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Jay Zweier

  • Professor, SBS-Physiology & Cell Biology
  • Professor - Joint Appointment, SBS-Biolog Chem & Pharmacology
  • Professor, Cardiovascular Medicine
  • Professor - Joint Appointment, Radiology
  • Room #0390
    460 W 12th Ave
    Columbus, OH 43210
  • 614-247-7788

Chapters

2003

  • 2003. "Cardiac Applications of In Vivo EPR Spectroscopy and Imaging." In Oxygen Transport to Tissue XXIV, edited by edited by Dunn and Swartz,
  • 2003. "Chemistry of free radicals in biological systems." In Oxidative Stress and Cardiac Failure, edited by edited by Kukin ML, Fuster V,

2001

  • 2001. "Free radicals as mediators of inflammation in atherosclerosis." In Inflammatory and Infectious Basis of Atherosclerosis, edited by edited by Jay L. Mehta,
  • 2001. "Superoxide anion release from inducible nitric oxide synthase." In Nitric Oxide and Inflammation, edited by edited by Salvemini D, Billiar T, & Vodovotz Y,

1998

  • 1998. "EPR Imaging of the Rat Heart." In Spatially Resolved Magnetic Resonance: Methods and Applications in Materials Science, Agriculture, and Biomedicine, edited by edited by B Blumich, P Blumler, R Botto, E Fukushima,
  • 1998. "Principles of Electron Paramagnetic Resonance Spectroscopy for Measurement of Free Radicals In Biological Tissues." In Nitric Oxide in Transplant Rejection and Anti-tumor Defense, edited by edited by Lukiewicz & Zweier,
  • 1998. "Mechanism of Leukocyte Accumulation in Postischemic Tissues:Role of Oxygen Free Radicals." In The Neutrophils: New Outlook for the Old Cells, edited by edited by D. Gabrilovich,
  • 1998. "Independent Formation of Nitric Oxide In Tissues." In Nitric Oxide in Transplant Rejection and Anti-tumor Defense, edited by edited by Lukiewicz & Zweier,
  • 1998. "EPR Imaging of Free Radicals in Biological Systems." In Nitric Oxide in Transplant Rejection and Anti-tumor Defense, edited by edited by Lukiewicz & Zweier,

1992

  • 1992. "Study of Free Radical Generation in Isolated Cells and Whole Tissues Using Electron Paramagnetic Resonance Spectroscopy." In Cellular Membrane: A Key to Disease Processes,

1991

  • 1991. "Free Radical Metabolism and DNA Damage by Organic Peroxide Tumor Promoters." In Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury,
  • 1991. "The Role of Iron in Myocardial Reperfusion Injury." In Iron and Human Disease,

1989

  • 1989. "Tumor promotion by butylated hydroxytoluene hyperoxide. In: Pharmacological effects of lipids.." In Role of lipid in carcinogenesis and therapy.,
  • 1989. "The Role of Free Radicals in the Pathogenesis of Postischemic Reperfusion Injury, in Early Interventions.." In Acute Myocardial Infarction,
  • 1989. "New Aspects of Drug Therapy: Free Radical Scavengers.." In Limitation of Infarct Size,

1988

  • 1988. "Oxygen-Derived Radicals and Myocardial Ischemic Injury.." In Heart Disease: Clinical Update (3),

Journal Articles

2011

  • Nishijima Y, Sridhar A, Bonilla I, Velayutham M, Khan M, Terentyeva R, Li C, Kuppusamy P, Elton TS, Terentyev D, Györke S, Zweier JL, Cardounel AJ, Carnes CA., 2011, "Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology." Cardiovasc Res
  • Nishijima Y, Sridhar A, Zweier JL, Cardounel AJ, Carnes CA., 2011, "Reply: Is NOS uncoupling the missing link between atrial fibrillation and chronic non-ischemic cardiomyopathy?." Cardiovasc Res.
  • Tewari AK, Popova-Butler A, El-Mahdy MA, Zweier JL, 2011, "Identification of differentially expressed proteins in blood plasma of control and cigarette smoke-exposed mice by 2-D DIGE/MS.." Proteomics 10, no. 11, 2051-62 - 2051-62.
  • Zweier JL, Chen CA, Druhan LJ, 2011, "S-glutathionylation reshapes our understanding of endothelial nitric oxide synthase uncoupling and nitric oxide/reactive oxygen species-mediated signaling.." Antioxid Redox Signal 10, no. 14(, 1769-75 - 1769-75.
  • Liu Y, Song Y, Rockenbauer A, Sun J, Hemann C, Villamena FA, Zweier JL, 2011, "Synthesis of trityl radical-conjugated disulfide biradicals for the measurement of thiol concentration.." J Org Chem
  • Efimova OV, Sun Z, Petryakov S, Kesselring E, Caia GL, Johnson D, Zweier JL, Khramtsov VV, Samouilov A, 2011, "Variable radio frequency proton-electron double-resonance imaging: Application to pH mapping of aqueous samples." J Magn Reson 2, no. 209, 227-32. - 227-32..
  • Chu, L; Hao, H; Luo, M; Huang, Y; Chen, ZY; Lu, TW; Zhao, X; Verfaillie, CM; Zweier, JL; Liu, ZG, 2011, "Ox-LDL modifies the behaviour of bone marrow stem cells and impairs their endothelial differentiation via inhibition of Akt phosphorylation." JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 15, no. 2, 423-432 - 423-432.
  • Chen CA, Lin CH, Druhan LJ, Wang TY, Chen YR, Zweier JL., 2011, "Superoxide induces eNOS protein Thiyl radical formation: a novel mechanism regulating eNOS function and coupling.." J Biol Chem.
  • Velayutham M, Hemann C, Zweier JL., 2011, "Removal of H(2)O(2) and generation of superoxide radical: Role of cytochrome c and NADH.." Free Radic Biol Med. (1), no. 51, 160-170 - 160-170.

