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Jun Liu

  • Professor, Ophthalmology
  • Professor, Biomedical Engineering
  • 1080 Carmack Road
    Room 298
    Columbus, OH 43210
  • 614-247-8904

About

Education

  • B.S., Zhejiang University, 1994
  • M.S., Zhejiang University, 1997
  • Ph.D., The Ohio State University, 2002

 

Key Honors and Distinctions

  • Lumley Research Award, College of Engineering, OSU (2012)

 

RESEARCH AREAS – Liu Lab

  • Biomechanics; Bioimaging; Ocular pathophysiology; Glaucoma

 

  • PUBLICATIONS 

https://scholar.google.com/citations?user=gSa_QKwAAAAJ&hl=en

 

Professor Liu’s lab works closely with clinicians to pursue a better understanding of biomechanics in ocular pathophysiology, particularly those related to glaucoma and keratoconus. Her lab applies quantitative ultrasound techniques to non-invasively characterize ocular biomechanics. Her work has been funded by the National Institutes of Health, the American Health Assistant Foundation National Glaucoma Research, and the Columbus Foundation

 

Honors

  • 2012

    Lumley Research Award. .

  • 2002

    Business Plan Competition First Prize. .

  • 1997

    University Fellowship. .

Edited Books

2016

  • Cynthia Roberts, Jun Liu. 2016. "Corneal Biomechanics." Amsterdam: Kugler Publications.

Journal Articles

2016

  • Pavlatos,Elias; Perez,Benjamin,Cruz; Morris,Hugh,J; Chen,Hong; Palko,Joel,R; Pan,Xueliang; Weber,Paul,A; Hart,Richard,T; Liu,Jun, 2016, "Three-Dimensional Strains in Human Posterior Sclera Using Ultrasound Speckle Tracking." JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME 138, no. 2, 021015 -
  • KM Metzler, CJ Roberts, AM Mahmoud, G Agarwal, J Liu, 2016, "Ex-Vivo Transepithelial Collagen Crosslinking in Porcine and Human Corneas Using Human Decorin Core Protein." Journal of Refractive Surgery 32, 410 - 417.
  • JR Palko, HJ Morris, X Pan, CD Harman, KL Koehl, KN Gelatt, CE Plummer, AM Komáromy, J Liu, 2016, "Influence of age on ocular biomechanical properties in a canine glaucoma model with ADAMTS10 mutation." PLoS ONE 11, no. 6, e0156466 -
  • C Boote, JR Palko, T Sorensen, A Mohammadvali, A Elsheikh, AM. Komáromy, X Pan and J Liu, 2016, "Changes in posterior scleral collagen microstructure in canine eyes with an ADAMTS10 mutation." Molecular Vision 22, 503 - 517.

2015

  • B Cruz Perez, ER Pavlatos, HJ Morris, H Chen, X Pan, RT Hart, and J Liu, 2015, "Mapping 3D Strains with Ultrasound Speckle Tracking: Method Validation and Initial Results in Porcine Scleral Inflation." Annals of Biomedical Engineering 11, epub ahead of print -
  • JK Pijanka, MT Spang, T Sorensen, J Liu, TD Nguyen, HA Quigley, C Boote, 2015, "Depth-dependent changes in collagen organization in the human peripapillary sclera." PLOS ONE 10, no. 2, e0118648 -
  • Pijanka,Jacek,K; Spang,Martin,T; Sorensen,Thomas; Liu,Jun; Nguyen,Thao,D; Quigley,Harry,A; Boote,Craig, 2015, "Depth-Dependent Changes in Collagen Organization in the Human Peripapillary Sclera." PLOS ONE 10, no. 2, e0118648 -

2014

  • Perez,Benjamin,Cruz; Tang,Junhua; Morris,Hugh,J; Palko,Joel,R; Pan,Xueliang; Hart,Richard,T; Liu,Jun, 2014, "Biaxial mechanical testing of posterior sclera using high-resolution ultrasound speckle tracking for strain measurements." JOURNAL OF BIOMECHANICS 47, no. 5, 1151 - 1156.
  • K Metzler, A M. Mahmoud, J Liu, CJ Roberts, 2014, "Biomechanical response of paired donor corneas to an air puff: isolated cornea vs intact whole globe." Journal of Cataract and Refractive Surgery 40, no. 6, 888 - 896.
  • Palko,Joel,R; Tang,Junhua; Perez,Benjamin,Cruz; Pan,Xueliang; Liu,Jun, 2014, "Spatially heterogeneous corneal mechanical responses before and after riboflavin-ultraviolet-A crosslinking." JOURNAL OF CATARACT AND REFRACTIVE SURGERY 40, no. 6, 1021 - 1031.

