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Peter Mohler

  • Professor, Cardiovascular Medicine
  • Vice Dean for Research, ADM-Medicine Administration
  • Professor, Pulmonary, Crit Care, & Sleep
  • Chair and Professor, SBS-Physiology & Cell Biology
  • Professor & Dir of DHLRI, Davis Heart & Lung Institute
  • Room #110
    473 W 12th Ave
    Columbus, OH 43210
  • 614-247-8610

Honors

  • 20090101

    Kavli Fellow of the US National Academy of Sciences (Representative for Medicine/Physiology).

  • 20070101

    Pew Scholar in the Biomedical Sciences.

  • 20000101

    Worthington Fellowship.

  • 19980101

    Glaxo-Wellcome Graduate Award.

Chapters

2011

  • 2011. "Long QT, Short QT, and Brugada Syndromes." In Cardiology: An Illustrated Text/Reference, edited by Kanu Chatterjee,

2010

  • 2010. "Defects in ankyrin-based protein targeting pathways in human arrhythmia." In Heart rate and rhythm: Molecular basis, pharmacological modulation, and clinical implications,
  • 2010. "Chapter 2: Principles of Cellular Architecture and Physiology with Applications in Electrophysiology." In Electrophysiological Disorders of the Heart, edited by Saksena and Camm,

2008

  • 2008. "Chapter 4: Structural and Molecular Basis of Ion Channel Function: Intracellular Signaling and Regulation of Cardiac Ion Channels." In Cardiac Electrophysiology: From Cell to Bedside, edited by Zipes and Jalife,

Journal Articles

2010

  • TJ Hund, OM Koval, J Li, PJ Wright, L Qian, JS Snyder, H Gudmundsson, CF Kline, NP Davidson, N Cardona, MN Rasband, ME Anderson, and PJ Mohler, 2010, "A ï�¢IV spectrin/CaMKII signaling complex is essential for vertebrate membrane excitability in mice." Journal of Clinical Investigation 120, 3508-3519 - 3508-3519.
  • J Li, CF Kline, TJ Hund, ME Anderson, and PJ Mohler, 2010, "Ankyrin-B regulates Kir6.2 membrane expression and function in heart." The Journal of Biological Chemistry 285, 28723-28730 - 28723-28730.
  • TJ Hund and PJ Mohler, 2010, "Cardiac spectrins: Alternative splicing encodes functional diversity." Journal of Molecular and Cellular Cardiology 48, 1031-1032 - 1031-1032.
  • H Gudmundsson, TJ Hund, PJ Wright, CF Kline, JS Snyder, L Qian, OM Koval, SR Cunha, M George, MA Rainey, FE Kashef, W Dun, PA Boyden, ME Anderson, H Band, and PJ Mohler, 2010, "EH domain proteins regulate cardiac membrane protein targeting." Circulation Research 107, no. 1, 84-95 - 84-95.
  • Z Gao, MV Singh, DD Hall, OM Koval, ED Luczak, MA Joiner, B Chen, Y Wu, AK Chaudhary, JB Martins, TJ Hund, PJ Mohler, LS Song, ME Anderson, 2010, "Catecholamine-independent heart rate increases require CaMKII." Circulation: Arrhythmia and Electrophysiology
  • Gao, Z, Chen B, Joiner ML, Wu Y, Guan X, Koval OM, Chaudhary AK, Cunha SR, Mohler PJ, Martins JB, Song LS, ME Anderson, 2010, "If and SR Ca2+ release both contribute to pacemaker activity in canine sinoatrial node cells." Journal of Molecular and Cellular Cardiology 49, 33-40 - 33-40.
  • PJ Mohler and TJ Hund, 2010, "Role for CaMKII in cardiovascular health, disease, and arrhythmia." Heart Rhythm
  • TJ Hund and PJ Mohler, 2010, "Differential roles for SUR subunits in KATP channel membrane targeting and regulation." American Journal of Physiology-Heart and Circulatory Physiology
  • RM Wolf, CC Mitchell, MD Christensen, PJ Mohler, and TJ. Hund, 2010, "Defining new insight into atypical arrhythmia: a computational model of ankyrin-B-syndrome." American Journal of Physiology - Heart and Circulatory Physiology 299, H1505-H1514 - H1505-H1514.
  • AL Leoni, B Gavillet, JS Rougier, C Marionneau, V Probst, S Le Scouarnec, JJ Schott, S Demolombe, P Bruneval, CLH Huang, WH Colledge, AA Grace, H Le Marec, AA Wilde, PJ Mohler, D Escande, H Abriel, F Charpentier, 2010, "Variable Nav1.5 protein expression from the WT allele controls phenotypic penetrance in the Scn5a+/- mouse model for conduction disease." Public Library of Science (PLoS) One 5, e9298 - e9298.

2009

  • MV Singh, A Kapoun, L Higgins, W Kutschke, JM Thurman, R Zhang, M Singh, J Yang, X Guan, JS Lowe, RM Weiss, K Zimmermann, FE Yull, TS Blackwell, PJ Mohler and ME Anderson, 2009, "CaMKII triggers cell membrane injury by inducing complement factor B gene expression in heart." J Clin Invest 119, 986-996 - 986-996.
  • SM Hashemi, TJ Hund, and PJ Mohler, 2009, "Cardiac ankyrins in health and disease." Journal of Molecular and Cellular Cardiology 47, 203-209 - 203-209.
  • MD Christensen, W Dun, PA Boyden, ME Anderson, PJ Mohler, and TJ Hund, 2009, "Oxidized calmodulin kinase II regulates conduction following myocardial infarction: A computational analysis." Public Library of Science (PLoS) Computational Biology 5, e1000583 - e1000583.
  • TJ Hund, PJ Wright, W Dun, JS Snyder, PA Boyden, and PJ Mohler, 2009, "Regulation of the ankyrin-B-based targeting pathway following myocardial infarction." Cardiovascular Research 81, 742-749 - 742-749.

