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Rengasayee Veeraraghavan

  • Assistant Professor, Biomedical Engineering
  • Assistant Professor
  • 333 W. 10th Ave
    Graves Hall
    Columbus, OH 43210

About

Education

  • B.Tech., Anna University, India, 2005
  • Ph.D., University of Utah, 2011

Key Honors and Distinctions

  • Ranked eleventh among all graduates in the B.Tech, Chemical Engineering Program, Anna University, India. (2005)
  • International Gap Junction Conference Travel Award (2011)
  • Travel Award, Gordon Research Conference on Cardiac Arrhythmia Mechanisms (2013)
  • The Clinical Research Award in Honor of Mark Josephson and Hein Wellens for 2013-14, Heart Rhythm Society (2013)
  • Postdoctoral Research Fellowship for 2013-15, American Heart Association (2013)
  • Best Oral Presentation Award, International Gap Junction Conference (2013)
  • Outstanding Postdoctoral Platform Presentation - Runner Up, Virginia Tech Carilion Research Institute Annual Retreat (2015)
  • Basic Cardiovascular Sciences Travel Grant, American Heart Association Scientific Sessions (2015)
  • George Palade Award for distinguished contributions to the field of microscopy and microanalysis in the life sciences, Microscopy Society of America (2017)
  • Young Investigator Award (Basic Science) from the Cardiac Electrophysiology Society (2017)

RESEARCH AREAS – Veeraraghavan Lab for Biomedical Engineering

  • Bioengineering; Cardiac Arrhythmia Mechanisms; Atrial Fibrillation; Super-resolution Microscopy; Quantitative Image Analysis
  • Graduate student and post-doctoral research opportunities are currently available.
  • PUBLICATIONS

 https://www.ncbi.nlm.nih.gov/sites/myncbi/1bGMZ5WJSqpAw/bibliography/45513136/public/?sort=date&direction=descending

  • PATENTS

Poelzing S, Veeraraghavan R, Smoot A, X-ray attenuating compositions and methods. U.S. Patent 8808668; filed April 2009.

Dr. Veeraraghavan’s research investigates the fundamental mechanisms of cardiac arrhythmias, atrial fibrillation in particular, using an array of structural and functional imaging tools that span scales from the single molecule to the whole organ. The lab’s research is driven by an engineering approach and aimed at simultaneously elucidating how the heart functions in health and in disease while developing novel peptide drugs to prevent life-threatening cardiac rhythm disturbances. Using this multi-pronged approach, he aims to uncover the mechanisms by which vascular dysfunction (and consequent cardiac edema) alters sodium channel-rich nanodomains within the cardiomyocyte intercalated disk and precipitates arrhythmogenic conduction defects. His work is supported by the American Heart Association.

 

 

Journal Articles

2018

  • Veeraraghavan, R.; Radwański, P.B., 2018, "Sodium channel clusters: harmonizing the cardiac conduction orchestra." Journal of Physiology 596, no. 4, 549-550 - 549-550.
  • Koleske, M.; Bonilla, I.; Thomas, J.; Zaman, N. et al., 2018, "Tetrodotoxin-sensitive Navs contribute to early and delayed afterdepolarizations in long QT arrhythmia models.." J Gen Physiol 150, no. 7, 991-1002 - 991-1002.

2017

  • Veeraraghavan, R.; Györke, S.; Radwański, P.B., 2017, "Neuronal sodium channels: emerging components of the nano-machinery of cardiac calcium cycling." Journal of Physiology 595, no. 12, 3823-3834 - 3823-3834.

