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Jonathan Song

  • Assistant Professor, Mechanical & Aerospace Engr
  • Scott Lab Building 148 E406
    201 W 19th Ave
    Columbus, OH 43210
  • 614-292-8519

Honors

  • January, 2019

    ASPIRE Award.

Journal Articles

2018

  • Pitarresi, J.R.; Liu, X.; Avendano, A.; Thies, K.A. et al., 2018, "Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth." Life Sci Alliance 1, no. 5, e201800190-e201800190 - e201800190-e201800190.
  • Nowak-Sliwinska, P.; Alitalo, K.; Allen, E.; Anisimov, A. et al., 2018, "Consensus guidelines for the use and interpretation of angiogenesis assays." ANGIOGENESIS 21, no. 3, 425-532 - 425-532.
  • LaPak, K.M.; Vroom, D.C.; Garg, A.A.; Guan, X. et al., 2018, "Melanoma-associated mutants within the serine-rich domain of PAK5 direct kinase activity to mitogenic pathways.." Oncotarget 9, no. 39, 25386-25401 - 25386-25401.
  • Akbari, E.; Spychalski, G.B.; Rangharajan, K.K.; Prakash, S. et al., 2018, "The Effect of Sphingosine 1-Phosphate on Endothelial Permeability Is Fluid Flow Dependent." The FASEB Journal 32, no. 1_supplement, 706.4-706.4 - 706.4-706.4.
  • Garg, A.A.; Jones, T.H.; Bushman, S.; Mishra, S.A. et al., 2018, "NON-CONTACT ELECTRIC FIELDS POTENTLY HINDER EGF PROMOTED BREAST CANCER MOTILITY BY DOWNREGULATING EGFR PHOSPHORYLATION." The FASEB Journal 32, no. 1_supplement, 677.21-677.21 - 677.21-677.21.
  • Chang, C.; Kumar, P.; Song, J.W., 2018, "A 3-D Biomicrofluidic Lymphatic Vessel Analogue for Studying Lymphangiogenesis and Lymphatic Vessel Function." The FASEB Journal 32, no. 1_supplement, 576.7-576.7 - 576.7-576.7.
  • Akbari, E.; Spychalski, G.B.; Rangharajan, K.K.; Prakash, S. et al., 2018, "Flow dynamics control endothelial permeability in a microfluidic vessel bifurcation model.." Lab Chip 18, no. 7, 1084-1093 - 1084-1093.
  • Walker, C.J.; Rush, C.M.; Dama, P.; O'Hern, M.J. et al., 2018, "MAX Mutations in Endometrial Cancer: Clinicopathologic Associations and Recurrent MAX p.His28Arg Functional Characterization.." Journal of the National Cancer Institute 110, no. 5, 517-526 - 517-526.

2017

  • Akbari, E.; Spychalski, G.B.; Rangharajan, K.K.; Prakash, S. et al., 2017, "Microfluidic Model of Angiogenic Remodeling at Blood Vessel Bifurcations." FASEB JOURNAL 31,
  • Hammer, A.M.; Sizemore, G.M.; Shukla, V.C.; Avendano, A. et al., 2017, "Stromal PDGFR-alpha Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth." NEOPLASIA 19, no. 6, 496-508 - 496-508.
  • Qazi, H.; Shi, Z-D.; Song, J.W.; Cancel, L.M. et al., 2017, "Heparan Sulfate Proteoglycans Mediate Renal Carcinoma Metastasis." FASEB JOURNAL 31,
  • Avendano, A.; Chang, J.; Ennis, C.; Stratton, A. et al., 2017, "PTEN Deletion in Pancreatic Cancer Associated Fibroblasts Decreases Hydraulic Permeability Independent of Collagen Fiber Alignment in a 3D Microfluidic Model of the Tumor Stroma." FASEB JOURNAL 31,
  • Akbari, E.; Spychalski, G.B.; Song, J.W., 2017, "Microfluidic approaches to the study of angiogenesis and the microcirculation.." Microcirculation 24, no. 5,

2016

  • Kloepper, J.; Riedemann, L.; Amoozgar, Z.; Seano, G. et al., 2016, "Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113, no. 16, 4476-4481 - 4476-4481.
  • Bazou, D.; Ng, M.R.; Song, J.W.; Chin, S.M. et al., 2016, "Flow-induced HDAC1 phosphorylation and nuclear export in angiogenic sprouting." SCIENTIFIC REPORTS 6,
  • Qazi, H.; Shi, Z-D.; Song, J.W.; Cancel, L.M. et al., 2016, "Heparan sulfate proteoglycans mediate renal carcinoma metastasis." INTERNATIONAL JOURNAL OF CANCER 139, no. 12, 2791-2801 - 2791-2801.

2015

  • Song, J.W.; Bazou, D.; Munn, L.L., 2015, "Microfluidic model of angiogenic sprouting." Methods in Molecular Biology 1214, 243-254 - 243-254.

2013

  • Bazou, D.; Song, J.; Munn, L., 2013, "Endothelial dynamics during sprouting morphogenesis." The FASEB Journal 27, 688-2 - 688-2.

