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Ronald Xu

  • Associate Professor, Ophthalmology
  • Associate Professor, Biomedical Engineering
  • 286 Bevis Hall
    1080 Carmack Road
    Columbus, OH 43210
  • 614-688-3635

About

Education

  • B.S., University of Science and Technolog of China, 1992
  • M.S., University of New York at Stony Brook, 1995
  • Ph.D., Massachusetts Institute of Technology, 1999

 

Key Honors and Distinctions

  • Fellow of Institute of Physics (2015)
  • Senior member of SPIE (2015)
  • Lumley Research Award (2015)
  • TechColumbus “Inventor of the Year” (2011).
  • R & D "Superstar" in Columbus CEO Magazine (2010)
  • Herman R. Weed Excellence in Teaching Award (2009)
  • National Eye Institute/ARVO Travel Award (2006).

 

RESEARCH AREAS – Smith Lab for Biomedical Engineering

  • Medical device design; tissue optics; multimodal imaging; 3D printing; microencapsulation; drug delivery. 
  • Graduate student research opportunities are currently available.

 

  • PUBLICATIONS

Xu, J., S. Yuan, J. Tian, K.A. Martin, J. Song, C. Li, Z. Wang, J. Lin, T. Si, and R.X. Xu*, Ultrasound mediated delivery of oxygen and LLL12 loaded stimuli responsive microdroplets for the treatment of hypoxic cancer cells. Sci Rep, 2017. 7: p. 44908.https://www.ncbi.nlm.nih.gov/pubmed/28322306

Zhang, Z., J. Pei, D. Wang, Q. Gan, J. Ye, J. Yue, B. Wang, S.P. Povoski, E.W. Martin, Jr., C.L. Hitchcock, A. Yilmaz, M.F. Tweedle, P. Shao, and R.X. Xu, A Wearable Goggle Navigation System for Dual-Mode Optical and Ultrasound Localization of Suspicious Lesions: Validation Studies Using Tissue-Simulating Phantoms and an Ex Vivo Human Breast Tissue Model. PLoS One, 2016. 11(7): p. e0157854.http://www.ncbi.nlm.nih.gov/pubmed/27367051

Si, T., C. Yin, P. Gao, G. Li, H. Ding, X. He, B. Xie, and R.X. Xu, Steady cone-jet mode in compound-fluidic electro-flow focusing for fabricating multicompartment microcapsules. Applied Physics Letters, 2016(108): p. 021601.http://scitation.aip.org/content/aip/journal/apl/108/2/10.1063/1.4939632

Gan, Q., D. Wang, J. Ye, Z. Zhang, X. Wang, C. Hu, P. Shao, and R.X. Xu, Benchtop and Animal Validation of a Projective Imaging System for Potential Use in Intraoperative Surgical Guidance. PLoS One, 2016. 11(7): p. e0157794.http://www.ncbi.nlm.nih.gov/pubmed/27391764

Yuan, S., F. Lei, Z. Liu, Q. Tong, T. Si, and R.X. Xu, Coaxial Electrospray of Curcumin-Loaded Microparticles for Sustained Drug Release. PLoS One, 2015. 10(7): p. e0132609.http://www.ncbi.nlm.nih.gov/pubmed/26208167

Si, T., H. Feng, X. Luo, and R.X. Xu, Formation of steady compound cone-jet modes and multilayered droplets in a tri-axial capillary flow focusing device. Microfluidics and Nanofluidics, 2015. 18(5): p. 967-977.http://link.springer.com/article/10.1007%2Fs10404-014-1486-8

Zhang, L., T. Si, A.J. Fischer, A. Letson, S. Yuan, C.J. Roberts, and R.X. Xu, Coaxial Electrospray of Ranibizumab-Loaded Microparticles for Sustained Release of Anti-VEGF Therapies. PLoS One, 2015. 10(8): p. e0135608.http://www.ncbi.nlm.nih.gov/pubmed/26273831

Zhu, Z., T. Si, and R.X. Xu, Microencapsulation of indocyanine green for potential applications in image-guided drug delivery. Lab Chip, 2015. 15(3): p. 646-9.http://www.ncbi.nlm.nih.gov/pubmed/25450664

Shao, P., H. Ding, Z. Zhang, J. Wang, and R.X. Xu, Author's Reply to the Reader's Comment on "Designing a Wearable Navigation System for Image-Guided Cancer Resection Surgery". Ann Biomed Eng, 2014. 42(12): p. 2602-2603.http://www.ncbi.nlm.nih.gov/pubmed/25323571

Xu, R.X., D.W. Allen, J. Huang, S. Gnyawali, J. Melvin, H. Elgharably, G. Gordillo, K. Huang, V. Bergdall, M. Litorja, J.P. Rice, J. Hwang, and C.K. Sen, Developing digital tissue phantoms for hyperspectral imaging of ischemic wounds. Biomed Opt Express, 2012. 3(6): p. 1433-45.http://www.ncbi.nlm.nih.gov/pubmed/22741088

Xu, J.S., J. Huang, R. Qin, G.H. Hinkle, S.P. Povoski, E.W. Martin, and R.X. Xu, Synthesizing and binding dual-mode poly (lactic-co-glycolic acid) (PLGA) nanobubbles for cancer targeting and imaging. Biomaterials, 2010. 31(7): p. 1716-22.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dop...

Huang, J., J.S. Xu, and R.X. Xu, Heat-sensitive microbubbles for intraoperative assessment of cancer ablation margins. Biomaterials, 2010. 31(6): p. 1278-86.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dop...

 

 

Our research program focuses on the design, synthesis, and characterization of polymeric biomaterials. A major focus of our work is... Our approach utilizes... [paragraph summary of your research program]

Our mission is to bridge the gap between clinical needs and engineering advances by developing multimodal imaging systems and multifunctional theranostic agents for intraoperative imaging and image-guided therapy. 
Multimodal imaging (including dual-mode imaging) represents the seamless integration of multiple imaging modalities into a single unit for simultaneous detection of various tissue parameters. Traditional biomedical imaging tools use static single modality to target limited disease markers. Each modality contributes to only a small

 

 

Honors

  • February, 2011

    Inventor of the Year.