2016

  • Veeraraghavan, R.; Lin, J.; Keener, J.P.; Gourdie, R. et al., 2016, "Potassium channels in the Cx43 gap junction perinexus modulate ephaptic coupling: an experimental and modeling study." Pflugers Archiv European Journal of Physiology 468, no. 10, 1651-1661 - 1651-1661.
  • Veeraraghavan, R.; Gourdie, R.G., 2016, "Stochastic optical reconstruction microscopy-based relative localization analysis (STORM-RLA) for quantitative nanoscale assessment of spatial protein organization." Molecular Biology of the Cell 27, no. 22, 3583-3590 - 3583-3590.
  • Radwanski, P.; Ho, H.T.; Veeraraghavan, R.; Brunello, L. et al., 2016, "Neuronal Na+ channels are integral components of pro-arrhytmic Na+/Ca2+ signaling nanodomain that promotes cardiac arrhyhmias during beta-adrenergic stimulation." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - BASIC AND TRANSLATIONAL SCIENCE 1,

2015

  • Veeraraghavan, R.; Lin, J.; Hoeker, G.S.; Keener, J.P. et al., 2015, "Sodium channels in the Cx43 gap junction perinexus may constitute a cardiac ephapse: an experimental and modeling study." Pflugers Archiv European Journal of Physiology 467, no. 10, 2093-2105 - 2093-2105.
  • Radwanski, P.; Brunello, L.; Veeraraghavan, R.; Ho, H.T. et al., 2015, "Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release.." Cardiovascular research 106, no. 1,

2014

  • Veeraraghavan, R.; Gourdie, R.G.; Poelzing, S., 2014, "Mechanisms of cardiac conduction: A history of revisions." American Journal of Physiology - Heart and Circulatory Physiology 306, no. 5,
  • Veeraraghavan, R.; Poelzing, S.; Gourdie, R.G., 2014, "Novel ligands for zipping and unzipping the intercalated disk: Today's experimental tools, tomorrow's therapies?." Cardiovascular Research 104, no. 2, 229-230 - 229-230.
  • Veeraraghavan, R.; Poelzing, S.; Gourdie, R.G., 2014, "Intercellular electrical communication in the heart: A new, active role for the intercalated disk." Cell Communication and Adhesion 21, no. 3, 161-167 - 161-167.
  • Veeraraghavan, R.; Poelzing, S.; Gourdie, R.G., 2014, "Old cogs, new tricks: A scaffolding role for connexin43 and a junctional role for sodium channels?." FEBS Letters 588, no. 8, 1244-1248 - 1244-1248.

2013

  • Veeraraghavan, R.; Larsen, A.P.; Torres, N.S.; Grunnet, M. et al., 2013, "Potassium channel activators differentially modulate the effect of sodium channel blockade on cardiac conduction." Acta Physiologica 207, no. 2, 280-289 - 280-289.
  • Rhett, J.M.; Veeraraghavan, R.; Poelzing, S.; Gourdie, R.G., 2013, "The perinexus: Sign-post on the path to a new model of cardiac conduction?." Trends in Cardiovascular Medicine 23, no. 6, 222-228 - 222-228.

2012

  • Veeraraghavan, R.; Salama, M.E.; Poelzing, S., 2012, "Interstitial volume modulates the conduction velocity-gap junction relationship." American Journal of Physiology - Heart and Circulatory Physiology 302, no. 1,

2010

  • Radwański, P.B.; Veeraraghavan, R.; Poelzing, S., 2010, "Cytosolic calcium accumulation and delayed repolarization associated with ventricular arrhythmias in a guinea pig model of Andersen-Tawil syndrome." Heart Rhythm 7, no. 10,

2008

  • Poelzing, S.; Smoot, A.F.; Veeraraghavan, R., 2008, "Novel x-ray attenuation mechanism: Role of interatomic distance." Medical Physics 35, no. 10, 4386-4395 - 4386-4395.
  • Veeraraghavan, R.; Poelzing, S., 2008, "Mechanisms underlying increased right ventricular conduction sensitivity to flecainide challenge." Cardiovascular Research 77, no. 4, 749-756 - 749-756.

