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Jun Liu

  • Professor, Ophthalmology
  • Professor, Biomedical Engineering
  • 1080 Carmack Road
    Room 298
    Columbus, OH 43210
  • 614-247-8904

About

Education

  • B.S., Zhejiang University, 1994
  • M.S., Zhejiang University, 1997
  • Ph.D., The Ohio State University, 2002

 

Key Honors and Distinctions

  • Lumley Research Award, College of Engineering, OSU (2012)

 

RESEARCH AREAS – Liu Lab

  • Biomechanics; Bioimaging; Ocular pathophysiology; Glaucoma

 

  • PUBLICATIONS 

https://scholar.google.com/citations?user=gSa_QKwAAAAJ&hl=en

 

Professor Liu’s lab works closely with clinicians to pursue a better understanding of biomechanics in ocular pathophysiology, particularly those related to glaucoma and keratoconus. Her lab applies quantitative ultrasound techniques to non-invasively characterize ocular biomechanics. Her work has been funded by the National Institutes of Health, the American Health Assistant Foundation National Glaucoma Research, and the Columbus Foundation

 

Honors

  • 20120401

    Lumley Research Award.

  • 20020501

    Business Plan Competition First Prize.

  • 19970901

    University Fellowship.

Edited Books

2016

  • Cynthia Roberts, Jun Liu. 2016. "Corneal Biomechanics." Kugler Publications.

Chapters

2016

  • 2016. "Definitions and concepts." In Corneal Biomechanics: From Theory to Practice, edited by Cynthia Roberts and Jun Liu,
  • 2016. "Ex vivo mechanical testing of the cornea." In Corneal Biomechanics: From Theory to Practice, edited by Cynthia Roberts and Jun Liu,
  • 2016. "Comparison of porcine and human cornea and sclera mechanical behavior." In Corneal Biomechanics: From Theory to Practice, edited by Cynthia Roberts and Jun Liu,
  • 2016. "Ocular pulse elastography." In Corneal Biomechanics: From Theory to Practice, edited by Cynthia Roberts and Jun Liu,

Journal Articles

2016

  • JR Palko, HJ Morris, X Pan, CD Harman, KL Koehl, KN Gelatt, CE Plummer, AM Komáromy, J Liu, 2016, "Influence of age on ocular biomechanical properties in a canine glaucoma model with ADAMTS10 mutation." PLoS ONE 11, no. 6, e0156466 - e0156466.
  • C Boote, JR Palko, T Sorensen, A Mohammadvali, A Elsheikh, AM. Komáromy, X Pan and J Liu, 2016, "Changes in posterior scleral collagen microstructure in canine eyes with an ADAMTS10 mutation." Molecular Vision 22, 503-517 - 503-517.
  • Cruz Perez, B.; Pavlatos, E.; Morris, H.J.; Chen, H. et al., 2016, "Mapping 3D Strains with Ultrasound Speckle Tracking: Method Validation and Initial Results in Porcine Scleral Inflation." Annals of Biomedical Engineering 44, no. 7, 2302-2312 - 2302-2312.
  • Pavlatos,Elias; Perez,Benjamin,Cruz; Morris,Hugh,J; Chen,Hong; Palko,Joel,R; Pan,Xueliang; Weber,Paul,A; Hart,Richard,T; Liu,Jun, 2016, "Three-Dimensional Strains in Human Posterior Sclera Using Ultrasound Speckle Tracking." JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME 138, no. 2, 021015 - 021015.

2015

  • Pijanka,Jacek,K; Spang,Martin,T; Sorensen,Thomas; Liu,Jun; Nguyen,Thao,D; Quigley,Harry,A; Boote,Craig, 2015, "Depth-Dependent Changes in Collagen Organization in the Human Peripapillary Sclera." PLOS ONE 10, no. 2, e0118648 - e0118648.
  • JK Pijanka, MT Spang, T Sorensen, J Liu, TD Nguyen, HA Quigley, C Boote, 2015, "Depth-dependent changes in collagen organization in the human peripapillary sclera." PLOS ONE 10, no. 2, e0118648 - e0118648.

