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Ronald Xu

  • Associate Professor, Ophthalmology
  • Associate Professor, Biomedical Engineering
  • 286 Bevis Hall
    1080 Carmack Road
    Columbus, OH 43210
  • 614-688-3635

Honors

  • 2011

    Inventor of the Year. .

  • 2010

    R & D "Superstar". .

  • 2009

    Herman R. Weed Excellence in Teaching Award. .

  • 2006

    National Eye Institute Travel Award. .

Chapters

2010

  • Ronald Xu. 2010. "Chapter 17: Selected topics in biomedical engineering." In Intelligent Energy Field Manufacturing, edited by Wenwu Zhang, 447 - 467. Boca Raton: CRC Press.

Journal Articles

2014

2013

2012

  • Xu,Ronald,X; Allen,David,W; Huang,Jiwei; Gnyawali,Surya; Melvin,James; Elgharably,Haytham; Gordillo,Gayle; Huang,Kun; Bergdall,Valerie; Litorja,Maritoni; Rice,Joseph,P; Hwang,Jeeseong; Sen,Chandan,K, 2012, "Developing digital tissue phantoms for hyperspectral imaging of ischemic wounds." BIOMEDICAL OPTICS EXPRESS 3, no. 6, 1433 - 1445.
  • Mitra,Kinshuk; Melvin,James; Chang,Shufang; Park,Kyoungjin; Yilmaz,Alper; Melvin,Scott; Xu,Ronald,X, 2012, "Indocyanine-green-loaded microballoons for biliary imaging in cholecystectomy." JOURNAL OF BIOMEDICAL OPTICS 17, no. 11, 116025 -
  • Zhang,Leilei; Huang,Jiwei; Si,Ting; Xu,Ronald,X, 2012, "Coaxial electrospray of microparticles and nanoparticles for biomedical applications." EXPERT REVIEW OF MEDICAL DEVICES 9, no. 6, 595 - 612.

2011

  • Xu,Ronald,X; Xu,Jeff,S; Zuo,Tao; Shen,Rulong; Huang,Tim,H; Tweedle,Michael,F, 2011, "Drug-loaded biodegradable microspheres for image-guided combinatory epigenetic therapy in cells." JOURNAL OF BIOMEDICAL OPTICS 16, no. 2, 020507 -
  • Xu,Ronald,X, 2011, "Multifunctional microbubbles and nanobubbles for photoacoustic imaging." CONTRAST MEDIA & MOLECULAR IMAGING 6, no. 5, 401 - 411.
  • Ronald Xu, Jeff Xu, Tao Zuo, Rulong Shen, Tim Huang, Michael Tweedle, 2011, Drug-loaded biodegradable microspheres for image-guided combinatory epigenetic therapy. Journal of Biomedical Optics 16, no. 2, 020507 -

