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Jay Zweier

  • Professor, SBS-Physiology & Cell Biology
  • Professor - Joint Appointment, SBS-Biolog Chem & Pharmacology
  • Professor, Cardiovascular Medicine
  • Professor - Joint Appointment, Radiology
  • Room #0390
    460 W 12th Ave
    Columbus, OH 43210
  • 614-247-7788

Chapters

2003

  • Zweier JL, He G, Samouilov A, Kuppusamy P. 2003. "Cardiac Applications of In Vivo EPR Spectroscopy and Imaging." In Oxygen Transport to Tissue XXIV, edited by edited by Dunn and Swartz, Norwell, MA: Kluwer Academic/Plenum Publishers.
  • Kuppusamy P, Chzhan M, Zweier JL. 2003. "Principles of Imaging." In Oxygen Transport to Tissue XXIV, edited by edited by Dunn and Swartz, Norwell, MA: Kluwer Academic/Plenum Publishers.
  • Zweier JL, Villamena FA. 2003. "Chemistry of free radicals in biological systems." In Oxidative Stress and Cardiac Failure, edited by edited by Kukin ML, Fuster V, New York: Futura Publishing, Armonk.

2001

  • deSouza H, Zweier JL. 2001. "Free radicals as mediators of inflammation in atherosclerosis." In Inflammatory and Infectious Basis of Atherosclerosis, edited by edited by Jay L. Mehta, Switzerland: Birkhauser Verlag Basel.
  • Xia Y, Zweier JL. 2001. "Superoxide anion release from inducible nitric oxide synthase." In Nitric Oxide and Inflammation, edited by edited by Salvemini D, Billiar T, & Vodovotz Y, Switzerland: Birkhauser Verlag Basel.

1998

  • Zweier JL, Kuppusamy P. 1998. "Principles of Electron Paramagnetic Resonance Spectroscopy for Measurement of Free Radicals In Biological Tissues." In Nitric Oxide in Transplant Rejection and Anti-tumor Defense, edited by edited by Lukiewicz & Zweier, MA: Kluwer Academic Publishers.
  • Kuppusamy P, Zweier JL. 1998. "EPR Imaging of Free Radicals in Biological Systems." In Nitric Oxide in Transplant Rejection and Anti-tumor Defense, edited by edited by Lukiewicz & Zweier, MA: Kluwer Academic Publishers.
  • Zweier JL, Samouilov A, Kuppusamy P. 1998. "Independent Formation of Nitric Oxide In Tissues." In Nitric Oxide in Transplant Rejection and Anti-tumor Defense, edited by edited by Lukiewicz & Zweier, Norwell, MA: Kluwer Academic Publishers.
  • Zweier JL. 1998. "Mechanism of Leukocyte Accumulation in Postischemic Tissues:Role of Oxygen Free Radicals." In The Neutrophils: New Outlook for the Old Cells, edited by edited by D. Gabrilovich, London: Imperial College Press.
  • Zweier JL, Kuppusamy P. 1998. "EPR Imaging of the Rat Heart." In Spatially Resolved Magnetic Resonance: Methods and Applications in Materials Science, Agriculture, and Biomedicine, edited by edited by B Blumich, P Blumler, R Botto, E Fukushima, Weinheim: VCH.

1997

  • Xu KY, Zweier JL, Becker LC. 1997. "Oxygen-free Radicals Directly Attack the ATP Binding Site of the Cardiac Na+,K+-ATPase." In Annals New York Academy of Sciences, New York: Annals New York Academy of Sciences.

1992

  • Kuppusamy P, Zweier JL. 1992. "Study of Free Radical Generation in Isolated Cells and Whole Tissues Using Electron Paramagnetic Resonance Spectroscopy." In Cellular Membrane: A Key to Disease Processes, edited by Ohnishi/Ohnishi: Chapter 10, CRC Press, Inc.

1991

  • Zweier JL. 1991. "The Role of Iron in Myocardial Reperfusion Injury." In Iron and Human Disease, edited by R.B. Lauffer: CRC Press, Inc.
  • Kensler T, Dolan P, Egner P, Lesko S, Swauger J, Zweier J, Akman S. 1991. "Free Radical Metabolism and DNA Damage by Organic Peroxide Tumor Promoters." In Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury, edited by S Nigam, KV Honn, LJ Marnett, TL Walden,Jr: Chapter 80, Proceedings of the 2nd International Conference.
  • Zweier JL, Kuppusamy P, Shandelya SML, Thompson-Gorman S, Weisman HF, Fearon DT, Weisfeldt ML. 1991. "Electron Paramagnetic Resonance Measurements of Free Radical Generation in Isolated Cells and Whole Tissues.." In Molecular Basis of Oxidative Damage by Leukocytes, edited by edited by Jesaitis/Dratz, edited by Jesaitis/Dratz: CRC Press, Inc.

1989

  • Zweier JL, Flaherty JT. 1989. "The Role of Free Radicals in the Pathogenesis of Postischemic Reperfusion Injury, in Early Interventions.." In Acute Myocardial Infarction, edited by E. Rapaport: Kluwer Academic Publishers.
  • Taffe BG, Zweier JL, Kensler TW. 1989. "Tumor promotion by butylated hydroxytoluene hyperoxide. In: Pharmacological effects of lipids.." In Role of lipid in carcinogenesis and therapy., 293 - 302. IL: American Oil Chemists Society, Champaign.
  • Weisfeldt ML, Zweier JL, Becker LC, Ambrosio G, Flaherty JT. 1989. "New Aspects of Drug Therapy: Free Radical Scavengers.." In Limitation of Infarct Size, 75 - 82. Springer Verlag: Schmutler H, Rutsch W, Doughtery FC.

1988

  • Weisfeldt ML, Zweier JL, Ambrosio G, Becker LC, Flaherty JT. 1988. "Evidence that free radicals result in reperfusion injury in heart muscle.." In Oxygen Radicals in Biology and Medicine, edited by edited by Simic ME, Taylor KA, Ward JF, Von Sonntag C, New York: Plenum.
  • Weisfeldt ML, Zweier JL, Flaherty JT. 1988. "Oxygen-Derived Radicals and Myocardial Ischemic Injury.." In Heart Disease: Clinical Update (3), edited by Braunwald E: W.B. Saunders & Co.

Journal Articles

2011

  • Joddar, B; Reen, RK; Firstenberg, MS; Varadharaj, S; McCord, JM; Zweier, JL; Gooch, KJ, 2011, "Protandim attenuates intimal hyperplasia in human saphenous veins cultured ex vivo via a catalase-dependent pathway." FREE RADICAL BIOLOGY AND MEDICINE 50, no. 6, 700 - 709.
  • Talukder, MAH; Johnson, WM; Varadharaj, S; Lian, JR; Kearns, PN; El-Mahdy, MA; Liu, XP; Zweier, JL, 2011, "Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 300, no. 1, H388 - H396.
  • Zweier, JL; Talukder, MAH, 2011, "Targeting Dimethylarginine Dimethylaminohydrolases in Pulmonary Arterial Hypertension A New Approach to Improve Vascular Dysfunction?." CIRCULATION 123, no. 11, 1156 - 1158.
  • Druhan L, Karuppiah K, Chen CA, Smith T, Zweier JL, Sessa WC, Cardounel AJ., 2011, "Suppression of eNOS-Derived Superoxide by Caveolin-1: A Biopterin-Dependent Mechanism.." Am J Physiol Heart Circ Physiol.
  • Olga Effimova, Alexandre Samouilov, Jay Zweier, 2011, "Standard-based method for proton–electron double resonance imaging of oxygen." JOURNAL OF MAGNETIC RESONANCE no. In Press,
  • Quarrie, R; Cramer, BM; Lee, DS; Steinbaugh, GE; Erdahl, W; Pfeiffer, DR; Zweier, JL; Crestanello, JA, 2011, "Ischemic Preconditioning Decreases Mitochondrial Proton Leak and Reactive Oxygen Species Production in the Postischemic Heart." JOURNAL OF SURGICAL RESEARCH 165, no. 1, 5 - 14.
  • Chu, L; Hao, H; Luo, M; Huang, Y; Chen, ZY; Lu, TW; Zhao, X; Verfaillie, CM; Zweier, JL; Liu, ZG, 2011, "Ox-LDL modifies the behaviour of bone marrow stem cells and impairs their endothelial differentiation via inhibition of Akt phosphorylation." JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 15, no. 2, 423 - 432.
  • Efimova OV, Sun Z, Petryakov S, Kesselring E, Caia GL, Johnson D, Zweier JL, Khramtsov VV, Samouilov A, 2011, "Variable radio frequency proton-electron double-resonance imaging: Application to pH mapping of aqueous samples." J Magn Reson 2, no. 209, 227 - 32..
  • Liu Y, Song Y, Rockenbauer A, Sun J, Hemann C, Villamena FA, Zweier JL, 2011, "Synthesis of trityl radical-conjugated disulfide biradicals for the measurement of thiol concentration.." J Org Chem
  • Velayutham M, Hemann C, Zweier JL., 2011, "Removal of H(2)O(2) and generation of superoxide radical: Role of cytochrome c and NADH.." Free Radic Biol Med. (1), no. 51, 160 - 170.
  • Chen CA, Lin CH, Druhan LJ, Wang TY, Chen YR, Zweier JL., 2011, "Superoxide induces eNOS protein Thiyl radical formation: a novel mechanism regulating eNOS function and coupling.." J Biol Chem.
  • Nishijima Y, Sridhar A, Bonilla I, Velayutham M, Khan M, Terentyeva R, Li C, Kuppusamy P, Elton TS, Terentyev D, Györke S, Zweier JL, Cardounel AJ, Carnes CA., 2011, "Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology." Cardiovasc Res
  • Muir WW, Ilangovan G, Zweier JL, Moon-Massat PF, Rentko VT, 2011, "Vital Organ Tissue Oxygenation after Serial Normovolemic Exchange Transfusion with HBOC-201 in Anesthetized Swine." Shock.
  • Nishijima Y, Sridhar A, Zweier JL, Cardounel AJ, Carnes CA., 2011, "Reply: Is NOS uncoupling the missing link between atrial fibrillation and chronic non-ischemic cardiomyopathy?." Cardiovasc Res.
  • Mital R, Zhang W, Cai M, Huttinger ZM, Goodman LA, Wheeler DG, Ziolo MT, Dwyer K, d'Apice A, Zweier JL, He G, Cowan P, Gumina RJ, 2011, "Antioxidant Network Expression Abrogates Oxidative Post-Translational Modifications in Mice." Am J Physiol Heart Circ Physiol
  • Chen J, Chen CL, Alevriadou BR, Zweier JL, Chen YR, 2011, "Excess NO predisposes mitochondrial succinate-cytochrome c reductase to produce hydroxyl radical." Biochim Biophys Acta 1807, no. 5, 491 - 502.
  • Tewari AK, Popova-Butler A, El-Mahdy MA, Zweier JL, 2011, "Identification of differentially expressed proteins in blood plasma of control and cigarette smoke-exposed mice by 2-D DIGE/MS.." Proteomics 10, no. 11, 2051 - 62.
  • Rajasekaran, NS; Varadharaj, S; Khanderao, GD; Davidson, CJ; Kannan, S; Firpo, MA; Zweier, JL; Benjamin, IJ, 2011, "Sustained Activation of Nuclear Erythroid 2-Related Factor 2/Antioxidant Response Element Signaling Promotes Reductive Stress in the Human Mutant Protein Aggregation Cardiomyopathy in Mice." ANTIOXIDANTS & REDOX SIGNALING 14, no. 6, 957 - 971.
  • Talukder, MAH; Yang, FC; Nishijima, Y; Chen, CA; Xie, L; Mahamud, SD; Kalyanasundaram, A; Bonagura, JD; Periasamy, M; Zweier, JL, 2011, "Detrimental effects of thyroid hormone analog DITPA in the mouse heart: increased mortality with in vivo acute myocardial ischemia-reperfusion." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 300, no. 2, H702 - H711.
  • Efimova, OV; Sun, ZQ; Petryakov, S; Kesselring, E; Caia, GL; Johnson, D; Zweier, JL; Khramtsov, VV; Samouilov, A, 2011, "Variable radio frequency proton-electron double-resonance imaging: Application to pH mapping of aqueous samples." JOURNAL OF MAGNETIC RESONANCE 209, no. 2, 227 - 232.
  • Zweier JL, Chen CA, Druhan LJ, 2011, "S-glutathionylation reshapes our understanding of endothelial nitric oxide synthase uncoupling and nitric oxide/reactive oxygen species-mediated signaling.." Antioxid Redox Signal 10, no. 14(, 1769 - 75.

2010

  • Kim, SU; Liu, Y; Nash, KM; Zweier, JL; Rockenbauer, A; Villamena, FA, 2010, "Fast Reactivity of a Cyclic Nitrone-Calix[4]pyrrole Conjugate with Superoxide Radical Anion: Theoretical and Experimental Studies." JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132, no. 48, 17157 - 17173.
  • Lee, DS; Steinbaugh, GE; Quarrie, R; Yang, FC; Talukder, MAH; Zweier, JL; Crestanello, JA, 2010, "Ischemic Postconditioning Does Not Provide Cardioprotection from Long-Term Ischemic Injury in Isolated Male or Female Rat Hearts." JOURNAL OF SURGICAL RESEARCH 164, no. 2, 175 - 181.
  • Ahmad, R; Caia, G; Potter, LC; Petryakov, S; Kuppusamy, P; Zweier, JL, 2010, "In vivo multisite oximetry using EPR-NMR coimaging." JOURNAL OF MAGNETIC RESONANCE 207, no. 1, 69 - 77.
  • Liu, XP; El-Sherbiny, GA; Collard, E; Huang, X; Follmer, D; El-Mandy, M; Zweier, JL, 2010, "Application of carbon fiber composite minielectrodes for measurement of kinetic constants of nitric oxide decay in solution." NITRIC OXIDE-BIOLOGY AND CHEMISTRY 23, no. 4, 311 - 318.
  • Dhimitruka, I; Grigorieva, O; Zweier, JL; Khramtsov, VV, 2010, "Synthesis, structure, and EPR characterization of deuterated derivatives of Finland trityl radical." BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20, no. 13, 3946 - 3949.
  • Chen, WG; Druhan, LJ; Chen, CA; Hemann, C; Chen, YR; Berka, V; Tsai, AL; Zweier, JL, 2010, "Peroxynitrite Induces Destruction of the Tetrahydrobiopterin and Heme in Endothelial Nitric Oxide Synthase: Transition from Reversible to Irreversible Enzyme Inhibition." BIOCHEMISTRY 49, no. 14, 3129 - 3137.
  • Sun, J; Druhan, LJ; Zweier, JL, 2010, "Reactive oxygen and nitrogen species regulate inducible nitric oxide synthase function shifting the balance of nitric oxide and superoxide production." ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 494, no. 2, 130 - 137.
  • Shet, K; Caia, GL; Kesselring, E; Samouilov, A; Petryakov, S; Lurie, DJ; Zweier, JL, 2010, "A novel variable field system for field-cycled dynamic nuclear polarization spectroscopy." JOURNAL OF MAGNETIC RESONANCE 205, no. 2, 202 - 208.
  • Chen, JF; Chen, CL; Rawale, S; Chen, CA; Zweier, JL; Kaumaya, PTP; Chen, YR, 2010, "Peptide-based Antibodies against Glutathione-binding Domains Suppress Superoxide Production Mediated by Mitochondrial Complex I." JOURNAL OF BIOLOGICAL CHEMISTRY 285, no. 5, 3168 - 3180.
  • Liu, YP; Song, YG; Villamena, FA; Zweier, JL, 2010, "Development of Trityl-conjugated Disulfide Biradical for the Measurement of Thiol Concentration and Oxygenation." FREE RADICAL BIOLOGY AND MEDICINE 49, S212 - S212.
  • Khramtsov, VV; Caia, GL; Shet, K; Kesselring, E; Petryakov, S; Zweier, JL; Samouilov, A, 2010, "Variable Field Proton-Electron Double-Resonance Imaging: Application to pH mapping of aqueous samples." JOURNAL OF MAGNETIC RESONANCE 202, no. 2, 267 - 273.
  • Talukder, MAH; Yang, FC; Shimokawa, H; Zweier, JL, 2010, "eNOS is required for acute in vivo ischemic preconditioning of the heart: effects of ischemic duration and sex." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 299, no. 2, H437 - H445.
  • Liu, YP; Villamena, FA; Rockenbauer, A; Zweier, JL, 2010, "Trityl-nitroxide biradicals as unique molecular probes for the simultaneous measurement of redox status and oxygenation." CHEMICAL COMMUNICATIONS 46, no. 4, 628 - 630.
  • Ahmad, R; Som, S; Kesselring, E; Kuppusamy, P; Zweier, JL; Potter, LC, 2010, "Digital detection and processing of multiple quadrature harmonics for EPR spectroscopy." JOURNAL OF MAGNETIC RESONANCE 207, no. 2, 322 - 331.
  • Liu, XP; Srinivasan, P; Collard, E; Grajdeanu, P; Lok, K; Boyle, SE; Friedman, A; Zweier, JL, 2010, "Oxygen regulates the effective diffusion distance of nitric oxide in the aortic wall." FREE RADICAL BIOLOGY AND MEDICINE 48, no. 4, 554 - 559.
  • Zweier, JL; Li, HT; Samouilov, A; Liu, XP, 2010, "Mechanisms of nitrite reduction to nitric oxide in the heart and vessel wall." NITRIC OXIDE-BIOLOGY AND CHEMISTRY 22, no. 2, 83 - 90.
  • Velayutham, M; Hemann, C; Zweier, JL, 2010, "Cytochrome c as a Source of Superoxide Radical: Role of H2O2 and NADH." FREE RADICAL BIOLOGY AND MEDICINE 49, S216 - S216.
  • Kundu, TK; Velayutham, M; Zweier, JL, 2010, "Generation of Reactive Oxygen Species by Aldehyde Oxidase through the Oxidation of NADH." FREE RADICAL BIOLOGY AND MEDICINE 49, S96 - S96.
  • Samouilov, A; Bobko, A; Colantuano, G; Zweier, JL, 2010, "Accelerated Autoxidation of Myoglobin During the Onset of Ischemia." FREE RADICAL BIOLOGY AND MEDICINE 49, S29 - S29.
  • Vedam, K; Nishijima, Y; Druhan, LJ; Khan, M; Moldovan, NI; Zweier, JL; Ilangovan, G, 2010, "Role of heat shock factor-1 activation in the doxorubicin-induced heart failure in mice." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 298, no. 6, H1832 - H1841.
  • Li, HT; Cui, HM; Wang, TY; Zweier, JL, 2010, "Endogenous Methyl-arginine in Regulation of Nitric Oxide Generation from Inducible Nitric Oxide synthase." FREE RADICAL BIOLOGY AND MEDICINE 49, S116 - S117.
  • Liu, YP; Villamena, FA; Song, YG; Sun, JA; Rockenbauer, A; Zweier, JL, 2010, "Synthesis of N-14- and N-15-labeled Trityl-nitroxide Bradicals with Strong Spin-Spin Interaction and Improved Sensitivity to Redox Status and Oxygen." JOURNAL OF ORGANIC CHEMISTRY 75, no. 22, 7796 - 7802.
  • Chen, CA; Wang, TY; Varadharaj, S; Reyes, LA; Hemann, C; Talukder, MAH; Chen, YR; Druhan, LJ; Zweier, JL, 2010, "S-glutathionylation uncouples eNOS and regulates its cellular and vascular function." NATURE 7327, no. 468, 1115 - 1118.
  • Petryakov, S; Samouilov, A; Kesselring, E; Caia, GL; Sun, ZQ; Zweier, JL, 2010, "Dual frequency resonator for 1.2 GHz EPR/16.2 MHz NMR co-imaging." JOURNAL OF MAGNETIC RESONANCE 205, no. 1, 1 - 8.