2010

  • Ahmad, R; Caia, G; Potter, LC; Petryakov, S; Kuppusamy, P; Zweier, JL, 2010, "In vivo multisite oximetry using EPR-NMR coimaging." JOURNAL OF MAGNETIC RESONANCE 207, no. 1, 69-77 - 69-77.
  • Liu, YP; Villamena, FA; Rockenbauer, A; Zweier, JL, 2010, "Trityl-nitroxide biradicals as unique molecular probes for the simultaneous measurement of redox status and oxygenation." CHEMICAL COMMUNICATIONS 46, no. 4, 628-630 - 628-630.
  • Vedam, K; Nishijima, Y; Druhan, LJ; Khan, M; Moldovan, NI; Zweier, JL; Ilangovan, G, 2010, "Role of heat shock factor-1 activation in the doxorubicin-induced heart failure in mice." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 298, no. 6, H1832-H1841 - H1832-H1841.
  • Chen, CA; Wang, TY; Varadharaj, S; Reyes, LA; Hemann, C; Talukder, MAH; Chen, YR; Druhan, LJ; Zweier, JL, 2010, "S-glutathionylation uncouples eNOS and regulates its cellular and vascular function." NATURE 7327, no. 468, 1115-1118 - 1115-1118.
  • Liu, YP; Villamena, FA; Song, YG; Sun, JA; Rockenbauer, A; Zweier, JL, 2010, "Synthesis of N-14- and N-15-labeled Trityl-nitroxide Bradicals with Strong Spin-Spin Interaction and Improved Sensitivity to Redox Status and Oxygen." JOURNAL OF ORGANIC CHEMISTRY 75, no. 22, 7796-7802 - 7796-7802.
  • Kim, SU; Liu, Y; Nash, KM; Zweier, JL; Rockenbauer, A; Villamena, FA, 2010, "Fast Reactivity of a Cyclic Nitrone-Calix[4]pyrrole Conjugate with Superoxide Radical Anion: Theoretical and Experimental Studies." JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132, no. 48, 17157-17173 - 17157-17173.
  • Ahmad, R; Som, S; Kesselring, E; Kuppusamy, P; Zweier, JL; Potter, LC, 2010, "Digital detection and processing of multiple quadrature harmonics for EPR spectroscopy." JOURNAL OF MAGNETIC RESONANCE 207, no. 2, 322-331 - 322-331.