2010

2009

2008

2007

2004

2001

1999

Unknown

  • Jiangchuan Sun, Mingyue Yin, Shufang Chang, ShenyinZhu, Li Liu, Yi Zhu, ZhigangWang, Ronald X. Xu, "Ultrasound-Mediated Destruction of Oxygen and Paclitaxel Loaded Lipid Microbubbles form Combination Therapy in Hypoxic Ovarian Cancer Cells." Cancer Lett
  • Li Liu, Shufang Chang, Jiangchuan Sun, ShenyinZhu, Minyue Yin, Yi Zhu, ZhigangWang, Ronald X. Xu, "Ultrasound-Mediated Destruction of Paclitaxel and Oxygen Loaded Lipid Microbubbles for Combination Therapy in Ovarian Cancer Xenografts." Cancer Lett
  • Ronald X. Xu, Kun Huang, Ruogu Qin, Jiwei Huang, Jeff S. Xu, Liya Ding, Urmila S. Gnyawali, Gayle Gordillo, Surya C. Gnyawali, and Chandan K. Sen, "Dual-mode imaging of cutaneous tissue oxygenation and tissue vascular thermal reactivity." Journal of Visualized Experiments
  • Shiwu Zhang, Surya C. Gnyawali, Jiwei Huang, Wenqi Ren, Gayle Gordillo, Chandan Sen, Ronald X. Xu, "Multimodal imaging of cutaneous wound tissue." Journal of Biomedical Optics
  • Wenqi Ren, Qi Gan, Qiang Wu, Shiwu Zhang, Ronald Xu, "Simultaneous multimodal imaging of cutaneous tissue oxygenation and perfusion." Journal of Biomedical Optics
  • P. Shao, H. Ding, J. Wang, P. Liu, Q. Ling, J. Chen, J. Xu, S. Zhang and R. Xu,, Designing a Wearable Navigation System for Image-Guided Cancer Resection Surgery. Annals of Biomedical Engineering
  • Ting Si, Hanxin Feng, Xisheng Luo, Ronald X. Xu, Formation of steady compound cone-jet modes and multilayered droplets in a tri-axial capillary flow focusing device. Microfluidics and Nanofluidics
  • Jiwei Huang, Shiwu Zhang, Surya Gnyawali, Chandan K. Sen, Ronald X. Xu, "A second derivative multispectral algorithm for quantitative assessment of cutaneous tissue oxygenation." Journal of Biomedical Optics
  • Shiwu Zhang, Surya Gnyawali, Jiwei Huang, Wenqi Ren, Gayle Gordillo, Chandan K. Sen, Ronald Xu, "Multimodal imaging of cutaneous wound tissue." Journal of Biomedical Optics

Presentations

  • "Gold nanoparticle assisted light activation of heat-sensitive nanobubbles for photothermal therapy." 2010, Presented at Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in PhotodynamicTherapy XIX. SPIE Photonics West 2010, San Francisco, US|USA
  • "Optical imaging of cutaneous tissue oxygen and vascular function." 2010, Presented at OSU Biophysics Seminar Day, Columbus, US|USA
  • "Multifunctional active agents for image-guided cancer therapy." 2010, Presented at Engineering and Medicine Symposium on Translational Research, Columbus, US|USA
  • "Multimodal Imaging and Image-guided Therapy in Cancer." 2010, Presented at Department of Radiology Seminar, Ann Arbor, US|USA
  • Innovations in Wound Imaging. 2010, Presented at Advances in Wound Care and HBO Update 2010, Columbus, US|USA

Papers in Proceedings

2012

  • Si,Ting; Zhang,Leilei; Li,Guangbin; Roberts,Cynthia,J; Jia,Laibing; Yin,Xiezhen; Xu,Ronald "Coaxial electrospray for multimodal imaging and image-guided therapy." in Conference on Multimodal Biomedical Imaging VII. BELLINGHAM, (1 2012). 82160M -
  • Huang,Jiwei; Xu,Jeff,S; Schmidt,Carl; Xu,Ronald,X "Heat sensitive microbubbles for intraoperative assessment of cancer ablation margin." in Conference on Multimodal Biomedical Imaging VII. BELLINGHAM, (1 2012). 821604 -
  • Gnyawali,Surya,C; Elghrably,Haytham; Melvin,James; Huang,Kun; Bergdall,Valerie; Allen,David,W; Hwang,Jeeseong; Litorja,Maritoni; Shirley,Eric; Sen,Chandan,K; Xu,Ronald "Hyperspectral imaging of ischemic wounds." in Conference on Optical Diagnostics and Sensing XII - Toward Point-of-Care Diagnostics / 4th Meeting of the Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissues. BELLINGHAM, (1 2012). 822910 -
  • Gnyawali,Surya,C; Elghrably,Haytham; Melvin,James; Huang,Kun; Bergdall,Valerie; Allen,David,W; Hwang,Jeeseong; Litorja,Maritoni; Shirley,Eric; Sen,Chandan,K; Xu,Ronald "Hyperspectral imaging of ischemic wounds." in Conference on Optical Diagnostics and Sensing XII - Toward Point-of-Care Diagnostics / 4th Meeting of the Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissues. BELLINGHAM, (1 2012). 822910 -
  • Zhang,Leilei; Yan,Yan; Mena,Joshua; Sun,Jingjing; Letson,Alan; Roberts,Cynthia; Zhou,Chuanqing; Chai,Xinyu; Ren,Qiushi; Xu,Ronald "Electrospray of multifunctional microparticles for image-guided drug delivery." in Conference on Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV. BELLINGHAM, (1 2012). 823303 -