2009

  • Petryakov, S; Samouilov, A; Chzhan-Roytenberg, M; Kesselring, E; Sun, ZQ; Zweier, JL, 2009, "Segmented surface coil resonator for in vivo EPR applications at 1.1 GHz." JOURNAL OF MAGNETIC RESONANCE 198, no. 1, 8 - 14.
  • Varadharaj, S; Druhan, LJ; Jackson, A; Soorappan, R; Zweier, JL, 2009, "Discrete Activation of the two Subcellular Nitric Oxide Synthase Pools Differentially Regulates Exocytosis in the Vascular Endothelium." FREE RADICAL BIOLOGY AND MEDICINE 47, S67 - S67.
  • Velayutham, M; Villamena, FA; Fishbein, JC; Zweier, JL, 2009, "Generation of Singlet Oxygen by Cancer Chemopreventive Oltipraz on Illumination with Visible Light: Role of Melatonin." FREE RADICAL BIOLOGY AND MEDICINE 47, S177 - S177.
  • Liu, ZH; Lei, MX; Jiang, YH; Hao, H; Chu, L; Xu, J; Luo, M; Verfaillie, CM; Zweier, JL; Liu, ZG, 2009, "High glucose attenuates VEGF expression in rat multipotent adult progenitor cells in association with inhibition of JAK2/STAT3 signalling." JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 13, no. 9B, 3427 - 3436.
  • Chen, CA; Druhan, LJ; Varadharaj, S; Wang, TY; Chen, YR; Zweier, JL, 2009, "Superoxide Generation from Endothelial Nitric Oxide Synthase Is Regulated by Posttranslational Modification and L-Arginine Binding." CIRCULATION RESEARCH 105, no. 7, E41 - E41.
  • Zhao, X; Zhang, JY; Mei, X; Liao, DN; Hu, JQ; Li, L; Liu, ZG; Zweier, JL, 2009, "Pulmonary vein electric shunting for therapy of atrial fibrillation." MEDICAL HYPOTHESES 72, no. 4, 474 - 475.
  • Talukder, MAH; Zweier, JL; Periasamy, M, 2009, "Targeting calcium transport in ischaemic heart disease." CARDIOVASCULAR RESEARCH 84, no. 3, 345 - 352.
  • Racoma, I; Wang, A; Zweier, JL; Villamena, FA, 2009, "Effects of Natural and Synthetic Antioxidants on Uncoupled Endothelial Nitric Oxide Synthase Function." FREE RADICAL BIOLOGY AND MEDICINE 47, S150 - S150.
  • Li, HT; Kundu, TK; Zweier, JL, 2009, "Characterization of the Magnitude and Mechanism of Aldehyde Oxidase-mediated Nitric Oxide Production." FREE RADICAL BIOLOGY AND MEDICINE 47, S189 - S189.
  • Bobko, AA; Dhimitruka, I; Eubank, TD; Marsh, CB; Zweier, JL; Khramtsov, VV, 2009, "Trityl-based EPR probe with enhanced sensitivity to oxygen." FREE RADICAL BIOLOGY AND MEDICINE 47, no. 5, 654 - 658.
  • Talukder, MAH; Yang, F; Nishijima, Y; Chen, CA; Kalyanasundaram, A; Periasamy, M; Zweier, JL, 2009, "Reduced SERCA2a converts sub-lethal myocardial injury to infarction and affects postischemic functional recovery." JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 46, no. 2, 285 - 287.
  • Kundu, TK; Velayutham, M; Hille, R; Zweier, JL, 2009, "Role of Aldehyde Oxidase in the Generation of Reactive Oxygen Species in Biological Tissues." FREE RADICAL BIOLOGY AND MEDICINE 47, S127 - S127.
  • Crestanello, JA; Lee, DS; Steinbaugh, G; Pfeiffer, D; Zweier, J, 2009, "Superoxide radical production by mitochondrial respiratory complexes I and III is decreased by ischemic preconditioning." JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 209, no. 3, S33 - S33.
  • Reyes, LA; Dumitrescu, C; Druhan, L; Zweier, JL, 2009, "Depletion of the Endothelial Nitric Oxide Synthase (eNOS) Substrate NADPH Triggers Endothelial Dysfunction in the Post-Ischemic Heart: Role of Glucose 6 Phosphate Dehydrogenase (G6PD)." CIRCULATION 120, no. 18, S1012 - S1012.
  • Presley, T; Vedam, K; Liu, XP; Zweier, JL; Ilangovan, G, 2009, "Activation of Hsp90/NOS and increased NO generation does not impair mitochondrial respiratory chain by competitive binding at cytochrome C Oxidase in low oxygen concentrations." CELL STRESS & CHAPERONES 14, no. 6, 611 - 627.
  • Zweier, JL, 2009, "Mechanisms of nitrite reduction to nitric oxide in the vessel wall." NITRIC OXIDE-BIOLOGY AND CHEMISTRY 20, S21 - S21.
  • Han, ZS; Varadharaj, S; Giedt, RJ; Zweier, JL; Szeto, HH; Alevriadou, BR, 2009, "Mitochondria-Derived Reactive Oxygen Species Mediate Heme Oxygenase-1 Expression in Sheared Endothelial Cells." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 329, no. 1, 94 - 101.
  • Chu, L; Hao, H; Liu, ZH; Xu, J; Luo, M; Huang, Y; Chen, ZY; Verfaillie, CM; Zweier, JL; Liu, ZG, 2009, "Ox-LDL Modifies the Behavior of Bone Marrow Stem Cells and Impairs Their Endothelial Differentiation via Inhibition of Akt Activation." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 53, no. 10, A199 - A199.
  • Yang, FC; Talukder, MAH; Zweier, JL, 2009, "Are There Gender Differences in Cardioprotection? Influence of Aging and Endothelial Nitric Oxide Synthase (eNOS)." CIRCULATION 120, no. 18, S737 - S737.
  • Woldman, YY; Sun, J; Zweier, JL; Khramtsov, VV, 2009, "Direct chemiluminescence detection of nitric oxide in aqueous solutions using the natural nitric oxide target soluble guanylyl cyclase." FREE RADICAL BIOLOGY AND MEDICINE 47, no. 10, 1339 - 1345.
  • Caia, G; Sun, ZQ; Yang, FC; Petryakov, S; Velayutham, M; Samouilov, A; Zweier, JL, 2009, "EPR/NMR Co-imaging of In Vivo Redox Status in Mice." FREE RADICAL BIOLOGY AND MEDICINE 47, S55 - S55.
  • Liu, B; Tewari, AK; Zhang, LW; Green-Church, KB; Zweier, JL; Chen, YR; He, GL, 2009, "Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: Mitochondria as the major target." BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1794, no. 3, 476 - 485.
  • Chan, SY; Zhang, YY; Hemann, C; Mahoney, CE; Zweier, JL; Loscalzo, J, 2009, "MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2." CELL METABOLISM 10, no. 4, 273 - 284.
  • Liu, ZG; Chu, L; Hao, H; Luo, M; Liu, ZH; Huang, Y; Chen, ZY; Verfaillie, CM; Zweier, JL, 2009, "Ox-LDL Modifies the Behavior of Bone Marrow Stem Cells and Impairs Their Endothelial Differentiation via Inhibition of Akt Phosphorylation." ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 29, no. 7, E38 - E38.
  • Talukder, MAH; Yang, FC; Wang, TS; Mammen, PP; Zweier, JL, 2009, "Role of Myoglobin in the Postischemic Heart." CIRCULATION 120, no. 18, S846 - S846.
  • Han, YB; Liu, YP; Rockenbauer, A; Zweier, JL; Durand, G; Villamena, FA, 2009, "Lipophilic beta-Cyclodextrin Cyclic-Nitrone Conjugate: Synthesis and Spin Trapping Studies." JOURNAL OF ORGANIC CHEMISTRY 74, no. 15, 5369 - 5380.
  • Chen, CA; Wang, TY; Varadharaj, S; Reyes, L; Talukder, MAH; Chen, YR; Druhan, LJ; Zweier, JL, 2009, "S-glutathiolation Uncouples Endothelial Nitric Oxide Synthase: A Novel Mechanism of Redox Signaling and Vascular Regulation." CIRCULATION 120, no. 18, S1070 - S1070.
  • Chen, CA; Druhan, LJ; Wang, TY; Chen, YR; Zweier, JL, 2009, "Oxidative Stress Uncouples eNOS in a BH4-independent Manner via the Formation of Protein Thiol-radicals." CIRCULATION 120, no. 18, S1070 - S1070.
  • Chan, SY; Zhang, YY; Hemann, C; Zweier, JL; Loscalzo, J, 2009, "MicroRNA-210 Controls Metabolic Adaptation During Hypoxia in Pulmonary Vascular Endothelium." CIRCULATION 120, no. 18, S743 - S743.
  • Chen, JF; Chen, CL; Chen, CA; Kaumaya, PP; Zweier, JL; Chen, YR, 2009, "Peptide-based Antibodies Against Glutathione-binding Domains Suppress Superoxide Production Mediated by Mitochondrial Complex I." CIRCULATION 120, no. 18, S1020 - S1020.
  • Soorappan, RN; Varadharaj, S; Khanderao, GD; Davidson, CJ; Zweier, JL; Benjamin, IJ, 2009, "Oxidative Stress and Activation of Nrf2 Precedes the Pathogenic Transition of Reductive Stress-Induced Cardiomyopathy in Mice." FREE RADICAL BIOLOGY AND MEDICINE 47, S65 - S65.
  • Holland, R; Navamal, M; Velayutham, M; Zweier, JL; Kensler, TW; Fishbein, JC, 2009, "Hydrogen Peroxide Is a Second Messenger in Phase 2 Enzyme Induction by Cancer Chemopreventive Dithiolethiones." CHEMICAL RESEARCH IN TOXICOLOGY 22, no. 8, 1427 - 1434.
  • Zuo, L; Chen, YR; Reyes, LA; Lee, HL; Chen, CL; Villamena, FA; Zweier, JL, 2009, "The Radical Trap 5,5-Dimethyl-1-Pyrroline N-Oxide Exerts Dose-Dependent Protection against Myocardial Ischemia-Reperfusion Injury through Preservation of Mitochondrial Electron Transport." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 329, no. 2, 515 - 523.
  • Souza, HP; Frediani, D; Cobra, AL; Moretti, AI; Jurado, MC; Fernandes, TR; Cardounel, AJ; Zweier, JL; Tostes, RC, 2009, "Angiotensin II modulates CD40 expression in vascular smooth muscle cells." CLINICAL SCIENCE 116, no. 5-6, 423 - 431.
  • Crestanello, JA; Lee, DS; Steinbaugh, GE; Pfeiffer, DR; Zweier, JL, 2009, "Ischemic Preconditioning Selectively Protects Subsarcolemmal Mitochondrial Respiration Against Ischemic Injury." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 53, no. 10, A307 - A307.
  • Vandewalle, J; Van Esch, H; Govaerts, K; Verbeeck, J; Zweier, C; Madrigal, I; Mila, M; Pijkels, E; Fernandez, I; Kohlhase, J; Spaich, C; Rauch, A; Fryns, JP; Marynen, P; Froyen, G, 2009, "Dosage-Dependent Severity of the Phenotype in Patients with Mental Retardation Due to a Recurrent Copy-Number Gain at Xq28 Mediated by an Unusual Recombination." AMERICAN JOURNAL OF HUMAN GENETICS 85, no. 6, 809 - 822.
  • Liu, YP; Villamena, FA; Rockenbauer, A; Zweier, JL, 2009, "Development of Trityl-nitroxide Biradicals: Unique Probes for Simultaneous Measurement of Redox Status and Oxygenation." FREE RADICAL BIOLOGY AND MEDICINE 47, S189 - S189.
  • Ilagan, RP; Tejero, J; Aulak, KS; Ray, SS; Hemann, C; Wang, ZQ; Gangoda, M; Zweier, JL; Stuehr, DJ, 2009, "Regulation of FMN Subdomain Interactions and Function in Neuronal Nitric Oxide Synthase." BIOCHEMISTRY 48, no. 18, 3864 - 3876.
  • Yang, FC; Talukder, MAH; Zweier, JL, 2009, "Ischemic Preconditioning Robustly Reduces In Vivo Myocardial Infarction in Both Male and Female Mice With Short or Long Ischemic Periods and This Protection Is Lost in the Absence of Endothelial Nitric Oxide Synthase." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 53, no. 10, A308 - A308.
  • Wang, TS; Wang, TY; Sun, J; Chen, CA; Yang, FC; Talukder, MAH; Zweier, JL, 2009, "In Vivo Myocardial Ischemia Reperfusion (I/R) Impairs Nitric Oxide Synthase (NOS) Activity: Potent Cardioprotection With BH4 Treatment." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 53, no. 10, A312 - A313.
  • Steinbaugh, GE; Lee, DS; Pfeiffer, DR; Zweier, JL; Crestanello, JA, 2009, "Ischemic Preconditioning Protects Mitochondrial Respiratory Function in Complex I and Complex II." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 53, no. 10, A309 - A309.
  • Talukder, MAH; Johnson, W; Varadharaj, S; Lian, JR; Kearns, P; Druhan, L; Liu, XP; Zweier, J, 2009, "Cigarette Smoke Exposure Results in Hypertension, Endothelial Dysfunction, Cardiac Hypertrophy, and Leukocyte-Specific Reactive Oxygen Species (ROS) Generation in Mice." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 53, no. 10, A400 - A400.
  • Lundberg, JO; Gladwin, MT; Ahluwalia, A; Benjamin, N; Bryan, NS; Butler, A; Cabrales, P; Fago, A; Feelisch, M; Ford, PC; Freeman, BA; Frenneaux, M; Friedman, J; Kelm, M; Kevil, CG; Kim-Shapiro, DB; Kozlov, AV; Lancaster, JR; Lefer, DJ; McColl, K; McCurry, K; Patel, RP; Petersson, J; Rassaf, T; Reutov, VP; Richter-Addo, GB; Schechter, A; Shiva, S; Tsuchiya, K; van Faassen, EE; Webb, AJ; Zuckerbraun, BS; Zweier, JL; Weitzberg, E, 2009, "Nitrate and nitrite in biology, nutrition and therapeutics." NATURE CHEMICAL BIOLOGY 5, no. 12, 865 - 869.
  • van Faassen, EE; Babrami, S; Feelisch, M; Hogg, N; Kelm, M; Kim-Shapiro, DB; Kozlov, AV; Li, HT; Lundberg, JO; Mason, R; Nohl, H; Rassaf, T; Samouilov, A; Slama-Schwok, A; Shiva, S; Vanin, AF; Weitzberg, E; Zweier, J; Gladwin, MT, 2009, "Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology." MEDICINAL RESEARCH REVIEWS 29, no. 5, 683 - 741.
  • Soorappan, RN; Block, K; Varadharaj, S; Davidson, CJ; Jones, DP; Zweier, JL; Benjamin, IJ, 2009, "Evidence Against ROS-Induced Macromolecular Damage as a Causal Mechanism for hR120GCryAB Cardiomyopathy in Mice." CIRCULATION RESEARCH 105, no. 7, E21 - E21.
  • Li, HT; Kundu, TK; Zweier, JL, 2009, "Characterization of the Magnitude and Mechanism of Aldehyde Oxidase-mediated Nitric Oxide Production from Nitrite." JOURNAL OF BIOLOGICAL CHEMISTRY 284, no. 49, 33850 - 33858.
  • Liu, YP; Villamena, FA; Sun, J; Wang, TY; Zweier, JL, 2009, "Esterified trityl radicals as intracellular oxygen probes." FREE RADICAL BIOLOGY AND MEDICINE 46, no. 7, 876 - 883.