2009

  • Chen, CA; Druhan, LJ; Varadharaj, S; Wang, TY; Chen, YR; Zweier, JL, 2009, "Superoxide Generation from Endothelial Nitric Oxide Synthase Is Regulated by Posttranslational Modification and L-Arginine Binding." CIRCULATION RESEARCH 105, no. 7, E41-E41 - E41-E41.
  • Chen, CA; Druhan, LJ; Wang, TY; Chen, YR; Zweier, JL, 2009, "Oxidative Stress Uncouples eNOS in a BH4-independent Manner via the Formation of Protein Thiol-radicals." CIRCULATION 120, no. 18, S1070-S1070 - S1070-S1070.
  • Crestanello, JA; Lee, DS; Steinbaugh, G; Pfeiffer, D; Zweier, J, 2009, "Superoxide radical production by mitochondrial respiratory complexes I and III is decreased by ischemic preconditioning." JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 209, no. 3, S33-S33 - S33-S33.
  • Liu, ZH; Lei, MX; Jiang, YH; Hao, H; Chu, L; Xu, J; Luo, M; Verfaillie, CM; Zweier, JL; Liu, ZG, 2009, "High glucose attenuates VEGF expression in rat multipotent adult progenitor cells in association with inhibition of JAK2/STAT3 signalling." JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 13, no. 9B, 3427-3436 - 3427-3436.
  • Talukder, MAH; Johnson, W; Varadharaj, S; Lian, JR; Kearns, P; Druhan, L; Liu, XP; Zweier, J, 2009, "Cigarette Smoke Exposure Results in Hypertension, Endothelial Dysfunction, Cardiac Hypertrophy, and Leukocyte-Specific Reactive Oxygen Species (ROS) Generation in Mice." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 53, no. 10, A400-A400 - A400-A400.
  • Zhao, X; Zhang, JY; Mei, X; Liao, DN; Hu, JQ; Li, L; Liu, ZG; Zweier, JL, 2009, "Pulmonary vein electric shunting for therapy of atrial fibrillation." MEDICAL HYPOTHESES 72, no. 4, 474-475 - 474-475.
  • Zuo, L; Chen, YR; Reyes, LA; Lee, HL; Chen, CL; Villamena, FA; Zweier, JL, 2009, "The Radical Trap 5,5-Dimethyl-1-Pyrroline N-Oxide Exerts Dose-Dependent Protection against Myocardial Ischemia-Reperfusion Injury through Preservation of Mitochondrial Electron Transport." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 329, no. 2, 515-523 - 515-523.
  • Han, YB; Liu, YP; Rockenbauer, A; Zweier, JL; Durand, G; Villamena, FA, 2009, "Lipophilic beta-Cyclodextrin Cyclic-Nitrone Conjugate: Synthesis and Spin Trapping Studies." JOURNAL OF ORGANIC CHEMISTRY 74, no. 15, 5369-5380 - 5369-5380.
  • Liu, YP; Villamena, FA; Sun, J; Wang, TY; Zweier, JL, 2009, "Esterified trityl radicals as intracellular oxygen probes." FREE RADICAL BIOLOGY AND MEDICINE 46, no. 7, 876-883 - 876-883.
  • Souza, HP; Frediani, D; Cobra, AL; Moretti, AI; Jurado, MC; Fernandes, TR; Cardounel, AJ; Zweier, JL; Tostes, RC, 2009, "Angiotensin II modulates CD40 expression in vascular smooth muscle cells." CLINICAL SCIENCE 116, no. 5-6, 423-431 - 423-431.
  • Talukder, MAH; Zweier, JL; Periasamy, M, 2009, "Targeting calcium transport in ischaemic heart disease." CARDIOVASCULAR RESEARCH 84, no. 3, 345-352 - 345-352.
  • Chen, CA; Wang, TY; Varadharaj, S; Reyes, L; Talukder, MAH; Chen, YR; Druhan, LJ; Zweier, JL, 2009, "S-glutathiolation Uncouples Endothelial Nitric Oxide Synthase: A Novel Mechanism of Redox Signaling and Vascular Regulation." CIRCULATION 120, no. 18, S1070-S1070 - S1070-S1070.
  • Racoma, I; Wang, A; Zweier, JL; Villamena, FA, 2009, "Effects of Natural and Synthetic Antioxidants on Uncoupled Endothelial Nitric Oxide Synthase Function." FREE RADICAL BIOLOGY AND MEDICINE 47, S150-S150 - S150-S150.
  • Vandewalle, J; Van Esch, H; Govaerts, K; Verbeeck, J; Zweier, C; Madrigal, I; Mila, M; Pijkels, E; Fernandez, I; Kohlhase, J; Spaich, C; Rauch, A; Fryns, JP; Marynen, P; Froyen, G, 2009, "Dosage-Dependent Severity of the Phenotype in Patients with Mental Retardation Due to a Recurrent Copy-Number Gain at Xq28 Mediated by an Unusual Recombination." AMERICAN JOURNAL OF HUMAN GENETICS 85, no. 6, 809-822 - 809-822.
  • Talukder, MAH; Yang, F; Nishijima, Y; Chen, CA; Kalyanasundaram, A; Periasamy, M; Zweier, JL, 2009, "Reduced SERCA2a converts sub-lethal myocardial injury to infarction and affects postischemic functional recovery." JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 46, no. 2, 285-287 - 285-287.