2007

  • Poelzing, S.; Veeraraghavan, R., 2007, "Heterogeneous ventricular chamber response to hypokalemia and inward rectifier potassium channel blockade underlies bifurcated T wave in guinea pig." American Journal of Physiology - Heart and Circulatory Physiology 292, no. 6,

Unknown

  • Bonilla, I.; Koleske, M.; Thomas, J.; Zaman, N. et al., "TTX-sensitive Nav Contribute to Early and Delayed Afterdepolarizations in Long QT Arrhythmia Models." JOURNAL OF GENERAL PHYSIOLOGY
  • Raisch, T.B.; Yanoff, M.S.; Larsen, T.R.; Farooqi, M.A. et al., "Intercalated Disc Extracellular Nanodomain Expansion in Patients with Atrial Fibrillation." Frontiers in Physiology

Papers in Proceedings

2018

  • Greer-Short, A.; Hund, T.J.; Veeraraghavan, R. "Vascular Endothelial Growth Factor Acutely Elevates Atrial Fibrillation Risk in the Murine Heart." in Heart Rhythm 2018. (5 2018).
  • Greer-Short, A.; Hund, T.J.; Veeraraghavan, R. "Structural Changes in Sodium Channel-Rich Nanodomains Contribute to the Progression of Atrial Fibrillation." in Microscopy & Microanalysis 2018. (8 2018).

2017

  • Veeraraghavan, R.; Hoeker, G.S.; Wan, X.; Deschenes, I. et al. "Sodium Channel Auxiliary Subunit β1 -mediated Cell Adhesion: A Novel Target for Antiarrhythmic Therapy." in Heart Rhythm 2017. (1 2017).
  • Veeraraghavan, R.; Hoeker, G.S.; Alvarez-LAviada, A.; Wan, X. et al. "STORM and TEM Identify the Cardiac Ephapse: An Intercalated Disk Nanodomain with Previously Unanticipated Functions in Cardiac Conduction." in Microscopy & Microanalysis 2017. (1 2017).
  • Veeraraghavan, R.; Hoeker, G.S.; Poelzing, S.; Gourdie, R.G. "The Sodium Channel Auxiliary Subunit beta 1 is Structurally Critical for Cardiac Conduction: Evidence from the Single Molecule Scale to the Whole Organ." in Biophysical Society 61st Annual Meeting 2017. (2 2017).
  • Veeraraghavan, R.; Hoeker, G.S.; Poelzing, S.; Gourdie, R.G. "The Proarrhythmic Impact of Inhibiting the Cell Adhesion Functions of the Sodium Channel Auxiliary Subunit NaVβ1." in Gordon Research Conference on Cardiac Arrhythmia Mechanisms 2017. (1 2017).
  • Veeraraghavan, R. "Integrating Imaging Tools From Single Molecule to Whole Organ Scales to Investigate the Heart’s Structure and Function." in Microscopy & Microanalysis 2017: Pre-Meeting Congress for Students and Early-Career Professionals. (1 2017).

2016

  • Veeraraghavan, R.; Goourdie, R.G. "STORM-based Quantitative Assessment of Sodium Channel Localization Relative to Junctional Proteins within the Cardiac Intercalated Disk." in Microscopy & Microanalysis 2016. (1 2016).
  • Veeraraghavan, R.; Gourdie, R.G. "Novel Storm-Based Quantitative Assessment of Relative Protein Localization Reveals New Role for Sodium Channel beta 1 Subunit in Cardiac Conduction." in Biophysical Society 60th Annual Meeting 2016. (2 2016).
  • Veeraraghavan, R.; Gourdie, R.G. "Spatial Organization of Proteins: Above and Below Abbe’s Diffraction Limit." in Heart Rhythm 2016. (1 2016).
  • Veeraraghavan, R.; Gourdie, R.G. "Novel STORM-based Quantitative Nanoscale Assessment Reveals Two Pools of Sodium Channels Within the Cardiac Intercalated Disk." in American Heart Association 2016 Scientific Sessions. (11 2016).
  • Veeraraghavan, R.; Hoeker, G.S.; Poelzing, S.; Gourdie, R.G. "Acute Inhibition of Sodium Channel Beta Subunit (beta 1) -mediated Adhesion is Highly Proarrhythmic." in American Heart Association 2016 Scientific Sessions. (11 2016).

