- Professor, Chemical & Biomolecular Eng
- Professor, Biomedical Engineering
151 W Woodruff Ave
Columbus, OH 43210
- B.S., Northwestern University, 1997
- M.S., University of Texas at Austin, 2001
- Ph.D., University of Texas at Austin, 2004
Key Honors and Distinctions
- Established leader in nanobiotechnology through the development of magnetic quantum dots for cell and molecular separations.
- Invited by National Science Foundation's Office of Legislative and Public Affairs to share her quantum dots imaging innovation with 200 congressional staff members at "Arc of Science: Research to Results," Washington, DC, 2017.
- Faculty Diversity Excellence Award, The Ohio State University College of Engineering, 2016
- AIMBE College of Fellows, 2016
- Top Forty Under Forty list, Business First, 2015
- Elected Fellow, American Association for the Advancement of Science, 2015
- Women Chemists Rising Star Award, American Chemical Society, 2014
- Inventor of the Year, TechColumbus Innovation Awards, 2013
- OSU Early Innovator Award, 2012
- OSU Distingsuihed Undergraduate Research Mentor, 2011
- OSU Lumley Research Award, 2010
- Elected Senior Member of IEEE, 2009
- ACS Progress/Dreyfus Lectureship Award, 2008
- Nanobiotechnology, Cell and Tissue Engineering, Neural Prosthetics.
- Graduate student research opportunities are currently available.
- PUBLICATIONS AND PATENTS
- Google Scholar citations
"Biology is not simply writing information; it is doing something about it. A biological system can be exceedingly small. Many of the cells are very tiny, but they are very active; they manufacture various substances; they walk around; they wiggle; and they do all kinds of marvelous things---all on a very small scale. Also, they store information. Consider the possibility that we too can make a thing very small which does what we want---that we can manufacture an object that maneuvers at that level!" --Richard P. Feynman, "There is Plenty of Room at the Bottom"
Professor Winter's primary research interest is the exploration of the relationship between nanoparticles and biological elements.
This work is divided into three areas:
- Development of nanoscale neural prosthetic devices
- Patterned chemical and physical cues for improved neural adhesion and synapse formation
- Creation of oriented, nanopatterned surfaces using biological elements
Nanoscale Neural Prosthetics
The nerve cell is a fascinating model system for subcellular manipulation because it responds to chemical, mechanical, and electrical cues. Neurons have been integrated with electronic components to create hybrid electronic devices that have been used for computation, neuroscience research, and as prosthetics. Adding nanoscale manipulation to those devices will provide new insight into the biomolecular basis of disease, allow for biosensors that might detect a single molecule, harness neural networks for computation, and lead to prosthetic devices that integrate with their hosts at the cellular-level. The first area focuses on the development of nanocomponents to directly manipulate the contents of nerve cells. My initial work in this area examines the selective binding of nanoparticles to subcellular structures (i.e., ion channels, neurotransmitters, and chemical-containing vesicles). It is straightforward to attach nanoparticles to the surface of cells, but targeting specific elements in the cell's interior is more challenging. The majority of nanoparticles introduced into the cytoplasm (the fluid inside of a cell) are eventually sequestered into endosomes or lysosomes, preventing their interaction with intracellular proteins. I am exploring alternative delivery and targeting methods using techniques developed for gene therapy.
Patterning for Neural Adhesion and Synapse Formation
There is a substantial body of evidence that nanometer spacing of chemical sequences of physical patterns can effect cellular gene expression, adhesion, and migration. I am investigating the effects of nano-patterned physical and chemical cues on neuron-neuron and neuron-electrode interactions. I am particularly interested in patterns which enhance physical and electrical interfaces among nerve cells and underlying electronic devices. This technology has the potential to greatly increase the sensitivity of nerual recording devices, biosensors, and prosthetics.
The third area examines one of the most critical problems facing nanotechnology: how do we organize and arrange objects at the nanoscale? Nature has created several elegant schemes to organize elements in this size regime. For example, protein folding, DNA replication, and transport along microtubules all occur with remarkable fidelity. I am exploiting some of these methods to create "bio-inspired" surfaces. These surfaces use biomolecules to assemble and manipulate nanoparticles into coherent structures. Ultimately these structures may serve as tissue engineering substrates, biomaterial coatings, or as elements of electronic devices.
