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Devina Purmessur, PhD

  • Assistant Professor, Biomedical Engineering
  • Dorothy Davis Heart and Lung Research Institute, Room 012L
    473 W 12th Avenue
    Columbus, OH 43210
  • 614-292-2731

About

Education

  • B.S., University of Sheffield UK, 2001
  • M.S., University of Nottingham UK, 2003
  • Ph.D., University of Manchester UK, 2008

 

Key Honors and Distinctions

  • Arnold and Madaleine Penner 2nd Annual Musculoskeletal Repair and Regeneration Symposium Young Investigator Award, NY (2013)
  • Young Investigator-Member at Large for the Orthopaedic Research Society (2013-2015)
  • Rising Star/ New Investigator at the ORS PSRS 3rd International Philadelphia Spine Research Symposium, Thomas Jefferson University, PA (2015)

 

RESEARCH AREAS – Purmessur Spinal Therapeutics Lab (Spine Research Institute) (https://stl.engineering.osu.edu/)

  • Spinal Disorders; Translational 3D and Animal Model Systems; Intervertebral Disc;  Developmental biology; Mechanobiology; Molecular, Cell & Tissue Engineering;  
  • Graduate student research opportunities for Fall 2018

  • PUBLICATIONS

https://scholar.google.com/citations?user=Dv_ZlVoAAAAJ&hl=en

http://www.ncbi.nlm.nih.gov/sites/myncbi/14aNdsPIrsiQn/bibliography/4367...

Dr. Purmessur’s research interests lie in understanding the pathophysiology of spinal disorders specifically examining discogenic back pain as an organ system; how the IVD and surrounding microenvironment (cellular, biochemical and mechanical) in development, growth and aging influence disease pathogenesis and pain with a focus on neurovascular ingrowth and developing suitable in vitro and clinically relevant in vivo animal models for clinical translation of therapeutic strategies. She has collaborations across departments and colleges within Ohio State which include Dr. William Marras, Professor in Integrated systems engineering and Director of the Spine Research Institute, Immunologist Dr. Megan Ballinger in the Department of Internal Medicine, clinicians in the Department of Orthopedics Drs. Safdar Khan, and Elizabeth Yu, and Veterinary neurosurgeon Dr. Sarah Moore. Dr. Purmessur’s work has received support either as a Principal Investigator or Co-Investigator from the National Institutes’ of Health, The Orthopedic Research Education Fund and the AO Foundation.

Journal Articles

2016

  • Lai,Alon; Moon,Andrew; Purmessur,Devina; Skovrlj,Branko; Laudier,Damien,M; Winkelstein,Beth,A; Cho,Samuel,K; Hecht,Andrew,C; Iatridis,James,C, 2016, "Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo." SPINE JOURNAL 16, no. 3, 420 - 431.
  • Marras,William,S; Walter,Benjamin,A; Purmessur,Devina; Mageswaran,Prasath; Wiet,Matthew,G, 2016, "The Contribution of Biomechanical-Biological Interactions of the Spine to Low Back Pain." HUMAN FACTORS 58, no. 7, 965 - 975.
  • Walter,B,A; Purmessur,D; Moon,A; Occhiogrosso,J; Laudier,D,M; Hecht,A,C; Iatridis,J,C, 2016, "REDUCED TISSUE OSMOLARITY INCREASES TRPV4 EXPRESSION AND PRO-INFLAMMATORY CYTOKINES IN INTERVERTEBRAL DISC CELLS." EUROPEAN CELLS & MATERIALS 32, 123 - 136.

2015

  • Cornejo,M,C; Cho,S,K; Giannarelli,C; Iatridis,J,C; Purmessur,D, 2015, "Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro-inflammatory cytokines." OSTEOARTHRITIS AND CARTILAGE 23, no. 3, 487 - 496.
  • Purmessur,Devina; Cornejo,Marisa,C; Cho,Samuel,K; Roughley,Peter,J; Linhardt,Robert,J; Hecht,Andrew,C; Iatridis,James,C, 2015, "Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability." SPINE JOURNAL 15, no. 5, 1060 - 1069.
  • Walter,Benjamin,A; Purmessur,Devina; Likhitpanichkul,Morakot; Weinberg,Alan; Cho,Samuel,K; Qureshi,Sheeraz,A; Hecht,Andrew,C; Iatridis,James,C, 2015, "Inflammatory Kinetics and Efficacy of Anti-inflammatory Treatments on Human Nucleus Pulposus Cells." SPINE 40, no. 13, 955 - 963.
  • Lai,Alon; Moon,Andrew; Purmessur,Devina; Skovrlj,Branko; Winkelstein,Beth,A; Cho,Samuel,K; Hecht,Andrew,C; Iatridis,James,C, 2015, "Assessment of Functional and Behavioral Changes Sensitive to Painful Disc Degeneration." JOURNAL OF ORTHOPAEDIC RESEARCH 33, no. 5, 755 - 764.