2015

  • Veeraraghavan, R.; Lin, J.; Keener, J.P.; Poelzing, S. et al. "Superresolution Microscopy Reveals Sodium Channel Localization within Intercalated Disk Microdomains: Implications for Ephaptic Coupling." in Biophysical Society 59th Annual Meeting 2015. (1 2015).
  • Veeraraghavan, R.; Ongstad, E.; Poelzing, S.; Gourdie, R.G. "Superresolution Microscopic Localization of Scn5a and Scn1b Subunits of the Sodium Channel Complex Within Intercalated Disk Microdomains: Implications for Ephaptic Coupling." in Gordon Research Conference on Cardiac Arrhythmia Mechanisms 2015. (1 2015).
  • Veeraraghavan, R.; Lin, J.T.; Keener, J.P.; Poelzing, S. et al. "Superresolution Studies of Sodium Channels Within Intercalated Disk Microdomains Suggest Novel Arrhythmia Mechanism." in American Heart Association Scientific Sessions 2015. (11 2015).
  • Veeraraghavan, R.; Ongstad, E.; George, S.; Poelzing, S. et al. "Can ephaptic coupling between fibroblasts and myocytes sustain conduction through a scar?." in 2015 Keystone Symposium: Cell Biology of the Heart: Beyond the Myocyte-Centric View. (1 2015).

2014

  • Veeraraghavan, R.; Lin, J.; Keener, J.P.; Gourdie, R.G. et al. "A Novel Role for Inward-rectifier Potassium Channels in Ephaptic Coupling." in Heart Rhythm 2014. (1 2014).
  • Veeraraghavan, R.; Lin, J.; Keener, J.P.; Gourdie, R.G. et al. "Anisotropic Conduction Slowing During Sodium Channel Blockade: A Role For Ephaptic Coupling?." in Cardiac Electrophysiology Society 2014 Annual Meeting. (1 2014).
  • Radwanski, P.; Veeraraghavan, R.; Knollmann, B.; Gyorke, S. "Two Distinct mechanisms by which Na+/Ca2+dysregulation contributes to Arrhythmogenic Diastolic Ca2+Release." in American Heart Association 2014 Annual Scientific Sessions. (11 2014).
  • Veeraraghavan, R.; Lin, J.; Keener, J.P.; Poelzing, S. et al. "Sodium Channels in the Cx43 Gap Junction Perinexus May Constitute a Cardiac Ephapse: An Experimental and Modeling Study." in Heart Rhythm 2014. (1 2014).

2013

  • Veeraraghavan, R.; Lin, J.; Keener, J.P.; Poelzing, S. et al. "Experimental Evidence that the Cx43 Gap Junction Perinexus Functions as a Cardiac Ephapse." in International Gap Junction Conference, 2013. (1 2013).
  • Veeraraghavan, R.; Lin, J.; Keener, J.P.; Gourdie, R.G. et al. "Sodium Channel Blockade Reveals Anisotropic Conduction Dependence on Ephaptic Coupling." in Heart Rhythm 2013. (1 2013).
  • Veeraraghavan, R.; Lin, J.; Keener, J.P.; Poelzing, S. et al. "Arrhythmogenic conduction slowing during edema is associated with selective widening of the perinexal sites within the intercalated disk." in Gordon Research Conference Conference on Cardiac Arrhythmia Mechanisms 2013. (1 2013).

2012

  • Veeraraghavan, R.; Lin, J.; Keener, J.P.; Poelzing, S. "Intercellular Uncoupling Unmasks Anisotropic Conduction Dependence on the Sodium Current." in Heart Rhythm 2012. (1 2012).
  • Veeraraghavan, R.; Lin, J.; Keener, J.P.; Poelzing, S. "A Novel Role for Ephaptic Coupling in Cardiac Conduction: An Experimental and Modeling Study." in Biophysical Society 56th Annual Meeting 2012. (1 2012).

