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Devina Purmessur, PhD

  • Assistant Professor, Biomedical Engineering
  • Dorothy Davis Heart and Lung Research Institute, Room 012L
    473 W 12th Avenue
    Columbus, OH 43210
  • 614-292-2731



  • B.S., University of Sheffield UK, 2001
  • M.S., University of Nottingham UK, 2003
  • Ph.D., University of Manchester UK, 2008


Key Honors and Distinctions

  • Arnold and Madaleine Penner 2nd Annual Musculoskeletal Repair and Regeneration Symposium Young Investigator Award, NY (2013)
  • Young Investigator-Member at Large for the Orthopaedic Research Society (2013-2015)
  • Rising Star/ New Investigator at the ORS PSRS 3rd International Philadelphia Spine Research Symposium, Thomas Jefferson University, PA (2015)


RESEARCH AREAS – Purmessur Spinal Therapeutics Lab (Spine Research Institute) (

  • Spinal Disorders; Translational 3D and Animal Model Systems; Intervertebral Disc;  Developmental biology; Mechanobiology; Molecular, Cell & Tissue Engineering;  
  • Graduate student research opportunities for Fall 2018


Dr. Purmessur’s research interests lie in understanding the pathophysiology of spinal disorders specifically examining discogenic back pain as an organ system; how the IVD and surrounding microenvironment (cellular, biochemical and mechanical) in development, growth and aging influence disease pathogenesis and pain with a focus on neurovascular ingrowth and developing suitable in vitro and clinically relevant in vivo animal models for clinical translation of therapeutic strategies. She has collaborations across departments and colleges within Ohio State which include Dr. William Marras, Professor in Integrated systems engineering and Director of the Spine Research Institute, Immunologist Dr. Megan Ballinger in the Department of Internal Medicine, clinicians in the Department of Orthopedics Drs. Safdar Khan, and Elizabeth Yu, and Veterinary neurosurgeon Dr. Sarah Moore. Dr. Purmessur’s work has received support either as a Principal Investigator or Co-Investigator from the National Institutes’ of Health, The Orthopedic Research Education Fund and the AO Foundation.

Journal Articles


  • Wiet, M.G.; Piscioneri, A.; Khan, S.N.; Ballinger, M.N. et al., 2017, "Mast Cell-Intervertebral disc cell interactions regulate inflammation, catabolism and angiogenesis in Discogenic Back Pain.." Sci Rep 7, no. 1, 12492 - 12492.




  • Cornejo,M,C; Cho,S,K; Giannarelli,C; Iatridis,J,C; Purmessur,D, 2015, "Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro-inflammatory cytokines." OSTEOARTHRITIS AND CARTILAGE 23, no. 3, 487-496 - 487-496.
  • Purmessur,Devina; Cornejo,Marisa,C; Cho,Samuel,K; Roughley,Peter,J; Linhardt,Robert,J; Hecht,Andrew,C; Iatridis,James,C, 2015, "Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability." SPINE JOURNAL 15, no. 5, 1060-1069 - 1060-1069.
  • Lai,Alon; Moon,Andrew; Purmessur,Devina; Skovrlj,Branko; Winkelstein,Beth,A; Cho,Samuel,K; Hecht,Andrew,C; Iatridis,James,C, 2015, "Assessment of Functional and Behavioral Changes Sensitive to Painful Disc Degeneration." JOURNAL OF ORTHOPAEDIC RESEARCH 33, no. 5, 755-764 - 755-764.


  • Guterl,Clare,C; Torre,Olivia,M; Purmessur,Devina; Dave,Khyati; Likhitpanichkul,Morakot; Hecht,Andrew,C; Nicoll,Steven,B; Iatridis,James,C, 2014, "Characterization of Mechanics and Cytocompatibility of Fibrin-Genipin Annulus Fibrosus Sealant with the Addition of Cell Adhesion Molecules." TISSUE ENGINEERING PART A 20, no. 17-18, 2536-2545 - 2536-2545.
  • Lu,Young; Guzman,Javier,Z; Purmessur,Devina; Iatridis,James,C; Hecht,Andrew,C; Qureshi,Sheeraz,A; Cho,Samuel,K, 2014, "Nonoperative Management of Discogenic Back Pain A Systematic Review." SPINE 39, no. 16, 1314-1324 - 1314-1324.
  • Illien-Juenger,Svenja; Lu,Young; Purmessur,Devina; Mayer,Jillian,E; Walter,Benjamin,A; Roughley,Peter,J; Qureshi,Sheeraz,A; Hecht,Andrew,C; Iatridis,James,C, 2014, "Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model." SPINE JOURNAL 14, no. 11, 2724-2732 - 2724-2732.