2008

  • West MB, Rokosh G, Obal D, Velayutham M, Xuan YT, Hill BG, Keith RJ, Schrader J, Guo Y, Conklin DJ, Prabhu SD, Zweier JL, Bolli R, Bhatnagar A, 2008, "Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition.." Circulation no. 118(19):, 1970 - 8.
  • Kundu, TK; Velayutham, M; Hille, R; Zweier, JL, 2008, "NADH Oxidase Activity of Rat Liver Aldehyde Oxidase: Evaluation of Its Role in the Generation of Reactive Oxygen Species." FREE RADICAL BIOLOGY AND MEDICINE 45, S19 - S19.
  • Alzawahra WF, Talukder MA, Liu X, Samouilov A, Zweier JL., 2008, "Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall." Am J Physiol Heart Circ Physiol no. 295(2), H499 - 508.
  • Presley T, Vedam K, Velayutham M, Zweier JL, Ilangovan G, 2008, "Activation of Hsp90-eNOS and increased NO generation attenuate respiration of hypoxia-treated endothelial cells.." Am J Physiol Cell Physiol no. 295(5):, C1281 -
  • Villamena FA, Liu Y, Zweier JL, 2008, "Superoxide Radical Anion Adduct of 5,5-Dimethyl-1-pyrroline N-Oxide. 4. Conformational Effects on the EPR Hyperfine Splitting Constants.." J Phys Chem A
  • Tejero J, Biswas A, Wang ZQ, Page RC, Haque MM, Hemann C, Zweier JL, Misra S, Stuehr DJ, 2008, "Stabilization and Characterization of a Heme-Oxy Reaction Intermediate in Inducible Nitric-oxide Synthase.." J Biol Chem no. 283(48):, 33498 - 507.
  • Tejero, JS; Biswas, A; Wang, ZQ; Page, RC; Haque, MM; Hemann, C; Zweier, JL; Misra, S; Stuehr, DJ, 2008, "Stabilization and Characterization of a Heme-Oxy Reaction Intermediate in Inducible Nitric-oxide Synthase." JOURNAL OF BIOLOGICAL CHEMISTRY 283, no. 48, 33498 - 33507.
  • Presley, T; Vedam, K; Velayutham, M; Zweier, JL; Ilangovan, G, 2008, "Activation of Hsp90-eNOS and increased NO generation attenuate respiration of hypoxia-treated endothelial cells." AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 295, no. 5, C1281 - C1291.
  • Liu Y, Villamena F, Sun J, Xu Y, Dhimitruka I, Zweier J., 2008, "Synthesis and Characterization of Ester-Derivatized Tetrathiatriarylmethyl Radicals as Intracellular Oxygen Probes.." Journal of Organic Chemistry
  • Venkatakrishnan, CD; Dunsmore, K; Wong, H; Roy, S; Sen, CK; Wani, A; Zweier, JL; Ilangovan, G, 2008, "HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G(2)/M phase cell cycle arrest." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 294, no. 4, H1736 - H1744.
  • Zweier, C; Trautmann, U; Ekici, A; Rauch, A, 2008, "A 15 Mb duplication of 6q24.1-q25.3 associated with typical but milder features of the duplication 6q syndrome." EUROPEAN JOURNAL OF MEDICAL GENETICS 51, no. 4, 358 - 361.
  • Souza HP, Frediani D, Cobra AL, Moretti AI, Jurado MC, Fernandes TR, Cardounel AJ, Zweier JL, Tostes RC, 2008, "Angiotension II modulates CD40 expression in vascular smooth muscle cells.." Clin Sci (Lond).
  • Cisse, B; Caton, ML; Lehner, M; Maeda, T; Scheu, S; Locksley, R; Holmberg, D; Zweier, C; den Hollander, NS; Kant, SG; Holter, W; Rauch, A; Zhuang, YA; Reizis, B, 2008, "Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development." CELL 135, no. 1, 37 - 48.
  • Liu, Y; Villamena, FA; Sun, J; Xu, Y; Dhimitruka, I; Zweier, JL, 2008, "Synthesis and characterization of ester-derivatized tetrathiatriarylmethyl radicals as intracellular oxygen probes." JOURNAL OF ORGANIC CHEMISTRY 73, no. 4, 1490 - 1497.
  • Chen CA, Druhan LJ, Varadharaj S, Chen YR, Zweier JL, 2008, "Phosphorylation of endothelial nitric oxide synthase (eNOS) regulates superoxide generation from the enzyme." J Biol Chem
  • Sun, Qinghua; Yue, Peibin; Ying, Zhekang; Cardounel, Arturo, J; Brook, Robert, D; Devlin, Robert; Hwang, Jing-Shiang; Zweier, Jay, L; Chen, Lung Chi; Rajagopalan, Sanjay, 2008, "Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK.." Arteriosclerosis, thrombosis, and vascular biology 28, no. 10, 1760 - 6.
  • Sun J, Druhan LJ, Zweier JL, 2008, "Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase." Arch. Biochem. Biophys 2, no. 471, 126 - 133.
  • Chen CL, Chen J, Rawale S, Varadharaj S, Kaumaya PP, Zweier JL, Chen YR, 2008, "Protein tyrosine nitration of flavin subunit is associated with oxidative modification of mitochondrial complex II in the post-ischemic myocardium." J Biol Chem
  • Chen, CL; Varadhara, S; Kaumaya, PP; Zweier, JL; Chen, YR, 2008, "Oxidative Modification with Protein Tyrosine Nitration Occurs following Deglutathiolation of the 70 kDa Flavoprotein of Mitochondrial Complex II Is Associated with Loss of Electron Transfer Activity In the Post-Ischemic Myocardium." CIRCULATION 118, no. 18, S273 - S273.
  • Chen, CL; Chen, JF; Rawale, S; Varadharaj, S; Kaumaya, PPT; Zweier, JL; Chen, YR, 2008, "Protein tyrosine nitration of the flavin subunit is associated with oxidative modification of mitochondrial Complex II in the post-ischemic myocardium." JOURNAL OF BIOLOGICAL CHEMISTRY 283, no. 41, 27991 - 28003.
  • Raman SV, Winner MW, Tran T, Velayutham M, Simonetti OP, Baker PB, Olesik J, McCarthy B, Ferketich AK, Zweier JL., 2008, "In Vivo Atherosclerotic Plaque Characterization Using Magnetic Susceptibility Distinguishes Symptom-Producing Plaques.." JACC: Cardiovascular Imaging
  • Alzawahra, WF; Talukder, MAH; Liu, XP; Samouilov, A; Zweier, JL, 2008, "Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 295, no. 2, H499 - H508.
  • Xu, J; Liu, X; Jiang, Y; Chu, L; Hao, H; Liua, Z; Verfaillie, C; Zweier, J; Gupta, K; Liu, Z, 2008, "MAPK/ERK signalling mediates VEGF-induced bone marrow stem cell differentiation into endothelial cell." JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 12, no. 6A, 2395 - 2406.
  • Talukder MA, Yang F, Nishijima Y, Chen CA, Kalyanasundaram A, Periasamy M, Zweier JL, 2008, "Reduced SERCA2a converts sub-lethal myocardial injury to infarction and affects postischemic functional recovery." J Mol Cell Cardiol
  • Raman, SV; Winner, MW; Tran, T; Velayutham, M; Simonetti, OP; Baker, PB; Olesik, J; McCarthy, B; Ferketich, AK; Zweier, JL, 2008, "In Vivo Atherosclerotic Plaque Characterization Using Magnetic Susceptibility Distinguishes Symptom-Producing Plaques." JACC-CARDIOVASCULAR IMAGING 1, no. 1, 49 - 57.
  • Xu Y, Liu B, Zweier JL, He G, 2008, "Formation of Hydrogen Peroxide and Reduction of Peroxynitrite via Dismutation of Superoxide at Reperfusion Enhances Myocardial Blood Flow and Oxygen Consumption in Postischemic Mouse Heart." J Pharmacol Exp Ther
  • Chen, CA; Druhan, LJ; Wang, TY; Chen, YR; Zweier, JL, 2008, "S-glutathiolation Uncouples Endothelial Nitric Oxide (NO) Synthase, Switching Enzyme from NO to Superoxide Production." CIRCULATION 118, no. 18, S274 - S274.
  • Chen, CA; Druhan, LJ; Varadharaj, S; Chen, YR; Zweier, JL, 2008, "Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzyme." JOURNAL OF BIOLOGICAL CHEMISTRY 283, no. 40, 27038 - 27047.
  • Chen, CA; Druhan, LJ; Varadharaj, S; Chen, YR; Zweier, JL, 2008, "Phosphorylation and L-Arginine Increase Superoxide Generation from Endothelial Nitric Oxide Synthase (eNOS)." CIRCULATION 118, no. 18, S273 - S273.
  • Talukder MAH, Kalyanasundaram A, Zuo L, Velayutham M, Nishijima Y, Periasamy M, Zweier JL, 2008, "Is reduced SERCA2a expression detrimental or beneficial to postischemic cardiac function and injury? Evidence from heterozygous SERCA2a knockout mice." American Journal of Physiology – Heart and Circulatory Physiology 3, no. 294, H1426 - H1434.
  • Liu Y, Villamena FA, Zweier JL, 2008, "Highly stable dendritic trityl radicals as oxygen and pH probe.." Chem Commun (Camb) no. 28;(36):, 4336 - 8.
  • Li, HT; Cui, HM; Kundu, TK; Alzawahra, W; Zweier, JL, 2008, "Nitric oxide production from nitrite occurs primarily in tissues not in the blood - Critical role of xanthine oxidase and aldehyde oxidase." JOURNAL OF BIOLOGICAL CHEMISTRY 283, no. 26, 17855 - 17863.
  • Holland, R; Velayutham, M; Hawkins, A; Eggler, AL; Zweier, JL; Fabris, D; Mesecar, AD; Kensler, TW; Fishbein, JC, 2008, "Examination of Reactive Oxygen Species as General Signaling Agents of Dithiolethiones and the Biochemical Repercussions of Their Action." CHEMICAL RESEARCH IN TOXICOLOGY 21, no. 12, 2436 - 2436.
  • Patt, B; Sun, J; Zweier, J; Cardounel, A; Schutzman, S; Khayat, R, 2008, "Endothelial dysfunction in obstructive sleep apnea is due to increased endogenous inhibitors of nitric oxide." SLEEP 31, A174 - A174.
  • Rauch, A; Thiel, CT; Schindler, D; Wick, U; Crow, YJ; Ekici, AB; van Essen, AJ; Goecke, TO; Al-Gazali, L; Chrzanowska, KH; Zweier, C; Brunner, HG; Becker, K; Curry, CJ; Dallapiccola, B; Devriendt, K; Dorfler, A; Kinning, E; Megarbane, A; Meinecke, P; Semple, RK; Spranger, S; Toutain, A; Trembath, RC; Voss, E; Wilson, L; Hennekam, R; de Zegher, F; Dorr, HG; Reis, A, 2008, "Mutations in the pericentrin (PCNT) gene cause primordial dwarfism." SCIENCE 319, no. 5864, 816 - 819.
  • Ojha, N; Roy, S; Radtke, J; Simonetti, O; Gnyawali, S; Zweier, JL; Kuppusamy, P; Sen, CK, 2008, "Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 294, no. 6, H2435 - H2443.
  • Han Y, Tuccio B, Lauricella R, Rockenbauer A, Zweier JL, Villamena FA, 2008, "Synthesis and spin-trapping properties of a new spirolactonyl nitrone.." Journal of Organic Chemistry 7, no. 73, 2533 - 2541.
  • Ojha N, Roy S, He G, Biswas S, Velayutham M, Khanna S, Kuppusamy P, Zweier JL, Sen CK, 2008, "Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing.." Free Radical Biology and Medicine 4, no. 44, 682 - 691.
  • Li H, Cui H, Kundu TK, Alzawahra W, Zweier JL, 2008, "Nitric Oxide production from nitrite occurs primarily in tissues not in the blood: Critical role of xanthine oxidase and aldehyde oxidase." J Biol Chem no. 283(26), 17855 - 63.
  • Lee, MCI; Velayutham, M; Shoji, H; Yoshino, F; Hille, R; Zweier, JL, 2008, "Measurement and Characterization of Superoxide Generation From Xanthine Dehydrogenase: a Redox Regulated Pathway of Radical Generation in Ischemic Tissues." FREE RADICAL BIOLOGY AND MEDICINE 45, S150 - S151.
  • Ojha, N; Roy, S; He, G; Biswas, S; Velayutham, M; Khanna, S; Kuppusamy, P; Zweier, JL; Sen, CK, 2008, "Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing." FREE RADICAL BIOLOGY AND MEDICINE 44, no. 4, 682 - 691.
  • Chu, L; Jiang, YH; Hao, H; Xia, Y; Xu, J; Liu, ZH; Verfaillie, CM; Zweier, JL; Liu, ZG, 2008, "Nitric oxide enhances Oct-4 expression in bone marrow stem cells and promotes endothelial differentiation." EUROPEAN JOURNAL OF PHARMACOLOGY 591, no. 1-3, 59 - 65.
  • Villamena, FA; Liu, YP; Zweier, JL, 2008, "Superoxide Radical Anion Adduct of 5,5-Dimethyl-1-pyrroline N-Oxide. 4. Conformational Effects on the EPR Hyperfine Splitting Constants." JOURNAL OF PHYSICAL CHEMISTRY A 112, no. 49, 12607 - 12615.
  • Venkatakrishnan CD, Dunsmore K, Wong H, Roy S, Sen CK, Wani A, Zweier JL, Ilangovan G, 2008, "HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G(2)/M phase cell cycle arrest.." American Journal of Physiology – Heart and Circulatory Physiology 4, no. 294, H1736 - H1744.
  • Jones CI 3rd, Han Z, Presley T, Varadharaj S, Zweier JL, Ilangovan G, Alevriadou BR, 2008, "Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite." Am J Physiol Cell Physiol no. 295(1), C180 - 91.
  • Huehne, K; Zweier, C; Raab, K; Odent, S; Bonnaure-Mallet, M; Sixou, JL; Landrieu, P; Goizet, C; Sarlangue, J; Baumann, M; Eggermann, T; Rauch, A; Ruppert, S; Stettner, GM; Rautenstrauss, B, 2008, "Novel missense, insertion and deletion mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with congenital insensitivity to pain with anhidrosis." NEUROMUSCULAR DISORDERS 18, no. 2, 159 - 166.
  • Dhimitruka, I; Bobko, AA; Hadad, CM; Zweier, JL; Khramtsov, VV, 2008, "Synthesis and characterization of amino derivatives of persistent trityl radicals as dual function pH and oxygen paramagnetic probes." JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 130, no. 32, 10780 - 10787.
  • Liu X, Srinivasan P, Collard E, Grajdeanu P, Zweier JL, Friedman A., 2008, "Nitric oxide diffusion rate is reduced in the aortic call.." Biophysical Journal no. 94, 1880 - 1889.
  • Liu Z, Lei M, Jiang Y, Hao H, Chu L, Xu J, Luo M, Verfaillie CM, Zweier JL, Liu Z., 2008, "High glucose attenuates VEGF expression in rat multipotent adult progenitor cells in association with inhibition of JAK2/STAT3 signaling.." J Cell Mol Med
  • Liu, YP; Villamena, FA; Zweier, JL, 2008, "Highly stable dendritic trityl radicals as oxygen and pH probe." CHEMICAL COMMUNICATIONS no. 36, 4336 - 4338.
  • West, MB; Rokosh, G; Obal, D; Velayutham, M; Xuan, YT; Hill, BG; Keith, RJ; Schrader, J; Guo, Y; Conklin, DJ; Prabhu, SD; Zweier, JL; Bolli, R; Bhatnagar, A, 2008, "Cardiac Myocyte-Specific Expression of Inducible Nitric Oxide Synthase Protects Against Ischemia/Reperfusion Injury by Preventing Mitochondrial Permeability Transition." CIRCULATION 118, no. 19, 1970 - 1978.
  • Ojha N, Roy S, Radtke J, Simonetti O, Gnyawali S, Zweier JL, Kuppusamy P, Sen CK, 2008, "Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury." Am J Physiol Heart Circ Physiol no. 294(6), H2435 - 43.
  • Druhan LJ, Forbes SP, Pope AJ, Chen CA, Zweier JL, Cardounel AJ, 2008, "Regulation of eNOS-derived superoxide by endogenous methylarginines." Biochemistry no. 47(27), 7256 - 63.
  • Talukder, MAH; Kalyanasundaram, A; Zuo, L; Velayutham, M; Nishijima, Y; Periasamy, M; Zweier, JL, 2008, "Is reduced SERCA2a expression detrimental or beneficial to postischemic cardiac function and injury? Evidence from heterozygous SERCA2a knockout mice." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 294, no. 3, H1426 - H1434.
  • Dhimitruka I, Bobko AA, Hadad CM, Zweier JL, Khramtsov VV, 2008, "Synthesis and characterization of amino derivatives of persistent trityl radicals as dual function pH and oxygen paramagnetic probes." J Am Chem Soc no. 130(32):, 10780 - 7.
  • Talukder, MAH; Zuo, L; Kalyanasundaram, A; Murugesan, V; Periasamy, M; Zweier, JL, 2008, "Is sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) inhibition detrimental or beneficial for postischemic myocardial function and injury? Evidence from SERCA2a-deficient mice." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 51, no. 10, A184 - A184.
  • Wu, W; Kehn-Hall, K; Pedati, C; Zweier, L; Castro, I; Klase, Z; Dowd, CS; Dubrovsky, L; Bukrinsky, M; Kashanchi, F, 2008, "Drug 9AA reactivates p21/Waf1 and Inhibits HIV-1 progeny formation." VIROLOGY JOURNAL 5,
  • Chu L, Jiang Y, Hao H, Xia Y, Xu J, Liu Z, Verfaillie CM, Zweier JL, Liu Z, 2008, "Nitric oxide enhances Oct-4 expression in bone marrow stem cells and promotes endothelial differentiation." Eur J Pharmacol no. 591(1-3), 59 - 65.
  • Roy, S; Ojha, N; He, GL; Biswas, S; Velayutham, M; Khanna, S; Kuppusamy, P; Zweier, JL; Sen, CK, 2008, "Rac2 in redox regulated wound healing." WOUND REPAIR AND REGENERATION 16, no. 2, A13 - A13.
  • Moldovan, NI; Anghelina, MI; Butt, OI; Wang, TS; Zweier, JL, 2008, "Role of oxygen and ROS in bone marrow derived progenitor cells accumulation in infarcted hearts: Implications for ventricular aneurysm formation." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 51, no. 10, A190 - A190.
  • Sun, QH; Yue, PB; Ying, ZK; Cardounel, AJ; Brook, RD; Devlin, R; Hwang, JS; Zweier, JL; Chen, LC; Rajagopalan, S, 2008, "Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK." ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 28, no. 10, 1760 - 1766.
  • Kohr, MJ; Wang, H; Wheeler, DG; Velayutham, M; Zweier, JL; Ziolo, MT, 2008, "Biphasic effect of SIN-1 is reliant upon cardiomyocyte contractile state." FREE RADICAL BIOLOGY AND MEDICINE 45, no. 1, 73 - 80.
  • Varadharaj, S; Druhan, LJ; Chen, CA; Wang, TY; Wani, MA; Zweier, JL, 2008, "Intracellular Protein Trafficking In The Vascular Endothelium Is Regulated By Golgi Resident Nitric Oxide Sythase." CIRCULATION 118, no. 18, S274 - S274.
  • Liu, XP; Srinivasant, P; Collard, E; Grajdeanu, P; Zweier, JL; Friedmant, A, 2008, "Nitric oxide diffusion rate is reduced in the aortic wall." BIOPHYSICAL JOURNAL 94, no. 5, 1880 - 1889.
  • Moldovan, L; Moldovan, NI; Sun, J; Bergdall, V; Biswas, S; Sen, CK; Zweier, JL, 2008, "Critical role of arginase in nitric oxide metabolism in preclinical swine wound healing." WOUND REPAIR AND REGENERATION 16, no. 2, A51 - A51.
  • Xu, Y; Liu, B; Zweier, JL; He, GL, 2008, "Formation of Hydrogen Peroxide and Reduction of Peroxynitrite via Dismutation of Superoxide at Reperfusion Enhances Myocardial Blood Flow and Oxygen Consumption in Postischemic Mouse Heart." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 327, no. 2, 402 - 410.
  • Sun, J; Druhan, LJ; Zweier, JL, 2008, "Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase." ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 471, no. 2, 126 - 133.
  • Han, Y; Tuccio, B; Lauricella, R; Rockenbauer, A; Zweier, JL; Villamena, FA, 2008, "Synthesis and spin-trapping properties of a new spirolactonyl nitrone." JOURNAL OF ORGANIC CHEMISTRY 73, no. 7, 2533 - 2541.
  • Hirata H, HeG, Deng Y, Salikhov I, Petryakov S, Zweier JL., 2008, "A loop resonator for slice-selective in vivo EPR imaging in rats.." J of Magnetic Resonance no. 190, 124 - 134.
  • Jones, CI; Han, ZS; Presley, T; Varadharaj, S; Zweier, JL; Ilangovan, G; Alevriadou, BR, 2008, "Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite." AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 295, no. 1, C180 - C191.
  • Druhan, LJ; Forbes, SP; Pope, AJ; Chen, CA; Zweier, JL; Cardounel, AJ, 2008, "Regulation of eNOS-derived superoxide by endogenous methylarginines." BIOCHEMISTRY 47, no. 27, 7256 - 7263.
  • Zweier, C; Sticht, H; Bijlsma, EK; Clayton-Smith, J; Boonen, SE; Fryer, A; Greally, MT; Hoffmann, L; den Hollander, NS; Jongmans, M; Kant, SG; King, MD; Lynch, SA; Mckee, S; Midro, AT; Park, SM; Ricotti, V; Tarantino, E; Wessels, M; Peippo, M; Rauch, A, 2008, "Further delineation of Pitt-Hopkins syndrome: phenotypic and genotypic description of 16 novel patients." JOURNAL OF MEDICAL GENETICS 45, no. 11, 738 - 744.
  • Hirata, H; He, GL; Deng, YM; Salikhov, I; Petryakov, S; Zweier, JL, 2008, "A loop resonator for slice-selective in vivo EPR imaging in rats." JOURNAL OF MAGNETIC RESONANCE 190, no. 1, 124 - 134.
  • Burns, PM; Kearns, PN; Nishijima, Y; Vargas-Pinto, P; Ding, Y; Jekic, M; Lian, J; Lin, HY; Huang, K; Simonetti, OP; Zweier, JL, 2008, "Real-time magnetic resonance imaging (MRI) of the time course of myocardial injury and cell death in a canine model of regional ischemia and reperfusion." JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 51, no. 10, A186 - A186.
  • Kohr MJ, Wang H, Wheeler DG, Velayutham M, Zweier JL, Ziolo MT., 2008, "Biphasic effect of SIN-1 is reliant upon cardiomyocyte contractile state." Free Radic Biol Med no. 45(1), 73 - 80.
  • Kohr MJ, Wang H, Wheeler DG, Velayutham M, Zweier JL, Ziolo MT, 2008, "Targeting of phospholamban by peroxynitrite decreases beta-adrenergic stimulation in cardiomyocytes." Cardiovascular Research 2, no. 77, 353 - 361.
  • Kohr, MJ; Wang, H; Wheeler, DG; Velayutham, M; Zweier, JL; Ziolo, MT, 2008, "Targeting of phospholamban by peroxynitrite decreases beta-adrenergic stimulation in cardiomyocytes." CARDIOVASCULAR RESEARCH 77, no. 2, 353 - 361.