2014

  • K Metzler, A M. Mahmoud, J Liu, CJ Roberts, 2014, "Biomechanical response of paired donor corneas to an air puff: isolated cornea vs intact whole globe." Journal of Cataract and Refractive Surgery 40, no. 6, 888-896 - 888-896.
  • Perez,Benjamin,Cruz; Tang,Junhua; Morris,Hugh,J; Palko,Joel,R; Pan,Xueliang; Hart,Richard,T; Liu,Jun, 2014, "Biaxial mechanical testing of posterior sclera using high-resolution ultrasound speckle tracking for strain measurements." JOURNAL OF BIOMECHANICS 47, no. 5, 1151-1156 - 1151-1156.
  • Palko,Joel,R; Tang,Junhua; Perez,Benjamin,Cruz; Pan,Xueliang; Liu,Jun, 2014, "Spatially heterogeneous corneal mechanical responses before and after riboflavin-ultraviolet-A crosslinking." JOURNAL OF CATARACT AND REFRACTIVE SURGERY 40, no. 6, 1021-1031 - 1021-1031.

2013

  • Morris,Hugh,J; Tang,Junhua; Perez,Benjamin,Cruz; Pan,Xueliang; Hart,Richard,T; Weber,Paul,A; Liu,Jun, 2013, "Correlation Between Biomechanical Responses of Posterior Sclera and IOP Elevations During Micro Intraocular Volume Change." INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54, no. 12, 7215-7222 - 7215-7222.
  • B Cruz Perez, HJ Morris, RT Hart, J Liu, 2013, "Finite element modeling of the viscoelastic responses of the eye during microvolumetric changes." Journal of Biomedical Science and Engineering 6, 29-37 - 29-37.
  • Palko,Joel,R; Iwabe,Simone; Pan,Xueliang; Agarwal,Gunjan; Komaromy,Andras,M; Liu,Jun, 2013, "Biomechanical Properties and Correlation With Collagen Solubility Profile in the Posterior Sclera of Canine Eyes With an ADAMTS10 Mutation." INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54, no. 4, 2685-2695 - 2685-2695.
  • HJ Morris, J Tang, B Cruz-Perez, X Pan, RT Hart, PA Weber, J Liu, 2013, "Correlation between biomechanical responses of posterior sclera and IOP elevations during micro intraocular volume change." Investigative Ophthalmology and Visual Science 54, no. 12, 7215-7222 - 7215-7222.

2012

  • ER Ritchey, C Zekinka, J Tang, J Liu, KA Code, S Petersen-Jones, AJ Fischer, 2012, "Vision-guided ocular growth in a mutant chicken model with diminished visual acuity." Experimental Eye Research 102, 59-69 - 59-69.
  • J Tang and J Liu, 2012, "Ultrasonic measurement of scleral cross-sectional strains during elevations of intraocular pressure: method validation and initial results in posterior porcine sclera." Journal of Biomechanical Engineering 134, no. 9, 091007-1 - 091007-1.
  • Ritchey,Eric,R; Zelinka,Christopher,P; Tang,Junhua; Liu,Jun; Fischer,Andy,J, 2012, "The combination of IGF1 and FGF2 and the induction of excessive ocular growth and extreme myopia." EXPERIMENTAL EYE RESEARCH 99, 1-16 - 1-16.
  • Tang,Junhua; Pan,Xueliang; Weber,Paul,A; Liu,Jun, 2012, "Effect of corneal stiffening on goldmann applanation tonometry and tono-pen measurements in canine eyes.." Investigative ophthalmology & visual science 53, no. 3, 1397-1405 - 1397-1405.

2011

  • J Tang, X Pan, PA Weber, and J Liu, 2011, "Corneal modulus and IOP measurements in canine eyes using Goldmann applanation tonometry and Tonopen." Investigative Ophthalmology and Visual Science 11, no. 52, 7866-7871 - 7866-7871.
  • X Jiang, X Liu, X Gong, F Zhang, R Wu, J Wu, and J Liu, 2011, "Model and experimental analysis of oblique incident ultrasound in a tissue layer using doublet mechanics theory." Journal of the Acoustical Society of America 130, no. 6, 4117-4125 - 4117-4125.
  • J Tang and J Liu, 2011, "Variance of speed of sound and correlation with acoustic impedance in canine corneas." Ultrasound in Medicine and Biology 10, no. 37, 1714-1721 - 1714-1721.
  • X He and J Liu, 2011, "Correlation of corneal acoustic and elastic properties in a canine eye model." Investigative Ophthalmology and Visual Science 2, no. 52, 731-736 - 731-736.
  • J Palko, X Pan, J Liu, 2011, "Dynamic testing of regional viscoelastic behavior of canine sclera." Experimental Eye Research 93, 825-832 - 825-832.