  • Abbott, R.D.; Purmessur, D.; Monsey, R.D.; Brigstock, D.R. et al., 2013, "Degenerative grade affects the responses of human nucleus pulposus cells to link-N, CTGF, and TGFβ3.." J Spinal Disord Tech 26, no. 3, E86-E94 - E86-E94.
  • Purmessur,Devina; Guterl,Clare,C; Cho,Samuel,K; Cornejo,Marisa,C; Lam,Ying,W; Ballif,Bryan,A; Laudier,Damien,M; Iatridis,James,C, 2013, "Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development." ARTHRITIS RESEARCH & THERAPY 15, no. 5, R122 - R122.
  • Purmessur,D; Cornejo,M,C; Cho,S,K; Hecht,A,C; Iatridis,J,C, 2013, "Notochordal cell-derived therapeutic strategies for discogenic back pain.." Global spine journal 3, no. 3, 201-218 - 201-218.


  • Richardson,Stephen,M; Purmessur,Devina; Baird,Pauline; Probyn,Ben; Freemont,Anthony,J; Hoyland,Judith,A, 2012, "Degenerate Human Nucleus Pulposus Cells Promote Neurite Outgrowth in Neural Cells." PLOS ONE 7, no. 10, e47735 - e47735.
  • Abbott,Rosalyn,Delia; Purmessur,Devina; Monsey,Robert,Daniel; Iatridis,James,Christopher, 2012, "Regenerative potential of TGF beta 3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells." JOURNAL OF ORTHOPAEDIC RESEARCH 30, no. 3, 482-488 - 482-488.


  • Walter,B,A; Korecki,C,L; Purmessur,D; Roughley,P,J; Michalek,A,J; Iatridis,J,C, 2011, "Complex loading affects intervertebral disc mechanics and biology." OSTEOARTHRITIS AND CARTILAGE 19, no. 8, 1011-1018 - 1011-1018.
  • Purmessur,Devina; Schek,Rachel,M; Abbott,Rosalyn,D; Ballif,Bryan,A; Godburn,Karolyn,E; Iatridis,James,C, 2011, "Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells." ARTHRITIS RESEARCH & THERAPY 13, no. 3, R81 - R81.


  • Iatridis,James,C; Michalek,A,J; Purmessur,D; Korecki,C,L, 2009, "Localized Intervertebral Disc Injury Leads to Organ Level Changes in Structure, Cellularity, and Biosynthesis." CELLULAR AND MOLECULAR BIOENGINEERING 2, no. 3, 437-447 - 437-447.


  • Purmessur,Devina; Freemont,Anthony,J; Hoyland,Judith,A, 2008, "Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc." ARTHRITIS RESEARCH & THERAPY 10, no. 4, R99 - R99.


  • Parker,S,M; Purmessur,D; Millward-Sadler,S,J; LeMaitre,C,L; Freemont,A,J; Hoyland,J,A, 2006, "The identification of large conductance potassium (MaxiK) channels in human intervertebral disc (IVD) cells." JOURNAL OF PATHOLOGY 210, 24-24 - 24-24.
  • Purmessur,D; Hoyland,J,A; Freemont,A,J, 2006, "Disc cell/neural cell interactions in the intervertebral disc (IVD) and their role in degeneration of the IVD." JOURNAL OF PATHOLOGY 210, 25-25 - 25-25.


  • Palacio-Mancheno, P.E.; Evashwick-Rogler, T.W.; Laudier, D.M.; Purmessur, D. et al., "Hyperosmolarity induces notochordal cell differentiation with aquaporin3 upregulation and reduced N-cadherin expression." Journal of Orthopaedic Research