2007

  • Samouilov, A; Woldman, Ya Yu; Zweier, J, L; Khramtsov, V V, 2007, "Magnetic resonance study of the transmembrane nitrite diffusion.." Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 16, no. 3,
  • Petryakov, Sergey; Samouilov, Alexandre; Kesselring, Eric; Wasowicz, Tomasz; Caia, George, L; Zweier, Jay L, 2007, "Single loop multi-gap resonator for whole body EPR imaging of mice at 1.2 GHz.." Journal of magnetic resonance (San Diego, Calif. : 1997) 188, no. 1,
  • Samouilov, Alexandre; Caia, George, L; Kesselring, Eric; Petryakov, Sergey; Wasowicz, Tomasz; Zweier, Jay L, 2007, "Development of a hybrid EPR/NMR coimaging system.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 58, no. 1,
  • Alzawahra, W; Liu, XP; Li, HT; Samouilov, A; Zweier, JL, 2007, "Nitrite functions as a vascular relaxing factor forming NO and activating guanylate cyclase (sGC): Role of sGG in nitrite-mediated NO formation." CIRCULATION 116, no. 16, 296 - 296.
  • Villamena, Frederick, A; Merle, John, K; Hadad, Christopher, M; Zweier, Jay L, 2007, "Rate constants of hydroperoxyl radical addition to cyclic nitrones: a DFT study.." The journal of physical chemistry. A 111, no. 39,
  • Villamena, Frederick, A; Locigno, Edward, J; Rockenbauer, Antal; Hadad, Christopher, M; Zweier, Jay L, 2007, "Theoretical and experimental studies of the spin trapping of inorganic radicals by 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. Carbonate radical anion.." The journal of physical chemistry. A 111, no. 2,
  • Han, Zhaosheng; Chen, Yeong-Renn; Jones, Charles I 3rd; Meenakshisundaram, Guruguhan; Zweier, Jay, L; Alevriadou, B Rita, 2007, "Shear-induced reactive nitrogen species inhibit mitochondrial respiratory complex activities in cultured vascular endothelial cells.." American journal of physiology. Cell physiology 292, no. 3,
  • Han, Y; Tuccio, B; Lauricella, R; Rockenbauer, A; Zweier, JL; Villamena, FA, 2007, "Synthesis and spin trapping properties of a new spirolactonyl-nitrone." FREE RADICAL BIOLOGY AND MEDICINE 43, S14 - S14.
  • Chen, CA; Druhan, LJ; Chen, YR; Zweier, JL, 2007, "S-glutathiolation of endothelial nitric oxide synthase modulates its enzymatic activity and protects against oxidative damage." CIRCULATION 116, no. 16, 7 - 7.
  • Liu, Xiaoping; Yan, Qingtao; Baskerville, Kim, L; Zweier, Jay L, 2007, "Estimation of nitric oxide concentration in blood for different rates of generation. Evidence that intravascular nitric oxide levels are too low to exert physiological effects.." The Journal of biological chemistry 282, no. 12,
  • Chen, J; Chen, CL; Palmer, B; Zweier, JL; Chen, YR, 2007, "Decreased mitochondrial biogenesis and increased pro-oxidant activity are associated with oxidative impairment of complex 11 in the postischemic heart." CIRCULATION 116, no. 16, 249 - 249.
  • Cardounel, Arturo, J; Cui, Hongmei; Samouilov, Alexandre; Johnson, Wesley; Kearns, Patrick; Tsai, Ah-Lim; Berka, Vladomir; Zweier, Jay L, 2007, "Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function.." The Journal of biological chemistry 282, no. 2,
  • Dumitrescu, Cristian; Biondi, Roberto; Xia, Yong; Cardounel, Arturo, J; Druhan, Lawrence, J; Ambrosio, Giuseppe; Zweier, Jay L, 2007, "Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4.." Proceedings of the National Academy of Sciences of the United States of America 104, no. 38,
  • Chen, YR; Chen, CL; Zweier, JL, 2007, "Nitric oxide generated by eNOS exerts cardioprotection by increasing the mitochondrial biogenesis and decreasing electron leakage for superoxide production by mitochondrial succinate cytochrome c reductase." CIRCULATION 116, no. 16, 183 - 183.
  • Villamena, Frederick, A; Xia, Shijing; Merle, John, K; Lauricella, Robert; Tuccio, Beatrice; Hadad, Christopher, M; Zweier, Jay L, 2007, "Reactivity of superoxide radical anion with cyclic nitrones: role of intramolecular H-bond and electrostatic effects.." Journal of the American Chemical Society 129, no. 26,
  • Ahmad, Rizwan; Vikram, Deepti, S; Clymer, Bradley; Potter, Lee, C; Deng, Yuanmu; Srinivasan, Parthasarathy; Zweier, Jay, L; Kuppusamy, Periannan, 2007, "Uniform distribution of projection data for improved reconstruction quality of 4D EPR imaging.." Journal of magnetic resonance (San Diego, Calif. : 1997) 187, no. 2,
  • Yangping, L; Villamena, FA; Sun, J; Xu, Y; Zweier, JL, 2007, "Assessment of various ester-derivatized tetrathiatriarylmethyl radicals as intracellular oxygen probes." FREE RADICAL BIOLOGY AND MEDICINE 43, S18 - S19.
  • Sun, J; Druhan, LJ; Zweier, JL, 2007, "Superoxide promotes reversible uncoupling of inducible nitric oxide synthase, while peroxynitrite induces irreversible and complete enzyme inactivation." CIRCULATION 116, no. 16, 7 - 7.
  • Yan, Qingtao; Liu, Qihui; Zweier, Jay, L; Liu, Xiaoping, 2007, "Potency of authentic nitric oxide in inducing aortic relaxation.." Pharmacological research : the official journal of the Italian Pharmacological Society 55, no. 4,
  • Xu, Y; Villamena, FA; Liu, Y; Zweier, JL, 2007, "EPR studies of a new isopropoxy-carbonylated TPP+-nitrone." FREE RADICAL BIOLOGY AND MEDICINE 43, S18 - S18.
  • Forbes, SP; Pope, AJ; Druhan, L; Zweier, J; Cardounel, A, 2007, "Regulation of eNOS derived superoxide by endogenous methylarginines." CIRCULATION 116, no. 16, 293 - 294.
  • Moustafa-Bayoumi M, Alhaj MA, El-Sayed O, Wisel S, Chotani MA, Aboelnaga ZA, Hassona MDH, Morris M, Nuovo G, Zweier JL, Goldschmidt-Clermont P, Hassanain H., 2007, "Vascular Hypertrophy and Hypertension Caused by Transgenic Overexpression of Profilin 1.." J Biol Chem
  • Bobko, Andrey, A; Kirilyuk, Igor, A; Grigor'ev, Igor, A; Zweier, Jay, L; Khramtsov, Valery V, 2007, "Reversible reduction of nitroxides to hydroxylamines: roles for ascorbate and glutathione.." Free radical biology & medicine 42, no. 3,
  • Chen, Yeong-Renn; Chen, Chwen-Lih; Pfeiffer, Douglas, R; Zweier, Jay L, 2007, "Mitochondrial complex II in the post-ischemic heart: oxidative injury and the role of protein S-glutathionylation.." The Journal of biological chemistry 282, no. 45,
  • Chen, Chwen-Lih; Zhang, Liwen; Yeh, Alexander; Chen, Chun-An; Green-Church, Kari, B; Zweier, Jay, L; Chen, Yeong-Renn, 2007, "Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase.." Biochemistry 46, no. 19,
  • Kundu, Tapan Kumar; Hille, Russ; Velayutham, Murugesan; Zweier, Jay L, 2007, "Characterization of superoxide production from aldehyde oxidase: an important source of oxidants in biological tissues.." Archives of biochemistry and biophysics 460, no. 1,
  • Talukder, MAH; Nishijima, Y; Bonagura, JD; Kalyanasundaram, A; Periasamy, M; Shimokawa, H; Zweier, JL, 2007, "Short-term treatment with DITPA, a thyroid hormone analog, improves postischemic coronary flow and cardiac contractile function in hypertensive endothelial nitric oxide synthase knockout (eNOS-KO) mice." CIRCULATION 116, no. 16, 199 - 199.
  • Bobko, Andrey, A; Dhimitruka, Ilirian; Zweier, Jay, L; Khramtsov, Valery V, 2007, "Trityl radicals as persistent dual function pH and oxygen probes for in vivo electron paramagnetic resonance spectroscopy and imaging: concept and experiment.." Journal of the American Chemical Society 129, no. 23,
  • Liu, X; Srinivasan, P; Collard, E; Grajdeanu, P; Zweier, JL; Friedman, A, 2007, "Oxygen regulates the flux of nitric oxide diffusion across the vascular wall." CIRCULATION 116, no. 16, 27 - 27.
  • Dhimitruka I, Velayutham M, Bobko AA, Khramtsov VV, villamena F, Hadad CM, Zweier JL., 2007, "Large scale synthesis of a trityl spin-probe for use in biomedical EPR imaging.." Bioorg Med Chem Lett 24, no. 17, 6801 - 6805.
  • Hassanain, Hamdy, H; Gregg, David; Marcelo, Maria Luisa; Zweier, Jay, L; Souza, Heraldo, P; Selvakumar, Balakrishnan; Ma, Qi; Moustafa-Bayoumi, Moustafa; Binkley, Phillip, F; Flavahan, Nicholas, A; Morris, Mariana; Dong, Chunming; Goldschmidt-Clermont, Pascal J, 2007, "Hypertension caused by transgenic overexpression of Rac1.." Antioxidants & redox signaling 9, no. 1,
  • Zhao, Xue; Chen, Yeong-Renn; He, Guanglong; Zhang, Aiwen; Druhan, Lawrence, J; Strauch, Arthur, R; Zweier, Jay L, 2007, "Endothelial nitric oxide synthase (NOS3) knockout decreases NOS2 induction, limiting hyperoxygenation and conferring protection in the postischemic heart.." American journal of physiology. Heart and circulatory physiology 292, no. 3,
  • He, Guanglong; Dumitrescu, Cristian; Petryakov, Sergey; Deng, Yuanmu; Kesselring, Eric; Zweier, Jay L, 2007, "Transverse oriented electric field re-entrant resonator (TERR) with automatic tuning and coupling control for EPR spectroscopy and imaging of the beating heart.." Journal of magnetic resonance (San Diego, Calif. : 1997) 187, no. 1,
  • Liu, Zhenguo; Jiang, Yuehua; Hao, Hong; Gupta, Kalpna; Xu, Jian; Chu, Ling; McFalls, Edward; Zweier, Jay; Verfaillie, Catherine; Bache, Robert J, 2007, "Endothelial nitric oxide synthase is dynamically expressed during bone marrow stem cell differentiation into endothelial cells.." American journal of physiology. Heart and circulatory physiology 293, no. 3,
  • Turakhia, Samir; Venkatakrishnan, C, D; Dunsmore, Kathy; Wong, Hector; Kuppusamy, Periannan; Zweier, Jay, L; Ilangovan, Govindasamy, 2007, "Doxorubicin-induced cardiotoxicity: direct correlation of cardiac fibroblast and H9c2 cell survival and aconitase activity with heat shock protein 27.." American journal of physiology. Heart and circulatory physiology 293, no. 5,
  • Ahmad, Rizwan; Deng, Yuanmu; Vikram, Deepti, S; Clymer, Bradley; Srinivasan, Parthasarathy; Zweier, Jay, L; Kuppusamy, Periannan, 2007, "Quasi Monte Carlo-based isotropic distribution of gradient directions for improved reconstruction quality of 3D EPR imaging.." Journal of magnetic resonance (San Diego, Calif. : 1997) 184, no. 2,
  • Ahmad R, Clymer B, Vikram DS, Deng Y, Hirata H, Zweier JL, Kuppusamy P., 2007, "Enhanced Resolution for EPR Imaging by Two-Step Deblurring.." J Magn Reson no. 184, 246 - 257.
  • Dinkova-Kostova, A, T; Cheah, J; Samouilov, A; Zweier, J, L; Bozak, R, E; Hicks, R, J; Talalay, P, 2007, "Phenolic Michael reaction acceptors: combined direct and indirect antioxidant defenses against electrophiles and oxidants.." Medicinal chemistry (Sh?ariqah, United Arab Emirates) 3, no. 3,
  • Dhimitruka, Ilirian; Velayutham, Murugesan; Bobko, Andrey, A; Khramtsov, Valery, V; Villamena, Frederick, A; Hadad, Christopher, M; Zweier, Jay L, 2007, "Large-scale synthesis of a persistent trityl radical for use in biomedical EPR applications and imaging.." Bioorganic & medicinal chemistry letters 17, no. 24,
  • Dinkova-Kostova, AT; Cheah, J; Samouilov, A; Zweier, JL; Bozak, RE; Hicks, RJ; Talalay, P, 2007, "Phenolic Michael reaction acceptors: Combined direct and indirect antioxidant Defenses against electrophiles and oxidants." MEDICINAL CHEMISTRY 3, no. 3, 261 - 268.
  • Khan, Mahmood; Kutala, Vijay Kumar; Vikram, Deepti, S; Wisel, Sheik; Chacko, Simi, M; Kuppusamy, M Lakshmi; Mohan, Iyyapu, K; Zweier, Jay, L; Kwiatkowski, Pawel; Kuppusamy, Periannan, 2007, "Skeletal myoblasts transplanted in the ischemic myocardium enhance in situ oxygenation and recovery of contractile function.." American journal of physiology. Heart and circulatory physiology 293, no. 4,
  • Talukder, M A Hassan; Kalyanasundaram, Anuradha; Zhao, Xue; Zuo, Li; Bhupathy, Poornima; Babu, Gopal, J; Cardounel, Arturo, J; Periasamy, Muthu; Zweier, Jay L, 2007, "Expression of SERCA isoform with faster Ca2+ transport properties improves postischemic cardiac function and Ca2+ handling and decreases myocardial infarction.." American journal of physiology. Heart and circulatory physiology 293, no. 4,
  • Velayutham, Murugesan; Muthukumaran, Rajendra, B; Sostaric, Joe, Z; McCraken, John; Fishbein, James, C; Zweier, Jay L, 2007, "Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: a novel pathway for cancer chemoprevention.." Free radical biology & medicine 43, no. 7,
  • Vikram, Deepti, S; Zweier, Jay, L; Kuppusamy, Periannan, 2007, "Methods for noninvasive imaging of tissue hypoxia.." Antioxidants & redox signaling 9, no. 10,
  • Zhu, Xuehai; Liu, Bin; Zhou, Shaotang; Chen, Yeong-Renn; Deng, Yuanmu; Zweier, Jay, L; He, Guanglong, 2007, "Ischemic preconditioning prevents in vivo hyperoxygenation in postischemic myocardium with preservation of mitochondrial oxygen consumption.." American journal of physiology. Heart and circulatory physiology 293, no. 3,
  • Deng, Yuanmu; Petryakov, Sergy; He, Guanglong; Kesselring, Eric; Kuppusamy, Periannan; Zweier, Jay L, 2007, "Fast 3D spatial EPR imaging using spiral magnetic field gradient.." Journal of magnetic resonance (San Diego, Calif. : 1997) 185, no. 2,
  • Lu, Dongning; Nadas, Janos; Zhang, Guisheng; Johnson, Wesley; Zweier, Jay, L; Cardounel, Arturo, J; Villamena, Frederick, A; Wang, Peng George, 2007, "4-Aryl-1,3,2-oxathiazolylium-5-olates as pH-controlled NO-donors: the next generation of S-nitrosothiols.." Journal of the American Chemical Society 129, no. 17,
  • Zhu, Xuehai; Zuo, Li; Cardounel, Arturo, J; Zweier, Jay, L; He, Guanglong, 2007, "Characterization of in vivo tissue redox status, oxygenation, and formation of reactive oxygen species in postischemic myocardium.." Antioxidants & redox signaling 9, no. 4,