2012

  • Song, J.W.; Bazou, D.; Munn, L.L., 2012, "Anastomosis of endothelial sprouts forms new vessels in a tissue analogue of angiogenesis." INTEGRATIVE BIOLOGY 4, no. 8, 857-862 - 857-862.
  • Song, J.W.; Daubriac, J.; Tse, J.M.; Bazou, D. et al., 2012, "RhoA mediates flow-induced endothelial sprouting in a 3-D tissue analogue of angiogenesis." LAB ON A CHIP 12, no. 23, 5000-5006 - 5000-5006.

2011

  • Song, J.W.; Munn, L.L., 2011, "Fluid forces control endothelial sprouting." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108, no. 37, 15342-15347 - 15342-15347.

2009

  • Song, J.W.; Cavnar, S.P.; Walker, A.C.; Luker, K.E. et al., 2009, "Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells." PLOS ONE 4, no. 6,

2008

  • Kamotani, Y.; Bersano-Begey, T.; Kato, N.; Tung, Y-C. et al., 2008, "Individually programmable cell stretching microwell arrays actuated by a Braille display." BIOMATERIALS 29, no. 17, 2646-2655 - 2646-2655.

2007

  • Mehta, G.; Mehta, K.; Sud, D.; Song, J.W. et al., 2007, "Quantitative measurement and control of oxygen levels in microfluidic poly(dimethylsiloxane) bioreactors during cell culture." BIOMEDICAL MICRODEVICES 9, no. 2, 123-134 - 123-134.
  • Heo, Y.S.; Cabrera, L.M.; Song, J.W.; Futai, N. et al., 2007, "Characterization and resolution of evaporation-mediated osmolality shifts that constrain microfluidic cell culture in poly(dimethylsiloxane) devices." ANALYTICAL CHEMISTRY 79, no. 3, 1126-1134 - 1126-1134.

2006

  • Futai, N.; Gu, W.; Song, J.W.; Takayama, S., 2006, "Handheld recirculation system and customized media for microfluidic cell culture." LAB ON A CHIP 6, no. 1, 149-154 - 149-154.

2005

  • Song, J.W.; Gu, W.; Futai, N.; Warner, K.A. et al., 2005, "Computer-controlled microcirculatory support system for endothelial cell culture and shearing." ANALYTICAL CHEMISTRY 77, no. 13, 3993-3999 - 3993-3999.

Presentations

  • "Controlled Microcirculatory Support System for Endothelial Cell Culture and Shearing." 2004, Presented at XIV International Conference on Mechanics in Medicine and Biology,
  • "Endothelial Cell Culture Under Computer-Controlled Flow in Microfluidic Channels." 2004, Presented at Biomedical Engineering Society Annual Fall Meeting,
  • "Response of Microvascular Endothelial Cells Overexpressing Bcl-2 to Microfluidic Shear Stress." 2005, Presented at Biomedical Engineering Society Annual Fall Meeting,
  • "Real-time Imaging of Shear-mediated Responses of Endothelial Cells in a Microfluidic Culture System." 2006, Presented at World Congress on Medical Physics and Biomedical Engineering,
  • "Shear Stress Controls Capillary Sprouting in a Microfluidic Device." 2010, Presented at Biomedical Engineering Society Annual Fall Meeting,
  • "Involvement of Fluid Flow in Vessel Guidance and Morphogenesis." 2012, Presented at Biomedical Engineering Society Annual Fall Meeting,
  • "Microscale Engineering of Vascular Morphogenesis." 2014, Presented at 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society,
  • "Microsystems Engineering for Bridging Angiogenesis with Mechanopathology." 2015, Presented at Summer Biomechanics, Bioengineering and Biotransport Conference,
  • "Inductive Electric Fields Hinder EGF Gradient Promoted Breast Cancer Cell Motility." 2017, Presented at Summer Biomechanics, Bioengineering, and Biotransport Conference,
  • "Sprouting Lymphangiogenesis Regulated By Combined Biochemical and Mechanical Stimulation in a 3-D Microfluidic Device." 2017, Presented at Summer Biomechanics, Bioengineering, and Biotransport Conference,
  • "Flow-induced HDAC1 phosphorylation and nuclear export in angiogenic sprouting." 2017, Presented at Biomedical Engineering Society Annual Meeting,
  • "PTEN Deletion in Pancreatic Cancer Associated Fibroblasts Decreases Hydraulic Permeability Through Hyaluronan and AKT Signaling in a 3D Microfluidic Tumor Stroma Model." 2017, Presented at Biomedical Engineering Society Annual Meeting,
  • "A Microfluidic Model to Study Endothelial Hydraulic Conductivity at Vessel Bifurcation." 2017, Presented at Biomedical Engineering Society Annual Meeting,
  • "Biomimetic and Biophysical Approach to Profile Metastatic Cancer Cell Migration." 2017, Presented at Biomedical Engineering Society Annual Meeting,
  • "Probing the Effect of Cancer-Associated Fibroblasts on Therapeutic Resistance in a 3-D Tumor Model." 2017, Presented at Biomedical Engineering Society Annual Meeting,
  • "CXCL12 Isoform-Specific Effects On Vessel Behavior And Function." 2017, Presented at Biomedical Engineering Society Annual Meeting,
  • "Local Fluid Forces Regulate Endothelial Hydraulic Conductivity." 2017, Presented at Biomedical Engineering Society Annual Meeting,
  • "Directing angiogenesis and vessel function with mechanical cues." 2018, Presented at 11th World Congress for Microcirculation,
  • "Engineering DNA Origami Structures on Cell Surface for Detection of Cancer Biomarkers in Cellular Microenvironment." 2018, Presented at ASME NanoEngineering for Medicine and Biology Conference,