2010

  • Qin,Ruogu; Huang,Jiwei; Xu,Jeff,S; Ding,Liya; Gnyawali,Surya; Sen,Chandan,K; Huang,Kun; Xu,Ronald,X "Dual-mode quantitative imaging of wound tissue oxygenation and perfusion." in Conference on Multimodal Biomedical Imaging V. BELLINGHAM, (1 2010). 75570J -
  • R. Xu*, J.S. Xu, J. Huang, M.F. Tweedle, C. Schmidt, S.P. Povoski, and E.W. Martin "Targeted delivery of cancer-specific multimodal contrast agents for intraoperative detection of tumor boundaries and therapeutic margins." in Proc. SPIE.. (1 2010). 7551 - 28.
  • Leilei Zhang, Jeff Xu, Jiwei Huang, Cynthia Roberts, Ronald Xu* "Bevacizumab (Avastin) conjugated microbubbles for anti-VEGF treatment of neovascular age-related macular degeneration." in Proc. SPIE. (1 2010). 7550 - 61.
  • Ronald X. Xu*, Jeff Xu, Ruogu Qin, Jiwei Huang "Developing multifunctional tissue simulating phantoms for quantitative biomedical optical imaging." in Proc. SPIE.. (1 2010). 7567 - 19.
  • Ruogu Qin, Jiwei Huang, Jeff S. Xu, Liya Ding, Surya Gnyawali, Chandan K. Sen, Kun Huang, and Ronald X. Xu* Dual-mode quantitative imaging of wound tissue oxygenation and perfusion. in Proc. SPIE. http://spiedigitallibrary.org/vsearch/servlet/VerityServlet?KEY=SPIEDL&possible1=Gnyawali%2C+Surya&possible1zone=author&maxdisp=25&smode=strresults&pjournals=OPEGAR%2CJBOPFO%2CPSISDG%2CJEIME5%2CJMMMGF%2CJARSC4%2CJNOACQ&deliveryType=spiedl&aqs=true, (1 2010). 75570J -
  • R. Qin, J. Xu, R. Xu*, C. Kim, and L. Wang* "Fabricating multifunctional microbubbles and nanobubbles for concurrent ultrasound and photoacoustic imaging." in Proc. SPIE. (1 2010). 7567 - 20.
  • Zhang,Leilei; Xu,Jeff; Huang,Jiwei; Roberts,Cynthia; Xu,Ronald "Bevacizumab (Avastin) conjugated microbubbles for anti-VEGF treatment of neovascular age-related macular degeneration." in Conference on Ophthalmic Technologies XX. BELLINGHAM, (1 2010). 75501P -
  • Qin,Ruogu; Xu,Jeff; Xu,Ronald; Kim,Chulhong; Wang,Lihong,V "Fabricating multifunctional microbubbles and nanobubbles for concurrent ultrasound and photoacoustic imaging." in Conference on Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurements of Tissue II. BELLINGHAM, (1 2010). 75670L -
  • Xu,Ronald,X; Xu,Jeff,S; Huang,Jiwei; Tweedle,Michael,F; Schmidt,Carl; Povoski,Stephen,P; Martin,Edward,W "Targeted delivery of cancer-specific multimodal contrast agents for intraoperative detection of tumor boundaries and therapeutic margins." in Conference on Design and Quality for Biomedical Technologies III. BELLINGHAM, (1 2010). 75560T -
  • Xu,Ronald; Xu,Jeff; Qin,Ruogu; Huang,Jiwei "Developing multifunctional tissue simulating phantoms for quantitative biomedical optical imaging." in Conference on Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurements of Tissue II. BELLINGHAM, (1 2010). 75670K -

