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Joy Lincoln

  • Associate Professor, Pediatrics
  • 700 Childrens Dr
    Columbus, OH 43205
  • 614-722-5152

Honors

  • 2015

    Invited Moderator; "Endocardium and cardiac valves". .

  • 2014

    Co-host, Weinstein Cardiovascular Development Meeting 2017. .

  • 2014

    Invited Moderator; "Emerging role of cardiac fibroblasts". .

  • 2014

    Outstanding Principal Investgator Award for Basic Science. .

  • 2013-2014

    Co-host, Midwest Heart Valve meeting. .

  • 2014

    Member, Weinstein Cardiovascular Development Meeting Committee Member. .

  • 2012

    Invited Moderator; "Valve Development". .

  • 2011

    Invited Moderator; "Valvuloseptal Development and Congenital Malformations". .

  • 2010

    Director, Postdoctoral Programs Office. .

  • 2007

    Florida Cardiovascular Researcher of the Year. .

  • 2006

    Travel Award for Scientific Excellence. .

  • 2006

    Winner, Presely Zeiss Postdoctoral Fellow Award. .

  • 2006

    Honorable Mention for Scientific Excellence. .

Chapters

Unknown

  • Danielle J. Huk and Joy Lincoln. "Oxidative Stress in Cardiovascular Disease: Basic Research and Clinical Practice. Oxidative Stress in Cardiac Valve Development." In Oxidative Stress in Cardiovascular Disease: Basic Research and Clinical Practice,

Journal Articles

2015

  • Tori E. Horne†, Matthew VandeKopple†, Kimberly Sauls, Sara N. Koenig, Lindsey J. Anstine, Vidu Garg, Russell A. Norris and Joy Lincoln., 2015, "Dynamic heterogeneity of the heart valve interstitial cell population in mitral valve health and disease.." Journal of Cardiac Development and Disease 2, 213 - 232.
  • Lincoln,Joy, 2015, "To 'cell' and back!." Journal of molecular and cellular cardiology 81, 94 - 95.
  • Hassan,Mohammed; Miao,Yongjie; Lincoln,Joy; Ricci,Marco, 2015, "Cost-benefit analysis of robotic versus nonrobotic minimally invasive mitral valve surgery.." Innovations (Philadelphia, Pa.) 10, no. 2, 90 - 95.

2014

  • Xu Zhang, Danielle J. Huk, Joy Lincoln and Yi Zhao, 2014, "A Microfluidic Shear Device that Accommodates Parallel High and Low Stress Zones Within the Same Culturing Chamber." Biomicrofluidics 8, no. 5, 054106 -
  • Miller, L. and Lincoln, J., 2014, "Isolation of Murine Heart Valve Endothelial Cells." JoVE 21, no. 90, XXX -
  • Barnette,Damien,N; VandeKopple,Matthew; Wu,Yonggan; Willoughby,David,A; Lincoln,Joy, 2014, "RNA-Seq Analysis to Identify Novel Roles of Scleraxis during Embryonic Mouse Heart Valve Remodeling." PLOS ONE 9, no. 7, e101425 -
  • Lahaye,Stephanie; Lincoln,Joy; Garg,Vidu, 2014, "Genetics of valvular heart disease.." Current cardiology reports 16, no. 6, 487 - ?.
  • Lincoln,Joy; Garg,Vidu, 2014, "Etiology of Valvular Heart Disease - Genetic and Developmental Origins." CIRCULATION JOURNAL 78, no. 8, 1801 - 1807.
  • Austin, B. F., Yoshimoto, Y., Shukinami, C., Lincoln, J., 2014, "Sox9- and Scleraxis-Cre lineage fate mapping in heart valve structures." Journal of Cardiac Development and Disease 1, no. 2, 163 - 176.