Papers in Proceedings

2017

  • Qazi, H.; Shi, Z-D.; Song, J.W.; Cancel, L.M. et al. "Heparan sulfate proteoglycans mediate tumor cell invasion and metastasis." (7 2017).
  • Qazi, H.; Shi, Z-D.; Song, J.W.; Cancel, L.M. et al. "Heparan sulfate proteoglycans mediate tumor cell invasion and metastasis." in Annual Meeting of the American-Association-for-Cancer-Research (AACR). (7 2017).
  • Qazi, H.; Shi, Z-D.; Song, J.W.; Cancel, L.M. et al. "Abstract 5796: Heparan sulfate proteoglycans mediate tumor cell invasion and metastasis." in AACR Annual Meeting 2017. (1 2017).
  • Qazi, H.; Shi, Z-D.; Song, J.W.; Cancel, L.M. et al. "Heparan sulfate proteoglycans mediate tumor cell invasion and metastasis." (1 2017).

2016

  • Kloepper, J.; Riedemann, L.; Amoozgar, Z.; Seano, G. et al. "Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival." (7 2016).
  • Riedemann, L.; Kloepper, J.; Amoozgar, Z.; Seano, G. et al. "IMST-40. REPROGRAMMING OF THE TUMOR IMMUNE MICROENVIRONMENT BY AN ANG-2/VEGF BISPECIFIC ANTIBODY DELAYS TUMOR GROWTH AND PROLONGS SURVIVAL IN PRECLINICAL GBM MODELS." (1 2016).
  • Kloepper, J.; Riedemann, L.; Amoozgar, Z.; Seano, G. et al. "Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival." in AACR 107th Annual Meeting on Bioinformatics and Systems Biology. (7 2016).

2013

  • Song, J.W.; Bazou, D.; Munn, L.L. "Flow-mediated Vessel Guidance." in Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB). (4 2013).
  • Song, J.W.; Bazou, D.; Munn, L.L. "Flow-mediated Vessel Guidance." (4 2013).

2012

  • Song, J.W.; Munn, L.L. "Biomechanical Determinants of Endothelial Sprouting and Morphogenesis." (4 2012).
  • Song, J.W.; Munn, L.L. "Biomechanical Determinants of Endothelial Sprouting and Morphogenesis." in Experimental Biology Meeting. (4 2012).

2011

  • Song, J.W.; Munn, L.L. "Biomechanical Determinants of Endothelial Cell Sprouting in a Microfluidic Device." (4 2011).
  • Song, J.W.; Munn, L.L. "Biomechanical Determinants of Endothelial Cell Sprouting in a Microfluidic Device." in Experimental Biology Meeting 2011. (4 2011).

2010

  • Song, J.W.; Munn, L.L. "Microfluidic Platform for Reproducing Blood Vessel Microenvironment." (4 2010).
  • Song, J.W.; Munn, L.L. "Microfluidic Platform for Reproducing Blood Vessel Microenvironment." (4 2010).

2009

  • Takayama, S.; Huh, D.; Song, J.; Cha, W. et al. "Micro-and Nanofluidics for Cell Biology, Cell Therapy, and Cell-Based Drug Testing." (1 2009).

2005

  • Gu, W.; Zhu, X.Y.; Futai, N.; Song, J.W. et al. "Regulated culture and assays of cells using braille displays." (1 2005).
  • Gu, W.; Zhu, X.Y.; Futai, N.; Song, J.W. et al. "Regulated culture and assays of cells using braille displays." in 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences. (1 2005).

2004

  • Gu, W.; Zhu, X.; Futai, N.; Song, J.W. et al. "REGULATED CULTURE AND ASSAYS OF CELLS USING BRAILLE DISPLAYS." (1 2004).

Unknown

  • Rangharajan, K.K.; Akbari, E.; Spychalski, G.B.; Song, J.W. et al. "Angiogenesis on Chip (AoC): Structural Analogies for Fluid Mechanical Determinants of Endothelial Sprouting." in The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017).
  • Garg, A.A.; Jones, T.H.; Bushman, S.; Shuman, J. et al. "Inductive Electric Fields Directionally Hinder EGF-Gradient Promoted Breast Cancer Motlitiy in Biomimetic Microtracks." in The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017).

Patents

  • "Microfluidic cell culture media."