2010

  • X He, E Spoerl, J Tang, and J Liu, 2010, "Measurement of corneal changes after collagen cross-linking by a non-invasive ultrasound system." Journal of Cataract and Refractive Surgery 7, no. 36, 1207-1212 - 1207-1212.
  • He,Xiaoyin; Spoerl,Eberhard; Tang,Junhua; Liu,Jun, 2010, "Measurement of corneal changes after collagen crosslinking using a noninvasive ultrasound system." JOURNAL OF CATARACT AND REFRACTIVE SURGERY 36, no. 7, 1207-1212 - 1207-1212.

2009

  • J Liu and X He, 2009, "Corneal stiffness affects IOP elevation during rapid volume change in the eye." Investigative Ophthalmology and Visual Science 5, no. 50, 2224-2229 - 2224-2229.
  • X He and J Liu, 2009, "A quantitative ultrasonic spectroscopy method for non-invasive determination of corneal biomechanical properties." Investigative Ophthalmology and Visual Science 11, no. 50, 5148-5154 - 5148-5154.

2006

  • J Liu, AL Levine, JS Mattoon, M Yamaguchi, RJ Lee, X Pan, TJ Rosol, 2006, "Nanoparticles as Image Enhancing Agents for Ultrasonography." Physics in Medicine and Biology 51, 2179-2189 - 2179-2189.

2005

  • J Liu and CJ Roberts, 2005, "Quantitative Analysis of the Influence of Corneal Biomechanical Properties on IOP Measurement." Journal of Cataract and Refractive Surgery 31, no. 1, 146-155 - 146-155.

2004

  • J Wu, C Layman, and J Liu, 2004, "Wave Equations, Dispersion Relations and van Hove Singularities for Applications of Doublet Mechanics to Ultrasound Propagations in Bio-Singularities for Applications of Doublet Mechanics to Ultrasound Propagations in Bio- and Nano-Materials." Journal of Acoustical Society of America 115, no. 2, 893-900 - 893-900.

2003

  • J Liu and M Ferrari, 2003, "A Discrete Model for the High Frequency Elastic Wave Examination on Biological Tissue." Computer Modeling in Engineering and Sciences 4, no. 3&4, 421-430 - 421-430.

2002

  • Liu,J; Ferrari,M, 2002, "Mechanical spectral signatures of malignant disease? A small-sample, comparative study, of continuum vs. nano-biomechanical data analyses." DISEASE MARKERS 18, no. 4, 175-183 - 175-183.
  • J Liu and M Ferrari, 2002, "Mechanical Spectral Signatures of Malignant Disease? A Small-Sample, Comparative Study of Continuum vs. Nano-Biomechanical Data Analyses." Disease Markers 18, no. 4, 175-183 - 175-183.

Unknown

  • KM Metzler, CJ Roberts, AM Mahmoud, G Agarwal, J Liu, "Transepithelial Collagen Crosslinking in Porcine and Human Corneas Using Human Decorin Core Protein." Journal of Refractive Surgery
  • C Boote, JR Palko, T Sorensen, A Mohammadvali, A Elsheikh, AM. Komáromy, X Pan and J Liu, "Changes in posterior scleral collagen microstructure in canine eyes with an ADAMTS10 mutation." Molecular Vision