2013

  • Tao G, Miller LJ, Lincoln J., 2013, "Snai1 is important for avian epicardial cell transformation and motility.." Dev Dyn. 2013 unknown, no. dvdy.23967, [Epub ahead of print] -
  • Barnette DN, Hulin A, Ahmed AS, Colige AC, Azhar M, Lincoln J., 2013, "Tgfβ-Smad and MAPK signaling mediate scleraxis and proteoglycan expression in heart valves.." Journal of Molecular and Cellular Cardiology 65, 137 - 46.
  • Ge, Tao, Miller, Lindsey J., Lincoln, Joy, 2013, "Snai1 is important for avian epicardial cell transformation and motility." Developmental Dynamics unknown, unknown -
  • Huk DJ, Hammond HL, Kegechika H, Lincoln J., 2013, "Increased dietary intake of vitamin A promotes aortic valve calcification in vivo.." Arterioscler Thromb Vasc Biol. 33(2), no. ATVBAHA.. Epub 2012 Nov 29, 285 - 93.
  • Kevin Bosse PhD, Chetan P. Hans PhD, Ning Zhao MS, Sara N. Koenig BA, Nianyuan Huang BS, Anuradha Guggilam PhD, Stephanie LaHaye, Ge Tao PhD, Pamela A. Lucchesi PhD, Joy Lincoln PhD, Brenda Lilly PhD and Vidu Garg MD., 2013, "Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.." Journal of Molecular and Cellular Cardiology unknown, unknown -

2012

  • Tao,Ge; Kotick,James,D; Lincoln,Joy, 2012, "HEART VALVE DEVELOPMENT, MAINTENANCE, AND DISEASE: THE ROLE OF ENDOTHELIAL CELLS." HEART DEVELOPMENT 100, 203 - 232.
  • Ricci M, Panos AL, Lincoln J, Salerno TA, Warshauer L., 2012, "Is aviation a good model to study human errors in health care?." Am J Surg. 203(6):, 798 - 801.
  • Dillon,Lloye,M; Williams,Sion,L; Hida,Aline; Peacock,Jacqueline,D; Prolla,Tomas,A; Lincoln,Joy; Moraes,Carlos,T, 2012, "Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse." HUMAN MOLECULAR GENETICS 21, no. 10, 2288 - 2297.
  • Tao,Ge; Levay,Agata,K; Peacock,Jacqueline,D; Huk,Danielle,J; Both,Sarah,N; Purcell,Nicole,H; Pinto,Jose,R; Galantowicz,Maarten,L; Koch,Manuel; Lucchesi,Pamela,A; Birk,David,E; Lincoln,Joy, 2012, "Collagen XIV is important for growth and structural integrity of the myocardium." JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 53, no. 5, 626 - 638.
  • Ricci,Marco; Xu,Yanji; Hammond,Harriet,L; Willoughby,David,A; Nathanson,Lubov; Rodriguez,Maria,M; Vatta,Matteo; Lipshultz,Steven,E; Lincoln,Joy, 2012, "Myocardial Alternative RNA Splicing and Gene Expression Profiling in Early Stage Hypoplastic Left Heart Syndrome." PLOS ONE 7, no. 1, e29784 -

2011

  • Peacock,Jacqueline,D; Huk,Danielle,J; Ediriweera,Hasini,N; Lincoln,Joy, 2011, "Sox9 Transcriptionally Represses Spp1 to Prevent Matrix Mineralization in Maturing Heart Valves and Chondrocytes." PLOS ONE 6, no. 10, e26769 -
  • Ricci, M. and Lincoln, J., 2011, "Molecular markers of cardiomyopathy in cyanotic heart disease." Progress in Pediatric Cardiology 32(1), 19 - 23.
  • Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-O M, Kusek JW, Keane MG, Wolf M., 2011, "FGF23 induces left ventricular hypertrophy.." J Clin Invest. 121(11):, 4393 - 408.
  • Lincoln,Joy; Yutzey,Katherine,E, 2011, "Molecular and Developmental Mechanisms of Congenital Heart Valve Disease." BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY 91, no. 6, 526 - 534.
  • Tao,Ge; Levay,Agata,K; Gridley,Thomas; Lincoln,Joy, 2011, "Mmp15 is a direct target of Snail during endothelial to mesenchymal transformation and endocardial cushion development." DEVELOPMENTAL BIOLOGY 359, no. 2, 209 - 221.

2010

  • Ricci M, Mohapatra B, Urbiztondo A, Birusingh RJ, Morgado M, Rodriguez MM, Lincoln J, Vatta M., 2010, "Differential changes in TGF-β/BMP signaling pathway in the right ventricular myocardium of newborns with hypoplastic left heart syndrome.." J Card Fail. 16(8):, 628 - 34.
  • Peacock,Jacqueline,D; Levay,Agata,K; Gillaspie,Devin,B; Tao,Ge; Lincoln,Joy, 2010, "Reduced Sox9 Function Promotes Heart Valve Calcification Phenotypes In Vivo." CIRCULATION RESEARCH 106, no. 4, 712 - U166.