  • January, 2010

    R & D "Superstar".

  • January, 2009

    Herman R. Weed Excellence in Teaching Award.

  • January, 2006

    National Eye Institute Travel Award.

Chapters

2010

  • 2010. "Chapter 17: Selected topics in biomedical engineering." In Intelligent Energy Field Manufacturing, edited by Wenwu Zhang,

Journal Articles

2017

  • Tian, J.; Xiao, H.; Wu, R.; Cao, Y. et al., 2017, "The Antiproliferative and Colony-suppressive Activities of STAT3 Inhibitors in Human Cancer Cells Is Compromised Under Hypoxic Conditions.." Anticancer Res 37, no. 2, 547-553 - 547-553.
  • Ma, R.; Wu, Q.; Si, T.; Chang, S. et al., 2017, "Oxygen and Indocyanine Green loaded microparticles for dual-mode imaging and sonodynamic treatment of cancer cells." Ultrasonics Sonochemistry 39, 197-207 - 197-207.

2016

  • Wang, C.; Zheng, W.; Bu, Y.; Chang, S. et al., 2016, "Multi-scale hyperspectral imaging of cervical neoplasia.." Arch Gynecol Obstet 293, no. 6, 1309-1317 - 1309-1317.
  • Sun, J.; Yin, M.; Zhu, S.; Liu, L. et al., 2016, "Ultrasound-mediated destruction of oxygen and paclitaxel loaded lipid microbubbles for combination therapy in hypoxic ovarian cancer cells.." Ultrason Sonochem 28, 319-326 - 319-326.
  • Chang, S.; Si, T.; Zhang, S.; Merrick, M.A. et al., 2016, "Ultrasound mediated destruction of multifunctional microbubbles for image guided delivery of oxygen and drugs.." Ultrason Sonochem 28, 31-38 - 31-38.

2015

  • Ren, W.; Gan, Q.; Wu, Q.; Zhang, S. et al., 2015, "Quasi-simultaneous multimodal imaging of cutaneous tissue oxygenation and perfusion.." J Biomed Opt 20, no. 12, 121307 - 121307.
  • Zhang, S.; Gnyawali, S.; Huang, J.; Ren, W. et al., 2015, "Multimodal imaging of cutaneous wound tissue." Journal of Biomedical Optics 20, no. 1,
  • Xu, L.; Zhang, S.; Jiang, N.; Xu, R., 2015, "A hybrid force model to estimate the dynamics of curved legs in granular material." Journal of Terramechanics 59, 59-70 - 59-70.
  • Wang, H.; Agarwal, P.; Zhao, S.; Xu, R.X. et al., 2015, "Hyaluronic acid-decorated dual responsive nanoparticles of Pluronic F127, PLGA, and chitosan for targeted co-delivery of doxorubicin and irinotecan to eliminate cancer stem-like cells." Biomaterials 72, 74-89 - 74-89.
  • Wu, Q.; Ren, W.; Yu, Z.; Dong, E. et al., 2015, "Microfabrication of polydimethylsiloxane phantoms to simulate tumor hypoxia and vascular anomaly." Journal of Biomedical Optics 20, no. 12,
  • Si, T.; Feng, H.; Luo, X.; Xu, R.X., 2015, "Formation of steady compound cone-jet modes and multilayered droplets in a tri-axial capillary flow focusing device." MICROFLUIDICS AND NANOFLUIDICS 18, no. 5-6, 967-977 - 967-977.
  • Huang, J.; Zhang, S.; Gnyawali, S.; Sen, C.K. et al., 2015, "Second derivative multispectral algorithm for quantitative assessment of cutaneous tissue oxygenation.." J Biomed Opt 20, no. 3, 036001 - 036001.
  • Liu, L.; Chang, S.; Sun, J.; Zhu, S. et al., 2015, "Ultrasound-mediated destruction of paclitaxel and oxygen loaded lipid microbubbles for combination therapy in ovarian cancer xenografts.." Cancer Lett 361, no. 1, 147-154 - 147-154.
  • Zheng, W.; Wang, C.; Chang, S.; Zhang, S. et al., 2015, "Hyperspectral wide gap second derivative analysis for in vivo detection of cervical intraepithelial neoplasia.." J Biomed Opt 20, no. 12, 121303 - 121303.
  • Yuan, S.; Lei, F.; Liu, Z.; Tong, Q. et al., 2015, "Coaxial Electrospray of Curcumin-Loaded Microparticles for Sustained Drug Release.." PLoS One 10, no. 7, e0132609 - e0132609.
  • Zhang, Y.; Chang, S.; Sun, J.; Zhu, S. et al., 2015, "Targeted Microbubbles for Ultrasound Mediated Short Hairpin RNA Plasmid Transfection to Inhibit Survivin Gene Expression and Induce Apoptosis of Ovarian Cancer A2780/DDP Cells." Molecular Pharmaceutics 12, no. 9, 3137-3145 - 3137-3145.
  • Zhang, L.; Si, T.; Fischer, A.J.; Letson, A. et al., 2015, "Coaxial Electrospray of Ranibizumab-Loaded Microparticles for Sustained Release of Anti-VEGF Therapies.." PLoS One 10, no. 8, e0135608 - e0135608.

2014

  • Shao, P.; Ding, H.; Zhang, Z.; Wang, J. et al., 2014, "Author's reply to the reader's comment on "designing a wearable navigation system for image-guided cancer resection surgery".." Ann Biomed Eng 42, no. 12, 2602-2603 - 2602-2603.
  • Zhu, Z.; Si, T.; Xu, R., 2014, Microencapsulation of indocyanine green for potential applications in image-guided drug delivery. Lab Chip 15,
  • Shao, P.; Ding, H.; Wang, J.; Liu, P. et al., 2014, "Designing a wearable navigation system for image-guided cancer resection surgery.." Ann Biomed Eng 42, no. 11, 2228-2237 - 2228-2237.
  • Pu, C.; Chang, S.; Sun, J.; Zhu, S. et al., 2014, "Ultrasound-mediated destruction of LHRHa-targeted and paclitaxel-loaded lipid microbubbles for the treatment of intraperitoneal ovarian cancer xenografts.." Mol Pharm 11, no. 1, 49-58 - 49-58.
  • Liu, H.; Chang, S.; Sun, J.; Zhu, S. et al., 2014, "Ultrasound-mediated destruction of LHRHa-targeted and paclitaxel-loaded lipid microbubbles induces proliferation inhibition and apoptosis in ovarian cancer cells.." Mol Pharm 11, no. 1, 40-48 - 40-48.
  • Cao, Y.; Xu, R.X.; Liu, Z., 2014, "A high-throughput quantification method of curcuminoids and curcumin metabolites in human plasma via high-performance liquid chromatography/tandem mass spectrometry.." J Chromatogr B Analyt Technol Biomed Life Sci 949-950, 70-78 - 70-78.
  • Li, G.; Luo, X.; Si, T.; Xu, R.X., 2014, "Temporal instability of coflowing liquid-gas jets under an electric field." PHYSICS OF FLUIDS 26, no. 5,

