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Jennifer Leight

  • Assistant Professor, Biomedical Engineering
  • 291 Bevis Hall
    1080 Carmack Road
    Columbus, OH 43210
  • 614-685-9147

About

Education

  • B.S., Tulane University, 2004
  • Ph.D., University of Pennsylvania, 2011

 

Key Honors and Distinctions

  • US Frontiers of Engineering Symposium Participant, National Academy of Engineering (2016)
  • Chair, Graduate Research Seminar – Signal Transduction by Engineered ECM Gordon Conference (2010)
  • National Science Foundation Graduate Research Fellowship (2005)

 

RESEARCH AREAS – Leight Lab for Engineering the Cancer Microenvironment [leightlab.engineering.osu.edu]

  • Polymers; Biomaterials; Molecular, cell and tissue engineering; Cancer

  • PUBLICATIONS

leightlab.engineering.osu.edu/publications

The Leight Lab focuses on the development and utilization of new tools to understand how the microenvironment is remodeled during tumorigenesis and how this remodeling impacts cancer cell function and response to treatment. Specifically, we use fluorogenic peptide biosensors in tunable 3D hydrogel platforms to investigate microenvironmental regulation of protease activity, cell viability, and migration. Applications for our technology are far reaching, not only for screening cancer therapeutics, but also in other contexts in which protease activity plays an important role, such as heart disease, arthritis, and tissue regeneration.

Honors

  • 20050101-20080101

    Graduate Research Fellowship.

  • 20000101-20040101

    Distinguished Scholar Award.

Chapters

2007

  • 2007. "Demystifying the Effects of a Three‐Dimensional Microenvironment in Tissue Morphogenesis." In Methods in Cell Biology - Cell Mechanics,
  • Johnson, K.R.; Leight, J.L.; Weaver, V.M.. 2007. "Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis.."

Journal Articles

2018

  • Shukla, V.; Barnhouse, V.; Ackerman, W.E.; Summerfield, T.L. et al., 2018, "Cellular Mechanics of Primary Human Cervical Fibroblasts: Influence of Progesterone and a Pro-inflammatory Cytokine.." Ann Biomed Eng 46, no. 1, 197-207 - 197-207.
  • Shin, D.S.; Tokuda, E.Y.; Leight, J.L.; Miksch, C.E. et al., 2018, "Synthesis of Microgel Sensors for Spatial and Temporal Monitoring of Protease Activity." ACS Biomaterials Science and Engineering 4, no. 2, 378-387 - 378-387.

2017

  • Leight, J.L.; Drain, A.P.; Weaver, V.M., 2017, "Extracellular Matrix Remodeling and Stiffening Modulate Tumor Phenotype and Treatment Response." Annual Review of Cancer Biology 1, no. 1, 313-334 - 313-334.
  • Leight, J.L.; Drain, A.P.; Weaver, V.M., 2017, "Extracellular Matrix Remodeling and Stiffening Modulate Tumor Phenotype and Treatment Response." Annual Review of Cancer Biology 1, no. 1, 313-334 - 313-334.

2015

  • Leight, J.L.; Tokuda, E.Y.; Jones, C.E.; Lin, A.J. et al., 2015, "Multifunctional bioscaffolds for 3D culture of melanoma cells reveal increased MMP activity and migration with BRAF kinase inhibition.." Proc Natl Acad Sci U S A 112, no. 17, 5366-5371 - 5366-5371.
  • 2015, "Development of a cellularly degradable PEG hydrogel to promote articular cartilage extracellular matrix deposition.." Advanced Healthcare Materials 4, no. 5,
  • Sridhar, B.V.; Brock, J.L.; Silver, J.S.; Leight, J.L. et al., 2015, "Development of a cellularly degradable PEG hydrogel to promote articular cartilage extracellular matrix deposition." Advanced Healthcare Materials 4, no. 5, 702-713 - 702-713.

2014

  • 2014, "Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness." Biomaterials 35, no. 14,
  • Tokuda, E.Y.; Leight, J.L.; Anseth, K.S., 2014, "Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness.." Biomaterials 35, no. 14, 4310-4318 - 4310-4318.

2013

  • 2013, "Direct measurement of matrix metalloproteinase activity in 3D cellular microenvironments using a fluorogenic peptide substrate." BIOMATERIALS 34, no. 30,
  • Leight, J.L.; Alge, D.L.; Maier, A.J.; Anseth, K.S., 2013, "Direct measurement of matrix metalloproteinase activity in 3D cellular microenvironments using a fluorogenic peptide substrate.." Biomaterials 34, no. 30, 7344-7352 - 7344-7352.