American Institute of Medical and Biological Engineers Fellow. AIMBE.
Cancer Today, Cover Story. AACR.
Diversity Award. College of Engineering.
Engineering Rising Star. Engineering Design News Golden Mousetrap Awards.
40 Under 40. Columbus Business First.
20 People to Know in Technology. Columbus Business First.
Women Chemists Rising Star Award. American Chemical Society.
AAAS Fellow. American Association for the Advancement of Science.
Heaven-and-Earth Distinguished Lecture. College of Engineering, Nanjing University.
Top 25 STEM Professors in Ohio. Online Schools Ohio.
COE Harrison Award. College of Engineering, The Ohio State University.
Senior Member Status. American Institute of Chemical Engineers (AIChE).
TechColumbus Inventor of the Year. TechColumbus.
Archer Award. Ohio STEM Ability Alliance.
Semi-finalist Columbus Tech Innovation Awards, Woman in Technology. TechColumbus.
Semi-Finalist Innovator of the Year. Columbus Tech Innovation Awards.
Ohio State University Early Innovator Award. The Ohio State University.
Distinguished Undergraduate Research Mentor. Denman Research Forum.
David C. McCarthy Engineering Teaching Award. College of Engineering.
COE Lumley Research Award. College of Engineering.
Senior Member Status. IEEE Society.
Outstanding Undergraduate Achievement Mentor. The Ohio State University.
ACS Progress/Dreyfus Lectureship Award. American Chemical Society.
OSU Office of Technology Enhanced Learning and Research (TELR) Professional Development Grant (OSU). The Ohio State University.
NSF Graduate Research Fellowship. National Science Foundation.
MRS Gold Graduate Student Award. Materials Research Society.
Graduate Student Award. Biomedical Engineering Society.
IGERT Graduate Research Fellowship. University of Texas at Austin.
Rom Rhome Endowment for Professional Development in Material Science Travel Award. University of Texas at Austin.
IGERT Travel Award. University of Texas at Austin.
- K.D. Mahajan, G. Ruan, C.J. Dorcena, G. Nabar, G. Vieira, N. Bouxsein, J.J. Chalmers, G.D. Bachand, R. Sooryakumar, J.O. Winter, 2016, "Steering Microtubule Shuttle Transport with Dynamically Controlled Magnetic Fields." Nanoscale 8, 8641 - 8649.
- Grodecki,Joseph; Short,Aaron,R; Winter,Jessica,O; Rao,Shreyas,S; Winter,Jessica,O; Otero,Jose,Javier; Lannutti,John,J; Sarkar,Atom, 2015, "Glioma-astrocyte interactions on white matter tract-mimetic aligned electrospun nanofibers." BIOTECHNOLOGY PROGRESS 31, no. 5, 1406 - 1415.
- Short,Aaron,R; Koralla,Deepthi; Deshmukh,Ameya; Wissel,Benjamin; Stocker,Benjamin; Calhoun,Mark; Dean,David; Winter,Jessica,O, 2015, "Hydrogels that allow and facilitate bone repair, remodeling, and regeneration." JOURNAL OF MATERIALS CHEMISTRY B 3, no. 40, 7818 - 7830.
- Duong,Anthony,D; Ruan,Gang; Mahajan,Kalpesh; Winter,Jessica,O; Wyslouzil,Barbara,E, 2014, "Scalable, Semicontinuous Production of Micelles Encapsulating Nanoparticles via Electrospray." LANGMUIR 30, no. 14, 3939 - 3948.
- A.D. Duong, G. Ruan, K. Mahajan, J.O. Winter, B.E. Wyslouzil, 2014, "Scalable, semi-continuous production of micelles encapsulating nanoparticles via electrospray." Langmuir 30, no. 14, 3939 - 3948.
- S.S. Rao, J.J. Lannutti, M.S. Viapiano, A. Sarkar, J.O. Winter, 2014, "Toward 3D Biomimetic Models to Understand the Behavior of Glioblastoma Multiforme Cells.." Tissue Engineering Part B Reviews. 20, no. 4, 314 - 327.