2013

  • Chang, S.; Guo, J.; Sun, J.; Zhu, S. et al., 2013, "Targeted microbubbles for ultrasound mediated gene transfection and apoptosis induction in ovarian cancer cells.." Ultrason Sonochem 20, no. 1, 171-179 - 171-179.
  • Si, T.; Zhang, L.; Li, G.; Roberts, C.J. et al., 2013, "Experimental design and instability analysis of coaxial electrospray process for microencapsulation of drugs and imaging agents.." J Biomed Opt 18, no. 7, 075003 - 075003.

2012

  • Zhang, L.; Huang, J.; Si, T.; Xu, R.X., 2012, "Coaxial electrospray of microparticles and nanoparticles for biomedical applications.." Expert Rev Med Devices 9, no. 6, 595-612 - 595-612.
  • Mitra, K.; Melvin, J.; Chang, S.; Park, K. et al., 2012, "Indocyanine-green-loaded microballoons for biliary imaging in cholecystectomy.." J Biomed Opt 17, no. 11, 116025 - 116025.
  • Xu, R.X.; Allen, D.W.; Huang, J.; Gnyawali, S. et al., 2012, "Developing digital tissue phantoms for hyperspectral imaging of ischemic wounds.." Biomed Opt Express 3, no. 6, 1433-1445 - 1433-1445.

2011

  • Xu, R.X.; Xu, J.S.; Zuo, T.; Shen, R. et al., 2011, "Drug-loaded biodegradable microspheres for image-guided combinatory epigenetic therapy in cells.." J Biomed Opt 16, no. 2, 020507 - 020507.
  • Xu, R.X., 2011, "Multifunctional microbubbles and nanobubbles for photoacoustic imaging.." Contrast Media Mol Imaging 6, no. 5, 401-411 - 401-411.

2010

  • Huang, J.; Xu, J.S.; Xu, R.X., 2010, "Heat-sensitive microbubbles for intraoperative assessment of cancer ablation margins.." Biomaterials 31, no. 6, 1278-1286 - 1278-1286.
  • Xu, J.S.; Huang, J.; Qin, R.; Hinkle, G.H. et al., 2010, "Synthesizing and binding dual-mode poly (lactic-co-glycolic acid) (PLGA) nanobubbles for cancer targeting and imaging.." Biomaterials 31, no. 7, 1716-1722 - 1716-1722.
  • Xu, R.X.; Povoski, S.P.; Martin, E.W., 2010, "Targeted delivery of microbubbles and nanobubbles for image-guided thermal ablation therapy of tumors.." Expert Rev Med Devices 7, no. 3, 303-306 - 303-306.
  • Zou, P.; Povoski, S.P.; Hall, N.C.; Carlton, M.M. et al., 2010, "124I-HuCC49deltaCH2 for TAG-72 antigen-directed positron emission tomography (PET) imaging of LS174T colon adenocarcinoma tumor implants in xenograft mice: preliminary results.." World J Surg Oncol 8, 65 - 65.
  • Zhang, L.; Xu, J.S.; Sanders, V.M.; Letson, A.D. et al., 2010, "Multifunctional microbubbles for image-guided antivascular endothelial growth factor therapy.." J Biomed Opt 15, no. 3, 030515 - 030515.
  • Xu, R.X.; Huang, K.; Qin, R.; Huang, J. et al., 2010, "Dual-mode imaging of cutaneous tissue oxygenation and vascular function.." J Vis Exp no. 46,
  • El-Dahdah, H.; Wang, B.; He, G.; Xu, R.X., 2010, "An automatic occlusion device for remote control of tumor tissue ischemia.." Technol Cancer Res Treat 9, no. 1, 71-76 - 71-76.
  • Kim, C.; Qin, R.; Xu, J.S.; Wang, L.V. et al., 2010, "Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging.." J Biomed Opt 15, no. 1, 010510 - 010510.

2009

  • Povoski, S.P.; Jimenez, R.E.; Wang, W.P.; Xu, R.X., 2009, "Standardized and reproducible methodology for the comprehensive and systematic assessment of surgical resection margins during breast-conserving surgery for invasive breast cancer.." BMC Cancer 9, 254 - 254.
  • Xu, R.X.; Sachs, E., 2009, "Rapid Thermal Cycling with Low Thermal Inertia Tools." POLYMER ENGINEERING AND SCIENCE 49, no. 2, 305-316 - 305-316.
  • Zou, P.; Xu, S.; Povoski, S.P.; Wang, A. et al., 2009, "Near-infrared fluorescence labeled anti-TAG-72 monoclonal antibodies for tumor imaging in colorectal cancer xenograft mice.." Mol Pharm 6, no. 2, 428-440 - 428-440.
  • Xu, R.X.; Huang, J.; Xu, J.S.; Sun, D. et al., 2009, "Fabrication of indocyanine green encapsulated biodegradable microbubbles for structural and functional imaging of cancer.." J Biomed Opt 14, no. 3, 034020 - 034020.

