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Jonathan Song

  • Assistant Professor, Mechanical & Aerospace Engr
  • Scott Lab Building 148 E406
    201 W 19th Ave
    Columbus, OH 43210
  • 614-292-8519

Honors

  • January, 2019

    ASPIRE Award.

Chapters

2015

  • Song, J.W.; Bazou, D.; Munn, L.L.. 2015. "Microfluidic model of angiogenic sprouting."

Journal Articles

2019

  • Garg, A.A.; Jones, T.H.; Moss, S.M.; Mishra, S. et al., 2019, "Electromagnetic fields alter the motility of metastatic breast cancer cells.." Communications Biology 2, 303 - 303.
  • Akbari, E.; Spychalski, G.B.; Rangharajan, K.K.; Prakash, S. et al., 2019, "Competing Fluid Forces Control Endothelial Sprouting in a 3-D Microfluidic Vessel Bifurcation Model.." Micromachines 10, no. 7,
  • Akbari, E.; Shahhosseini, M.; Baetz, J.C.; Song, J.W. et al., 2019, "Functionalizing Cell Membranes with DNA Origami for Multiplexed Biomolecular Sensing." The FASEB Journal 33, 785-1 - 785-1.
  • Chang, C-W.; Seibel, A.J.; Song, J.W., 2019, "Application of microscale culture technologies for studying lymphatic vessel biology.." Microcirculation (New York, N.Y. : 1994) e12547 - e12547.
  • Avendano, A.; Cortes-Medina, M.; Song, J.W., 2019, "Application of 3-D Microfluidic Models for Studying Mass Transport Properties of the Tumor Interstitial Matrix.." Frontiers in bioengineering and biotechnology 7, 6 - 6.

2018

  • Pitarresi, J.R.; Liu, X.; Avendano, A.; Thies, K.A. et al., 2018, "Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth.." Life science alliance 1, no. 5, e201800190 - e201800190.
  • LaPak, K.M.; Vroom, D.C.; Garg, A.A.; Guan, X. et al., 2018, "Melanoma-associated mutants within the serine-rich domain of PAK5 direct kinase activity to mitogenic pathways.." Oncotarget 9, no. 39, 25386-25401 - 25386-25401.
  • Nowak-Sliwinska, P.; Alitalo, K.; Allen, E.; Anisimov, A. et al., 2018, "Consensus guidelines for the use and interpretation of angiogenesis assays.." Angiogenesis 21, no. 3, 425-532 - 425-532.
  • Akbari, E.; Spychalski, G.B.; Rangharajan, K.K.; Prakash, S. et al., 2018, "The Effect of Sphingosine 1-Phosphate on Endothelial Permeability Is Fluid Flow Dependent." The FASEB Journal 32, 706-4 - 706-4.
  • Garg, A.A.; Jones, T.H.; Bushman, S.; Mishra, S.A. et al., 2018, "NON-CONTACT ELECTRIC FIELDS POTENTLY HINDER EGF PROMOTED BREAST CANCER MOTILITY BY DOWNREGULATING EGFR PHOSPHORYLATION." The FASEB Journal 32, 677-21 - 677-21.
  • Chang, C-W.; Kumar, P.; Song, J.W., 2018, "A 3-D Biomicrofluidic Lymphatic Vessel Analogue for Studying Lymphangiogenesis and Lymphatic Vessel Function." The FASEB Journal 32, 576-7 - 576-7.
  • Akbari, E.; Spychalski, G.B.; Rangharajan, K.K.; Prakash, S. et al., 2018, "Flow dynamics control endothelial permeability in a microfluidic vessel bifurcation model.." Lab Chip 18, no. 7, 1084-1093 - 1084-1093.
  • Walker, C.J.; Rush, C.M.; Dama, P.; O'Hern, M.J. et al., 2018, "MAX Mutations in Endometrial Cancer: Clinicopathologic Associations and Recurrent MAX p.His28Arg Functional Characterization.." Journal of the National Cancer Institute 110, no. 5, 517-526 - 517-526.