2008

  • Peacock,Jacqueline,D; Lu,Yinhui; Koch,Manuel; Kadler,Karl,E; Lincoln,Joy, 2008, "Temporal and Spatial Expression of Collagens During Murine Atrioventricular Heart Valve Development and Maintenance." DEVELOPMENTAL DYNAMICS 237, no. 10, 3051 - 3058.
  • Levay,Agata,K; Peacock,Jacqueline,D; Lu,Yinhui; Koch,Manuel; Hinton,Robert,B; Kadler,Karl,E; Lincoln,Joy, 2008, "Scleraxis Is Required for Cell Lineage Differentiation and Extracellular Matrix Remodeling During Murine Heart Valve Formation In Vivo." CIRCULATION RESEARCH 103, no. 9, 948 - U100.

2007

  • Lincoln,Joy; Kist,Ralf; Scherer,Gerd; Yutzey,Kathenine,E, 2007, "Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development." DEVELOPMENTAL BIOLOGY 305, no. 1, 120 - 132.

2006

  • Lincoln,Joy; Alfieri,Christina,M; Yutzey,Katherine,E, 2006, "BMP and FGF regulatory pathways control cell lineage diversification of heart valve precursor cells.." Developmental biology 292, no. 2, 292 - 302.
  • Lincoln,Joy; Florer,Jane,B; Deutsch,Gail,H; Wenstrup,Richard,J; Yutzey,Katherine,E, 2006, "ColVa1 and ColXIa1 are required for myocardial morphogenesis and heart valve development." DEVELOPMENTAL DYNAMICS 235, no. 12, 3295 - 3305.
  • Lincoln,Joy; Lange,Alexander,W; Yutzey,Katherine,E, 2006, "Hearts and bones: Shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development." DEVELOPMENTAL BIOLOGY 294, no. 2, 292 - 302.
  • Lincoln,J; Alfieri,C,M; Yutzey,K,E, 2006, "BMP and FGF regulatory pathways control cell lineage diversification of heart valve precursor cells." DEVELOPMENTAL BIOLOGY 292, no. 2, 290 - 302.
  • Hinton,Robert,B; Lincoln,Joy; Deutsch,Gail,H; Osinska,Hanna; Manning,Peter,B; Benson,D,Woodrow; Yutzey,Katherine,E, 2006, "Extracellular matrix remodeling and organization in developing and diseased aortic valves." CIRCULATION RESEARCH 98, no. 11, 1431 - 1438.

2004

  • Lincoln,J; Alfieri,C,M; Yutzey,K,E, 2004, "Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos." DEVELOPMENTAL DYNAMICS 230, no. 2, 239 - 250.

2001

  • Lako, M., Lindsay, S., Lincoln, J., Cairns, P.M., Armstrong, L., Hole, N., 2001, "Charaterisation of Wnt gene expression during the differentiation of murine embryonic stem cells in vitro: role of Wnt3 in enhancing haematopoietic differentiation.." Mechanisms of Development 103, 49 - 59.

2000

  • Armstrong, L., Lako, M., Lincoln, J., Cairns, P.M., Hole, N., 2000, "mTert expression correlates with telomerase activity during the differentiation of murine embryonic stem cells.." Mechanisms of Development 97, 109 - 116.

Unknown

  • Danielle J Huk, Blair F. Austin, Tori E. Horne, Robert B. Hinton, William C. Ray, Donald D. Heistad and Joy Lincoln, "Valve endothelial cell-derived Tgfβ1 signaling promotes nuclear localization of Sox9 in interstitial cells associated with attenuated calcification.." Atherosclerosis, Thrombosis and Vascular Biology
  • James I, Yi T, Tara S, Best CA, Stuber AJ, Shah KV, Austin BF, Sugiura T, Lee YU, Lincoln J, Trask AJ, Shinoka T and Breuer CK, "Hemodynamic Characterization of a Mouse Model for Investigating the Cellular and Molecular Mechanisms of Neotissue Formation in Tissue Engineered Heart Valves." Tissue Engineering Part C Methods
  • James IA, Yi T, Tara S, Best CA, Stuber AJ, Shah KV, Austin BF, Sugiura T, Lee YU, Lincoln J, Trask AJ, Shinoka T, Breuer CK, "Hemodynamic Characterization of a Mouse Model for Investigating the Cellular and Molecular Mechanisms of Neotissue Formation in Tissue-Engineered Heart Valves.." Tissue Eng Part C Methods