2008

  • Wang, B.; Povoski, S.P.; Cao, X.; Sun, D. et al., 2008, "Dynamic schema for near infrared detection of pressure-induced changes in solid tumors.." Appl Opt 47, no. 16, 3053-3063 - 3053-3063.
  • Xu, R.X.; Ewing, J.; El-Dahdah, H.; Wang, B. et al., 2008, "Design and benchtop validation of a handheld integrated dynamic breast imaging system for noninvasive characterization of suspicious breast lesions.." Technol Cancer Res Treat 7, no. 6, 471-481 - 471-481.

2007

  • Kashou, N.H.; Xu, R.; Roberts, C.J.; Leguire, L.E., 2007, "Using FMRI and FNIRS for localization and monitoring of visual cortex activities.." Conf Proc IEEE Eng Med Biol Soc 2007, 2634-2638 - 2634-2638.
  • Xu, R.X.; Povoski, S.P., 2007, "Diffuse optical imaging and spectroscopy for cancer.." Expert Rev Med Devices 4, no. 1, 83-95 - 83-95.
  • Xu, R.X.; Qiang, B.; Mao, J.J.; Povoski, S.P., 2007, "Development of a handheld near-infrared imager for dynamic characterization of in vivo biological tissue systems.." Appl Opt 46, no. 30, 7442-7451 - 7442-7451.
  • Xu, R.X.; Young, D.C.; Mao, J.J.; Povoski, S.P., 2007, "A prospective pilot clinical trial evaluating the utility of a dynamic near-infrared imaging device for characterizing suspicious breast lesions.." Breast Cancer Res 9, no. 6, R88 - R88.
  • Xu, R.; Qiang, B.; Mao, J.; Povoski, S., 2007, Development of a handheld near-infrared imager for dynamic characterization of in vivo biological tissue systems. Appl Opt 46, no. 30, 7442-7451 - 7442-7451.

2005

  • Xu, R.; Qiang, B.; Mao, J., 2005, "Near infrared imaging of tissue heterogeneity: probe design and sensitivity analysis.." Conf Proc IEEE Eng Med Biol Soc 1, 278-281 - 278-281.
  • Xu, R.; Qiang, B.; Olsen, J.; Povoski, S. et al., 2005, "Localization and functional parameter reconstruction of suspicious breast lesions by near infrared/ultrasound dual modal imaging.." Conf Proc IEEE Eng Med Biol Soc 5, 4473-4476 - 4473-4476.

1999

  • Huang, P.S.; Xu, X.R., 1999, "Design of an optical probe for surface profile measurement." Optical Engineering 38, no. 7, 1223-1228 - 1223-1228.

Presentations

  • "Near Infrared Tissue Oximetry and Its Clinical Applications." 2004, Presented at College of Alliance Medical Professionals Seminar,
  • "Brain Functional Study by Near Infrared Light and Ultrasound." 2005, Presented at BITSI seminar,
  • "Biomedical Engineering for a Mechanical Engineer." 2005, Presented at Mechanical Engineering Seminar,
  • "Near Infrared Imaging of Tissue Structure and Function." 2006, Presented at Biomedical Imaging meeting,
  • "Biomedical Imaging and Tissue Oximetry by Near Infrared Light." 2006, Presented at College of Engineering Seminar,
  • "Multimodal Dynamic Imaging for Wound Assessment." 2007, Presented at DHLRI technical presentation,
  • "Multimodal dynamic imaging of biological tissue." 2008, Presented at OSU Biophysics Program Preceptor Talks,
  • "Gold nanoparticle assisted light activation of heat-sensitive nanobubbles for photothermal therapy." 2010, Presented at Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in PhotodynamicTherapy XIX. SPIE Photonics West 2010,
  • "Developing multifunctional tissue simulating phantoms for quantitative biomedical optical imaging." 2010, Presented at Design and Performance Validation of Phantoms used in Conjunction with Optical Measurement of Tissue, SPIE Photonics West 2010,
  • Innovations in Wound Imaging. 2010, Presented at Advances in Wound Care and HBO Update 2010,
  • "Structural and Functional Imaging by Near Infrared Light." 2006, Presented at Seminar: EPR weekly meeting,
  • "Non-invasive, Real Time Monitoring of Cortical and RetinaTissue Physiology During Visual Stimulation." 2006, Presented at Association for Research in Vision and Ophthalmology Annual Meeting,
  • "Biomedical Optical Imaging Lab at OSU BME." 2006, Presented at Brookhaven High School student field trip,
  • "NIR oximetry." 2007, Presented at DHLRI oxygen series seminar,
  • "Multimodal, dynamic, intraoperative imaging of cancer." 2008, Presented at National Institute of Standard and Technology Colloquium,
  • "Multimodal dynamic imaging of cancer." 2008, Presented at Meeting with OSU Technology License Office and TechColumbus,
  • "Multimodal imaging for wound assessment and healing." 2009, Presented at Mathematical Biosciences Institute Wound Healing Workshop,
  • "Multispectral Quantitative Optical Imaging of Biological Tissue." 2009, Presented at NIST Biophotonics Lecure Series and Brainstorming Sessions,
  • "Accelerating the clinical translation of Optical Medical Imaging (OMI)." 2009, Presented at NIST Biophotonics Lecure Series and Brainstorming Sessions,
  • "Optical imaging of cutaneous tissue oxygen and vascular function." 2010, Presented at OSU Biophysics Seminar Day,
  • "Multifunctional active agents for image-guided cancer therapy." 2010, Presented at Engineering and Medicine Symposium on Translational Research,
  • "Biomedical Imaging by Near Infrared Light." 2005, Presented at BISTI imaging workshop,
  • "Multimodality imaging platform to characterize mechanical andphysiological characteristics of biological tissue." 2006, Presented at SPIE Great Lake Symposium,
  • "Non-invasive, Multi-modal Imaging of Tissue Oxygen Dynamics." 2007, Presented at Big 10 Seminar,
  • "Intraoperative, Multimodal, Dynamic Imaging of Cancer." 2007, Presented at MBI Seminar,
  • "Optical imaging in multimodal platforms for preoperative, intraoperative, and postoperative assessment of surgical margins and occult disease in the cancer patient." 2007, Presented at Department of Radiology,
  • "Near Infrared Spectroscopy for Assessment of Cortical Function." 2008, Presented at OSU/Nationwide Children’s Hospital Collaborative Award Seminar,
  • "Intra-operative detection of ablation margin in minimally invasive cancer surgery." 2009, Presented at the meeting with Ethicon Endo-Surgery,
  • "Integrated schema for multimodal, dynamic, intraoperative cancer imaging and therapy." 2009, Presented at the meeting with Pharmaforce,
  • "Multimodal theranostics: an integrated engineering platform for clinical imaging and therapy." 2009, Presented at Biomedical Engineering Department Seminar,
  • "Multifunctional theranostics." 2009, Presented at Davis Heart and Lung Research Institute Discovery Series,
  • Multi-Modal Wound Imaging: Prospects of the Future. 2009, Presented at Heal Ohio 2009…Showcasing Emerging Wound Care Technologies and Treatments,
  • "Multimodal intraoperative imaging of cancer." 2009, Presented at Biomedical Engineering Society Annual Meeting 2009,
  • "Multimodal Imaging and Image-guided Therapy in Cancer." 2010, Presented at Department of Radiology Seminar,
  • "Multimodal, intraoperative cancer imaging with microbubbles and antibody-fluorophore conjugates." 2008, Presented at Biomedical Engineering Society Annual Fall Meeting,
  • "Optical imaging in multimodal platforms for preoperative, intraoperative, and postoperative assessment of surgical margins and occult disease in the cancer patient." 2008, Presented at Department of Radiation Medicine Seminar,
  • "Near infrared diffuse optical imaging and spectroscopy." 2008, Presented at SJTU Bimedical Engineering Seminar,
  • "Clinical Applications for In Vivo, Multi-modal, Dynamic Imaging of Biological Tissue." 2008, Presented at SJTU Biomedical Engineering Seminar,
  • "Multimodal imaging of cancer." 2009, Presented at Comprehensive Cancer Center Small Animal Imaging Seminar,