2011

  • Veeraraghavan, R.; Poelzing, S. "Myocardial Interstitial Volume Modulates the Cardiac Conduction Velocity- Gap Junction Relationship." in International Gap Junction Conference 2011. (1 2011).
  • Veeraraghavan, R.; Larsen, A.P.; Poelzing, S. "Pharmacological IKs Activation Slows Cardiac Conduction and Exacerbates the Effect of INa Blockade." in Biophysical Society 55th Annual Meeting 2011. (2 2011).
  • Veeraraghavan, R.; Poelzing, S. "Gap Junctions and Cardiac Conduction: Is Edema the Missing Link?." in Gordon Research Conference on Cardiac Arrhythmia Mechanisms 2011. (1 2011).

2010

  • Veeraraghavan, R.; Poelzing, S. "Edema: A Missing Link in the Conduction Velocity-Gap Junction Relationship." in Biophysical Society 54th Annual Meeting 2010. (1 2010).
  • Veeraraghavan, R.; Poelzing, S. "Myocardial Edema Sensitizes Conduction to Gap Junction Uncoupling." in Heart Rhythm 2010. (1 2010).

2009

  • Radwanski, P.B.; Veeraraghavan, R.; Poelzing, S. "SERCA2a/NCX Ratio Determines Regional Propensity for Triggered Activity During Calcium Overload." in American Heart Association Scientific Sessions 2009. (11 2009).

2008

  • Radwanski, P.B.; Veeraraghavan, R.; Poelzing, S. "Heterogeneous Calcium Handling Modulates Spatio-Temporal Initiation of Premature Beats During Conditions of Calcium Overload." in American Heart Association Scientific Sessions 2008. (10 2008).
  • Radwanski, P.; Veeraraghavan, R.; Poelzing, S. "Pinacidil Reduces Interventricular Heterogeneities and Arrhythmia Inducibility During Loss of Inward Rectifier Potassium Channel Function." in 2008 ACCP Spring Practice and Research Forum. (1 2008).
  • Veeraraghavan, R.; Poelzing, S. "Edema Increases Conduction Anisotropy Heterogeneously Between the Left and Right Ventricles." in Annual Mountain West Biomedical Conference 2008. (1 2008).

2007

  • Veeraraghavan, R. "Heterogeneous Nav1.5 Distribution Between Ventricles Underlies Conduction Heterogeneities In the Brugada Syndrome." in 2007 Annual Mountain West Biomedical Conference. (1 2007).
  • Poelzing, S.; Veeraraghavan, R. "Heterogeneous Ventricular Chamber Response to Gap Junction Blockade." in 2007 International Gap Junction Conference. (1 2007).
  • Veeraraghavan, R.; Poelzing, S. "Interventricular Nav1.5 Heterogeneities Underlie Conduction Heterogeneities In the Brugada Syndrome." in Heart Rhythm 2007. (1 2007).

2006

  • Veeraraghavan, R.; Poelzing, S. "Heterogeneous SCN5A Distribution Between Ventricles Underlies Conduction Heterogeneities In the Brugada Syndrome." in Annual Mountain West Biomedical Conference 2006. (1 2006).
  • Poelzing, S.; Veeraraghavan, R. "Interventricular heterogeneities underlie electrophysiologic manifestations in Andersen-Tawil Syndrome (LQT7)." in American Heart Association Scientific Sessions 2006. (10 2006).

Patents

  • "Two Novel Methods for the Assessment of Relative Protein Localization from Three Dimensional Single Molecule Localization Data."
  • "Pharmacologic Targeting of Cell Adhesion to Modulate Conduction."
  • "Automatic Centerline Isolation and Continuous Width Measurements Between Two Edges."
  • "X-ray attenuating compositions and methods."