2007

  • Nasser Kashou*, Ronald Xu, Cynthia Roberts, Larwence Leguire "Using FMRI and FNIRS for localization and monitoring of visual cortex activities." in 29th International Conference of the IEEE Engineering in Medicine and Biology Society. (1 2007).

2006

2005

  • R. Xu*, B. Qiang, J. Olsen, S. Povoski, L. Yee, and J. Mao "Localization and functional parameter reconstruction of suspicious breast lesions by near infrared/ultrasound dualmodal imaging." in Conf Proc IEEE Eng Med Biol Soc. (1 2005). 4473 - 4476.
  • R. Xu*, B. Qiang, and J. Mao "Near infrared imaging of tissue heterogeneity: probe designand sensitivity analysis." in Conf Proc IEEE Eng Med Biol Soc. (1 2005). 278 - 281.
  • Ronald Xu*, Bo Qiang, and Jun Liu Ultrasound-guided near-infrared spectroscopy for brain functional study: feasibility analysis and preliminary work. in Proc. SPIE. http://spiedigitallibrary.org/getpdf/servlet/GetPDFServlet?filetype=pdf&id=PSISDG005686000001000464000001&idtype=cvips, (1 2005). 464 - 472.
  • B. Qiang, A. Rana, and R. Xu* "Reconstruction of tissue heterogeneity by near infraredimaging: a novel algorithm and benchtop validation." in Conf Proc IEEE Eng Med Biol Soc. (1 2005). 3137 - 3140.

Patents

  • Edward Martin, Ronald Xu, Duxin Sun, Stephen Povoski, Joseph Heremans, Robert Lee, Vish Subramaniam. "Fluorescence Detection System." Patent number: WO2009/089543 A3
  • Edward Martin, Ronald Xu, Duxin Sun, Stephen Povoski, Joseph Heremans, Robert Lee, Vish Subramaniam. "Fluorescence Detection System." Patent number: US2009/0234227 A1
  • Chandan Sen, Ronald Xu. "Wound goggles." Patent number: US2010/0113940
  • Chandan Sen, Ronald Xu. "Wound goggles." Patent number: EP2319414
  • Ronald Xu, Cynthia Roberts, Leilei Zhang. "Multi-functional biodegradable paraticles for selectable targeting, imaging, and therapeutic delivery and use thereof for treating ocular disorders." Patent number: WO2011/053803
  • Ronald Xu, Cynthia Roberts, Leilei Zhang. "Multi-functional biodegradable paraticles for selectable targeting, imaging, and therapeutic delivery and use thereof for treating ocular disorders." Patent number: 0104069
  • Ronald Xu, Jeff Xu, Jiwei Huang. "Targeted delivery of heat-sensitive nanobubbles and microbubbles for the assessment of thermal ablation margins in bresat cancer and other malignancies."
  • Michael Tweedle, Ronald Xu. "Tumor Therapy with Heat Burst Micro Capsules."
  • Ronald Xu, Robert Lee, Abdul Rana, Stephen Povoski. "Dynamic near infrared/ultrasound dual modal imaging for tissue structure and function." Patent number: 60/760,640
  • Ronald Xu, Joseph Heremans, Robert Lee, Edward Martin, Stephen Povoski, Vish Subramanian, and Duxin Sun. "Fluorescence Detection System." Patent number: 60/020,345
  • Ronald Xu, Cynthia Roberts, Leilei Zhang. "Targeted delivery of biodegradable multifunctional nanoparticles for integrated imaging and therapy of age-related macular degeneration."