2017

  • Avendano, A.; Chang, J.; Ennis, C.; Stratton, A. et al., 2017, "PTEN Deletion in Pancreatic Cancer Associated Fibroblasts Decreases Hydraulic Permeability Independent of Collagen Fiber Alignment in a 3D Microfluidic Model of the Tumor Stroma." FASEB JOURNAL 31,
  • Akbari, E.; Spychalski, G.B.; Song, J.W., 2017, "Microfluidic approaches to the study of angiogenesis and the microcirculation.." Microcirculation 24, no. 5,
  • Akbari, E.; Spychalski, G.B.; Rangharajan, K.K.; Prakash, S. et al., 2017, "Microfluidic Model of Angiogenic Remodeling at Blood Vessel Bifurcations." FASEB JOURNAL 31,
  • Hammer, A.M.; Sizemore, G.M.; Shukla, V.C.; Avendano, A. et al., 2017, "Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth.." Neoplasia 19, no. 6, 496-508 - 496-508.
  • Qazi, H.; Shi, Z-D.; Song, J.W.; Cancel, L.M. et al., 2017, "Heparan Sulfate Proteoglycans Mediate Renal Carcinoma Metastasis." FASEB JOURNAL 31,

2016

  • Qazi, H.; Shi, Z-D.; Song, J.W.; Cancel, L.M. et al., 2016, "Heparan sulfate proteoglycans mediate renal carcinoma metastasis.." Int J Cancer 139, no. 12, 2791-2801 - 2791-2801.
  • Kloepper, J.; Riedemann, L.; Amoozgar, Z.; Seano, G. et al., 2016, "Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival.." Proceedings of the National Academy of Sciences of the United States of America 113, no. 16, 4476-4481 - 4476-4481.
  • Bazou, D.; Ng, M.R.; Song, J.W.; Chin, S.M. et al., 2016, "Flow-induced HDAC1 phosphorylation and nuclear export in angiogenic sprouting.." Scientific reports 6, 34046 - 34046.

2013

  • Bazou, D.; Song, J.; Munn, L., 2013, "Endothelial dynamics during sprouting morphogenesis." FASEB JOURNAL 27,

2012

  • Song, J.W.; Bazou, D.; Munn, L.L., 2012, "Anastomosis of endothelial sprouts forms new vessels in a tissue analogue of angiogenesis.." Integrative biology : quantitative biosciences from nano to macro 4, no. 8, 857-862 - 857-862.
  • Song, J.W.; Daubriac, J.; Tse, J.M.; Bazou, D. et al., 2012, "RhoA mediates flow-induced endothelial sprouting in a 3-D tissue analogue of angiogenesis.." Lab on a chip 12, no. 23, 5000-5006 - 5000-5006.

2011

  • Song, J.W.; Munn, L.L., 2011, "Fluid forces control endothelial sprouting.." Proceedings of the National Academy of Sciences of the United States of America 108, no. 37, 15342-15347 - 15342-15347.

2009

  • Song, J.W.; Cavnar, S.P.; Walker, A.C.; Luker, K.E. et al., 2009, "Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells.." PloS one 4, no. 6, e5756 - e5756.
  • Takayama, S.; Huh, D.; Song, J.; Cha, W. et al., 2009, "KEYNOTE PAPER."

2008

  • Kamotani, Y.; Bersano-Begey, T.; Kato, N.; Tung, Y-C. et al., 2008, "Individually programmable cell stretching microwell arrays actuated by a Braille display.." Biomaterials 29, no. 17, 2646-2655 - 2646-2655.

2007

  • Mehta, G.; Mehta, K.; Sud, D.; Song, J.W. et al., 2007, "Quantitative measurement and control of oxygen levels in microfluidic poly(dimethylsiloxane) bioreactors during cell culture.." Biomedical microdevices 9, no. 2, 123-134 - 123-134.
  • Heo, Y.S.; Cabrera, L.M.; Song, J.W.; Futai, N. et al., 2007, "Characterization and resolution of evaporation-mediated osmolality shifts that constrain microfluidic cell culture in poly(dimethylsiloxane) devices.." Analytical chemistry 79, no. 3, 1126-1134 - 1126-1134.

2006

  • Futai, N.; Gu, W.; Song, J.W.; Takayama, S., 2006, "Handheld recirculation system and customized media for microfluidic cell culture.." Lab on a chip 6, no. 1, 149-154 - 149-154.

2005

  • Song, J.W.; Gu, W.; Futai, N.; Warner, K.A. et al., 2005, "Computer-controlled microcirculatory support system for endothelial cell culture and shearing.." Analytical chemistry 77, no. 13, 3993-3999 - 3993-3999.

Unknown

  • Akbari, E.; Mollica, M.Y.; Lucas, C.R.; Bushman, S.M. et al., "Engineering Cell Surface Function with DNA Origami." Advanced Materials 1703632-1703632 - 1703632-1703632.