2012

  • Leight, J.L.; Liu, W.F.; Chaturvedi, R.R.; Chen, S. et al., 2012, "Manipulation of 3D cluster size and geometry by release from 2D micropatterns." Cellular and Molecular Bioengineering 5, no. 3, 299-306 - 299-306.
  • 2012, "Manipulation of 3D Cluster Size and Geometry by Release from 2D Micropatterns." CELLULAR AND MOLECULAR BIOENGINEERING 5, no. 3,
  • Leight, J.L.; Wozniak, M.A.; Chen, S.; Lynch, M.L. et al., 2012, "Matrix rigidity regulates a switch between TGF-β1-induced apoptosis and epithelial-mesenchymal transition.." Mol Biol Cell 23, no. 5, 781-791 - 781-791.

2009

  • 2009, "Filamin A-beta 1 Integrin Complex Tunes Epithelial Cell Response to Matrix Tension." MOLECULAR BIOLOGY OF THE CELL 20, no. 14,
  • Gehler, S.; Baldassarre, M.; Lad, Y.; Leight, J.L. et al., 2009, "Filamin A-β1 integrin complex tunes epithelial cell response to matrix tension." Molecular Biology of the Cell 20, no. 14, 3224-3238 - 3224-3238.

2007

  • Janmey, P.A.; McCormick, M.E.; Rammensee, S.; Leight, J.L. et al., 2007, "Negative normal stress in semiflexible biopolymer gels.." Nat Mater 6, no. 1, 48-51 - 48-51.
  • 2007, "Negative normal stress in semiflexible biopolymer gels." Nature Materials 6, no. 1,

Presentations

  • "Characterizing MMP expression using modular fluorescent peptide biosensors.." 2012, Presented at Polymer Networks Group Annual Conference,
  • "Tissue engineering implications of inflammatory cytokine induced MMP upregulation by hMSCs.." 2012, Presented at Biomedical Engineering Society Annual Meeting,
  • "Mechanical properties of the microenvironment regulate TGF-β1-induced cell fate through Akt.." 2009, Presented at American Society for Cell Biology Annual Meeting,,
  • "Mechanical properties of the microenvironment regulate TGF-β1-induced cell fate through Akt.." 2010, Presented at Signal Transduction by Engineered ECM Gordon Conference,,
  • "Anseth KS. Matrix elasticity regulates melanoma cell survival.." 2014, Presented at Society for Biomaterials,,
  • "Measuring protease activity in 3D microenvironments." 2014, Presented at American Society for Matrix Biology,
  • "Microenvironmental cues regulate epithelial-mesenchymal transition." 2007, Presented at Biomedical Engineering Society Annual Meeting,,
  • "Mechanical properties of the microenvironment modulate the oncogenic potential of TGF-β.." 2008, Presented at Signal Transduction by Engineered Extracellular Matrices,,
  • "Mechanical properties of the microenvironment modulate the oncogenic potential of TGF-β.." 2008, Presented at Adhesion Receptors Gordon Conference,,
  • "Elucidating the role of microenvironmental cues on melanoma drug resistance." 2013, Presented at Society for Biomaterials,,
  • "Direct measurement of MMP activity in 3D cellular microenvironments using fluorigenic peptide substrates.." 2013, Presented at Engineering Society Annual,
  • "Hydrogel culture platforms to investigate the regulation of cancer cell function.." 2014, Presented at Ohio State University,,
  • "Functionalization of hydrogels with a MMP-sensitive fluorogenic substrate to measure cellular response to drug treatment.." 2014, Presented at Society for Biomaterials,
  • "Matrix stiffness differentially regulates Jun Kinase to modulate apoptosis responsiveness of a mammary epithelium." 2005, Presented at American Society for Cell Biology Annual Meeting,
  • "Force-dependent apoptosis resistance and breast tumorigenesis." 2005, Presented at American Society for Cell Biology Annual Meeting,
  • "Spatial-mechanical regulation of apoptosis resistance in breast cancer." 2005, Presented at Biomedical Engineering Society Annual Meeting,
  • "Engineered 3D models to study force-dependent mammary morphogenesis and malignancy.." 2005, Presented at American Society for Cell Biology Annual Meeting,
  • "Multiplex biomaterials for high throughput cancer drug screening.." 2015, Presented at Big Ten Speaker Exchange,
  • "3D hydrogel culture platforms to direct and measure cancer cell function.." 2014, Presented at Signaling and Cellular Regulation Symposium,
  • "Matrix compliance regulates a switch between TGF-β1-induced apoptosis and epithelial-mesenchymal transition.." 2010, Presented at American Society for Cell Biology Annual Meeting,