2006

  • Li, Haitao; Liu, Xiaoping; Cui, Hongmei; Chen, Yeong-Renn; Cardounel, Arturo, J; Zweier, Jay L, 2006, "Characterization of the mechanism of cytochrome P450 reductase-cytochrome P450-mediated nitric oxide and nitrosothiol generation from organic nitrates.." The Journal of biological chemistry 281, no. 18, 12546 - 54.
  • Presley T, Kuppusamy P, Zweier JL., 2006, "The role of heat shock protein 90 and endothelial nitric oxide synthase signaling in cardiovascular therapy.." Current Signal transduction Therapy 3, no. 1, 305 - 315.
  • Li, Haihong; He, Guanglong; Deng, Yuanmu; Kuppusamy, Periannan; Zweier, Jay L, 2006, "In vivo proton electron double resonance imaging of the distribution and clearance of nitroxide radicals in mice.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 55, no. 3, 669 - 75.
  • Xia, Shijing; Villamena, Frederick, A; Hadad, Christopher, M; Kuppusamy, Periannan; Li, Yunbo; Zhu, Hong; Zweier, Jay L, 2006, "Reactivity of molecular oxygen with ethoxycarbonyl derivatives of tetrathiatriarylmethyl radicals.." The Journal of organic chemistry 71, no. 19,
  • Xia, Yong; Berlowitz, Carlos, O; Zweier, Jay L, 2006, "PIN inhibits nitric oxide and superoxide production from purified neuronal nitric oxide synthase.." Biochimica et biophysica acta 1760, no. 9, 1445 - 9.
  • Bratasz, Anna; Weir, Nathan, M; Parinandi, Narasimham, L; Zweier, Jay, L; Sridhar, Rajagopalan; Ignarro, Louis, J; Kuppusamy, Periannan, 2006, "Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin.." Proceedings of the National Academy of Sciences of the United States of America 103, no. 10, 3914 - 9.
  • Pandian RP, Kim YI, Woodward PM, Zweier JL, Manoharan PT, Kuppusamy P., 2006, "The open molecular framework of paramagnetic lithium octabutoxy-naphthalocyanine: implications for the detection of oxygen and nitric oxide using EPR spectroscopy.." Journals of Materials Chemistry no. 16, 1 - 11.
  • Zhu, Hong; Zhang, Li; Itoh, Ken; Yamamoto, Masayuki; Ross, David; Trush, Michael, A; Zweier, Jay, L; Li, Yunbo, 2006, "Nrf2 controls bone marrow stromal cell susceptibility to oxidative and electrophilic stress.." Free radical biology & medicine 41, no. 1, 132 - 43.
  • Zhu, Hong; Zhang, Li; Xi, Xiaoqing; Zweier, Jay, L; Li, Yunbo, 2006, "4-Hydroxy-2-nonenal upregulates endogenous antioxidants and phase 2 enzymes in rat H9c2 myocardiac cells: protection against overt oxidative and electrophilic injury.." Free radical research 40, no. 8,
  • Zhou, Yingbi; Mitra, Srabani; Varadharaj, Saradhadevi; Parinandi, Narasimham; Zweier, Jay, L; Flavahan, Nicholas A, 2006, "Increased expression of cyclooxygenase-2 mediates enhanced contraction to endothelin ETA receptor stimulation in endothelial nitric oxide synthase knockout mice.." Circulation research 98, no. 11, 1439 - 45.
  • Zhao X, Chen RR, He G, Zhang A, Strauch AR, Druhan L, Zweier JL., 2006, "Endothelial Nitric Oxide synthase (NOS3) Knockout Decreases NOS2 Induction Limiting Hyperoxygenation and Conferring Protection in the Postischemic Heart.." Am J Physiol Heart Circ Physiol 3, no. 292, H1541 - H1550.
  • Roy, Sashwati; Khanna, Savita; Kuhn, Donald, E; Rink, Cameron; Williams, Willis, T; Zweier, Jay, L; Sen, Chandan K, 2006, "Transcriptome analysis of the ischemia-reperfused remodeling myocardium: temporal changes in inflammation and extracellular matrix.." Physiological genomics 25, no. 3,
  • Pandian, Ramasamy, P; Dang, Vinh; Manoharan, Periakaruppan, T; Zweier, Jay, L; Kuppusamy, Periannan, 2006, "Effect of nitrogen dioxide on the EPR property of lithium octa-n-butoxy 2,3-naphthalocyanine (LiNc-BuO) microcrystals.." J Magn Reson 181, no. 1, 154 - 61.
  • Nadolski, Geoff; Cardounel, Arturo, J; Zweier, Jay, L; Lockwood, Samuel F, 2006, "The synthesis and aqueous superoxide anion scavenging of water-dispersible lutein esters.." Bioorganic & medicinal chemistry letters 16, no. 4, 775 - 81.
  • Venkatakrishnan, C, D; Tewari, Arun, K; Moldovan, Leni; Cardounel, Arturo, J; Zweier, Jay, L; Kuppusamy, Periannan; Ilangovan, Govindasamy, 2006, "Heat shock protects cardiac cells from doxorubicin-induced toxicity by activating p38 MAPK and phosphorylation of small heat shock protein 27.." American journal of physiology. Heart and circulatory physiology 291, no. 6,
  • Varadharaj, Saradhadevi; Steinhour, Emily; Hunter, Melissa, G; Watkins, Tonya; Baran, Christopher, P; Magalang, Ulysses; Kuppusamy, Periannan; Zweier, Jay, L; Marsh, Clay, B; Natarajan, Viswanathan; Parinandi, Narasimham L, 2006, "Vitamin C-induced activation of phospholipase D in lung microvascular endothelial cells: regulation by MAP kinases.." Cellular signalling 18, no. 9,
  • Villamena, Frederick, A; Locigno, Edward, J; Rockenbauer, Antal; Hadad, Christopher, M; Zweier, Jay L, 2006, "Theoretical and experimental studies of the spin trapping of inorganic radicals by 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 1. Carbon dioxide radical anion.." The journal of physical chemistry. A 110, no. 49,
  • Deng, Yuanmu; Shet, Keerthi; Li, Haihong; Kuppusamy, Periannan; Zweier, Jay L, 2006, "Real-time calculation and visualization of spectra in field-cycled dynamic nuclear polarization spectroscopy.." Computer methods and programs in biomedicine 82, no. 1, 67 - 72.
  • Deng, Yuanmu; Pandian, Ramasamy, P; Ahmad, Rizwan; Kuppusamy, Periannan; Zweier, Jay L, 2006, "Application of magnetic field over-modulation for improved EPR linewidth measurements using probes with Lorentzian lineshape.." J Magn Reson 181, no. 2, 254 - 61.
  • Petryakov, Sergey; Samouilov, Alexandre; Roytenberg, Michael; Li, Haihong; Zweier, Jay L, 2006, "Modified Alderman-Grant resonator with high-power stability for proton electron double resonance imaging.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 56, no. 3,
  • Biondi, Roberto; Ambrosio, Giuseppe; Liebgott, Tibaud; Cardounel, Arturo, J; Bettini, Marco; Tritto, Isabella; Zweier, Jay L, 2006, "Hydroxylation of D-phenylalanine as a novel approach to detect hydroxyl radicals: application to cardiac pathophysiology.." Cardiovascular research 71, no. 2,
  • Ilangovan, Govindasamy; Venkatakrishnan, C, D; Bratasz, Anna; Osinbowale, Sola; Cardounel, Arturo, J; Zweier, Jay, L; Kuppusamy, Periannan, 2006, "Heat shock-induced attenuation of hydroxyl radical generation and mitochondrial aconitase activity in cardiac H9c2 cells.." American journal of physiology. Cell physiology 290, no. 2, C313 - 24.
  • Zweier, Jay, L; Talukder, M A Hassan, 2006, "The role of oxidants and free radicals in reperfusion injury.." Cardiovascular research 70, no. 2, 181 - 90.
  • Cao, Zhuoxiao; Zhu, Hong; Zhang, Li; Zhao, Xue; Zweier, Jay, L; Li, Yunbo, 2006, "Antioxidants and phase 2 enzymes in cardiomyocytes: Chemical inducibility and chemoprotection against oxidant and simulated ischemia-reperfusion injury.." Exp Biol Med (Maywood) 231, no. 8, 1353 - 64.
  • Ahmad, Rizwan; Vikram, Deepti, S; Petryakov, Sergey; Deng, Yuanmu; Zweier, Jay, L; Kuppusamy, Periannan; Clymer, Bradley, 2006, "Automated on-the-fly detection and correction procedure for EPR imaging data acquisition.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 56, no. 3,
  • Ahmad, Rizwan; Clymer, Bradley; Deng, Yuanmu; He, Guanglong; Vikram, Deepti; Kuppusamy, Periannan; Zweier, Jay L, 2006, "Optimization of data acquisition for EPR imaging.." J Magn Reson 179, no. 2, 263 - 72.
  • Chen, Yeong-Renn; Chen, Chwen-Lih; Yeh, Alexander; Liu, Xiaoping; Zweier, Jay L, 2006, "Direct and indirect roles of cytochrome b in the mediation of superoxide generation and NO catabolism by mitochondrial succinate-cytochrome c reductase.." The Journal of biological chemistry 281, no. 19, 13159 - 68.
  • Presley, Tennille; Kuppusamy, Periannan; Zweier, Jay, L; Ilangovan, Govindasamy, 2006, "Electron paramagnetic resonance oximetry as a quantitative method to measure cellular respiration: a consideration of oxygen diffusion interference.." Biophysical journal 91, no. 12,

2005

  • Cardounel, Arturo, J; Xia, Yong; Zweier, Jay L, 2005, "Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin.." The Journal of biological chemistry 280, no. 9, 7540 - 9.
  • Zhu, Hong; Itoh, Ken; Yamamoto, Masayuki; Zweier, Jay, L; Li, Yunbo, 2005, "Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury.." FEBS letters 579, no. 14, 3029 - 36.
  • Villamena, Frederick, A; Merle, John, K; Hadad, Christopher, M; Zweier, Jay L, 2005, "Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. The thermodynamics of decay and EPR spectral properties.." The journal of physical chemistry. A 109, no. 27,
  • Chen, Yeong-Renn; Chen, Chwen-Lih; Liu, Xiaoping; He, Guanglong; Zweier, Jay L, 2005, "Involvement of phospholipid, biomembrane integrity, and NO peroxidase activity in the NO catabolism by cytochrome c oxidase.." Archives of biochemistry and biophysics 439, no. 2, 200 - 10.
  • Tritto, Isabella; Wang, Penghai; Kuppusamy, Periannan; Giraldez, Roberto; Zweier, Jay, L; Ambrosio, Giuseppe, 2005, "The anti-anginal drug trimetazidine reduces neutrophil-mediated cardiac reperfusion injury.." Journal of cardiovascular pharmacology 46, no. 1, 89 - 98.
  • Varadharaj, Saradhadevi; Watkins, Tonya; Cardounel, Arturo, J; Garcia, Joe G, N; Zweier, Jay, L; Kuppusamy, Periannan; Natarajan, Viswanathan; Parinandi, Narasimham L, 2005, "Vitamin C-induced loss of redox-dependent viability in lung microvascular endothelial cells.." Antioxidants & redox signaling 7, no. 1-2, 287 - 300.
  • Velayutham, Murugesan; Villamena, Frederick, A; Navamal, Mettachit; Fishbein, James, C; Zweier, Jay L, 2005, "Glutathione-mediated formation of oxygen free radicals by the major metabolite of oltipraz.." Chemical research in toxicology 18, no. 6, 970 - 5.
  • Velayutham, Murugesan; Villamena, Frederick, A; Fishbein, James, C; Zweier, Jay L, 2005, "Cancer chemopreventive oltipraz generates superoxide anion radical.." Archives of biochemistry and biophysics 435, no. 1, 83 - 8.
  • Serrano, Carlos V Jr; Rocha Giraldez, Roberto; de Lara Fernandes, Juliano; Nicolau, Jose Carlos; Zweier, Jay, L; Ramires, Jose Antonio F, 2005, "Platelet and leukocyte adhesion and activation in unstable angina and post-PTCA.." International journal of cardiology 99, no. 3, 423 - 8.
  • Liu, Xiaoping; Liu, Qihui; Gupta, Era; Zorko, Nicholas; Brownlee, Emma; Zweier, Jay L, 2005, "Quantitative measurements of NO reaction kinetics with a Clark-type electrode.." Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 13, no. 1, 68 - 77.
  • Henry, Jon, C; Bonar, Mary, M; Kearns, Patrick, N; Cui, Hongmei; Mutchler, Megan, M; Martin, Michael, V; Orsini, Anthony, R; Elford, Howard, L; Bush, Charles, A; Zweier, Jay, L; Cardounel, Arturo J, 2005, "Inhibition of ribonucleotide reductase reduces neointimal formation following balloon injury.." The Journal of pharmacology and experimental therapeutics 314, no. 1, 70 - 6.
  • Chen, Yeong-Renn; Chen, Chwen-Lih; Zhang, Liwen; Green-Church, Kari, B; Zweier, Jay L, 2005, "Superoxide generation from mitochondrial NADH dehydrogenase induces self-inactivation with specific protein radical formation.." The Journal of biological chemistry 280, no. 45, 37339 - 48.
  • Li, Haitao; Cui, Hongmei; Liu, Xiaoping; Zweier, Jay L, 2005, "Xanthine oxidase catalyzes anaerobic transformation of organic nitrates to nitric oxide and nitrosothiols: characterization of this mechanism and the link between organic nitrate and guanylyl cyclase activation.." The Journal of biological chemistry 280, no. 17, 16594 - 600.
  • Deng, Yuanmu; Kuppusamy, Periannan; Zweier, Jay L, 2005, "Progressive EPR imaging with adaptive projection acquisition.." J Magn Reson 174, no. 2, 177 - 87.
  • Locigno, Edward, J; Zweier, Jay, L; Villamena, Frederick A, 2005, "Nitric oxide release from the unimolecular decomposition of the superoxide radical anion adduct of cyclic nitrones in aqueous medium.." Organic & biomolecular chemistry 3, no. 17, 3220 - 7.
  • Zhao, Xue; He, Guanglong; Chen, Yeong-Renn; Pandian, Ramasamy, P; Kuppusamy, Periannan; Zweier, Jay L, 2005, "Endothelium-derived nitric oxide regulates postischemic myocardial oxygenation and oxygen consumption by modulation of mitochondrial electron transport.." Circulation 111, no. 22, 2966 - 72.
  • Villamena, Frederick, A; Hadad, Christopher, M; Zweier, Jay L, 2005, "Comparative DFT study of the spin trapping of methyl, mercapto, hydroperoxy, superoxide, and nitric oxide radicals by various substituted cyclic nitrones.." The journal of physical chemistry. A 109, no. 8,
  • Zhou, Yingbi; Varadharaj, Saradhadevi; Zhao, Xue; Parinandi, Narasimham; Flavahan, Nicholas, A; Zweier, Jay L, 2005, "Acetylcholine causes endothelium-dependent contraction of mouse arteries.." American journal of physiology. Heart and circulatory physiology 289, no. 3, H1027 - 32.
  • Zhou, Yingbi; Dirksen, Wessel, P; Chen, Yanfang; Morris, Mariana; Zweier, Jay, L; Periasamy, Muthu, 2005, "A major role for AT1b receptor in mouse mesenteric resistance vessels and its distribution in heart and neuroendocrine tissues.." Journal of molecular and cellular cardiology 38, no. 4, 693 - 6.