Presentations

  • "Controlled Microcirculatory Support System for Endothelial Cell Culture and Shearing." 2004, Presented at XIV International Conference on Mechanics in Medicine and Biology,
  • "Endothelial Cell Culture Under Computer-Controlled Flow in Microfluidic Channels." 2004, Presented at Biomedical Engineering Society Annual Fall Meeting,
  • "Three-Dimensional Protein Matrices for Cell Adhesion And Spreading." 2005, Presented at Biomedical Engineering Society Annual Fall Meeting,
  • "Response of Microvascular Endothelial Cells Overexpressing Bcl-2 to Microfluidic Shear Stress." 2005, Presented at Biomedical Engineering Society Annual Fall Meeting,
  • "Real-time Imaging of Shear-mediated Responses of Endothelial Cells in a Microfluidic Culture System." 2006, Presented at World Congress on Medical Physics and Biomedical Engineering,
  • "Spatially Physiological Microfluidic Metastasis on a Chip." 2009, Presented at 5thInternational Conference on Microtechnologies in Medicine andBiology,
  • "Shear Stress Controls Capillary Sprouting in a Microfluidic Device." 2010, Presented at Biomedical Engineering Society Annual Fall Meeting,
  • "Involvement of Fluid Flow in Vessel Guidance and Morphogenesis." 2012, Presented at Biomedical Engineering Society Annual Fall Meeting,
  • "Microscale Engineering of Vascular Morphogenesis." 2014, Presented at 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society,
  • "Microsystems Engineering for Bridging Angiogenesis with Mechanopathology." 2015, Presented at Summer Biomechanics, Bioengineering and Biotransport Conference,
  • "Functionalization of Cell Membranes with a Programmable DNA Origami NanoPlatform." 2016, Presented at ASME NanoEngineering for Medicine and Biology Conference,
  • "A Microfluidic Model to Direct Angiogenesis with Fluid Mechanics at Vessel Bifurcation." 2016, Presented at Summer Biomechanics, Bioengineering and Biotransport Conference,
  • "Profiling The Effect Of Cancer-Associated Fibroblasts On Matrix Alignment And Hydraulic Permeability." 2016, Presented at Biomedical Engineering Society Annual Meeting,
  • "Isolation Of The Opposing Effects Of Fluid Mechanical Forces On Endothelial Sprouting." 2016, Presented at Biomedical Engineering Society Annual Meeting,
  • "Functionalization of Cell Membranes with a Programmable DNA Origami NanoPlatform." 2017, Presented at IEEE-FNANO 2017,
  • "Deletion in Pancreatic Cancer Associated Fibroblasts Decreases Hydraulic Permeability in a 3D Microfluidic Model of the Tumor Stroma." 2017, Presented at Summer Biomechanics, Bioengineering, and Biotransport Conference,
  • "Inductive Electric Fields Hinder EGF Gradient Promoted Breast Cancer Cell Motility." 2017, Presented at Summer Biomechanics, Bioengineering, and Biotransport Conference,
  • "Sprouting Lymphangiogenesis Regulated By Combined Biochemical and Mechanical Stimulation in a 3-D Microfluidic Device." 2017, Presented at Summer Biomechanics, Bioengineering, and Biotransport Conference,
  • "The Impact of CXCL-12 Isoforms on Breast Cancer Invasion." 2017, Presented at Summer Biomechanics, Bioengineering, and Biotransport Conference,
  • "Flow-induced HDAC1 phosphorylation and nuclear export in angiogenic sprouting." 2017, Presented at Biomedical Engineering Society Annual Meeting,
  • "PTEN Deletion in Pancreatic Cancer Associated Fibroblasts Decreases Hydraulic Permeability Through Hyaluronan and AKT Signaling in a 3D Microfluidic Tumor Stroma Model." 2017, Presented at Biomedical Engineering Society Annual Meeting,
  • "A Microfluidic Model to Study Endothelial Hydraulic Conductivity at Vessel Bifurcation." 2017, Presented at Biomedical Engineering Society Annual Meeting,
  • "Biomimetic and Biophysical Approach to Profile Metastatic Cancer Cell Migration." 2017, Presented at Biomedical Engineering Society Annual Meeting,
  • "Probing the Effect of Cancer-Associated Fibroblasts on Therapeutic Resistance in a 3-D Tumor Model." 2017, Presented at Biomedical Engineering Society Annual Meeting,
  • "CXCL12 Isoform-Specific Effects On Vessel Behavior And Function." 2017, Presented at Biomedical Engineering Society Annual Meeting,
  • "Local Fluid Forces Regulate Endothelial Hydraulic Conductivity." 2017, Presented at Biomedical Engineering Society Annual Meeting,
  • "Directing angiogenesis and vessel function with mechanical cues." 2018, Presented at 11th World Congress for Microcirculation,
  • "Engineering DNA Origami Structures on Cell Surface for Detection of Cancer Biomarkers in Cellular Microenvironment." 2018, Presented at ASME NanoEngineering for Medicine and Biology Conference,
  • "Effects of Inductive Electric Fields on TNBC Cell Motility." 2018, Presented at Biomedical Engineering Society Annual Meeting,
  • Functionalizing Cell Membrane with a Multifunctional DNA-Origami Platform for Biomolecular Detection. 2019, Presented at 2019 AIChE Annual Meeting,
  • "Engineering vascular and tumor stroma dynamics with microfluidics." 2018, Presented at Microfluidics/3D Printing/Tissue Engineering Seminar (host: Prof. Takayama),
  • "Understanding the Biological Basis of Alternating Electric Field Therapy on Breast Cancer Metastasis." 2019, Presented at 41th Annual International Conference of the IEEE Engineering in Medicine and Biology Society,
  • "A Multifunctional DNA-origami platform for Biomolecular Detection in Cellular Microenvironments." 2019, Presented at International Conference on Biofabrication,

