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Ronald Xu

  • Associate Professor, Ophthalmology
  • Associate Professor, Biomedical Engineering
  • 286 Bevis Hall
    1080 Carmack Road
    Columbus, OH 43210
  • 614-688-3635

Honors

  • 2011

    Inventor of the Year. .

  • 2010

    R & D "Superstar". .

  • 2009

    Herman R. Weed Excellence in Teaching Award. .

  • 2006

    National Eye Institute Travel Award. .

Chapters

2010

  • Ronald Xu. 2010. "Chapter 17: Selected topics in biomedical engineering." In Intelligent Energy Field Manufacturing, edited by Wenwu Zhang, 447-467 - 447-467.

Journal Articles

2016

  • 2016, "Ultrasound-mediated destruction of oxygen and paclitaxel loaded lipid microbubbles for combination therapy in hypoxic ovarian cancer cells.." Ultrason Sonochem 28,
  • 2016, "Multi-scale hyperspectral imaging of cervical neoplasia.." Archives of gynecology and obstetrics 293, no. 6,

2015

  • 2015, "Second derivative multispectral algorithm for quantitative assessment of cutaneous tissue oxygenation." JOURNAL OF BIOMEDICAL OPTICS 20, no. 3,
  • 2015, "Ultrasound-mediated destruction of paclitaxel and oxygen loaded lipid microbubbles for combination therapy in ovarian cancer xenografts.." Cancer Lett 361, no. 1,
  • 2015, "Microencapsulation of indocyanine green for potential applications in image-guided drug delivery.." Lab Chip 15, no. 3,

2014

  • 2014, "A high-throughput quantification method of curcuminoids and curcumin metabolites in human plasma via high-performance liquid chromatography/tandem mass spectrometry.." J Chromatogr B Analyt Technol Biomed Life Sci 949-950,
  • 2014, "Author's reply to the reader's comment on "designing a wearable navigation system for image-guided cancer resection surgery".." Ann Biomed Eng 42, no. 12,
  • Guangbin Li, Xisheng Luo, Ting Si, Ronald X. Xu, 2014, Temporal instability of coflowing liquid-gas jets under an electric field. Physics of Fluids 26, 054101 - 054101.
  • Shao, P., Ding, H., Wang, J., Liu, P., Ling, Q., Chen, J., Xu, J., Zhang, S., Xu, R., 2014, Designing a wearable navigation system for image-guided cancer resection surgery. Ann Biomed Eng 42, no. 11, 2228-37 - 2228-37.
  • 2014, "Ultrasound-mediated destruction of LHRHa-targeted and paclitaxel-loaded lipid microbubbles for the treatment of intraperitoneal ovarian cancer xenografts.." Mol Pharm 11, no. 1,
  • 2014, "Ultrasound-mediated destruction of LHRHa-targeted and paclitaxel-loaded lipid microbubbles induces proliferation inhibition and apoptosis in ovarian cancer cells.." Mol Pharm 11, no. 1,

2013

2012

  • Xu,Ronald,X; Allen,David,W; Huang,Jiwei; Gnyawali,Surya; Melvin,James; Elgharably,Haytham; Gordillo,Gayle; Huang,Kun; Bergdall,Valerie; Litorja,Maritoni; Rice,Joseph,P; Hwang,Jeeseong; Sen,Chandan,K, 2012, "Developing digital tissue phantoms for hyperspectral imaging of ischemic wounds." BIOMEDICAL OPTICS EXPRESS 3, no. 6, 1433-1445 - 1433-1445.
  • 2012, "Coaxial electrospray of microparticles and nanoparticles for biomedical applications.." Expert Rev Med Devices 9, no. 6,
  • 2012, "Indocyanine-green-loaded microballoons for biliary imaging in cholecystectomy.." J Biomed Opt 17, no. 11,

2011

  • Ronald Xu, Jeff Xu, Tao Zuo, Rulong Shen, Tim Huang, Michael Tweedle, 2011, Drug-loaded biodegradable microspheres for image-guided combinatory epigenetic therapy. Journal of Biomedical Optics 16, no. 2, 020507 - 020507.
  • Xu,Ronald,X; Xu,Jeff,S; Zuo,Tao; Shen,Rulong; Huang,Tim,H; Tweedle,Michael,F, 2011, "Drug-loaded biodegradable microspheres for image-guided combinatory epigenetic therapy in cells." JOURNAL OF BIOMEDICAL OPTICS 16, no. 2, 020507 - 020507.
  • 2011, "Multifunctional microbubbles and nanobubbles for photoacoustic imaging.." Contrast Media Mol Imaging 6, no. 5,