2014

  • Illien-Juenger,Svenja; Lu,Young; Purmessur,Devina; Mayer,Jillian,E; Walter,Benjamin,A; Roughley,Peter,J; Qureshi,Sheeraz,A; Hecht,Andrew,C; Iatridis,James,C, 2014, "Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model." SPINE JOURNAL 14, no. 11, 2724 - 2732.
  • Illien-Jünger,Svenja; Lu,Young; Purmessur,Devina; Mayer,Jillian,E; Walter,Benjamin,A; Roughley,Peter,J; Qureshi,Sheeraz,A; Hecht,Andrew,C; Iatridis,James,C, 2014, "Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model.." spine journal 14, no. 11, 2724 - 2732.
  • Guterl,Clare,C; Torre,Olivia,M; Purmessur,Devina; Dave,Khyati; Likhitpanichkul,Morakot; Hecht,Andrew,C; Nicoll,Steven,B; Iatridis,James,C, 2014, "Characterization of Mechanics and Cytocompatibility of Fibrin-Genipin Annulus Fibrosus Sealant with the Addition of Cell Adhesion Molecules." TISSUE ENGINEERING PART A 20, no. 17-18, 2536 - 2545.
  • Lu,Young; Guzman,Javier,Z; Purmessur,Devina; Iatridis,James,C; Hecht,Andrew,C; Qureshi,Sheeraz,A; Cho,Samuel,K, 2014, "Nonoperative Management of Discogenic Back Pain A Systematic Review." SPINE 39, no. 16, 1314 - 1324.

2013

  • Abbott,Rosalyn,D; Purmessur,Devina; Monsey,Robert,D; Brigstock,David,R; Laudier,Damien,M; Iatridis,James,C, 2013, "Degenerative Grade Affects the Responses of Human Nucleus Pulposus Cells to Link-N, CTGF, and TGF beta 3." JOURNAL OF SPINAL DISORDERS & TECHNIQUES 26, no. 3, E86 - E94.
  • Purmessur,Devina; Guterl,Clare,C; Cho,Samuel,K; Cornejo,Marisa,C; Lam,Ying,W; Ballif,Bryan,A; Laudier,Damien,M; Iatridis,James,C, 2013, "Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development." ARTHRITIS RESEARCH & THERAPY 15, no. 5, R122 -
  • Purmessur,D; Walter,B,A; Roughley,P,J; Laudier,D,M; Hecht,A,C; Iatridis,James, 2013, "A role for TNF alpha in intervertebral disc degeneration: A non-recoverable catabolic shift." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 433, no. 1, 151 - 156.
  • Purmessur,D; Cornejo,M,C; Cho,S,K; Hecht,A,C; Iatridis,J,C, 2013, "Notochordal cell-derived therapeutic strategies for discogenic back pain.." Global spine journal 3, no. 3, 201 - 218.

2012

  • Abbott,Rosalyn,Delia; Purmessur,Devina; Monsey,Robert,Daniel; Iatridis,James,Christopher, 2012, "Regenerative potential of TGF beta 3 + Dex and notochordal cell conditioned media on degenerated human intervertebral disc cells." JOURNAL OF ORTHOPAEDIC RESEARCH 30, no. 3, 482 - 488.
  • Richardson,Stephen,M; Purmessur,Devina; Baird,Pauline; Probyn,Ben; Freemont,Anthony,J; Hoyland,Judith,A, 2012, "Degenerate Human Nucleus Pulposus Cells Promote Neurite Outgrowth in Neural Cells." PLOS ONE 7, no. 10, e47735 -

2011

  • Walter,B,A; Korecki,C,L; Purmessur,D; Roughley,P,J; Michalek,A,J; Iatridis,J,C, 2011, "Complex loading affects intervertebral disc mechanics and biology." OSTEOARTHRITIS AND CARTILAGE 19, no. 8, 1011 - 1018.
  • Purmessur,Devina; Schek,Rachel,M; Abbott,Rosalyn,D; Ballif,Bryan,A; Godburn,Karolyn,E; Iatridis,James,C, 2011, "Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells." ARTHRITIS RESEARCH & THERAPY 13, no. 3, R81 -

2009

  • Iatridis,James,C; Michalek,A,J; Purmessur,D; Korecki,C,L, 2009, "Localized Intervertebral Disc Injury Leads to Organ Level Changes in Structure, Cellularity, and Biosynthesis." CELLULAR AND MOLECULAR BIOENGINEERING 2, no. 3, 437 - 447.

2008

  • Purmessur,Devina; Freemont,Anthony,J; Hoyland,Judith,A, 2008, "Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc." ARTHRITIS RESEARCH & THERAPY 10, no. 4, R99 -

2006

  • Purmessur,D; Hoyland,J,A; Freemont,A,J, 2006, "Disc cell/neural cell interactions in the intervertebral disc (IVD) and their role in degeneration of the IVD." JOURNAL OF PATHOLOGY 210, 25 - 25.
  • Parker,S,M; Purmessur,D; Millward-Sadler,S,J; LeMaitre,C,L; Freemont,A,J; Hoyland,J,A, 2006, "The identification of large conductance potassium (MaxiK) channels in human intervertebral disc (IVD) cells." JOURNAL OF PATHOLOGY 210, 24 - 24.