2008

  • Presley T, Vedam K, Velayutham M, Zweier JL, Ilangovan G, 2008, "Activation of Hsp90-eNOS and increased NO generation attenuate respiration of hypoxia-treated endothelial cells.." Am J Physiol Cell Physiol no. 295(5):, C1281 - C1281.
  • Druhan, LJ; Forbes, SP; Pope, AJ; Chen, CA; Zweier, JL; Cardounel, AJ, 2008, "Regulation of eNOS-derived superoxide by endogenous methylarginines." BIOCHEMISTRY 47, no. 27, 7256-7263 - 7256-7263.
  • Raman SV, Winner MW, Tran T, Velayutham M, Simonetti OP, Baker PB, Olesik J, McCarthy B, Ferketich AK, Zweier JL., 2008, "In Vivo Atherosclerotic Plaque Characterization Using Magnetic Susceptibility Distinguishes Symptom-Producing Plaques.." JACC: Cardiovascular Imaging
  • Chen, CA; Druhan, LJ; Varadharaj, S; Chen, YR; Zweier, JL, 2008, "Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzyme." JOURNAL OF BIOLOGICAL CHEMISTRY 283, no. 40, 27038-27047 - 27038-27047.
  • Talukder MAH, Kalyanasundaram A, Zuo L, Velayutham M, Nishijima Y, Periasamy M, Zweier JL, 2008, "Is reduced SERCA2a expression detrimental or beneficial to postischemic cardiac function and injury? Evidence from heterozygous SERCA2a knockout mice." American Journal of Physiology – Heart and Circulatory Physiology 3, no. 294, H1426-H1434 - H1426-H1434.
  • Talukder, MAH; Kalyanasundaram, A; Zuo, L; Velayutham, M; Nishijima, Y; Periasamy, M; Zweier, JL, 2008, "Is reduced SERCA2a expression detrimental or beneficial to postischemic cardiac function and injury? Evidence from heterozygous SERCA2a knockout mice." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 294, no. 3, H1426-H1434 - H1426-H1434.
  • Liu Y, Villamena F, Sun J, Xu Y, Dhimitruka I, Zweier J., 2008, "Synthesis and Characterization of Ester-Derivatized Tetrathiatriarylmethyl Radicals as Intracellular Oxygen Probes.." Journal of Organic Chemistry
  • Villamena FA, Liu Y, Zweier JL, 2008, "Superoxide Radical Anion Adduct of 5,5-Dimethyl-1-pyrroline N-Oxide. 4. Conformational Effects on the EPR Hyperfine Splitting Constants.." J Phys Chem A
  • Xu, J; Liu, X; Jiang, Y; Chu, L; Hao, H; Liua, Z; Verfaillie, C; Zweier, J; Gupta, K; Liu, Z, 2008, "MAPK/ERK signalling mediates VEGF-induced bone marrow stem cell differentiation into endothelial cell." JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 12, no. 6A, 2395-2406 - 2395-2406.
  • West MB, Rokosh G, Obal D, Velayutham M, Xuan YT, Hill BG, Keith RJ, Schrader J, Guo Y, Conklin DJ, Prabhu SD, Zweier JL, Bolli R, Bhatnagar A, 2008, "Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition.." Circulation no. 118(19):, 1970-8 - 1970-8.
  • Liu Z, Lei M, Jiang Y, Hao H, Chu L, Xu J, Luo M, Verfaillie CM, Zweier JL, Liu Z., 2008, "High glucose attenuates VEGF expression in rat multipotent adult progenitor cells in association with inhibition of JAK2/STAT3 signaling.." J Cell Mol Med
  • Kohr MJ, Wang H, Wheeler DG, Velayutham M, Zweier JL, Ziolo MT, 2008, "Targeting of phospholamban by peroxynitrite decreases beta-adrenergic stimulation in cardiomyocytes." Cardiovascular Research 2, no. 77, 353-361 - 353-361.
  • Alzawahra, WF; Talukder, MAH; Liu, XP; Samouilov, A; Zweier, JL, 2008, "Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 295, no. 2, H499-H508 - H499-H508.
  • Chu L, Jiang Y, Hao H, Xia Y, Xu J, Liu Z, Verfaillie CM, Zweier JL, Liu Z, 2008, "Nitric oxide enhances Oct-4 expression in bone marrow stem cells and promotes endothelial differentiation." Eur J Pharmacol no. 591(1-3), 59-65 - 59-65.
  • Chu, L; Jiang, YH; Hao, H; Xia, Y; Xu, J; Liu, ZH; Verfaillie, CM; Zweier, JL; Liu, ZG, 2008, "Nitric oxide enhances Oct-4 expression in bone marrow stem cells and promotes endothelial differentiation." EUROPEAN JOURNAL OF PHARMACOLOGY 591, no. 1-3, 59-65 - 59-65.
  • Zweier, C; Trautmann, U; Ekici, A; Rauch, A, 2008, "A 15 Mb duplication of 6q24.1-q25.3 associated with typical but milder features of the duplication 6q syndrome." EUROPEAN JOURNAL OF MEDICAL GENETICS 51, no. 4, 358-361 - 358-361.