- Nelson,Mark,Tyler; Short,Aaron; Cole,Sara,L; Gross,Amy,C; Winter,Jessica; Eubank,Tim,D; Lannutti,John,J, 2014, "Preferential, enhanced breast cancer cell migration on biomimetic electrospun nanofiber 'cell highways'." BMC CANCER 14, 825 -
- J. Xu, Q. Fan, K.D. Mahajan, G. Ruan, A. Herrington, K.F. Tehrani, P. Kner, J.O. Winter, 2014, "Micelle-templated composite quantum dots for super-resolution imaging." Nanotechnology 25, no. 19, 195601 -
- Rao, S.S., J.J. Lannutti, M.S. Viapiano, A. Sarkar, J.O. Winter, 2014, "Toward 3D Biomimetic Models to Understand the Behavior of Glioblastoma Multiforme Cells." Tissue Engineering Part B Reviews 20, no. 4, 314 - 327.
- Nabar, G., J.O. Winter (Invited), 2014, "Tunable Self-Assembly of Block Copolymer-Nanoparticle Composites for Nanomedicine." Chemical Engineering Progress 51, 1 -
- Nelson, M.T. , A. Short, S.L. Cole, A.C. Gross, J. Winter, T.D. Eubank, J.J. Lannutti Preferential, 2014, "Enhanced Breast Cancer Cell Migration on Biomimetic Electrospun Nanofiber 'Cell Highways'." BMC Cancer 14, no. 825, 1 -
- C.J. Dorcena, K.M Olesik, O.G Wetta, J.O. Winter, 2013, "Characterization and Toxicity of Carbon Dot-Poly(lactic-co-glycolic acid) Nanocomposites for Biomedical Imaging." Nano LIFE 3, no. 1, 1340002 -
- N. Han, P. Bradley, J. Johnson, K.S. Parikh, A. Hissong, J.J. Lannutti, J.O. Winter, 2013, "Effects of Hydrophobicity and Mat Thickness on Release from Hydrogel-Electrospun Fiber Mat Composites." Journal of Biomaterials Science, Polymer Edition 24, no. 17, 2018 - 30.
- K.D. Mahajan, Q. Fan, J. DorcÃ©na, G. Ruan, J.O. Winter, 2013, "Magnetic Quantum Dots in Biotechnology- Synthesis and Applications." Biotechnology Journal 8, 1424 - 1434.
- S.S. Rao, T.M. Nelson, R. Xue, J.K. DeJesus, M.S. Viapiano, J.J. Lannutti, A. Sarkar, J.O. Winter, 2013, "Mimicking white matter tract topography using core-shell electrospun nanofibers to examine migration of malignant brain tumors." Biomaterials 34, no. 11, 5181 - 90.
- Rao,Shreyas,S; Dejesus,Jessica; Short,Aaron,R; Otero,Jose,J; Sarkar,Atom; Winter,Jessica,O, 2013, "Invited: Glioblastoma Behaviors in Three-Dimensional Collagen-Hyaluronan Composite Hydrogels." ACS APPLIED MATERIALS & INTERFACES 5, no. 19, 9276 - 9284.
- K.D. Mahajan, G. Vieira, G. Ruan, B.L. Miller, M. Lustberg, J.J. Chalmers, R. Sooryakumar, J.O. Winter, 2012, "MagDot-Nanoconveyer Assay for Detection and Isolation of Molecular Biomarkers." Chemical Engineering Progress December 2012, 41 - 51.
- S.S. Rao, S. Bentil, J. DeJesus, J. Larison†, A. Hissong†, R. Dupaix, A. Sarkar, J.O. Winter, 2012, "Inherent Interfacial Mechanical Gradients in 3D Hydrogels Influence Tumor Cell Behaviors." PloS One 7, no. 4, e35852 -
- K.S. Parikh, S.S. Rao, H. Ansari, L.B. Zimmerman, L.J. Lee, S.A. Akbar, J.O. Winter, 2012, "Ceramic Nanopatterned Surfaces to Explore the Effects of Nanotopography on Cell Attachment." Materials Science and Engineering C 32, 2469–2475 -
- G. Ruan, J.O. Winter, 2012, "Chemical Engineering at the Intersection of Nanotechnology and Biology." Chemical Engineering Progress December 2012, 36 - 40.