2004

  • Ilangovan, Govindasamy; Zweier, Jay, L; Kuppusamy, Periannan, 2004, "Microximetry: simultaneous determination of oxygen consumption and free radical production using electron paramagnetic resonance spectroscopy.." Methods in enzymology 381, 747 - 62.
  • Crowther, Joy, E; Kutala, Vijay Kumar; Kuppusamy, Periannan; Ferguson, J Scott; Beharka, Alison, A; Zweier, Jay, L; McCormack, Francis, ; XSchlesinger, Larry S, 2004, "Pulmonary surfactant protein a inhibits macrophage reactive oxygen intermediate production in response to stimuli by reducing NADPH oxidase activity.." J Immunol 172, no. 11, 6866 - 74.
  • Samouilov, Alexandre; Roubaud, Valerie; Kuppusamy, Periannan; Zweier, Jay L, 2004, "Kinetic analysis-based quantitation of free radical generation in EPR spin trapping.." Analytical biochemistry 334, no. 1, 145 - 54.
  • Kuppusamy, Periannan; Zweier, Jay L, 2004, "Cardiac applications of EPR imaging.." NMR in biomedicine 17, no. 5, 226 - 39.
  • Dodd-o, Jeffrey, M; Welsh, Laura, E; Salazar, Jorge, D; Walinsky, Peter, L; Peck, Eric, A; Shake, Jay, G; Caparrelli, David, J; Ziegelstein, Roy, C; Zweier, Jay, L; Baumgartner, William, A; Pearse, David B, 2004, "Effect of NADPH oxidase inhibition on cardiopulmonary bypass-induced lung injury.." American journal of physiology. Heart and circulatory physiology 287, no. 2, H927 - 36.
  • Kutala, Vijay Kumar; Parinandi, Narasimham, L; Zweier, Jay, L; Kuppusamy, Periannan, 2004, "Reaction of superoxide with trityl radical: implications for the determination of superoxide by spectrophotometry.." Archives of biochemistry and biophysics 424, no. 1, 81 - 8.
  • Zhou, Yingbi; Dirksen, Wessel, P; Zweier, Jay, L; Periasamy, Muthu, 2004, "Endothelin-1-induced responses in isolated mouse vessels: the expression and function of receptor types.." American journal of physiology. Heart and circulatory physiology 287, no. 2, H573 - 8.
  • Liu, Xiaoping; Cheng, Crystal; Zorko, Nicholas; Cronin, Scott; Chen, Yeong-Renn; Zweier, Jay L, 2004, "Biphasic modulation of vascular nitric oxide catabolism by oxygen.." American journal of physiology. Heart and circulatory physiology 287, no. 6, H2421 - 6.
  • Li, Haitao; Samouilov, Alexandre; Liu, Xiaoping; Zweier, Jay L, 2004, "Characterization of the effects of oxygen on xanthine oxidase-mediated nitric oxide formation.." The Journal of biological chemistry 279, no. 17, 16939 - 46.
  • Villamena, Frederick, A; Hadad, Christopher, M; Zweier, Jay L, 2004, "Theoretical study of the spin trapping of hydroxyl radical by cyclic nitrones: a density functional theory approach.." Journal of the American Chemical Society 126, no. 6, 1816 - 29.
  • Villamena, Frederick, A; Zweier, Jay L, 2004, "Detection of reactive oxygen and nitrogen species by EPR spin trapping.." Antioxidants & redox signaling 6, no. 3, 619 - 29.
  • He, Guanglong; Kutala, Vijay Kumar; Kuppusamy, Periannan; Zweier, Jay L, 2004, "In vivo measurement and mapping of skin redox stress induced by ultraviolet light exposure.." Free radical biology & medicine 36, no. 5, 665 - 72.
  • Jackson, Henry, L; Cardounel, Arturo, J; Zweier, Jay, L; Lockwood, Samuel F, 2004, "Synthesis, characterization, and direct aqueous superoxide anion scavenging of a highly water-dispersible astaxanthin-amino acid conjugate.." Bioorganic & medicinal chemistry letters 14, no. 15, 3985 - 91.
  • Deng, Yuanmu; He, Guanglong; Petryakov, Sergy; Kuppusamy, Periannan; Zweier, Jay L, 2004, "Fast EPR imaging at 300 MHz using spinning magnetic field gradients.." J Magn Reson 168, no. 2, 220 - 7.
  • Ilangovan, Govindasamy; Zweier, Jay, L; Kuppusamy, Periannan, 2004, "Mechanism of oxygen-induced EPR line broadening in lithium phthalocyanine microcrystals.." J Magn Reson 170, no. 1, 42 - 8.
  • Foss, Bente Jeanette; Sliwka, Hans-Richard; Partali, Vassilia; Cardounel, Arturo, J; Zweier, Jay, L; Lockwood, Samuel F, 2004, "Direct superoxide anion scavenging by a highly water-dispersible carotenoid phospholipid evaluated by electron paramagnetic resonance (EPR) spectroscopy.." Bioorganic & medicinal chemistry letters 14, no. 11, 2807 - 12.
  • Tiravanti, Edy; Samouilov, Alexandre; Zweier, Jay L, 2004, "Nitrosyl-heme complexes are formed in the ischemic heart: evidence of nitrite-derived nitric oxide formation, storage, and signaling in post-ischemic tissues.." The Journal of biological chemistry 279, no. 12, 11065 - 73.
  • Ilangovan, Govindasamy; Osinbowale, Sola; Bratasz, Anna; Bonar, Mary; Cardounel, Arturo, J; Zweier, Jay, L; Kuppusamy, Periannan, 2004, "Heat shock regulates the respiration of cardiac H9c2 cells through upregulation of nitric oxide synthase.." American journal of physiology. Cell physiology 287, no. 5, C1472 - 81.
  • Villamena, Frederick, A; Rockenbauer, Antal; Gallucci, Judith; Velayutham, Murugesan; Hadad, Christopher, M; Zweier, Jay L, 2004, "Spin trapping by 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO): theoretical and experimental studies.." The Journal of organic chemistry 69, no. 23, 7994 - 8004.
  • Ilangovan, Govindasamy; Liebgott, Thibaut; Kutala, Vijay Kumar; Petryakov, Sergey; Zweier, Jay, L; Kuppusamy, Periannan, 2004, "EPR oximetry in the beating heart: myocardial oxygen consumption rate as an index of postischemic recovery.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 51, no. 4, 835 - 42.
  • Mikuni, Tomiko; He, Guanglong; Petryakov, Sergey; Fallouh, Mohanad, M; Deng, Yuanmu; Ishihara, Ryu; Kuppusamy, Periannan; Tatsuta, Masaharu; Zweier, Jay L, 2004, "In vivo detection of gastric cancer in rats by electron paramagnetic resonance imaging.." Cancer research 64, no. 18, 6495 - 502.
  • Chen, Yeong-Renn; Chen, Chwen-Lih; Liu, Xiaoping; Li, Haitao; Zweier, Jay, L; Mason, Ronald P, 2004, "Involvement of protein radical, protein aggregation, and effects on NO metabolism in the hypochlorite-mediated oxidation of mitochondrial cytochrome c.." Free radical biology & medicine 37, no. 10, 1591 - 603.
  • Chen, Yeong-Renn; Chen, Chwen-Lih; Chen, Weiguo; Zweier, Jay, L; Augusto, Ohara; Radi, Rafael; Mason, Ronald P, 2004, "Formation of protein tyrosine ortho-semiquinone radical and nitrotyrosine from cytochrome c-derived tyrosyl radical.." The Journal of biological chemistry 279, no. 17, 18054 - 62.
  • Ilangovan, Govindasamy; Bratasz, Anna; Li, Haiquan; Schmalbrock, Petra; Zweier, Jay, L; Kuppusamy, Periannan, 2004, "In vivo measurement and imaging of tumor oxygenation using coembedded paramagnetic particulates.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 52, no. 3, 650 - 7.

2003

  • Cai, Zheqing; Manalo, Dominador, J; Wei, Guo; Rodriguez, E Rene; Fox-Talbot, Karen; Lu, Huasheng; Zweier, Jay, L; Semenza, Gregg L, 2003, "Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury.." Circulation 108, no. 1, 79 - 85.
  • Velayutham, Murugesan; Li, Haiquan; Kuppusamy, Periannan; Zweier, Jay L, 2003, "Mapping ischemic risk region and necrosis in the isolated heart using EPR imaging.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 49, no. 6, 1181 - 7.
  • Cardounel, Arturo, J; Dumitrescu, Christian; Zweier, Jay, L; Lockwood, Samuel F, 2003, "Direct superoxide anion scavenging by a disodium disuccinate astaxanthin derivative: Relative efficacy of individual stereoisomers versus the statistical mixture of stereoisomers by electron paramagnetic resonance imaging.." Biochemical and biophysical research communications 307, no. 3, 704 - 12.
  • Ilangovan, Govindasamy; Li, Haiquan; Zweier, Jay, L; Kuppusamy, Periannan, 2003, "Effect of carbogen-breathing on redox status of the RIF-1 tumor.." Advances in experimental medicine and biology 510, 13 - 7.
  • Liebgott, Thibaut; Li, Haihong; Deng, Yuanmu; Zweier, Jay L, 2003, "Proton electron double resonance imaging (PEDRI) of the isolated beating rat heart.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 50, no. 2, 391 - 9.
  • Zeigler, Mandy, M; Doseff, Andrea, I; Galloway, Michelle, F; Opalek, Judy, M; Nowicki, Philip, T; Zweier, Jay, L; Sen, Chandan, K; Marsh, Clay B, 2003, "Presentation of nitric oxide regulates monocyte survival through effects on caspase-9 and caspase-3 activation.." The Journal of biological chemistry 278, no. 15, 12894 - 902.
  • Li, Haitao; Samouilov, Alexandre; Liu, Xiaoping; Zweier, Jay L, 2003, "Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrate reduction: evaluation of its role in nitrite and nitric oxide generation in anoxic tissues.." Biochemistry 42, no. 4, 1150 - 9.
  • Zweier, Jay, L; He, Guanglong; Samouilov, Alexandre; Kuppusamy, Periannan, 2003, "EPR spectroscopy and imaging of oxygen: applications to the gastrointestinal tract.." Advances in experimental medicine and biology 530, 123 - 31.
  • Pandian, Ramasamy, P; Kutala, Vijay Kumar; Parinandi, Narasimham, L; Zweier, Jay, L; Kuppusamy, Periannan, 2003, "Measurement of oxygen consumption in mouse aortic endothelial cells using a microparticulate oximetry probe.." Archives of biochemistry and biophysics 420, no. 1, 169 - 75.
  • Souza, Heraldo, P; Cardounel, Arturo, J; Zweier, Jay L, 2003, "Mechanisms of free radical production in the vascular wall.." Coronary artery disease 14, no. 2, 101 - 7.
  • Deng, Yuanmu; He, Guanglong; Kuppusamy, Periannan; Zweier, Jay L, 2003, "Deconvolution algorithm based on automatic cutoff frequency selection for EPR imaging.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 50, no. 2, 444 - 8.
  • Roy, Sashwati; Khanna, Savita; Wallace, William, A; Lappalainen, Jani; Rink, Cameron; Cardounel, Arturo, J; Zweier, Jay, L; Sen, Chandan K, 2003, "Characterization of perceived hyperoxia in isolated primary cardiac fibroblasts and in the reoxygenated heart.." The Journal of biological chemistry 278, no. 47, 47129 - 35.
  • Pandian, Ramasamy, P; Parinandi, Narasimham, L; Ilangovan, Govindasamy; Zweier, Jay, L; Kuppusamy, Periannan, 2003, "Novel particulate spin probe for targeted determination of oxygen in cells and tissues.." Free radical biology & medicine 35, no. 9, 1138 - 48.
  • Rizzi, Cecile; Samouilov, Alexandre; Kutala, Vijay Kumar; Parinandi, Narasimham, L; Zweier, Jay, L; Kuppusamy, Periannan, 2003, "Application of a trityl-based radical probe for measuring superoxide.." Free radical biology & medicine 35, no. 12, 1608 - 18.
  • Muscoli, Carolina; Cuzzocrea, Salvatore; Riley, Dennis, P; Zweier, Jay, L; Thiemermann, Christoph; Wang, Zhi-Qiang; Salvemini, Daniela, 2003, "On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies.." British journal of pharmacology 140, no. 3, 445 - 60.
  • Parinandi, Narasimham, L; Kleinberg, Michael, A; Usatyuk, Peter, V; Cummings, Rhett, J; Pennathur, Arjun; Cardounel, Arturo, J; Zweier, Jay, L; Garcia, Joe G, N; Natarajan, Viswanathan, 2003, "Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells.." American journal of physiology. Lung cellular and molecular physiology 284, no. 1, L26 - 38.

2002

  • Li, Haihong; Deng, Yuanmu; He, Guanglong; Kuppusamy, Periannan; Lurie, David, J; Zweier, Jay L, 2002, "Proton electron double resonance imaging of the in vivo distribution and clearance of a triaryl methyl radical in mice.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 48, no. 3, 530 - 4.
  • Lurie, David, J; Li, Haihong; Petryakov, Sergey; Zweier, Jay L, 2002, "Development of a PEDRI free-radical imager using a 0.38 T clinical MRI system.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 47, no. 1, 181 - 6.
  • Li, Haiquan; Ma, Li; Hsia, Carleton J, C; Zweier, Jay, L; Kuppusamy, Periannan, 2002, "Polynitroxyl-albumin (PNA) enhances myocardial infarction therapeutic effect of tempol in rat hearts subjected to regional ischemia-reperfusion.." Free radical biology & medicine 32, no. 8, 712 - 9.
  • Janiszewski, Mariano; Souza, Heraldo, P; Liu, Xiaoping; Pedro, Marcelo, A; Zweier, Jay, L; Laurindo, Francisco R M, 2002, "Overestimation of NADH-driven vascular oxidase activity due to lucigenin artifacts.." Free radical biology & medicine 32, no. 5, 446 - 53.
  • Samouilov, Alexandre; Zweier, Jay L, 2002, "Analytical implications of iron dithiocarbamates for measurement of nitric oxide.." Methods in enzymology 352, 506 - 22.
  • Liu, Xiaoping; Samouilov, Alexandre; Lancaster, Jack R Jr; Zweier, Jay L, 2002, "Nitric oxide uptake by erythrocytes is primarily limited by extracellular diffusion not membrane resistance.." The Journal of biological chemistry 277, no. 29, 26194 - 9.
  • Ilangovan, Govindasamy; Li, Haiquan; Zweier, Jay, L; Krishna, Murali, C; Mitchell, James, B; Kuppusamy, Periannan, 2002, "In vivo measurement of regional oxygenation and imaging of redox status in RIF-1 murine tumor: effect of carbogen-breathing.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 48, no. 4, 723 - 30.
  • Ilangovan, Govindasamy; Manivannan, Ayyakkannu; Li, Haiquan; Yanagi, Hisao; Zweier, Jay, L; Kuppusamy, Periannan, 2002, "A naphthalocyanine-based EPR probe for localized measurements of tissue oxygenation.." Free radical biology & medicine 32, no. 2, 139 - 47.
  • He, Guanglong; Samouilov, Alexandre; Kuppusamy, Periannan; Zweier, Jay L, 2002, "In vivo imaging of free radicals: applications from mouse to man.." Molecular and cellular biochemistry 234-235, no. 1-2, 359 - 67.
  • Souza, Heraldo, P; Liu, Xiaoping; Samouilov, Alexandre; Kuppusamy, Periannan; Laurindo, Francisco R, M; Zweier, Jay L, 2002, "Quantitation of superoxide generation and substrate utilization by vascular NAD(P)H oxidase.." American journal of physiology. Heart and circulatory physiology 282, no. 2, H466 - 74.
  • Ilangovan, Govindasamy; Li, Haiquan; Zweier, Jay, L; Kuppusamy, Periannan, 2002, "In vivo measurement of tumor redox environment using EPR spectroscopy.." Molecular and cellular biochemistry 234-235, no. 1-2, 393 - 8.
  • Lee, Masaichi-Chang-il; Shoji, Hirofumi; Komatsu, Tomoko; Yoshino, Fumihiko; Ohmori, Yoichi; Zweier, Jay L, 2002, "Inhibition of superoxide generation from fMLP-stimulated leukocytes by high concentrations of nitric oxide or peroxynitrite: characterization by electron spin resonance spectroscopy.." Redox report : communications in free radical research 7, no. 5, 271 - 5.
  • He, Guanglong; Evalappan, Sathesh, P; Hirata, Hiroshi; Deng, Yuanmu; Petryakov, Sergey; Kuppusamy, Periannan; Zweier, Jay L, 2002, "Mapping of the B1 field distribution of a surface coil resonator using EPR imaging.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 48, no. 6, 1057 - 62.
  • Lam, Y Amy; Lawson, T Glen; Velayutham, Murugesan; Zweier, Jay, L; Pickart, Cecile M, 2002, "A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal.." Nature 416, no. 6882, 763 - 7.
  • Song, Yao; Cardounel, A, J; Zweier, Jay, L; Xia, Yong, 2002, "Inhibition of superoxide generation from neuronal nitric oxide synthase by heat shock protein 90: implications in NOS regulation.." Biochemistry 41, no. 34, 10616 - 22.
  • Kuppusamy, Periannan; Li, Haiquan; Ilangovan, Govindasamy; Cardounel, Arturo, J; Zweier, Jay, L; Yamada, Kenichi; Krishna, Murali, C; Mitchell, James B, 2002, "Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels.." Cancer research 62, no. 1, 307 - 12.
  • Cardounel, Arturo, J; Zweier, Jay L, 2002, "Endogenous methylarginines regulate neuronal nitric-oxide synthase and prevent excitotoxic injury.." The Journal of biological chemistry 277, no. 37, 33995 - 4002.
  • He, Guanglong; Deng, Yuanmu; Li, Haihong; Kuppusamy, Periannan; Zweier, Jay L, 2002, "EPR/NMR co-imaging for anatomic registration of free-radical images.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 47, no. 3, 571 - 8.
  • Li, Yunbo; Seacat, Andrew; Kuppusamy, Periannan; Zweier, Jay, L; Yager, James, D; Trush, Michael A, 2002, "Copper redox-dependent activation of 2-tert-butyl(1,4)hydroquinone: formation of reactive oxygen species and induction of oxidative DNA damage in isolated DNA and cultured rat hepatocytes.." Mutation research 518, no. 2, 123 - 33.