Presentations

  • "BMP and FGF regulate valve precursor cell diversification." 2004, Presented at Weinstein Cardiovascular Development Meeting, Tucson, US|USA
  • "The role of Scleraxis in heart valve development and disease." 2008, Presented at Heart Valve Biology and Tissue Engineering, London, GB|GBR
  • "The “Heart valve” matrix: Revolutions." 2008, Presented at Pediatric Grand Rounds, Miami, US|USA
  • "Mechanisms of heart valve development." 2009, Presented at Nova Southeastern University Seminar Series, Miami, US|USA
  • "Heart valves: Cartilage and Bone." 2011, Presented at Nephrology Grand Rounds, Miami, US|USA
  • "Signaling Pathways in Valve Homeostasis and Disease." 2015, Presented at Heart Valve Society, Monte Carlo, MC|MCO
  • "New Insights into Remodeling Mechanisms Involved in Mitral Valve Prolapse." 2015, Presented at Heart Valve Society, Monte Carlo, MC|MCO
  • "Molecular regulation of heart valve development." 2007, Presented at Florida International University Seminar Series, Miami, US|USA
  • "Snai1 is required for mmp15 expression during endocardial cushion formation." 2011, Presented at Spring Symposium of the Cardiovascular Developmental Biology Center, Charleston, US|USA
  • "Embryonic origins of adult aortic valve disease." 2014, Presented at Bench to Outcomes Seminar Series, Columbus, US|USA
  • "Molecular mechanisms of heart valve development and disease." 2006, Presented at Biological Sciences Seminar Series, Durham, GB|GBR
  • "Heart valve disease; Differential contributions of valve cell populations." 2014, Presented at Department of Internal Medicine Seminar Series, Iowa City, US|USA
  • "Endothelial Tgfβ-mediated nuclear exclusion of Sox9 in valve interstitial cells promotes calcification." 2014, Presented at International SOX meeting, Cleveland, US|USA
  • "Heart valve disease; Differential contributions of valve cell populations." 2015, Presented at Center for Life Cardiovascular Seminar Series, Newcastle, GB|GBR
  • "Sox9 is required for heart valve remodeling." 2006, Presented at American Association of Anatomists Meeting at Experimental Biology, San Francisco, US|USA
  • "Molecular mechanisms of heart valve development and disease." 2006, Presented at Department of Pharmacology seminar series, Miami, US|USA
  • "Molecular Mechanisms of Heart Valve Development." 2006, Presented at CDBC Symposium, Charleston, US|USA
  • "The role of Scleraxis in heart valve development and disease." 2007, Presented at Weinstein Cardiovascular Development Meeting, Houston, US|USA
  • "Stem cells: What do we know?." 2007, Presented at The Miami Science Museum Public Seminar Series, Miami, US|USA
  • "The role of Sox9 in heart valve connective tissue homeostasis." 2007, Presented at Gordon Conference; Collagen, US|USA
  • "Molecular Mechanisms of heart valve disease." 2009, Presented at The Stem Cell Institute Seminar Series, Miami, US|USA
  • "Heart valves: Cartilage and bone." 2010, Presented at Department of Cell Biology and Anatomy seminar series, Miami, GB|GBR
  • "Heart valves: Cartilage, tendon and bone." 2010, Presented at Department of Biological Sciences seminar series, Durham, GB|GBR
  • "Molecular mechanisms of heart valve development and disease." 2010, Presented at The Research Institute at Nationwide Children's Hospital Seminar Series, Columbus, US|USA
  • "The role of Sox9 and Scleraxis in heart valve remodeling and disease." 2010, Presented at New insights into cell & tissue interactions in cardiovascular development and disease workshop, Madrid, ES|ESP
  • "Heart valve development and disease: Cartilage, tendon and Bone." 2012, Presented at Clinical and Translational Seminar Series, Columbus, US|USA
  • "Molecular mechanisms of adult heart valve disease." 2013, Presented at Case Western Cardiovascualr Research Seminar Series, Cleveland, US|USA
  • "Endothelial Tgfβ-mediated nuclear exclusion of Sox9 in valve interstitial cells promotes calcification." 2014, Presented at International Society for Heart Research, Miami, US|USA
  • "The role of Scleraxis in heart valve development and disease." 2012, Presented at Experimental Biology, San Diego, US|USA
  • "Maintaining homeostasis of the heart valve cell populations." 2015, Presented at American Heart Association Scientific Sessions,
  • "Defining valve interstitial cell heterogeneity in health and disease." 2015, Presented at Mid West Valve Day,