- Xu,Jie; Mahajan,Kalpesh; Xue,Wei; Winter,Jessica,O; Zborowski,Maciej; Chalmers,Jeffrey,J, 2012, "Simultaneous, single particle, magnetization and size measurements of micron sized, magnetic particles." Journal of Magnetism and Magnetic Materials 324, no. 24, 4189 - 4199.
- N. Han, J. Johnson, P. Bradley, K.S. Parikh, J.J. Lannutti, J.O. Winter, 2012, "Cell Attachment to Hydrogel-Electrospun Fiber Mat Composite Materials." Journal of Functional Biomaterials 3, no. 3, 497 - 513.
- Han,Ning; Johnson,Jed; Lannutti,John,J; Winter,Jessica,O, 2012, "Hydrogel-electrospun fiber composite materials for hydrophilic protein release.." Journal of controlled release : official journal of the Controlled Release Society 158, no. 1, 165 - 170.
- Rao,Shreyas,S; Bentil,Sarah; Dejesus,Jessica; Larison,John; Hissong,Alex; Dupaix,Rebecca; Sarkar,Atom; Winter,Jessica,O, 2012, "Inherent Interfacial Mechanical Gradients in 3D Hydrogels Influence Tumor Cell Behaviors." PLOS ONE 7, no. 4, e35852 -
- G. Ruan, J.O. Winter, 2011, "Alternating-color Quantum Dot Nanocomposites for Particle Tracking." Nano Letters 11, no. 3, 941 - 945.
- S.S. Rao, N. Han, J.O. Winter, 2011, "Polylysine-Modified PEG-Based Hydrogels to Enhance the Neuro-Electrode Interface." JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 22, 611 - 625.
- Han,Ning; Rao,Shreyas,S; Johnson,Jed; Parikh,Kunal,S; Bradley,Patrick,A; Lannutti,John,J; Winter,Jessica,O, 2011, "Hydrogel-electrospun fiber mat composite coatings for neural prostheses.." Frontiers in neuroengineering 4, no. 2, 1 - 8.
- G. Ruan, D. Thakur, S. Deng, S. Hawkins, J.O. Winter, 2011, "Fluorescent-magnetic nanoparticles for imaging and cell manipulation." Journal of Nanoengineering and Nanosystems 223, no. N3/4, 81 - 86.
- G. Ruan, G. Vieira, D. Thakur, T. Henighan, A. Chen, R. Sooryakumar, J.O. Winter, 2010, "Simultaneous Magnetic Manipulation and Fluorescent Tracking of Single Sub-100 nm Nanoparticles.." Nano Letters 10, no. 6, 2220 - 2224.
- S. Deng, G. Ruan, N. Han, J.O. Winter, 2010, "Interactions in Fluorescent-Magnetic Heterodimer Nanocomposites." Nanotechnology 21, no. 14, 145605 -
- S.S. Rao, J.O. Winter, 2009, "Adhesion molecule-modified biomaterials for neural tissue engineering.." Frontiers In Neuroengineering 2, no. 6, 1 - 14.
- D. Thakur, S. Deng, T. Baldet, J.O. Winter, 2009, "pH Sensitive CdS-Iron Oxide Fluorescent-Magnetic Nanocomposites." Nanotechnology 20, no. 48, 485601 -
- N.A. Kotov, J.O. Winter, I.P. Clements, E. Jan, B.P. Timko, S. Campidelli, S. Pathak, A. Mazzatenta, C.M. Lieber, M. Prato, R.V. Bellamkonda, G.A. Silva, N.W. Shi Kam, F. Patolsky, L. Ballerini, 2009, Nanomaterials for Neural Interfaces. Advanced Materials 21, no. 40, 3970 - 4004.
- 17. J.O. Winter*, M. Gokhale, R.J. Jensen, S.F. Cogan, J.F. Rizzo, III, 2008, "Tissue Engineering Applied to the Retinal Prosthesis: Neurotrophin-Eluting Polymeric Hydrogel Coatings." Materials Science and Engineering C 28, no. 3, 448 - 453.