2001

  • Paolocci, N; Biondi, R; Bettini, M; Lee, C, I; Berlowitz, C, O; Rossi, R; Xia, Y; Ambrosio, G; L'Abbate, A; Kass, D, A; Zweier, J L, 2001, "Oxygen radical-mediated reduction in basal and agonist-evoked NO release in isolated rat heart.." Journal of molecular and cellular cardiology 33, no. 4, 671 - 9.
  • He, G; Samouilov, A; Kuppusamy, P; Zweier, J L, 2001, "In vivo EPR imaging of the distribution and metabolism of nitroxide radicals in human skin.." J Magn Reson 148, no. 1, 155 - 64.
  • Zweier, J, L; Fertmann, J; Wei, G, 2001, "Nitric oxide and peroxynitrite in postischemic myocardium.." Antioxidants & redox signaling 3, no. 1, 11 - 22.
  • Petryakov, S; Chzhan, M; Samouilov, A; He, G; Kuppusamy, P; Zweier, J L, 2001, "A bridged loop-gap S-band surface resonator for topical EPR spectroscopy.." J Magn Reson 151, no. 1, 124 - 8.
  • He, G; Petryakov, S; Samouilov, A; Chzhan, M; Kuppusamy, P; Zweier, J L, 2001, "Development of a resonator with automatic tuning and coupling capability to minimize sample motion noise for in vivo EPR spectroscopy.." J Magn Reson 149, no. 2, 218 - 27.
  • Biondi, R; Xia, Y; Rossi, R; Paolocci, N; Ambrosio, G; Zweier, J L, 2001, "Detection of hydroxyl radicals by D-phenylalanine hydroxylation: a specific assay for hydroxyl radical generation in biological systems.." Analytical biochemistry 290, no. 1, 138 - 45.
  • Song, Y; Zweier, J, L; Xia, Y, 2001, "Heat-shock protein 90 augments neuronal nitric oxide synthase activity by enhancing Ca2+/calmodulin binding.." The Biochemical journal 355, no. Pt 2, 357 - 60.
  • Ellis, S, J; Velayutham, M; Velan, S, S; Petersen, E, F; Zweier, J, L; Kuppusamy, P; Spencer, R G, 2001, "EPR oxygen mapping (EPROM) of engineered cartilage grown in a hollow-fiber bioreactor.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 46, no. 4, 819 - 26.
  • Li, H; Samouilov, A; Liu, ; XZweier, J L, 2001, "Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrite reduction. Evaluation of its role in nitric oxide generation in anoxic tissues.." The Journal of biological chemistry 276, no. 27, 24482 - 9.
  • Duilio, C; Ambrosio, G; Kuppusamy, P; DiPaula, A; Becker, L, C; Zweier, J L, 2001, "Neutrophils are primary source of O2 radicals during reperfusion after prolonged myocardial ischemia.." American journal of physiology. Heart and circulatory physiology 280, no. 6, H2649 - 57.
  • Song, Y; Zweier, J, L; Xia, Y, 2001, "Determination of the enhancing action of HSP90 on neuronal nitric oxide synthase by EPR spectroscopy.." American journal of physiology. Cell physiology 281, no. 6, C1819 - 24.
  • Gabrielson, K, L; Hogue, B, A; Bohr, V, A; Cardounel, A, J; Nakajima, W; Kofler, J; Zweier, J, L; Rodriguez, E, R; Martin, L, J; de Souza-Pinto, N, C; Bressler, J, 2001, "Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice.." American journal of pathology 159, no. 4, 1507 - 20.
  • Souza, H, P; Laurindo, F, R; Ziegelstein, R, C; Berlowitz, C, O; Zweier, J L, 2001, "Vascular NAD(P)H oxidase is distinct from the phagocytic enzyme and modulates vascular reactivity control.." American journal of physiology. Heart and circulatory physiology 280, no. 2, H658 - 67.
  • Liu, ; XZweier, J L, 2001, "A real-time electrochemical technique for measurement of cellular hydrogen peroxide generation and consumption: evaluation in human polymorphonuclear leukocytes.." Free radical biology & medicine 31, no. 7, 894 - 901.
  • Kuppusamy, P; Shankar, R, A; Roubaud, V, M; Zweier, J L, 2001, "Whole body detection and imaging of nitric oxide generation in mice following cardiopulmonary arrest: detection of intrinsic nitrosoheme complexes.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 45, no. 4, 700 - 7.

2000

  • Sanders, S, P; Bassett, D, J; Harrison, S, J; Pearse, D; Zweier, J, L; Becker, P M, 2000, "Measurements of free radicals in isolated, ischemic lungs and lung mitochondria.." Lung 178, no. 2, 105 - 18.
  • Velan, S, S; Spencer, R, G; Zweier, J, L; Kuppusamy, P, 2000, "Electron paramagnetic resonance oxygen mapping (EPROM): direct visualization of oxygen concentration in tissue.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 43, no. 6, 804 - 9.
  • Pieper, A, A; Walles, T; Wei, G; Clements, E, E; Verma, A; Snyder, S, H; Zweier, J L, 2000, "Myocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruption.." Mol Med 6, no. 4, 271 - 82.
  • Li, H; Xu, K, Y; Zhou, L; Kalai, T; Zweier, J, L; Hideg, K; Kuppusamy, P, 2000, "A pyrroline derivative of mexiletine offers marked protection against ischemia/reperfusion-induced myocardial contractile dysfunction.." The Journal of pharmacology and experimental therapeutics 295, no. 2, 563 - 71.
  • Giraldez, R, R; Panda, A; Zweier, J L, 2000, "Endothelial dysfunction does not require loss of endothelial nitric oxide synthase.." American journal of physiology. Heart and circulatory physiology 278, no. 6, H2020 - 7.
  • Vanin, A, F; Liu, ; XSamouilov, A; Stukan, R, A; Zweier, J L, 2000, "Redox properties of iron-dithiocarbamates and their nitrosyl derivatives: implications for their use as traps of nitric oxide in biological systems.." Biochimica et biophysica acta 1474, no. 3, 365 - 77.
  • Shankar, R, A; Hideg, K; Zweier, J, L; Kuppusamy, P, 2000, "Targeted antioxidant properties of N-[(tetramethyl-3-pyrroline-3-carboxamido)propyl]phthalimide and its nitroxide metabolite in preventing postischemic myocardial injury.." The Journal of pharmacology and experimental therapeutics 292, no. 3, 838 - 45.
  • Lee, C, I; Liu, ; XZweier, J L, 2000, "Regulation of xanthine oxidase by nitric oxide and peroxynitrite.." The Journal of biological chemistry 275, no. 13, 9369 - 76.
  • Xia, Y; Cardounel, A, J; Vanin, A, F; Zweier, J L, 2000, "Electron paramagnetic resonance spectroscopy with N-methyl-D-glucamine dithiocarbamate iron complexes distinguishes nitric oxide and nitroxyl anion in a redox-dependent manner: applications in identifying nitrogen monoxide products from nitric." Free radical biology & medicine 29, no. 8, 793 - 7.
  • Zorov, D, B; Filburn, C, R; Klotz, L, O; Zweier, J, L; Sollott, S J, 2000, "Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes.." The Journal of experimental medicine 192, no. 7, 1001 - 14.
  • Lee, C; Miura, K; Liu, ; XZweier, J L, 2000, "Biphasic regulation of leukocyte superoxide generation by nitric oxide and peroxynitrite.." The Journal of biological chemistry 275, no. 50, 38965 - 72.
  • Hu, Q; Zheng, G; Zweier, J, L; Deshpande, S; Irani, K; Ziegelstein, R C, 2000, "NADPH oxidase activation increases the sensitivity of intracellular Ca2+ stores to inositol 1,4,5-trisphosphate in human endothelial cells.." The Journal of biological chemistry 275, no. 21, 15749 - 57.

1999

  • Lu, R; Wang, P; Wartofsky, L; Sutton, B, D; Zweier, J, L; Bahn, R, S; Garrity, J; Burman, K D, 1999, "Oxygen free radicals in interleukin-1beta-induced glycosaminoglycan production by retro-ocular fibroblasts from normal subjects and Graves' ophthalmopathy patients.." Thyroid : official journal of the American Thyroid Association 9, no. 3, 297 - 303.
  • Sankarapandi, S; Zweier, J L, 1999, "Evidence against the generation of free hydroxyl radicals from the interaction of copper,zinc-superoxide dismutase and hydrogen peroxide.." The Journal of biological chemistry 274, no. 49, 34576 - 83.
  • He, G; Shankar, R, A; Chzhan, M; Samouilov, A; Kuppusamy, P; Zweier, J L, 1999, "Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging.." Proceedings of the National Academy of Sciences of the United States of America 96, no. 8, 4586 - 91.
  • Salvemini, D; Wang, Z, Q; Zweier, J, L; Samouilov, A; Macarthur, H; Misko, T, P; Currie, M, G; Cuzzocrea, S; Sikorski, J, A; Riley, D P, 1999, "A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats.." Science 286, no. 5438, 304 - 6.
  • Sankarapandi, S; Zweier, J L, 1999, "Bicarbonate is required for the peroxidase function of Cu, Zn-superoxide dismutase at physiological pH.." The Journal of biological chemistry 274, no. 3, 1226 - 32.
  • Wei, G; Dawson, V, L; Zweier, J L, 1999, "Role of neuronal and endothelial nitric oxide synthase in nitric oxide generation in the brain following cerebral ischemia.." Biochimica et biophysica acta 1455, no. 1, 23 - 34.
  • Zweier, J, L; Samouilov, A; Kuppusamy, P, 1999, "Non-enzymatic nitric oxide synthesis in biological systems.." Biochimica et biophysica acta 1411, no. 2-3, 250 - 62.
  • Chzhan, M; Kuppusamy, P; Samouilov, A; He, G; Zweier, J L, 1999, "A tunable reentrant resonator with transverse orientation of electric field for in vivo EPR spectroscopy.." J Magn Reson 137, no. 2, 373 - 8.

1998

  • Kuppusamy, P; Afeworki, M; Shankar, R, A; Coffin, D; Krishna, M, C; Hahn, S, M; Mitchell, J, B; Zweier, J L, 1998, "In vivo electron paramagnetic resonance imaging of tumor heterogeneity and oxygenation in a murine model.." Cancer research 58, no. 7, 1562 - 8.
  • Kuppusamy, P; Shankar, R, A; Zweier, J L, 1998, "In vivo measurement of arterial and venous oxygenation in the rat using 3D spectral-spatial electron paramagnetic resonance imaging.." Physics in medicine and biology 43, no. 7, 1837 - 44.
  • Li, Y; Zhu, H; Kuppusamy, P; Roubaud, V; Zweier, J, L; Trush, M A, 1998, "Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems.." The Journal of biological chemistry 273, no. 4, 2015 - 23.
  • Samouilov, A; Kuppusamy, P; Zweier, J L, 1998, "Evaluation of the magnitude and rate of nitric oxide production from nitrite in biological systems.." Archives of biochemistry and biophysics 357, no. 1, 1 - 7.
  • Samouilov, A; Zweier, J L, 1998, "Development of chemiluminescence-based methods for specific quantitation of nitrosylated thiols.." Analytical biochemistry 258, no. 2, 322 - 30.
  • Ambrosio, G; Zweier, J, L; Becker, L C, 1998, "Apoptosis is prevented by administration of superoxide dismutase in dogs with reperfused myocardial infarction.." Basic research in cardiology 93, no. 2, 94 - 6.
  • Roubaud, V; Sankarapandi, S; Kuppusamy, P; Tordo, P; Zweier, J L, 1998, "Quantitative measurement of superoxide generation and oxygen consumption from leukocytes using electron paramagnetic resonance spectroscopy.." Analytical biochemistry 257, no. 2, 210 - 7.
  • Wang, P; Chen, H; Qin, H; Sankarapandi, S; Becher, M, W; Wong, P, C; Zweier, J L, 1998, "Overexpression of human copper, zinc-superoxide dismutase (SOD1) prevents postischemic injury.." Proceedings of the National Academy of Sciences of the United States of America 95, no. 8, 4556 - 60.
  • Hu, Q; Corda, S; Zweier, J, L; Capogrossi, M, C; Ziegelstein, R C, 1998, "Hydrogen peroxide induces intracellular calcium oscillations in human aortic endothelial cells.." Circulation 97, no. 3, 268 - 75.
  • Hu, Q; Xia, Y; Corda, S; Zweier, J, L; Ziegelstein, R C, 1998, "Hydrogen peroxide decreases pHi in human aortic endothelial cells by inhibiting Na+/H+ exchange.." Circulation research 83, no. 6, 644 - 51.
  • Kuppusamy, P; Wang, P; Shankar, R, A; Ma, L; Trimble, C, E; Hsia, C, J; Zweier, J L, 1998, "In vivo topical EPR spectroscopy and imaging of nitroxide free radicals and polynitroxyl-albumin.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 40, no. 6, 806 - 11.
  • Xia, Y; Roman, L, J; Masters, B, S; Zweier, J L, 1998, "Inducible nitric-oxide synthase generates superoxide from the reductase domain.." The Journal of biological chemistry 273, no. 35, 22635 - 9.
  • Xia, Y; Tsai, A, L; Berka, V; Zweier, J L, 1998, "Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process.." The Journal of biological chemistry 273, no. 40, 25804 - 8.
  • Zweier, J L, 1998, "Free radical generation in human endothelial cells exposed to anoxia and reoxygenation.." Transplantation proceedings 30, no. 8, 4228 - 32.
  • Zweier, J, L; Chzhan, M; Samouilov, A; Kuppusamy, P, 1998, "Electron paramagnetic resonance imaging of the rat heart.." Physics in medicine and biology 43, no. 7, 1823 - 35.
  • Sankarapandi, S; Zweier, J, L; Mukherjee, G; Quinn, M, T; Huso, D L, 1998, "Measurement and characterization of superoxide generation in microglial cells: evidence for an NADPH oxidase-dependent pathway.." Archives of biochemistry and biophysics 353, no. 2, 312 - 21.
  • Ha, H, C; Sirisoma, N, S; Kuppusamy, P; Zweier, J, L; Woster, P, M; Casero, R A Jr, 1998, "The natural polyamine spermine functions directly as a free radical scavenger.." Proceedings of the National Academy of Sciences of the United States of America 95, no. 19, 11140 - 5.
  • Giraldez, R, R; Zweier, J L, 1998, "An improved assay for measurement of nitric oxide synthase activity in biological tissues.." Analytical biochemistry 261, no. 1, 29 - 35.

1997

  • Xu, K, Y; Zweier, J, L; Becker, L C, 1997, "Hydroxyl radical inhibits sarcoplasmic reticulum Ca(2+)-ATPase function by direct attack on the ATP binding site.." Circulation research 80, no. 1, 76 - 81.
  • Xia, Y; Zweier, J L, 1997, "Direct measurement of nitric oxide generation from nitric oxide synthase.." Proceedings of the National Academy of Sciences of the United States of America 94, no. 23, 12705 - 10.
  • Xia, Y; Zweier, J L, 1997, "Measurement of myeloperoxidase in leukocyte-containing tissues.." Analytical biochemistry 245, no. 1, 93 - 6.
  • Giraldez, R, R; Panda, A; Xia, Y; Sanders, S, P; Zweier, J L, 1997, "Decreased nitric-oxide synthase activity causes impaired endothelium-dependent relaxation in the postischemic heart.." The Journal of biological chemistry 272, no. 34, 21420 - 6.
  • Xu, K, Y; Zweier, J, L; Becker, L C, 1997, "Oxygen-free radicals directly attack the ATP binding site of the cardiac Na+,K(+)-ATPase.." Annals of the New York Academy of Sciences 834, 680 - 3.
  • Seacat, A, M; Kuppusamy, P; Zweier, J, L; Yager, J D, 1997, "ESR identification of free radicals formed from the oxidation of catechol estrogens by Cu2+.." Archives of biochemistry and biophysics 347, no. 1, 45 - 52.
  • Serrano, C V Jr; Ramires, J, A; Venturinelli, M; Arie, S; D'Amico, E; Zweier, J, L; Pileggi, F; da Luz, P L, 1997, "Coronary angioplasty results in leukocyte and platelet activation with adhesion molecule expression. Evidence of inflammatory responses in coronary angioplasty.." Journal of the American College of Cardiology 29, no. 6, 1276 - 83.
  • Roubaud, V; Sankarapandi, S; Kuppusamy, P; Tordo, P; Zweier, J L, 1997, "Quantitative measurement of superoxide generation using the spin trap 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide.." Analytical biochemistry 247, no. 2, 404 - 11.
  • Xia, Y; Zweier, J L, 1997, "Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages.." Proceedings of the National Academy of Sciences of the United States of America 94, no. 13, 6954 - 8.
  • Kuppusamy, P; Wang, P; Chzhan, M; Zweier, J L, 1997, "High resolution electron paramagnetic resonance imaging of biological samples with a single line paramagnetic label.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 37, no. 4, 479 - 83.
  • Irani, K; Xia, Y; Zweier, J, L; Sollott, S, J; Der, C, J; Fearon, E, R; Sundaresan, M; Finkel, T; Goldschmidt-Clermont, P J, 1997, "Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts.." Science 275, no. 5306, 1649 - 52.
  • Polyak, K; Xia, Y; Zweier, J, L; Kinzler, K, W; Vogelstein, B, 1997, "A model for p53-induced apoptosis.." Nature 389, no. 6648, 300 - 5.