  • Ojha, N; Roy, S; He, G; Biswas, S; Velayutham, M; Khanna, S; Kuppusamy, P; Zweier, JL; Sen, CK, 2008, "Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing." FREE RADICAL BIOLOGY AND MEDICINE 44, no. 4, 682-691 - 682-691.
  • Ojha N, Roy S, He G, Biswas S, Velayutham M, Khanna S, Kuppusamy P, Zweier JL, Sen CK, 2008, "Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing.." Free Radical Biology and Medicine 4, no. 44, 682-691 - 682-691.
  • Ojha N, Roy S, Radtke J, Simonetti O, Gnyawali S, Zweier JL, Kuppusamy P, Sen CK, 2008, "Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury." Am J Physiol Heart Circ Physiol no. 294(6), H2435-43 - H2435-43.
  • Hirata H, HeG, Deng Y, Salikhov I, Petryakov S, Zweier JL., 2008, "A loop resonator for slice-selective in vivo EPR imaging in rats.." J of Magnetic Resonance no. 190, 124-134 - 124-134.
  • Venkatakrishnan CD, Dunsmore K, Wong H, Roy S, Sen CK, Wani A, Zweier JL, Ilangovan G, 2008, "HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G(2)/M phase cell cycle arrest.." American Journal of Physiology – Heart and Circulatory Physiology 4, no. 294, H1736-H1744 - H1736-H1744.
  • Han, Y; Tuccio, B; Lauricella, R; Rockenbauer, A; Zweier, JL; Villamena, FA, 2008, "Synthesis and spin-trapping properties of a new spirolactonyl nitrone." JOURNAL OF ORGANIC CHEMISTRY 73, no. 7, 2533-2541 - 2533-2541.
  • Liu, YP; Villamena, FA; Zweier, JL, 2008, "Highly stable dendritic trityl radicals as oxygen and pH probe." CHEMICAL COMMUNICATIONS no. 36, 4336-4338 - 4336-4338.
  • Xu, Y; Liu, B; Zweier, JL; He, GL, 2008, "Formation of Hydrogen Peroxide and Reduction of Peroxynitrite via Dismutation of Superoxide at Reperfusion Enhances Myocardial Blood Flow and Oxygen Consumption in Postischemic Mouse Heart." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 327, no. 2, 402-410 - 402-410.
  • Presley, T; Vedam, K; Velayutham, M; Zweier, JL; Ilangovan, G, 2008, "Activation of Hsp90-eNOS and increased NO generation attenuate respiration of hypoxia-treated endothelial cells." AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 295, no. 5, C1281-C1291 - C1281-C1291.
  • Liu, Y; Villamena, FA; Sun, J; Xu, Y; Dhimitruka, I; Zweier, JL, 2008, "Synthesis and characterization of ester-derivatized tetrathiatriarylmethyl radicals as intracellular oxygen probes." JOURNAL OF ORGANIC CHEMISTRY 73, no. 4, 1490-1497 - 1490-1497.
  • Patt, B; Sun, J; Zweier, J; Cardounel, A; Schutzman, S; Khayat, R, 2008, "Endothelial dysfunction in obstructive sleep apnea is due to increased endogenous inhibitors of nitric oxide." SLEEP 31, A174-A174 - A174-A174.
  • Huehne, K; Zweier, C; Raab, K; Odent, S; Bonnaure-Mallet, M; Sixou, JL; Landrieu, P; Goizet, C; Sarlangue, J; Baumann, M; Eggermann, T; Rauch, A; Ruppert, S; Stettner, GM; Rautenstrauss, B, 2008, "Novel missense, insertion and deletion mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with congenital insensitivity to pain with anhidrosis." NEUROMUSCULAR DISORDERS 18, no. 2, 159-166 - 159-166.
  • Talukder MA, Yang F, Nishijima Y, Chen CA, Kalyanasundaram A, Periasamy M, Zweier JL, 2008, "Reduced SERCA2a converts sub-lethal myocardial injury to infarction and affects postischemic functional recovery." J Mol Cell Cardiol
  • Jones CI 3rd, Han Z, Presley T, Varadharaj S, Zweier JL, Ilangovan G, Alevriadou BR, 2008, "Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite." Am J Physiol Cell Physiol no. 295(1), C180-91 - C180-91.
  • Han Y, Tuccio B, Lauricella R, Rockenbauer A, Zweier JL, Villamena FA, 2008, "Synthesis and spin-trapping properties of a new spirolactonyl nitrone.." Journal of Organic Chemistry 7, no. 73, 2533-2541 - 2533-2541.
  • Wu, W; Kehn-Hall, K; Pedati, C; Zweier, L; Castro, I; Klase, Z; Dowd, CS; Dubrovsky, L; Bukrinsky, M; Kashanchi, F, 2008, "Drug 9AA reactivates p21/Waf1 and Inhibits HIV-1 progeny formation." VIROLOGY JOURNAL 5,