Papers in Proceedings

2015

  • Sheng, S.; Wu, Q.; Han, Y.; Dong, E. et al. "Fabricating optical phantoms to simulate skin tissue properties and microvasculatures." (1 2015).

2014

  • Ren, W.; Zhang, Z.; Wu, Q.; Zhang, S. et al. "A simultaneous multimodal imaging system for tissue functional parameters." (3 2014).
  • Lei, F.; Si, T.; Luo, X.; Xu, R.X. "Microencapsulation of curcumin in PLGA microcapsules by coaxial flow focusing." (1 2014).
  • Wang, C.; Zheng, W.; Bu, Y.; Chang, S. et al. "In vivo and in vitro hyperspectral imaging of cervical neoplasia." in Conference on Optical Diagnostics and Sensing XIV - Toward Point-of-Care Diagnostics. (1 2014).
  • Yuan, S.; Si, T.; Liu, Z.; Xu, R.X. "Microfabrication of curcumin-loaded microparticles using coaxial electrohydrodynamic atomization." in Conference on Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VI. (1 2014).
  • Lei, F.; Si, T.; Luo, X.; Xu, R.X. "Microencapsulation of curcumin in PLGA microcapsules by coaxial flow focusing." in Conference on Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VI. (1 2014).
  • Yin, C.; Si, T.; Gao, P.; Xu, R.X. "Microencapsulation of multiple components by compound-fluidic electro-flow focusing." (1 2014).
  • Wang, C.; Zheng, W.; Bu, Y.; Chang, S. et al. "In vivo and in vitro hyperspectral imaging of cervical neoplasia." (1 2014).
  • Yuan, S.; Si, T.; Liu, Z.; Xu, R.X. "Microfabrication of curcumin-loaded microparticles using coaxial electrohydrodynamic atomization." (1 2014).
  • Lei, F.; Si, T.; Luo, X.; Xu, R.X. "Microencapsulation of curcumin in PLGA microcapsules by coaxial flow focusing." (1 2014).
  • Wang, C.; Zheng, W.; Bu, Y.; Chang, S. et al. "In vivo and in vitro hyperspectral imaging of cervical neoplasia." (1 2014).
  • Yuan, S.; Si, T.; Liu, Z.; Xu, R.X. "Microfabrication of curcumin-loaded microparticles using coaxial electrohydrodynamic atomization." (1 2014).
  • Zhang, Z.; Ren, W.; Yu, Z.; Zhang, S. et al. "Image-guided plasma therapy of cutaneous wound." (1 2014).
  • Yin, C.; Si, T.; Gao, P.; Xu, R.X. "Microencapsulation of multiple components by compound-fluidic electro-flow focusing." (3 2014).
  • Li, G.; Si, T.; Luo, X.; Xu, R. "One-step microencapulation of nanoparticles and perfluorocarbon in microbubbles for potential application in controlled activation." (3 2014).
  • Si, T.; Feng, H.; Xie, B.; Xu, R. "Design and fabrication of tri-axial capillary needles in flow focusing for microencapsulation of multiple drugs and imaging agents." (1 2014).
  • Wang, M.; Shen, S.; Yang, J.; Dong, E. et al. "3D printing method for freeform fabrication of optical phantoms simulating heterogeneous biological tissue." (1 2014).
  • Si, T.; Feng, H.; Li, Y.; Luo, X. et al. "One-step production of multilayered microparticles by tri-axial electro-flow focusing." (1 2014).
  • Xu, J.; Shao, P.; Yue, T.; Zhang, S. et al. "A goggle navigation system for cancer resection surgery." (1 2014).
  • Liu, P.; Zhang, S.; Xu, R. "3D topography of biologic tissue by multiview imaging and structured light illumination." (1 2014).
  • Yin, C.; Si, T.; Gao, P.; Xu, R.X. "Microencapsulation of multiple components by compound-fluidic electro-flow focusing." in Conference on Multimodal Biomedical Imaging IX. (1 2014).

2013

  • Zhang, S.; Liu, P.; Xu, R. "Multimodal and multiview imaging of cutaneous tissue in vivo." (11 2013).
  • Ren, X.; Liang, X.; Kong, Z.; Xu, M. et al. "An experimental study on the locomotion performance of elliptic-curve leg in muddy terrain." (9 2013).