Presentations

  • "Nanoparticles as Molecular Imaging Agents for Ultrasound." 2009, Presented at Small Animal Imaging Center Seminars,
  • "Quantitative Analysis of Corneal Effect on IOP Measurement." 2005, Presented at Ophthalmology Grandrounds,
  • "Nanoparticles as Molecular Imaging Agents for Ultrasound." 2007, Presented at Biophysics Seminar,
  • "Nanoparticles as Molecular Imaging Agents for Ultrasound." 2007, Presented at College of Veterinary Medicine Biomedical Imaging Signature Program,
  • "Corneal Biomechanics and IOP Measurement." 2008, Presented at College of Optometry Graduate Seminar,
  • "Changes in Corneal Stiffness After Riboflavin-UVA Treatment as Measured by Ultrasound." 2008, Presented at International Congress of Corneal Crosslinking,
  • "Targeted Nanoparticles for Ultrasound Imaging." 2006, Presented at Mini-Symposium of the Nanospectroscopy Consortium,
  • "Biomedical Ultrasound and Imaging Laboratory for Disease Diagnosis." 2006, Presented at Biophysics Preceptor Talk,
  • "Ultrasonic Detection Of Changes in Corneal Biomechanical Properties Associated with Hydration Effects." 2007, Presented at International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity,
  • "Detection of Changes in Corneal Biomechanical Properties after Collagen Crosslinking Using a Novel Immersion Ultrasound Technique." 2009, Presented at The American Society of Cataract and Refractive Surgery Symposium: Controversies in Corneal Collagen Crosslinking,
  • Characterization of distributive scleral strains during physiological loadings using high frequency ultrasound radiofrequency analysis. 2012, Presented at International Society for Eye Research,
  • "Corneoscleral Biomechanics and Intraocular Pressure." 2014, Presented at The COBB Rich Lecture at University of Alabama at Birmingham Department of Ophthalmology,
  • "Corneal and Scleral Strains Measured from Ultrasound Speckle Tracking." 2014, Presented at World Congress of Biomechanics,
  • "Ocular Biomechanics: Advances in 3D and in vivo Measurements." 2016, Presented at Devers Eye Institute,
  • "In Vivo Assessment of Ocular Coat Dynamics: Is It Relevant in Glaucoma?." 2016, Presented at Annual Meeting of the American Society of Glaucoma,
  • "3D and in vivo measurements of biomechanics using ultrasound." 2016, Presented at OSU Biophysics Program,
  • "Differentiating mechanical properties of corneal phantoms using an ultrasound method." 2005, Presented at International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity,
  • "Biomechanics in the Health and Disease of the Eye." 2014, Presented at OSU Biophysics Program,
  • "Ocular Pulse Elastography of the Cornea Using High Frequency Ultrasound." 2015, Presented at Asia-Pacific Academy of Ophthalmology Congress,
  • "Viscoelastic Properties of Human Sclera and Influence on Acute IOP Elevation." 2010, Presented at World Congress of Biomechanics,
  • "Correlation between Acoustic Properties and Young’s Modulus in Canine Corneas." 2010, Presented at World Congress of Biomechanics,
  • "Ocular Biomechanics:Clinical Implications and Beyond." 2011, Presented at Ophthalmology Grandrounds,
  • "Characterizing Heterogeneous Tissue Deformation using Ultrasound Speckle Tracking." 2014, Presented at World Congress of Biomechanics,
  • "Biomechanics in the Health and Disease of the Eye." 2015, Presented at OSU College of Optometry,
  • "Nonlinearity of cornea biomechanical properties measured by an ultrasonic system." 2006, Presented at International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity,

Papers in Proceedings

2016

  • ER Pavlatos, X Pan, RT Hart, PA Weber, J Liu "IOP-induced strains in the optic nerve head using ultrasound speckle tracking." in Summer Biomechanics, Bioengineering and Biotransport Conference. (8 2016).
  • KL Clayson, ER Pavlatos, J Liu "3D characterization of corneal deformation using ultrasound speckle tracking." in Proceeding of Summer Biomechanics, Bioengineering and Biotransport Conference. (8 2016).

2015

  • ER Pavlatos, B Cruz Perez, HJ Morris, H Chen, RT Hart, J Liu "3D strains in posterior sclera using ultrasound speckle tracking." in Summer Biomechanics, Bioengineering and Biotransport Conference. (9 2015).

2013

  • B Cruz-Perez, HJ Morris, J Tang, RT Hart, X Pan, and J Liu "Biaxial mechanical testing of porcine sclera using ultrasound speckle tracking for strain measurements." in American Society of Mechanical Engineering Summer Bioengineering Conference. (9 2013).

2011

  • J Tang and J Liu "Ultrasonic speckle tracking for measurement of scleral cross-sectional strains due to intraocular pressure elevation." in American Society of Mechanical Engineering Summer Bioengineering Conference. (6 2011).

2006

  • X He; J Liu "Measurements of ocular properties in response to intraocular pressure changes using an ultrasonic system." in 28th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society. (8 2006).

2005

  • L Cooper, J Liu, K Huang "Spatial segementation of temporal texture using mixture linear models." in International Conference of Computer Vision. (8 2005).
  • R Xu, B Qiang and J Liu "Ultrasound-guided near-infrared spectroscopy for brain functional study: feasibility analysis and preliminary work." in SPIE. (1 2005).

Patents

  • Jun Liu, Hong Chen. "Ophthalmic Elastography."
  • Jun Liu, Mauro Ferrari, Stanislav Rokhlin and Daniel Sedmak. "System and Method for Screening Tissue." Patent number: 7993271