 2011).
  • Khan, M.; Meduru, S.; Bryant, A.; Martin, M. et al. "Mir-133 Transfection in Mscs Downregulates Critical Pro-Apoptotic Genes in the Infarct Heart and Improves Cardiac Function." (11 2011).
  • Elnakish, M.T.; Hassona, M.D.H.; Awad, M.M.; Abouelnaga, Z.A. et al. "Over-expression of a Corn Rac Gene Induces Cardiac Hypertrophy in Old Transgenic Mice: a Putative Role of Profilin1-Induced Signaling." (4 2011).
  • Elnakish, M.T.; Hassona, M.D.H.; Awad, M.M.; Abouelnaga, Z.A. et al. "Over-expression of a Corn Rac Gene Induces Cardiac Hypertrophy in Old Transgenic Mice: a Putative Role of Profilin1-Induced Signaling." in Experimental Biology Meeting 2011. (4 2011).

2010

  • Mundy, B.L.; Lesinski, G.; Benninger, K.; Khan, M. et al. "Myeloid-derived Suppressor Cells and Decreased Interferon Responsiveness in Tumor-Bearing Mice." (10 2010).
  • Mundy, B.L.; Lesinski, G.; Benninger, K.; Khan, M. et al. "Myeloid-derived Suppressor Cells and Decreased Interferon Responsiveness in Tumor-Bearing Mice." (10 2010).

2008

  • Khan, M.; Wisel, S.; Lyyapu, K.M.; Lakshmi, M. et al. "Hyperbaric Oxygen Therapy Enchances the Survival and Engraftment of Mesenchymal Stem Cells in the Infarct Heart." in 15th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine. (1 2008).
  • Khan, M.; Wisel, S.; Lyyapu, K.M.; Lakshmi, M. et al. "Hyperbaric Oxygen Therapy Enchances the Survival and Engraftment of Mesenchymal Stem Cells in the Infarct Heart." (1 2008).

2007

  • Angelos, M.G.; Khan, M.; Aune, S.E.; Clanton, T.L. et al. "Controlled myocardial tissue reoxygenation (PO2) with low flow reperfusion improves post ischemic LV function." (10 2007).
  • Moldovan, N.I.; Butt, O.; Alzawhra, W.; Khan, M. et al. "Composition of bone marrow-derived progenitor cells in the cellular infiltrate of infareted hearts: Role of local oxygen tension." in Experimental Biology 2007 Annual Meeting. (4 2007).
  • Moldovan, N.I.; Butt, O.; Alzawhra, W.; Khan, M. et al. "Composition of bone marrow-derived progenitor cells in the cellular infiltrate of infareted hearts: Role of local oxygen tension." (4 2007).
  • Angelos, M.G.; Khan, M.; Aune, S.E.; Clanton, T.L. et al. "Controlled myocardial tissue reoxygenation (PO2) with low flow reperfusion improves post ischemic LV function." in 80th Annual Scientific Session of the American-Heart-Association. (10 2007).

2006

  • Khan, M.; Kutala, V.K.; Vikram, D.; Wisel, S. et al. "Non-invasive monitoring of in situ oxygenation and engraftment of skeletal myoblasts transplanted in ischemic mouse heart." (1 2006).
  • Khan, M.; Kutala, V.K.; Vikram, D.; Wisel, S. et al. "Non-invasive monitoring of in situ oxygenation and engraftment of skeletal myoblasts transplanted in ischemic mouse heart." in 13th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine. (1 2006).