  • Tejero J, Biswas A, Wang ZQ, Page RC, Haque MM, Hemann C, Zweier JL, Misra S, Stuehr DJ, 2008, "Stabilization and Characterization of a Heme-Oxy Reaction Intermediate in Inducible Nitric-oxide Synthase.." J Biol Chem no. 283(48):, 33498-507 - 33498-507.
  • Chen, CA; Druhan, LJ; Varadharaj, S; Chen, YR; Zweier, JL, 2008, "Phosphorylation and L-Arginine Increase Superoxide Generation from Endothelial Nitric Oxide Synthase (eNOS)." CIRCULATION 118, no. 18, S273-S273 - S273-S273.
  • Villamena, FA; Liu, YP; Zweier, JL, 2008, "Superoxide Radical Anion Adduct of 5,5-Dimethyl-1-pyrroline N-Oxide. 4. Conformational Effects on the EPR Hyperfine Splitting Constants." JOURNAL OF PHYSICAL CHEMISTRY A 112, no. 49, 12607-12615 - 12607-12615.
  • Chen, CA; Druhan, LJ; Wang, TY; Chen, YR; Zweier, JL, 2008, "S-glutathiolation Uncouples Endothelial Nitric Oxide (NO) Synthase, Switching Enzyme from NO to Superoxide Production." CIRCULATION 118, no. 18, S274-S274 - S274-S274.
  • Cisse, B; Caton, ML; Lehner, M; Maeda, T; Scheu, S; Locksley, R; Holmberg, D; Zweier, C; den Hollander, NS; Kant, SG; Holter, W; Rauch, A; Zhuang, YA; Reizis, B, 2008, "Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development." CELL 135, no. 1, 37-48 - 37-48.
  • Venkatakrishnan, CD; Dunsmore, K; Wong, H; Roy, S; Sen, CK; Wani, A; Zweier, JL; Ilangovan, G, 2008, "HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G(2)/M phase cell cycle arrest." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 294, no. 4, H1736-H1744 - H1736-H1744.
  • Sun J, Druhan LJ, Zweier JL, 2008, "Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase." Arch. Biochem. Biophys 2, no. 471, 126-133 - 126-133.
  • Jones, CI; Han, ZS; Presley, T; Varadharaj, S; Zweier, JL; Ilangovan, G; Alevriadou, BR, 2008, "Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite." AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 295, no. 1, C180-C191 - C180-C191.
  • Ojha, N; Roy, S; Radtke, J; Simonetti, O; Gnyawali, S; Zweier, JL; Kuppusamy, P; Sen, CK, 2008, "Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 294, no. 6, H2435-H2443 - H2435-H2443.
  • Rauch, A; Thiel, CT; Schindler, D; Wick, U; Crow, YJ; Ekici, AB; van Essen, AJ; Goecke, TO; Al-Gazali, L; Chrzanowska, KH; Zweier, C; Brunner, HG; Becker, K; Curry, CJ; Dallapiccola, B; Devriendt, K; Dorfler, A; Kinning, E; Megarbane, A; Meinecke, P; Semple, RK; Spranger, S; Toutain, A; Trembath, RC; Voss, E; Wilson, L; Hennekam, R; de Zegher, F; Dorr, HG; Reis, A, 2008, "Mutations in the pericentrin (PCNT) gene cause primordial dwarfism." SCIENCE 319, no. 5864, 816-819 - 816-819.
  • Dhimitruka, I; Bobko, AA; Hadad, CM; Zweier, JL; Khramtsov, VV, 2008, "Synthesis and characterization of amino derivatives of persistent trityl radicals as dual function pH and oxygen paramagnetic probes." JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 130, no. 32, 10780-10787 - 10780-10787.
  • Varadharaj, S; Druhan, LJ; Chen, CA; Wang, TY; Wani, MA; Zweier, JL, 2008, "Intracellular Protein Trafficking In The Vascular Endothelium Is Regulated By Golgi Resident Nitric Oxide Sythase." CIRCULATION 118, no. 18, S274-S274 - S274-S274.
  • Sun, QH; Yue, PB; Ying, ZK; Cardounel, AJ; Brook, RD; Devlin, R; Hwang, JS; Zweier, JL; Chen, LC; Rajagopalan, S, 2008, "Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK." ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 28, no. 10, 1760-1766 - 1760-1766.
  • Kohr MJ, Wang H, Wheeler DG, Velayutham M, Zweier JL, Ziolo MT., 2008, "Biphasic effect of SIN-1 is reliant upon cardiomyocyte contractile state." Free Radic Biol Med no. 45(1), 73-80 - 73-80.
  • Chen CL, Chen J, Rawale S, Varadharaj S, Kaumaya PP, Zweier JL, Chen YR, 2008, "Protein tyrosine nitration of flavin subunit is associated with oxidative modification of mitochondrial complex II in the post-ischemic myocardium." J Biol Chem