2010

2009

2008

2007

2005

  • 2005, "Localization and functional parameter reconstruction of suspicious breast lesions by near infrared/ultrasound dual modal imaging." 2005 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-7
  • 2005, "Near infrared imaging of tissue heterogeneity: Probe design and sensitivity analysis." 2005 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-7

2004

2001

1999

Unknown

  • P. Shao, H. Ding, J. Wang, P. Liu, Q. Ling, J. Chen, J. Xu, S. Zhang and R. Xu,, Designing a Wearable Navigation System for Image-Guided Cancer Resection Surgery. Annals of Biomedical Engineering
  • Ronald X. Xu, Kun Huang, Ruogu Qin, Jiwei Huang, Jeff S. Xu, Liya Ding, Urmila S. Gnyawali, Gayle Gordillo, Surya C. Gnyawali, and Chandan K. Sen, "Dual-mode imaging of cutaneous tissue oxygenation and tissue vascular thermal reactivity." Journal of Visualized Experiments
  • Shiwu Zhang, Surya C. Gnyawali, Jiwei Huang, Wenqi Ren, Gayle Gordillo, Chandan Sen, Ronald X. Xu, "Multimodal imaging of cutaneous wound tissue." Journal of Biomedical Optics
  • Ting Si, Hanxin Feng, Xisheng Luo, Ronald X. Xu, Formation of steady compound cone-jet modes and multilayered droplets in a tri-axial capillary flow focusing device. Microfluidics and Nanofluidics
  • Wenqi Ren, Qi Gan, Qiang Wu, Shiwu Zhang, Ronald Xu, "Simultaneous multimodal imaging of cutaneous tissue oxygenation and perfusion." Journal of Biomedical Optics
  • Shiwu Zhang, Surya Gnyawali, Jiwei Huang, Wenqi Ren, Gayle Gordillo, Chandan K. Sen, Ronald Xu, "Multimodal imaging of cutaneous wound tissue." Journal of Biomedical Optics

Presentations

  • "Near Infrared Tissue Oximetry and Its Clinical Applications." 2004,
  • "Brain Functional Study by Near Infrared Light and Ultrasound." 2005,
  • "Biomedical Engineering for a Mechanical Engineer." 2005,
  • "Near Infrared Imaging of Tissue Structure and Function." 2006,
  • "Biomedical Imaging and Tissue Oximetry by Near Infrared Light." 2006,
  • "Multimodal Dynamic Imaging for Wound Assessment." 2007,
  • "Multimodal dynamic imaging of biological tissue." 2008,
  • "Gold nanoparticle assisted light activation of heat-sensitive nanobubbles for photothermal therapy." 2010,
  • "Developing multifunctional tissue simulating phantoms for quantitative biomedical optical imaging." 2010,
  • Innovations in Wound Imaging. 2010,
  • "Structural and Functional Imaging by Near Infrared Light." 2006,
  • "Non-invasive, Real Time Monitoring of Cortical and RetinaTissue Physiology During Visual Stimulation." 2006,
  • "Biomedical Optical Imaging Lab at OSU BME." 2006,
  • "NIR oximetry." 2007,
  • "Multimodal, dynamic, intraoperative imaging of cancer." 2008,
  • "Multimodal dynamic imaging of cancer." 2008,
  • "Multimodal imaging for wound assessment and healing." 2009,
  • "Multispectral Quantitative Optical Imaging of Biological Tissue." 2009,
  • "Accelerating the clinical translation of Optical Medical Imaging (OMI)." 2009,
  • "Optical imaging of cutaneous tissue oxygen and vascular function." 2010,
  • "Multifunctional active agents for image-guided cancer therapy." 2010,
  • "Biomedical Imaging by Near Infrared Light." 2005,
  • "Multimodality imaging platform to characterize mechanical andphysiological characteristics of biological tissue." 2006,
  • "Non-invasive, Multi-modal Imaging of Tissue Oxygen Dynamics." 2007,
  • "Intraoperative, Multimodal, Dynamic Imaging of Cancer." 2007,
  • "Optical imaging in multimodal platforms for preoperative, intraoperative, and postoperative assessment of surgical margins and occult disease in the cancer patient." 2007,
  • "Near Infrared Spectroscopy for Assessment of Cortical Function." 2008,
  • "Intra-operative detection of ablation margin in minimally invasive cancer surgery." 2009,
  • "Integrated schema for multimodal, dynamic, intraoperative cancer imaging and therapy." 2009,
  • "Multimodal theranostics: an integrated engineering platform for clinical imaging and therapy." 2009,
  • "Multifunctional theranostics." 2009,
  • Multi-Modal Wound Imaging: Prospects of the Future. 2009,
  • "Multimodal intraoperative imaging of cancer." 2009,
  • "Multimodal Imaging and Image-guided Therapy in Cancer." 2010,
  • "Multimodal, intraoperative cancer imaging with microbubbles and antibody-fluorophore conjugates." 2008,
  • "Optical imaging in multimodal platforms for preoperative, intraoperative, and postoperative assessment of surgical margins and occult disease in the cancer patient." 2008,
  • "Near infrared diffuse optical imaging and spectroscopy." 2008,
  • "Clinical Applications for In Vivo, Multi-modal, Dynamic Imaging of Biological Tissue." 2008,
  • "Multimodal imaging of cancer." 2009,