2012

  • Zhang,Leilei; Yan,Yan; Mena,Joshua; Sun,Jingjing; Letson,Alan; Roberts,Cynthia; Zhou,Chuanqing; Chai,Xinyu; Ren,Qiushi; Xu,Ronald "Electrospray of multifunctional microparticles for image-guided drug delivery." in Conference on Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV. (1 2012).
  • Qin, R.; Melvin, S.; Xu, R.X. "ICG-loaded microbubbles for multimodal biliary imaging in cholecystectomy." in Conference on Optics in Health Care and Biomedical Optics V. (1 2012).
  • Gnyawali, S.C.; Elghrably, H.; Melvin, J.; Huang, K. et al. "Hyperspectral imaging of ischemic wounds." (1 2012).
  • Zhang, S.; Gnyawali, S.; Huang, J.; Liu, P. et al. "Multimodal imaging of ischemic wounds." (1 2012).
  • Zhang, S.; Gnyawali, S.; Huang, J.; Liu, P. et al. "Multimodal imaging of ischemic wounds." (12 2012).
  • Huang, J.; Xu, J.S.; Schmidt, C.; Xu, R.X. "Heat sensitive microbubbles for intraoperative assessment of cancer ablation margin." in Photonics West. (1 2012).
  • Si, T.; Zhang, L.; Li, G.; Roberts, C.J. et al. "Coaxial electrospray for multimodal imaging and image-guided therapy." (6 2012).
  • Gnyawali, S.C.; Elghrably, H.; Melvin, J.; Huang, K. et al. "Hyperspectral imaging of ischemic wounds." in Conference on Optical Diagnostics and Sensing XII - Toward Point-of-Care Diagnostics / 4th Meeting of the Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissues. (1 2012).
  • Zhang, S.; Gnyawali, S.; Huang, J.; Liu, P. et al. "Multimodal imaging of ischemic wounds." in Conference on Optics in Health Care and Biomedical Optics V. (1 2012).
  • Si, T.; Zhang, L.; Li, G.; Roberts, C.J. et al. "Coaxial electrospray for multimodal imaging and image-guided therapy." (1 2012).
  • Huang, J.; Xu, J.S.; Schmidt, C.; Xu, R.X. "Heat sensitive microbubbles for intraoperative assessment of cancer ablation margin." (6 2012).
  • Gnyawali,Surya,C; Elghrably,Haytham; Melvin,James; Huang,Kun; Bergdall,Valerie; Allen,David,W; Hwang,Jeeseong; Litorja,Maritoni; Shirley,Eric; Sen,Chandan,K; Xu,Ronald "Hyperspectral imaging of ischemic wounds." in Conference on Optical Diagnostics and Sensing XII - Toward Point-of-Care Diagnostics / 4th Meeting of the Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissues. (1 2012).
  • Huang, J.; Xu, J.S.; Schmidt, C.; Xu, R.X. "Heat sensitive microbubbles for intraoperative assessment of cancer ablation margin." (1 2012).
  • Qin, R.; Melvin, S.; Xu, R.X. "ICG-loaded microbubbles for multimodal biliary imaging in cholecystectomy." (1 2012).
  • Huang, J.; Xu, J.S.; Schmidt, C.; Xu, R.X. "Heat sensitive microbubbles for intraoperative assessment of cancer ablation margin." in Conference on Multimodal Biomedical Imaging VII. (1 2012).
  • Si,Ting; Zhang,Leilei; Li,Guangbin; Roberts,Cynthia,J; Jia,Laibing; Yin,Xiezhen; Xu,Ronald "Coaxial electrospray for multimodal imaging and image-guided therapy." in Conference on Multimodal Biomedical Imaging VII. (1 2012).
  • Gnyawali,Surya,C; Elghrably,Haytham; Melvin,James; Huang,Kun; Bergdall,Valerie; Allen,David,W; Hwang,Jeeseong; Litorja,Maritoni; Shirley,Eric; Sen,Chandan,K; Xu,Ronald "Hyperspectral imaging of ischemic wounds." in Conference on Optical Diagnostics and Sensing XII - Toward Point-of-Care Diagnostics / 4th Meeting of the Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissues. (1 2012).
  • Huang,Jiwei; Xu,Jeff,S; Schmidt,Carl; Xu,Ronald,X "Heat sensitive microbubbles for intraoperative assessment of cancer ablation margin." in Conference on Multimodal Biomedical Imaging VII. (1 2012).
  • Huang,Jiwei; Xu,Jeff,S; Schmidt,Carl; Xu,Ronald,X "Heat sensitive microbubbles for intraoperative assessment of cancer ablation margin." in Conference on Multimodal Biomedical Imaging VII. (1 2012).
  • Zhang, L.; Yan, Y.; Mena, J.; Sun, J. et al. "Electrospray of multifunctional microparticles for image-guided drug delivery." (4 2012).
  • Zhang, S.; Liu, P.; Huang, J.; Xu, R. "Multiview hyperspectral topography of tissue structural and functional characteristics." (12 2012).
  • Si, T.; Zhang, L.; Li, G.; Xu, R. "Novel coaxial atomization processes for microfabrication of multi-layered biodegradable microcapsules." (12 2012).
  • Qin, R.; Melvin, S.; Xu, R.X. "ICG-loaded microbubbles for multimodal billiary imaging in cholecystectomy." (12 2012).
  • Si, T.; Zhang, L.; Li, G.; Roberts, C.J. et al. "Coaxial electrospray for multimodal imaging and image-guided therapy." in Conference on Multimodal Biomedical Imaging VII. (1 2012).