2007

  • Liu, Zhenguo; Jiang, Yuehua; Hao, Hong; Gupta, Kalpna; Xu, Jian; Chu, Ling; McFalls, Edward; Zweier, Jay; Verfaillie, Catherine; Bache, Robert J, 2007, "Endothelial nitric oxide synthase is dynamically expressed during bone marrow stem cell differentiation into endothelial cells.." American journal of physiology. Heart and circulatory physiology 293, no. 3,
  • Villamena, Frederick, A; Locigno, Edward, J; Rockenbauer, Antal; Hadad, Christopher, M; Zweier, Jay L, 2007, "Theoretical and experimental studies of the spin trapping of inorganic radicals by 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. Carbonate radical anion.." The journal of physical chemistry. A 111, no. 2,
  • Han, Y; Tuccio, B; Lauricella, R; Rockenbauer, A; Zweier, JL; Villamena, FA, 2007, "Synthesis and spin trapping properties of a new spirolactonyl-nitrone." FREE RADICAL BIOLOGY AND MEDICINE 43, S14-S14 - S14-S14.
  • Ahmad, Rizwan; Vikram, Deepti, S; Clymer, Bradley; Potter, Lee, C; Deng, Yuanmu; Srinivasan, Parthasarathy; Zweier, Jay, L; Kuppusamy, Periannan, 2007, "Uniform distribution of projection data for improved reconstruction quality of 4D EPR imaging.." Journal of magnetic resonance (San Diego, Calif. : 1997) 187, no. 2,
  • Turakhia, Samir; Venkatakrishnan, C, D; Dunsmore, Kathy; Wong, Hector; Kuppusamy, Periannan; Zweier, Jay, L; Ilangovan, Govindasamy, 2007, "Doxorubicin-induced cardiotoxicity: direct correlation of cardiac fibroblast and H9c2 cell survival and aconitase activity with heat shock protein 27.." American journal of physiology. Heart and circulatory physiology 293, no. 5,
  • Forbes, SP; Pope, AJ; Druhan, L; Zweier, J; Cardounel, A, 2007, "Regulation of eNOS derived superoxide by endogenous methylarginines." CIRCULATION 116, no. 16, 293-294 - 293-294.
  • Khan, Mahmood; Kutala, Vijay Kumar; Vikram, Deepti, S; Wisel, Sheik; Chacko, Simi, M; Kuppusamy, M Lakshmi; Mohan, Iyyapu, K; Zweier, Jay, L; Kwiatkowski, Pawel; Kuppusamy, Periannan, 2007, "Skeletal myoblasts transplanted in the ischemic myocardium enhance in situ oxygenation and recovery of contractile function.." American journal of physiology. Heart and circulatory physiology 293, no. 4,
  • Talukder, M A Hassan; Kalyanasundaram, Anuradha; Zhao, Xue; Zuo, Li; Bhupathy, Poornima; Babu, Gopal, J; Cardounel, Arturo, J; Periasamy, Muthu; Zweier, Jay L, 2007, "Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction.." American journal of physiology. Heart and circulatory physiology 293, no. 4,
  • Dinkova-Kostova, AT; Cheah, J; Samouilov, A; Zweier, JL; Bozak, RE; Hicks, RJ; Talalay, P, 2007, "Phenolic Michael reaction acceptors: Combined direct and indirect antioxidant Defenses against electrophiles and oxidants." MEDICINAL CHEMISTRY 3, no. 3, 261-268 - 261-268.
  • Villamena, Frederick, A; Merle, John, K; Hadad, Christopher, M; Zweier, Jay L, 2007, "Rate constants of hydroperoxyl radical addition to cyclic nitrones: a DFT study.." The journal of physical chemistry. A 111, no. 39,
  • Dhimitruka I, Velayutham M, Bobko AA, Khramtsov VV, villamena F, Hadad CM, Zweier JL., 2007, "Large scale synthesis of a trityl spin-probe for use in biomedical EPR imaging.." Bioorg Med Chem Lett 24, no. 17, 6801-6805 - 6801-6805.
  • Dhimitruka, Ilirian; Velayutham, Murugesan; Bobko, Andrey, A; Khramtsov, Valery, V; Villamena, Frederick, A; Hadad, Christopher, M; Zweier, Jay L, 2007, "Large-scale synthesis of a persistent trityl radical for use in biomedical EPR applications and imaging.." Bioorganic & medicinal chemistry letters 17, no. 24,
  • Chen, CA; Druhan, LJ; Chen, YR; Zweier, JL, 2007, "S-glutathiolation of endothelial nitric oxide synthase modulates its enzymatic activity and protects against oxidative damage." CIRCULATION 116, no. 16, 7-7 - 7-7.

2006

  • Villamena, Frederick, A; Locigno, Edward, J; Rockenbauer, Antal; Hadad, Christopher, M; Zweier, Jay L, 2006, "Theoretical and experimental studies of the spin trapping of inorganic radicals by 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 1. Carbon dioxide radical anion.." The journal of physical chemistry. A 110, no. 49,
  • Presley T, Kuppusamy P, Zweier JL., 2006, "The role of heat shock protein 90 and endothelial nitric oxide synthase signaling in cardiovascular therapy.." Current Signal transduction Therapy 3, no. 1, 305-315 - 305-315.
  • Roy, Sashwati; Khanna, Savita; Kuhn, Donald, E; Rink, Cameron; Williams, Willis, T; Zweier, Jay, L; Sen, Chandan K, 2006, "Transcriptome analysis of the ischemia-reperfused remodeling myocardium: temporal changes in inflammation and extracellular matrix.." Physiological genomics 25, no. 3,
  • Zhao X, Chen RR, He G, Zhang A, Strauch AR, Druhan L, Zweier JL., 2006, "Endothelial Nitric Oxide synthase (NOS3) Knockout Decreases NOS2 Induction Limiting Hyperoxygenation and Conferring Protection in the Postischemic Heart.." Am J Physiol Heart Circ Physiol 3, no. 292, H1541-H1550 - H1541-H1550.
  • Xia, Shijing; Villamena, Frederick, A; Hadad, Christopher, M; Kuppusamy, Periannan; Li, Yunbo; Zhu, Hong; Zweier, Jay L, 2006, "Reactivity of molecular oxygen with ethoxycarbonyl derivatives of tetrathiatriarylmethyl radicals.." The Journal of organic chemistry 71, no. 19,