2013

  • B Cruz Perez, HJ Morris, RT Hart, J Liu, 2013, "Finite element modeling of the viscoelastic responses of the eye during microvolumetric changes." Journal of Biomedical Science and Engineering 6, 29 - 37.
  • HJ Morris, J Tang, B Cruz-Perez, X Pan, RT Hart, PA Weber, J Liu, 2013, "Correlation between biomechanical responses of posterior sclera and IOP elevations during micro intraocular volume change." Investigative Ophthalmology and Visual Science 54, no. 12, 7215 - 7222.
  • Morris,Hugh,J; Tang,Junhua; Perez,Benjamin,Cruz; Pan,Xueliang; Hart,Richard,T; Weber,Paul,A; Liu,Jun, 2013, "Correlation Between Biomechanical Responses of Posterior Sclera and IOP Elevations During Micro Intraocular Volume Change." INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54, no. 12, 7215 - 7222.
  • 12. JR Palko, S Iwabe, X Pan, G Agarwal, AM Komáromy, and J Liu, 2013, "Biomechanical Properties and Correlation With Collagen Solubility Profile in the Posterior Sclera of Canine Eyes With an ADAMTS10 Mutation." Investigative Ophthalmology and Visual Science 54, no. 4, 2685 - 2695.
  • Palko,Joel,R; Iwabe,Simone; Pan,Xueliang; Agarwal,Gunjan; Komaromy,Andras,M; Liu,Jun, 2013, "Biomechanical Properties and Correlation With Collagen Solubility Profile in the Posterior Sclera of Canine Eyes With an ADAMTS10 Mutation." INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54, no. 4, 2685 - 2695.

2012

  • ER Ritchey, C Zekinka, J Tang, J Liu, KA Code, S Petersen-Jones, AJ Fischer, 2012, "Vision-guided ocular growth in a mutant chicken model with diminished visual acuity." Experimental Eye Research 102, 59 - 69.
  • J Tang and J Liu, 2012, "Ultrasonic measurement of scleral cross-sectional strains during elevations of intraocular pressure: method validation and initial results in posterior porcine sclera." Journal of Biomechanical Engineering 134, no. 9, 091007 - 1.
  • Junhua Tang, Xueliang Pan, Paul A Weber, and Jun Liu, 2012, "Effect of corneal stiffening on Goldmann Applanation Tonometry and Tonopen measurements in canine eyes." Investigative Ophthalmology and Visual Science
  • Tang,Junhua; Pan,Xueliang; Weber,Paul,A; Liu,Jun, 2012, "Effect of corneal stiffening on goldmann applanation tonometry and tono-pen measurements in canine eyes.." Investigative ophthalmology & visual science 53, no. 3, 1397 - 1405.
  • Ritchey,Eric,R; Zelinka,Christopher,P; Tang,Junhua; Liu,Jun; Fischer,Andy,J, 2012, "The combination of IGF1 and FGF2 and the induction of excessive ocular growth and extreme myopia." EXPERIMENTAL EYE RESEARCH 99, 1 - 16.

2011

  • X Jiang, X Liu, X Gong, F Zhang, R Wu, J Wu, and J Liu, 2011, "Model and experimental analysis of oblique incident ultrasound in a tissue layer using doublet mechanics theory." Journal of the Acoustical Society of America 130, no. 6, 4117 - 4125.
  • J Palko, X Pan, J Liu, 2011, "Dynamic testing of regional viscoelastic behavior of canine sclera." Experimental Eye Research 93, 825 - 832.
  • J Tang, X Pan, PA Weber, and J Liu, 2011, "Corneal modulus and IOP measurements in canine eyes using Goldmann applanation tonometry and Tonopen." Investigative Ophthalmology and Visual Science 11, no. 52, 7866 - 7871.
  • X He and J Liu, 2011, "Correlation of corneal acoustic and elastic properties in a canine eye model." Investigative Ophthalmology and Visual Science 2, no. 52, 731 - 736.
  • J Tang and J Liu, 2011, "Variance of speed of sound and correlation with acoustic impedance in canine corneas." Ultrasound in Medicine and Biology 10, no. 37, 1714 - 1721.