Papers in Proceedings

2012

  • Si,Ting; Zhang,Leilei; Li,Guangbin; Roberts,Cynthia,J; Jia,Laibing; Yin,Xiezhen; Xu,Ronald "Coaxial electrospray for multimodal imaging and image-guided therapy." in Conference on Multimodal Biomedical Imaging VII. (1 2012). 82160M - 82160M.
  • Gnyawali,Surya,C; Elghrably,Haytham; Melvin,James; Huang,Kun; Bergdall,Valerie; Allen,David,W; Hwang,Jeeseong; Litorja,Maritoni; Shirley,Eric; Sen,Chandan,K; Xu,Ronald "Hyperspectral imaging of ischemic wounds." in Conference on Optical Diagnostics and Sensing XII - Toward Point-of-Care Diagnostics / 4th Meeting of the Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissues. (1 2012). 822910 - 822910.
  • Huang,Jiwei; Xu,Jeff,S; Schmidt,Carl; Xu,Ronald,X "Heat sensitive microbubbles for intraoperative assessment of cancer ablation margin." in Conference on Multimodal Biomedical Imaging VII. (1 2012). 821604 - 821604.
  • "Hyperspectral imaging of ischemic wounds." (1 2012).
  • Zhang,Leilei; Yan,Yan; Mena,Joshua; Sun,Jingjing; Letson,Alan; Roberts,Cynthia; Zhou,Chuanqing; Chai,Xinyu; Ren,Qiushi; Xu,Ronald "Electrospray of multifunctional microparticles for image-guided drug delivery." in Conference on Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV. (1 2012). 823303 - 823303.

2010

  • "Targeted delivery of cancer-specific multimodal contrast agents for intraoperative detection of tumor boundaries and therapeutic margins." in Conference on Design and Quality for Biomedical Technologies III. (1 2010).
  • Xu,Ronald; Xu,Jeff; Qin,Ruogu; Huang,Jiwei "Developing multifunctional tissue simulating phantoms for quantitative biomedical optical imaging." in Conference on Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurements of Tissue II. (1 2010). 75670K - 75670K.
  • Qin,Ruogu; Xu,Jeff; Xu,Ronald; Kim,Chulhong; Wang,Lihong,V "Fabricating multifunctional microbubbles and nanobubbles for concurrent ultrasound and photoacoustic imaging." in Conference on Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurements of Tissue II. (1 2010). 75670L - 75670L.
  • "Fabricating multifunctional microbubbles and nanobubbles for concurrent ultrasound and photoacoustic imaging." (5 2010).
  • Ruogu Qin, Jiwei Huang, Jeff S. Xu, Liya Ding, Surya Gnyawali, Chandan K. Sen, Kun Huang, and Ronald X. Xu* Dual-mode quantitative imaging of wound tissue oxygenation and perfusion. in Proc. SPIE. http://spiedigitallibrary.org/vsearch/servlet/VerityServlet?KEY=SPIEDL&possible1=Gnyawali%2C+Surya&possible1zone=author&maxdisp=25&smode=strresults&pjournals=OPEGAR%2CJBOPFO%2CPSISDG%2CJEIME5%2CJMMMGF, (1 2010). 75570J - 75570J.
  • "Developing multifunctional tissue simulating phantoms for quantitative biomedical optical imaging." (5 2010).
  • R. Xu*, J.S. Xu, J. Huang, M.F. Tweedle, C. Schmidt, S.P. Povoski, and E.W. Martin "Targeted delivery of cancer-specific multimodal contrast agents for intraoperative detection of tumor boundaries and therapeutic margins." in Proc. SPIE.. (1 2010). 7551-28 - 7551-28.
  • Leilei Zhang, Jeff Xu, Jiwei Huang, Cynthia Roberts, Ronald Xu* "Bevacizumab (Avastin) conjugated microbubbles for anti-VEGF treatment of neovascular age-related macular degeneration." in Proc. SPIE. (1 2010). 7550-61 - 7550-61.
  • "Dual-mode quantitative imaging of wound tissue oxygenation and perfusion." (5 2010).
  • Zhang,Leilei; Xu,Jeff; Huang,Jiwei; Roberts,Cynthia; Xu,Ronald "Bevacizumab (Avastin) conjugated microbubbles for anti-VEGF treatment of neovascular age-related macular degeneration." in Conference on Ophthalmic Technologies XX. (1 2010). 75501P - 75501P.
  • Xu,Ronald,X; Xu,Jeff,S; Huang,Jiwei; Tweedle,Michael,F; Schmidt,Carl; Povoski,Stephen,P; Martin,Edward,W "Targeted delivery of cancer-specific multimodal contrast agents for intraoperative detection of tumor boundaries and therapeutic margins." in Conference on Design and Quality for Biomedical Technologies III. (1 2010). 75560T - 75560T.