2008

  • Thiel WH, Chen B, Hund TJ, Koval OM, Purohit A, Song LS, Mohler PJ, and Anderson ME, 2008, "Proarrhythmic defects in a ventricular myocyte model of Timothy Syndrome require calmodulin kinase II." Circulation 118, 2225-2234 - 2225-2234.
  • Kline CF, Cunha SR, Lowe JS, Hund TJ, Mohler PJ, 2008, "Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor." Journal of Cellular Biochemistry 104, 1244-1253 - 1244-1253.
  • Hund TJ, Decker KF, Kanter E, Mohler PJ, Boyden PA, Schuessler RB, Yamada KA, and Rudy Y, 2008, "Role of activated CaMKII in abnormal calcium homeostasis and INa remodeling after myocardial infarction: Insights from mathematical modeling." Journal of Molecular and Cellular Cardiology 45, 420-428 - 420-428.
  • Lowe JS, Palygin O, Bhasin N, Hund TJ, Boyden PA, Shibata E, Anderson ME, Mohler PJ, 2008, "Voltage-gated Nav channel targeting in heart requires an ankyrin-G-dependent cellular pathway." Journal of Cell Biology 180, 173-186 - 173-186.
  • Hund TJ, Ziman AJ, Lederer WJ, and Mohler PJ, 2008, "The cardiac IP3 receptor: Uncovering the role of “the other” calcium-release channel." Journal of Molecular and Cellular Cardiology 45, 159-161 - 159-161.

2007

  • Lehnart SE, Ackerman MJ, Brugada R, Benson DW Jr, Clancey CE, Donahue JK, George AL Jr, Grant AO, Groft SC, January CT, Lathrop DA, Lederer WJ, Makielski JC, Mohler PJ, Moss A, Nerbonne JM, Olson TM, Przywara DA, Towbin JA, Wang LH, Marks AR, 2007, "Inherited Arrhythmias--an NHLBI-ORD workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion transport function." Circulation 116, 2325-2345 - 2325-2345.

2006

  • Grueter CE, Abiria SA, Dzhura I, Wu Y, Ham AJ, Mohler PJ, Anderson ME, Colbran RJ, 2006, "Calmodulin Kinase II facilitates L-type Ca2+ channels by beta subunit phosphorylation." Molecular Cell 23, 641-650 - 641-650.
  • Kline CF, and Mohler PJ, 2006, "Weighing in on molecular anchors: The role of ankyrins in cardiac channelopa-thies and human arrhythmia." Expert Review in Cardiovascular Therapy 4, 477-485 - 477-485.

2005

  • Mohler PJ, Davis JQ, Bennett V, 2005, "Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac transverse-tubule/sarcoplasmic reticulum microdomain." Public Library of Science Biology (PLOS Biology) 3, 423 - 423.

2004

  • Mohler PJ, Davis JQ, Davis LH, Hoffman JA, Michaely P, Bennett V, 2004, "InsP3 receptor localization and stability in cardiomyocytes requires interaction with ankyrin-B." Journal of Biological Chemistry 279, 12980-12987 - 12980-12987.

1996

  • Browne CL, Creton R, Karplus E, Mohler PJ, Palazzo RE, Miller AL, 1996, "Analysis of the Ca2+ transient at nuclear envelope breakdown during the first cell cycle in dividing sea urchin eggs." Biological Bulletin 191, 5-16 - 5-16.

Papers in Proceedings

2010

  • Koval OM, Guan X, Wu Y, Joiner M, Gao Z, Chen B, Grumbach IM, Luczak ED, Colbran RJ, Song LS, Hund TJ, Mohler PJ, and Anderson ME "The Cav1.2 β subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations." in Proc Natl Acad Sci U S A. (1 2010).

2009

  • CF Kline, HT Kurata, TJ Hund, SR Cunha, OM Koval, PJ Wright, M Christensen, ME Anderson, CG Nichols, and PJ Mohler "Dual role of KATP channel C-terminal motif in membrane targeting and metabolic regulation." in Proc Natl Acad Sci., USA. (1 2009).
  • Y Wu, Z Gao, B Chen, OM Koval, MV Singh, X Guan, TJ Hund, WJ Kutschke, S Sarma, IM Grumbach, XHT Wehrens, PJ Mohler, LS Song, ME Anderson "Calmodulin kinase II is required for fight or flight sinoatrial node physiology." in Proc Natl Acad Sci., USA. (1 2009).

2008

  • Le Scouarnec S, Bhasin N, Vieyres C, Hund TJ, Cunha SR, Koval O, Marionneau C, Chen B, Wu Y, Demolombe S, Song LS, Le Marec H, Probst V, Schott JJ, Anderson ME, and Mohler PJ "Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease." in Proc Natl Acad Sci., USA. (1 2008).

2004

  • Mohler PJ, Splawski I, Napolitano C, Bottelli G, Sharpe L, Timothy K, Priori SG, Keating MT, Bennett V "A cardiac arrhythmia syndrome caused by loss of ankyrin-B function." in Proc Natl Acad Sci., USA. (1 2004).

Patents

  • PJ Mohler. "Methods of Modulating Localization and Physiological Function of InsP3 Receptors." Patent number: 10/336,031