2005

  • Locigno, Edward, J; Zweier, Jay, L; Villamena, Frederick A, 2005, "Nitric oxide release from the unimolecular decomposition of the superoxide radical anion adduct of cyclic nitrones in aqueous medium.." Organic & biomolecular chemistry 3, no. 17, 3220-7 - 3220-7.
  • Zhou, Yingbi; Dirksen, Wessel, P; Chen, Yanfang; Morris, Mariana; Zweier, Jay, L; Periasamy, Muthu, 2005, "A major role for AT1b receptor in mouse mesenteric resistance vessels and its distribution in heart and neuroendocrine tissues.." Journal of molecular and cellular cardiology 38, no. 4, 693-6 - 693-6.
  • Villamena, Frederick, A; Hadad, Christopher, M; Zweier, Jay L, 2005, "Comparative DFT study of the spin trapping of methyl, mercapto, hydroperoxy, superoxide, and nitric oxide radicals by various substituted cyclic nitrones.." The journal of physical chemistry. A 109, no. 8,
  • Velayutham, Murugesan; Villamena, Frederick, A; Navamal, Mettachit; Fishbein, James, C; Zweier, Jay L, 2005, "Glutathione-mediated formation of oxygen free radicals by the major metabolite of oltipraz.." Chemical research in toxicology 18, no. 6, 970-5 - 970-5.
  • Villamena, Frederick, A; Merle, John, K; Hadad, Christopher, M; Zweier, Jay L, 2005, "Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. The thermodynamics of decay and EPR spectral properties.." The journal of physical chemistry. A 109, no. 27,

2004

  • Villamena, Frederick, A; Hadad, Christopher, M; Zweier, Jay L, 2004, "Theoretical study of the spin trapping of hydroxyl radical by cyclic nitrones: a density functional theory approach.." Journal of the American Chemical Society 126, no. 6, 1816-29 - 1816-29.
  • Zhou, Yingbi; Dirksen, Wessel, P; Zweier, Jay, L; Periasamy, Muthu, 2004, "Endothelin-1-induced responses in isolated mouse vessels: the expression and function of receptor types.." American journal of physiology. Heart and circulatory physiology 287, no. 2, H573-8 - H573-8.
  • Villamena, Frederick, A; Rockenbauer, Antal; Gallucci, Judith; Velayutham, Murugesan; Hadad, Christopher, M; Zweier, Jay L, 2004, "Spin trapping by 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO): theoretical and experimental studies.." The Journal of organic chemistry 69, no. 23, 7994-8004 - 7994-8004.
  • Villamena, Frederick, A; Zweier, Jay L, 2004, "Detection of reactive oxygen and nitrogen species by EPR spin trapping.." Antioxidants & redox signaling 6, no. 3, 619-29 - 619-29.

2003

  • Zeigler, Mandy, M; Doseff, Andrea, I; Galloway, Michelle, F; Opalek, Judy, M; Nowicki, Philip, T; Zweier, Jay, L; Sen, Chandan, K; Marsh, Clay B, 2003, "Presentation of nitric oxide regulates monocyte survival through effects on caspase-9 and caspase-3 activation.." The Journal of biological chemistry 278, no. 15, 12894-902 - 12894-902.
  • Zweier, Jay, L; He, Guanglong; Samouilov, Alexandre; Kuppusamy, Periannan, 2003, "EPR spectroscopy and imaging of oxygen: applications to the gastrointestinal tract.." Advances in experimental medicine and biology 530, 123-31 - 123-31.
  • Roy, Sashwati; Khanna, Savita; Wallace, William, A; Lappalainen, Jani; Rink, Cameron; Cardounel, Arturo, J; Zweier, Jay, L; Sen, Chandan K, 2003, "Characterization of perceived hyperoxia in isolated primary cardiac fibroblasts and in the reoxygenated heart.." The Journal of biological chemistry 278, no. 47, 47129-35 - 47129-35.

2002

  • He, Guanglong; Samouilov, Alexandre; Kuppusamy, Periannan; Zweier, Jay L, 2002, "In vivo imaging of free radicals: applications from mouse to man.." Molecular and cellular biochemistry 234-235, no. 1-2, 359-67 - 359-67.
  • Samouilov, Alexandre; Zweier, Jay L, 2002, "Analytical implications of iron dithiocarbamates for measurement of nitric oxide.." Methods in enzymology 352, 506-22 - 506-22.

1997

  • Xu, K, Y; Zweier, J, L; Becker, L C, 1997, "Oxygen-free radicals directly attack the ATP binding site of the cardiac Na+,K(+)-ATPase.." Annals of the New York Academy of Sciences 834, 680-3 - 680-3.