Papers in Proceedings

2018

  • Chang, C-W.; Kumar, P.; Song, J.W. "A 3-D Biomicrofluidic Lymphatic Vessel Analogue for Studying Lymphangiogenesis and Lymphatic Vessel Function." in Experimental Biology Meeting. (4 2018).
  • Garg, A.A.; Jones, T.H.; Bushman, S.; Mishra, S.A. et al. "NON-CONTACT ELECTRIC FIELDS POTENTLY HINDER EGF PROMOTED BREAST CANCER MOTILITY BY DOWNREGULATING EGFR PHOSPHORYLATION." in Annual Meeting of Amer-Assoc-of-Anatomists (AAA), Amer-Physiol-Soc (APS), Amer-Soc-for-Biochemistry-and-Mol-Biol (ASBMB), Amer-Soc-for-Investigat-Pathol (ASIP), Amer-Soc-for-Pharmacol-and-Experimental-Therapeut (ASPET) on Experimental Biology (EB). (4 2018).
  • Akbari, E.; Spychalski, G.B.; Rangharajan, K.K.; Prakash, S. et al. "The Effect of Sphingosine 1-Phosphate on Endothelial Permeability Is Fluid Flow Dependent." in Experimental Biology Meeting. (4 2018).

2017

  • Rangharajan, K.K.; Akbari, E.; Spychalski, G.B.; Song, J.W. et al. "Angiogenesis on Chip (AoC): Structural Analogies for Fluid Mechanical Determinants of Endothelial Sprouting." in The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017). (10 2017).
  • Qazi, H.; Shi, Z-D.; Song, J.W.; Cancel, L.M. et al. "Heparan sulfate proteoglycans mediate tumor cell invasion and metastasis." in Annual Meeting of the American-Association-for-Cancer-Research (AACR). (7 2017).

2016

  • Riedemann, L.; Kloepper, J.; Amoozgar, Z.; Seano, G. et al. "IMST-40. REPROGRAMMING OF THE TUMOR IMMUNE MICROENVIRONMENT BY AN ANG-2/VEGF BISPECIFIC ANTIBODY DELAYS TUMOR GROWTH AND PROLONGS SURVIVAL IN PRECLINICAL GBM MODELS." (1 2016).
  • Kloepper, J.; Riedemann, L.; Amoozgar, Z.; Seano, G. et al. "Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival." in AACR 107th Annual Meeting on Bioinformatics and Systems Biology. (7 2016).

2013

  • Song, J.W.; Bazou, D.; Munn, L.L. "Flow-mediated Vessel Guidance." in Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB). (4 2013).

2012

  • Song, J.W.; Munn, L.L. "Biomechanical Determinants of Endothelial Sprouting and Morphogenesis." in Experimental Biology Meeting. (4 2012).

2011

  • Song, J.W.; Munn, L.L. "Biomechanical Determinants of Endothelial Cell Sprouting in a Microfluidic Device." in Experimental Biology Meeting 2011. (4 2011).

2010

  • Song, J.W.; Munn, L.L. "Microfluidic Platform for Reproducing Blood Vessel Microenvironment." (4 2010).

2009

  • Takayama, S.; Huh, D.; Song, J.; Cha, W. et al. "Micro- and nanofluidics for cell biology, cell therapy, and cell-based drug testing." (12 2009).

2005

  • Gu, W.; Zhu, X.Y.; Futai, N.; Song, J.W. et al. "Regulated culture and assays of cells using braille displays." in 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences. (1 2005).

Unknown

  • Garg, A.A.; Jones, T.H.; Bushman, S.; Shuman, J. et al. "Inductive Electric Fields Directionally Hinder EGF-Gradient Promoted Breast Cancer Motlitiy in Biomimetic Microtracks." in The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017).

Patents

  • "Microfluidic cell culture media."