2010

  • He,Xiaoyin; Spoerl,Eberhard; Tang,Junhua; Liu,Jun, 2010, "Measurement of corneal changes after collagen crosslinking using a noninvasive ultrasound system." JOURNAL OF CATARACT AND REFRACTIVE SURGERY 36, no. 7, 1207 - 1212.
  • X He, E Spoerl, J Tang, and J Liu, 2010, "Measurement of corneal changes after collagen cross-linking by a non-invasive ultrasound system." Journal of Cataract and Refractive Surgery 7, no. 36, 1207 - 1212.

2009

  • J Liu and X He, 2009, "Corneal stiffness affects IOP elevation during rapid volume change in the eye." Investigative Ophthalmology and Visual Science 5, no. 50, 2224 - 2229.
  • X He and J Liu, 2009, "A quantitative ultrasonic spectroscopy method for non-invasive determination of corneal biomechanical properties." Investigative Ophthalmology and Visual Science 11, no. 50, 5148 - 5154.

2007

  • J Liu, X He, X Pan and C Roberts, 2007, "Ultrasonic Model and System for Measurement of Corneal Biomechanical Properties and Validation on Phantoms." Journal of Biomechanics 40, no. 5, 1177 - 1182.
  • J Liu, J Li, TJ Rosol, X Pan, and JL Voorhees, 2007, "Biodegradable Nanoparticles for Targeted Ultrasound Imaging of Breast Cancer Cells in Vitro." Physics in Medicine and Biology 52, 4739 - 4747.

2006

  • J Liu, AL Levine, JS Mattoon, M Yamaguchi, RJ Lee, X Pan, TJ Rosol, 2006, "Nanoparticles as Image Enhancing Agents for Ultrasonography." Physics in Medicine and Biology 51, 2179 - 2189.

2005

  • J Liu and CJ Roberts, 2005, "Quantitative Analysis of the Influence of Corneal Biomechanical Properties on IOP Measurement." Journal of Cataract and Refractive Surgery 31, no. 1, 146 - 155.

2004

  • J Wu, C Layman, and J Liu, 2004, "Wave Equations, Dispersion Relations and van Hove Singularities for Applications of Doublet Mechanics to Ultrasound Propagations in Bio-Singularities for Applications of Doublet Mechanics to Ultrasound Propagations in Bio- and Nano-Materials." Journal of Acoustical Society of America 115, no. 2, 893 - 900.

2003

  • J Liu and M Ferrari, 2003, "A Discrete Model for the High Frequency Elastic Wave Examination on Biological Tissue." Computer Modeling in Engineering and Sciences 4, no. 3&4, 421 - 430.

2002

  • J Liu and M Ferrari, 2002, "Mechanical Spectral Signatures of Malignant Disease? A Small-Sample, Comparative Study of Continuum vs. Nano-Biomechanical Data Analyses." Disease Markers 18, no. 4, 175 - 183.
  • Liu,J; Ferrari,M, 2002, "Mechanical spectral signatures of malignant disease? A small-sample, comparative study, of continuum vs. nano-biomechanical data analyses." DISEASE MARKERS 18, no. 4, 175 - 183.

Unknown

  • C Boote, JR Palko, T Sorensen, A Mohammadvali, A Elsheikh, AM. Komáromy, X Pan and J Liu, "Changes in posterior scleral collagen microstructure in canine eyes with an ADAMTS10 mutation." Molecular Vision
  • KM Metzler, CJ Roberts, AM Mahmoud, G Agarwal, J Liu, "Transepithelial Collagen Crosslinking in Porcine and Human Corneas Using Human Decorin Core Protein." Journal of Refractive Surgery
  • 1. JR Palko, HJ Morris, X Pan, CD Harman, KL Koehl, KN Gelatt, CE Plummer, AM Komáromy, J Liu, "Influence of age on ocular biomechanical properties in a canine glaucoma model with ADAMTS10 mutation." PLOS ONE