2010

  • Qin, R.; Huang, J.; Xu, J.S.; Ding, L. et al. "Dual-mode quantitative imaging of wound tissue oxygenation and perfusion." in Conference on Multimodal Biomedical Imaging V. (1 2010).
  • Xu,Ronald; Xu,Jeff; Qin,Ruogu; Huang,Jiwei "Developing multifunctional tissue simulating phantoms for quantitative biomedical optical imaging." in Conference on Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurements of Tissue II. (1 2010).
  • Xu,Ronald,X; Xu,Jeff,S; Huang,Jiwei; Tweedle,Michael,F; Schmidt,Carl; Povoski,Stephen,P; Martin,Edward,W "Targeted delivery of cancer-specific multimodal contrast agents for intraoperative detection of tumor boundaries and therapeutic margins." in Conference on Design and Quality for Biomedical Technologies III. (1 2010).
  • Qin, R.; Huang, J.; Xu, J.S.; Ding, L. et al. "Dual-mode quantitative imaging of wound tissue oxygenation and perfusion." (1 2010).
  • Qin, R.; Xu, J.; Xu, R.; Kim, C. et al. "Fabricating multifunctional microbubbles and nanobubbles for concurrent ultrasound and photoacoustic imaging." in Conference on Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurements of Tissue II. (1 2010).
  • R. Xu*, J.S. Xu, J. Huang, M.F. Tweedle, C. Schmidt, S.P. Povoski, and E.W. Martin "Targeted delivery of cancer-specific multimodal contrast agents for intraoperative detection of tumor boundaries and therapeutic margins." in Proc. SPIE.. (1 2010).
  • Ruogu Qin, Jiwei Huang, Jeff S. Xu, Liya Ding, Surya Gnyawali, Chandan K. Sen, Kun Huang, and Ronald X. Xu* Dual-mode quantitative imaging of wound tissue oxygenation and perfusion. in Proc. SPIE. http://spiedigitallibrary.org/vsearch/servlet/VerityServlet?KEY=SPIEDL&possible1=Gnyawali%2C+Surya&possible1zone=author&maxdisp=25&smode=strresults&pjournals=OPEGAR%2CJBOPFO%2CPSISDG%2CJEIME5%2CJMMMGF, (1 2010).
  • Xu, R.X.; Xu, J.S.; Huang, J.; Tweedle, M.F. et al. "Targeted delivery of cancer-specific multimodal contrast agents for intraoperative detection of tumor boundaries and therapeutic margins." in Conference on Design and Quality for Biomedical Technologies III. (1 2010).
  • Qin,Ruogu; Xu,Jeff; Xu,Ronald; Kim,Chulhong; Wang,Lihong,V "Fabricating multifunctional microbubbles and nanobubbles for concurrent ultrasound and photoacoustic imaging." in Conference on Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurements of Tissue II. (1 2010).
  • Zhang,Leilei; Xu,Jeff; Huang,Jiwei; Roberts,Cynthia; Xu,Ronald "Bevacizumab (Avastin) conjugated microbubbles for anti-VEGF treatment of neovascular age-related macular degeneration." in Conference on Ophthalmic Technologies XX. (1 2010).
  • Xu,Ronald,X; Xu,Jeff,S; Huang,Jiwei; Tweedle,Michael,F; Schmidt,Carl; Povoski,Stephen,P; Martin,Edward,W "Targeted delivery of cancer-specific multimodal contrast agents for intraoperative detection of tumor boundaries and therapeutic margins." in Conference on Design and Quality for Biomedical Technologies III. (1 2010).
  • Xu, R.X.; Xu, J.S.; Huang, J.; Tweedle, M.F. et al. "Targeted delivery of cancer-specific multimodal contrast agents for intraoperative detection of tumor boundaries and therapeutic margins." (1 2010).
  • Ronald X. Xu*, Jeff Xu, Ruogu Qin, Jiwei Huang "Developing multifunctional tissue simulating phantoms for quantitative biomedical optical imaging." in Proc. SPIE.. (1 2010).
  • Qin, R.; Huang, J.; Xu, J.S.; Ding, L. et al. "Dual-mode quantitative imaging of wound tissue oxygenation and perfusion." (5 2010).
  • Qin,Ruogu; Huang,Jiwei; Xu,Jeff,S; Ding,Liya; Gnyawali,Surya; Sen,Chandan,K; Huang,Kun; Xu,Ronald,X "Dual-mode quantitative imaging of wound tissue oxygenation and perfusion." in Conference on Multimodal Biomedical Imaging V. (1 2010).
  • Leilei Zhang, Jeff Xu, Jiwei Huang, Cynthia Roberts, Ronald Xu* "Bevacizumab (Avastin) conjugated microbubbles for anti-VEGF treatment of neovascular age-related macular degeneration." in Proc. SPIE. (1 2010).
  • Xu, R.; Xu, J.; Qin, R.; Huang, J. "Developing multifunctional tissue simulating phantoms for quantitative biomedical optical imaging." (5 2010).
  • Xu, R.X.; Xu, J.S.; Huang, J.; Tweedle, M.F. et al. "Targeted delivery of cancer-specific multimodal contrast agents for intraoperative detection of tumor boundaries and therapeutic margins." (5 2010).
  • Zhang, L.; Xu, J.; Huang, J.; Roberts, C. et al. "Bevacizumab (Avastin) conjugated microbubbles for anti-VEGF treatment of neovascular age-related macular degeneration." (12 2010).
  • Xu, R.X.; Xu, J.S.; Huang, J.; Tweedle, M.F. et al. "Targeted delivery of cancer-specific multimodal contrast agents for intraoperative detection of tumor boundaries and therapeutic margins." in Conference on Design and Quality for Biomedical Technologies III. (1 2010).

2008

  • Mao, J.J.M.; Xu, R.; Lash, B.; Wright, L. "Quantitative evaluation of ViOptix's tissue oximeter in an ex-vivo animal model." (4 2008).

2007

  • Kashou, N.; Xu, R.; Roberts, C.; Leguire, L. "Using FMRI and FNIRS for localization and monitoring of visual cortex activities." in 29th International Conference of the IEEE Engineering in Medicine and Biology Society. (1 2007).
  • Nasser Kashou*, Ronald Xu, Cynthia Roberts, Larwence Leguire "Using FMRI and FNIRS for localization and monitoring of visual cortex activities." in 29th International Conference of the IEEE Engineering in Medicine and Biology Society. (1 2007).