2007

  • Nasser Kashou*, Ronald Xu, Cynthia Roberts, Larwence Leguire "Using FMRI and FNIRS for localization and monitoring of visual cortex activities." in 29th International Conference of the IEEE Engineering in Medicine and Biology Society. (1 2007).

2006

2005

  • Ronald Xu*, Bo Qiang, and Jun Liu Ultrasound-guided near-infrared spectroscopy for brain functional study: feasibility analysis and preliminary work. in Proc. SPIE. http://spiedigitallibrary.org/getpdf/servlet/GetPDFServlet?filetype=pdf&id=PSISDG005686000001000464000001&idtype=cvips, (1 2005). 464-472 - 464-472.
  • B. Qiang, A. Rana, and R. Xu* "Reconstruction of tissue heterogeneity by near infraredimaging: a novel algorithm and benchtop validation." in Conf Proc IEEE Eng Med Biol Soc. (1 2005). 3137-3140 - 3137-3140.
  • R. Xu*, B. Qiang, J. Olsen, S. Povoski, L. Yee, and J. Mao "Localization and functional parameter reconstruction of suspicious breast lesions by near infrared/ultrasound dualmodal imaging." in Conf Proc IEEE Eng Med Biol Soc. (1 2005). 4473-4476 - 4473-4476.

Patents

  • Edward Martin, Ronald Xu, Duxin Sun, Stephen Povoski, Joseph Heremans, Robert Lee, Vish Subramaniam. "Fluorescence Detection System." Patent number: WO2009/089543 A3
  • Edward Martin, Ronald Xu, Duxin Sun, Stephen Povoski, Joseph Heremans, Robert Lee, Vish Subramaniam. "Fluorescence Detection System." Patent number: US2009/0234227 A1
  • Chandan Sen, Ronald Xu. "Wound goggles." Patent number: US2010/0113940
  • Chandan Sen, Ronald Xu. "Wound goggles." Patent number: EP2319414
  • Ronald Xu, Cynthia Roberts, Leilei Zhang. "Multi-functional biodegradable paraticles for selectable targeting, imaging, and therapeutic delivery and use thereof for treating ocular disorders." Patent number: WO2011/053803
  • Ronald Xu, Cynthia Roberts, Leilei Zhang. "Multi-functional biodegradable paraticles for selectable targeting, imaging, and therapeutic delivery and use thereof for treating ocular disorders." Patent number: 0104069
  • Ronald Xu, Robert Lee, Abdul Rana, Stephen Povoski. "Dynamic near infrared/ultrasound dual modal imaging for tissue structure and function." Patent number: 60/760,640
  • Ronald Xu, Jeff Xu, Jiwei Huang. "Targeted delivery of heat-sensitive nanobubbles and microbubbles for the assessment of thermal ablation margins in bresat cancer and other malignancies."
  • Ronald Xu, Joseph Heremans, Robert Lee, Edward Martin, Stephen Povoski, Vish Subramanian, and Duxin Sun. "Fluorescence Detection System." Patent number: 60/020,345
  • Ronald Xu, Cynthia Roberts, Leilei Zhang. "Targeted delivery of biodegradable multifunctional nanoparticles for integrated imaging and therapy of age-related macular degeneration."
  • Michael Tweedle, Ronald Xu. "Tumor Therapy with Heat Burst Micro Capsules."