- J.O. Winter, M. Gokhale, R.J. Jensen, S.F. Cogan, J.F. Rizzo, 3rd, 2008, "Tissue Engineering Applied to the Retinal Prosthesis: Neurotrophin-Eluting Polymeric Hydrogel Coatings." Materials Science and Engineering C 28, no. 3, 448 - 453.
- Winter,Jessica,O; Cogan,Stuart,F; Rizzo,Joseph,F, 2007, "Neurotrophin-Eluting Hydrogel Coatings for Neural Stimulating Electrodes." Journal of Biomedical Materials Research. Part B, Applied Biomaterials 81, no. 2, 551 - 563.
- Winter,Jessica,O; Cogan,Stuart,F; Rizzo,Joseph,F, 2007, "Retinal prostheses: current challenges and future outlook." JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 18, no. 8, 1031 - 1055.
- Winter,Jessica,O; Cogan,Stuart,F; Rizzo,Joseph,F, 2007, "Neurotrophin-eluting hydrogel coatings for neural stimulating electrodes." JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 81B, no. 2, 551 - 563.
- Gomez,N; Winter,J,O; Shieh,F; Saunders,A,E; Korgel,B,A; Schmidt,C,E, 2005, "Challenges in Quantum Dot-Neuron Active Interfacing.." Talanta 67, no. 3, 462 - 471.
- Winter,J,O; Gomez,N; Gatzert,S; Schmidt,C,E; Korgel,B,A, 2005, "Variation of cadmium sulfide nanoparticle size and photoluminescence intensity with altered aqueous synthesis conditions." COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 254, no. 1-3, 147 - 157.
- J.O. Winter, T.Y. Liu, B.A. Korgel, C.E. Schmidt, 2001, "Recognition Molecule Directed Interfacing Between Semiconductor Quantum Dots and Nerve Cells." Advanced Materials 13, no. 22, 1673 - 1677.
- S.S. Rao, J. DeJesus, A. Sarkar, J.O. Winter, "Investigating Glioblastoma Behaviors in 3D using Hyaluronan-Collagen Blend Hydrogels." Integrative Biology
- J.O. Winter, G. Ruan. "Centrifugation-assisted Magnetic Separation of Magnetic Nanoparticles, and Methods of Use."
- J.O. Winter, D. Thakur. "Biocompatible fluorescent carbon nanoparticles from carbon black, and Formulations Thereof, and Methods of Use."
- J.O. Winter, G. Ruan. "Nanocontainers of Block Copolymer Micelles to Co-encapsulate Multiple Types of Nanospecies, and Formulations Thereof, and Methods of Use." Patent number: 61/483,091
- B. Wyslouzil, J.O. Winter, T. Doug, G. Ruan. "Semi-continuous, Large Scale Production Process of Sub-100 nm Hybrid Nanoparticles by Electrospray Coupled with Self-assembly."
- J.O. Winter and G. Ruan. "Non-Blinking and Color-Changing Nanoparticles for Single Particle Tracking."
- J.O. Winter, K. Mahajan, G. Ruan. "Method to Use Self-assembly to Fabricate Polymeric Nanoparticles with Sub-100 nm Size, Narrow Size Distribution, Controllable Shape, and Versatile Molecular Release Kinetics, and the Resultant Nanodevice." Patent number: 61/433,794
- J.O. Winter, R. Sooryakumar, K. Mahajan, G. Vieira, G. Ruan, A. Chen. "One pot separation and analysis of biomarkers by nano-conveyor belts."
- J.O. Winter, K. Mahajan, G. Ruan, A. Duong, B. Wyslouzil. "Methods for Producing Nanoparticles and Using Same."
- J.O. Winter, H. Chander. "Nanopatterned Contact Lenses to Promote Corneal Wound Healing."
- J.O. Winter, K. Mahajan, Q. Fan. "An engineered nanofactory for reversible nanoassembly and transport."
- J.O. Winter, G. Ruan, Q. Fan. "Quantum Dot Light Switches: Photo-switchable quantum dots based on light-modulated fluorescence resonant energy transfer."