2006

  • Qiang, B.; Cao, X.; Sun, D.; He, G. et al. "Development of a multi-modal sensor for in vivo monitoring of tumor oxygen dynamics." (12 2006).
  • Rana, A.; Cao, X.; Sun, D.; Xu, R. "Monitoring oxygen dynamics during pressure induced ischemia on cancer xenograft models." (12 2006).
  • Xu, R.; Qiang, B.; Roberts, C. "Retinal tissue oxygen imaging by near infrared light and white light interferometry." (6 2006).
  • Xu, R.X.; Povoski, S.P.; Yee, L.D.; Olsen, J.O. et al. "Near infrared/ultrasound dual modal imaging for breast cancer detection." (5 2006).
  • Xu, R.; Qiang, B.; Roberts, C. "Retinal tissue oxygen imaging by near infrared light and white light interferometry." (1 2006).
  • Xu, R.X.; Povoski, S.P.; Yee, L.D.; Olsen, J.O. et al. "Near infrared/ultrasound dual modal imaging for breast cancer detection - art. no. 608107." in Conference on Multimodal Biomedical Imaging. (1 2006).
  • Xu, R.X.; Povoski, S.P.; Yee, L.D.; Olsen, J.O. et al. "Near infrared/ultrasound dual modal imaging for breast cancer detection - art. no. 608107." (1 2006).
  • R. Xu*, B. Qiang and C. Roberts "Retinal Tissue Oxygen Imaging by Near Infrared Lightand White Light Interferometry." in Proc. SPIE. (1 2006).
  • Ronald Xu*, Bo Qiang, John Olsen, Stephen Povoski, Lisa Yee, Jimmy Mao "Near Infrared/ Ultrasound Dual Modal Imaging for Breast Cancer Detection." in Proc. SPIE. (1 2006).
  • Xu, R.; Qiang, B.; Roberts, C. "Retinal tissue oxygen imaging by near infrared light and white light interferometry." in 16th Conference on Ophthalmic Technologies. (1 2006).

2005

  • B. Qiang, A. Rana, and R. Xu* "Reconstruction of tissue heterogeneity by near infraredimaging: a novel algorithm and benchtop validation." in Conf Proc IEEE Eng Med Biol Soc. (1 2005).
  • Xu, R.; Qiang, B.; Olsen, J.; Povoski, S. et al. "Localization and functional parameter reconstruction of suspicious breast lesions by near infrared/ultrasound dual modal imaging." in Conference Proceedings of the IEEE Engineering in Medicine and Biology Society (EMBS). (1 2005).
  • R Xu, B Qiang and J Liu "Ultrasound-guided near-infrared spectroscopy for brain functional study: feasibility analysis and preliminary work." in SPIE. (1 2005).
  • Xu, R.; Qiang, B.; Liu, J. "Ultrasound guided near infrared spectroscopy for brain functional study: Feasibility analysis and preliminary work." (8 2005).
  • Xu R, Qiang B, Olsen J, Povoski S, Yee L, and Mao J "Localization and functional parameter reconstruction of suspicious breast lesions by near infrared/ultrasound dual modal imaging." in Conference Proceedings of the IEEE Engineering in Medicine and Biology Society (EMBS). (1 2005).
  • Qiang, B.; Rana, A.; Xu, R. "Reconstruction of tissue heterogeneity by near infrared imaging: A novel algorithm and benchtop validation." (12 2005).
  • R. Xu*, B. Qiang, J. Olsen, S. Povoski, L. Yee, and J. Mao "Localization and functional parameter reconstruction of suspicious breast lesions by near infrared/ultrasound dualmodal imaging." in Conf Proc IEEE Eng Med Biol Soc. (1 2005).
  • Ronald Xu*, Bo Qiang, and Jun Liu Ultrasound-guided near-infrared spectroscopy for brain functional study: feasibility analysis and preliminary work. in Proc. SPIE. http://spiedigitallibrary.org/getpdf/servlet/GetPDFServlet?filetype=pdf&id=PSISDG005686000001000464000001&idtype=cvips, (1 2005).
  • Qiang, B.; Rana, A.; Xu, R. "Reconstruction of tissue heterogeneity by near infraredimaging: a novel algorithm and benchtop validation." in Conf Proc IEEE Eng Med Biol Soc. (1 2005).

Unknown

  • "Near infrared/ultrasound dual modal imaging for breast cancer detection." in Photonics West 2006 Annual Symposium.
  • "Targeted delivery of cancer-specific multimodal contrast agents for intraoperative detection of tumor boundaries and therapeutic margins." in Design and Quality for Biomedical Technologies III, SPIE Photonics West 2010.

Patents

  • Edward Martin, Ronald Xu, Duxin Sun, Stephen Povoski, Joseph Heremans, Robert Lee, Vish Subramaniam. "Fluorescence Detection System." Patent number: WO2009/089543 A3
  • Edward Martin, Ronald Xu, Duxin Sun, Stephen Povoski, Joseph Heremans, Robert Lee, Vish Subramaniam. "Fluorescence Detection System." Patent number: US2009/0234227 A1
  • Chandan Sen, Ronald Xu. "Wound goggles." Patent number: US2010/0113940
  • Chandan Sen, Ronald Xu. "Wound goggles." Patent number: EP2319414
  • Ronald Xu, Cynthia Roberts, Leilei Zhang. "Multi-functional biodegradable paraticles for selectable targeting, imaging, and therapeutic delivery and use thereof for treating ocular disorders." Patent number: WO2011/053803
  • Ronald Xu, Cynthia Roberts, Leilei Zhang. "Multi-functional biodegradable paraticles for selectable targeting, imaging, and therapeutic delivery and use thereof for treating ocular disorders." Patent number: 0104069
  • Ronald Xu, Robert Lee, Abdul Rana, Stephen Povoski. "Dynamic near infrared/ultrasound dual modal imaging for tissue structure and function." Patent number: 60/760,640
  • Ronald Xu, Jeff Xu, Jiwei Huang. "Targeted delivery of heat-sensitive nanobubbles and microbubbles for the assessment of thermal ablation margins in bresat cancer and other malignancies."
  • Ronald Xu, Joseph Heremans, Robert Lee, Edward Martin, Stephen Povoski, Vish Subramanian, and Duxin Sun. "Fluorescence Detection System." Patent number: 60/020,345
  • Ronald Xu, Cynthia Roberts, Leilei Zhang. "Targeted delivery of biodegradable multifunctional nanoparticles for integrated imaging and therapy of age-related macular degeneration."
  • Michael Tweedle, Ronald Xu. "Tumor Therapy with Heat Burst Micro Capsules."