1996

  • Kuppusamy, P; Wang, P; Zweier, J, L; Krishna, M, C; Mitchell, J, B; Ma, L; Trimble, C, E; Hsia, C J, 1996, "Electron paramagnetic resonance imaging of rat heart with nitroxide and polynitroxyl-albumin.." Biochemistry 35, no. 22, 7051 - 7.
  • Kuppusamy, P; Wang, P; Samouilov, A; Zweier, J L, 1996, "Spatial mapping of nitric oxide generation in the ischemic heart using electron paramagnetic resonance imaging.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 36, no. 2, 212 - 8.
  • Serrano, C V Jr; Fraticelli, A; Paniccia, R; Teti, A; Noble, B; Corda, S; Faraggiana, T; Ziegelstein, R, C; Zweier, J, L; Capogrossi, M C, 1996, "pH dependence of neutrophil-endothelial cell adhesion and adhesion molecule expression.." The American journal of physiology 271, no. 3 Pt 1, C962 - 70.
  • Kuppusamy, P; Zweier, J L, 1996, "A forward-subtraction procedure for removing hyperfine artifacts in electron paramagnetic resonance imaging.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 35, no. 3, 316 - 22.
  • Wang, P; Zweier, J L, 1996, "Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury.." The Journal of biological chemistry 271, no. 46, 29223 - 30.
  • Crawford, L, E; Milliken, E, E; Irani, K; Zweier, J, L; Becker, L, C; Johnson, T, M; Eissa, N, T; Crystal, R, G; Finkel, T; Goldschmidt-Clermont, P J, 1996, "Superoxide-mediated actin response in post-hypoxic endothelial cells.." The Journal of biological chemistry 271, no. 43, 26863 - 7.
  • Serrano, C V Jr; Mikhail, E, A; Wang, P; Noble, B; Kuppusamy, P; Zweier, J L, 1996, "Superoxide and hydrogen peroxide induce CD18-mediated adhesion in the postischemic heart.." Biochimica et biophysica acta 1316, no. 3, 191 - 202.
  • Primiano, T; Kensler, T, W; Kuppusamy, P; Zweier, J, L; Sutter, T R, 1996, "Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones.." Carcinogenesis 17, no. 11, 2291 - 6.
  • Fraticelli, A; Serrano, C V Jr; Bochner, B, S; Capogrossi, M, C; Zweier, J L, 1996, "Hydrogen peroxide and superoxide modulate leukocyte adhesion molecule expression and leukocyte endothelial adhesion.." Biochimica et biophysica acta 1310, no. 3, 251 - 9.
  • Xia, Y; Khatchikian, G; Zweier, J L, 1996, "Adenosine deaminase inhibition prevents free radical-mediated injury in the postischemic heart.." The Journal of biological chemistry 271, no. 17, 10096 - 102.
  • Xia, Y; Dawson, V, L; Dawson, T, M; Snyder, S, H; Zweier, J L, 1996, "Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.." Proceedings of the National Academy of Sciences of the United States of America 93, no. 13, 6770 - 4.
  • Li, Y; Kuppusamy, P; Zweier, J, L; Trush, M A, 1996, "Role of Cu/Zn-superoxide dismutase in xenobiotic activation. I. Chemical reactions involved in the Cu/Zn-superoxide dismutase-accelerated oxidation of the benzene metabolite 1,4-hydroquinone.." Molecular pharmacology 49, no. 3, 404 - 11.
  • MacGowan, G, A; Burkhoff, D; Rogers, W, J; Salvador, D; Azhari, H; Hees, P, S; Zweier, J, L; Halperin, H, R; Siu, C, O; Lima, J, A; Weiss, J, L; Shapiro, E P, 1996, "Effects of afterload on regional left ventricular torsion.." Cardiovascular research 31, no. 6, 917 - 25.
  • Schauer, D, A; Desrosiers, M, F; Kuppusamy, P; Zweier, J L, 1996, "Radiation dosimetry of an accidental overexposure using EPR spectrometry and imaging of human bone.." Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 47, no. 11-12, 1345 - 50.
  • Kuppusamy, P; Chzhan, M; Wang, P; Zweier, J L, 1996, "Three-dimensional gated EPR imaging of the beating heart: time-resolved measurements of free radical distribution during the cardiac contractile cycle.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 35, no. 3, 323 - 8.

1995

  • Serrano Junior, C, V; Ramires, J, A; Cesar, L, A; Zweier, J, L; Rati, M; De Luz, P; Pileggi, F, 1995, "Prognostic significance of right ventricular dysfunction in patients with acute inferior myocardial infarction and right ventricular involvement.." Clinical cardiology 18, no. 4, 199 - 205.
  • Zweier, J, L; Samouilov, A; Chzhan, M, 1995, "Measurement of nitric oxide with a solid-state-char EPR probe.." Journal of magnetic resonance. Series B 109, no. 3, 259 - 63.
  • Xu, K, Y; Zweier, J, L; Becker, L C, 1995, "Functional coupling between glycolysis and sarcoplasmic reticulum Ca2+ transport.." Circulation research 77, no. 1, 88 - 97.
  • Li, Y; Kuppusamy, P; Zweier, J, L; Trush, M A, 1995, "ESR evidence for the generation of reactive oxygen species from the copper-mediated oxidation of the benzene metabolite, hydroquinone: role in DNA damage.." Chemico-biological interactions 94, no. 2, 101 - 20.
  • Zweier, J, L; Wang, P; Kuppusamy, P, 1995, "Direct measurement of nitric oxide generation in the ischemic heart using electron paramagnetic resonance spectroscopy.." The Journal of biological chemistry 270, no. 1, 304 - 7.
  • Xia, Y; Zweier, J L, 1995, "Substrate control of free radical generation from xanthine oxidase in the postischemic heart.." The Journal of biological chemistry 270, no. 32, 18797 - 803.
  • Zweier, J, L; Wang, P; Samouilov, A; Kuppusamy, P, 1995, "Enzyme-independent formation of nitric oxide in biological tissues.." Nature medicine 1, no. 8, 804 - 9.
  • Kuppusamy, P; Chzhan, M; Zweier, J L, 1995, "Development and optimization of three-dimensional spatial EPR imaging for biological organs and tissues.." Journal of magnetic resonance. Series B 106, no. 2, 122 - 30.
  • Kuppusamy, P; Ohnishi, S, T; Numagami, Y; Ohnishi, T; Zweier, J L, 1995, "Three-dimensional imaging of nitric oxide production in the rat brain subjected to ischemia-hypoxia.." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 15, no. 6, 899 - 903.
  • Chzhan, M; Kuppusamy, P; Zweier, J L, 1995, "Development of an electronically tunable L-band resonator for EPR spectroscopy and imaging of biological samples.." Journal of magnetic resonance. Series B 108, no. 1, 67 - 72.
  • Kuppusamy, P; Chzhan, M; Samouilov, A; Wang, P; Zweier, J L, 1995, "Mapping the spin-density and lineshape distribution of free radicals using 4D spectral-spatial EPR imaging.." Journal of magnetic resonance. Series B 107, no. 2, 116 - 25.
  • Kuppusamy, P; Wang, P; Zweier, J L, 1995, "Three-dimensional spatial EPR imaging of the rat heart.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 34, no. 1, 99 - 105.
  • Sanders, S, P; Zweier, J, L; Harrison, S, J; Trush, M, A; Rembish, S, J; Liu, M C, 1995, "Spontaneous oxygen radical production at sites of antigen challenge in allergic subjects.." American journal of respiratory and critical care medicine 151, no. 6, 1725 - 33.

1994

  • Zweier, J, L; Broderick, R; Kuppusamy, P; Thompson-Gorman, S; Lutty, G A, 1994, "Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation.." The Journal of biological chemistry 269, no. 39, 24156 - 62.
  • Zweier, J, L; Chzhan, M; Ewert, U; Schneider, G; Kuppusamy, P, 1994, "Development of a highly sensitive probe for measuring oxygen in biological tissues.." Journal of magnetic resonance. Series B 105, no. 1, 52 - 7.
  • Sanders, S, P; Harrison, S, J; Kuppusamy, P; Sylvester, J, T; Zweier, J L, 1994, "A comparative study of EPR spin trapping and cytochrome c reduction techniques for the measurement of superoxide anions.." Free radical biology & medicine 16, no. 6, 753 - 61.
  • Zweier, J, L; Kuppusamy, P, 1994, "In vivo EPR spectroscopy of free radicals in the heart.." Environmental health perspectives 102 Suppl 10, 45 - 51.
  • Chen, K; Ng, C, E; Zweier, J, L; Kuppusamy, P; Glickson, J, D; Swartz, H M, 1994, "Measurement of the intracellular concentration of oxygen in a cell perfusion system.." Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 31, no. 6, 668 - 72.
  • Ziegelstein, R, C; Corda, S; Pili, R; Passaniti, A; Lefer, D; Zweier, J, L; Fraticelli, A; Capogrossi, M C, 1994, "Initial contact and subsequent adhesion of human neutrophils or monocytes to human aortic endothelial cells releases an endothelial intracellular calcium store.." Circulation 90, no. 4, 1899 - 907.
  • Kuppusamy, P; Chzhan, M; Vij, K; Shteynbuk, M; Lefer, D, J; Giannella, E; Zweier, J L, 1994, "Three-dimensional spectral-spatial EPR imaging of free radicals in the heart: a technique for imaging tissue metabolism and oxygenation.." Proceedings of the National Academy of Sciences of the United States of America 91, no. 8, 3388 - 92.
  • Zweier, J, L; Kuppusamy, P; Thompson-Gorman, S; Klunk, D; Lutty, G A, 1994, "Measurement and characterization of free radical generation in reoxygenated human endothelial cells.." The American journal of physiology 266, no. 3 Pt 1, C700 - 8.
  • Hano, O; Thompson-Gorman, S, L; Zweier, J, L; Lakatta, E G, 1994, "Coenzyme Q10 enhances cardiac functional and metabolic recovery and reduces Ca2+ overload during postischemic reperfusion.." The American journal of physiology 266, no. 6 Pt 2, H2174 - 81.

1993

  • Sanders, S, P; Zweier, J, L; Kuppusamy, P; Harrison, S, J; Bassett, D, J; Gabrielson, E, W; Sylvester, J T, 1993, "Hyperoxic sheep pulmonary microvascular endothelial cells generate free radicals via mitochondrial electron transport.." The Journal of clinical investigation 91, no. 1, 46 - 52.
  • Ambrosio, G; Zweier, J, L; Duilio, C; Kuppusamy, P; Santoro, G; Elia, P, P; Tritto, I; Cirillo, P; Condorelli, M; Chiariello, M, 1993, "Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow.." The Journal of biological chemistry 268, no. 25, 18532 - 41.
  • Lefer, D, J; Shandelya, S, M; Serrano, C V Jr; Becker, L, C; Kuppusamy, P; Zweier, J L, 1993, "Cardioprotective actions of a monoclonal antibody against CD-18 in myocardial ischemia-reperfusion injury.." Circulation 88, no. 4 Pt 1, 1779 - 87.
  • Shandelya, S, M; Kuppusamy, P; Herskowitz, A; Weisfeldt, M, L; Zweier, J L, 1993, "Soluble complement receptor type 1 inhibits the complement pathway and prevents contractile failure in the postischemic heart. Evidence that complement activation is required for neutrophil-mediated reperfusion injury.." Circulation 88, no. 6, 2812 - 26.
  • Shandelya, S, M; Kuppusamy, P; Weisfeldt, M, L; Zweier, J L, 1993, "Evaluation of the role of polymorphonuclear leukocytes on contractile function in myocardial reperfusion injury. Evidence for plasma-mediated leukocyte activation.." Circulation 87, no. 2, 536 - 46.

1992

  • Gabrielson, E, W; Kuppusamy, P; Povey, A, C; Zweier, J, L; Harris, C C, 1992, "Measurement of neutrophil activation and epidermal cell toxicity by palytoxin and 12-O-tetradecanoylphorbol-13-acetate.." Carcinogenesis 13, no. 9, 1671 - 4.
  • Grill, H, P; Zweier, J, L; Kuppusamy, P; Weisfeldt, M, L; Flaherty, J T, 1992, "Direct measurement of myocardial free radical generation in an in vivo model: effects of postischemic reperfusion and treatment with human recombinant superoxide dismutase.." Journal of the American College of Cardiology 20, no. 7, 1604 - 11.
  • Ziegelstein, R, C; Zweier, J, L; Mellits, E, D; Younes, A; Lakatta, E, G; Stern, M, D; Silverman, H S, 1992, "Dimethylthiourea, an oxygen radical scavenger, protects isolated cardiac myocytes from hypoxic injury by inhibition of Na(+)-Ca2+ exchange and not by its antioxidant effects.." Circulation research 70, no. 4, 804 - 11.
  • Povey, A, C; Wilson, V, L; Zweier, J, L; Kuppusamy, P; O'Neill, I, K; Harris, C C, 1992, "Detection by 32P-postlabelling of DNA adducts induced by free radicals and unsaturated aldehydes formed during the aerobic decomposition of fecapentaene-12.." Carcinogenesis 13, no. 3, 395 - 401.

1991

  • Zweier, J, L; Thompson-Gorman, S; Kuppusamy, P, 1991, "Measurement of oxygen concentrations in the intact beating heart using electron paramagnetic resonance spectroscopy: a technique for measuring oxygen concentrations in situ.." Journal of bioenergetics and biomembranes 23, no. 6, 855 - 71.
  • Flaherty, J, T; Zweier, J L, 1991, "Role of oxygen radicals in myocardial reperfusion injury: experimental and clinical evidence.." Klinische Wochenschrift 69, no. 21-23, 1061 - 5.
  • Swauger, J, E; Dolan, P, M; Zweier, J, L; Kuppusamy, P; Kensler, T W, 1991, "Role of the benzoyloxyl radical in DNA damage mediated by benzoyl peroxide.." Chemical research in toxicology 4, no. 2, 223 - 8.
  • Williams, R, E; Zweier, J, L; Flaherty, J T, 1991, "Treatment with deferoxamine during ischemia improves functional and metabolic recovery and reduces reperfusion-induced oxygen radical generation in rabbit hearts.." Circulation 83, no. 3, 1006 - 14.
  • Guyton, K, Z; Bhan, P; Kuppusamy, P; Zweier, J, L; Trush, M, A; Kensler, T W, 1991, "Free radical-derived quinone methide mediates skin tumor promotion by butylated hydroxytoluene hydroperoxide: expanded role for electrophiles in multistage carcinogenesis.." Proceedings of the National Academy of Sciences of the United States of America 88, no. 3, 946 - 50.
  • Zweier, J, L; Jacobus, W, E; Korecky, B; Brandejs-Barry, Y, 1991, "Bioenergetic consequences of cardiac phosphocreatine depletion induced by creatine analogue feeding.." The Journal of biological chemistry 266, no. 30, 20296 - 304.
  • Corretti, M, C; Koretsune, Y; Kusuoka, H; Chacko, V, P; Zweier, J, L; Marban, E, 1991, "Glycolytic inhibition and calcium overload as consequences of exogenously generated free radicals in rabbit hearts.." The Journal of clinical investigation 88, no. 3, 1014 - 25.
  • Ambrosio, G; Zweier, J, L; Flaherty, J T, 1991, "The relationship between oxygen radical generation and impairment of myocardial energy metabolism following post-ischemic reperfusion.." Journal of molecular and cellular cardiology 23, no. 12, 1359 - 74.
  • Josephson, R, A; Silverman, H, S; Lakatta, E, G; Stern, M, D; Zweier, J L, 1991, "Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes.." The Journal of biological chemistry 266, no. 4, 2354 - 61.
  • Kukreja, R, C; Kearns, A, A; Zweier, J, L; Kuppusamy, P; Hess, M L, 1991, "Singlet oxygen interaction with Ca(2+)-ATPase of cardiac sarcoplasmic reticulum.." Circulation research 69, no. 4, 1003 - 14.

1990

  • Thompson-Gorman, S, L; Zweier, J L, 1990, "Evaluation of the role of xanthine oxidase in myocardial reperfusion injury.." The Journal of biological chemistry 265, no. 12, 6656 - 63.

1989

  • Zweier, J, L; Duke, S, S; Kuppusamy, P; Sylvester, J, T; Gabrielson, E W, 1989, "Electron paramagnetic resonance evidence that cellular oxygen toxicity is caused by the generation of superoxide and hydroxyl free radicals.." FEBS letters 252, no. 1-2, 12 - 6.
  • Kuppusamy, P; Zweier, J L, 1989, "Characterization of free radical generation by xanthine oxidase. Evidence for hydroxyl radical generation.." The Journal of biological chemistry 264, no. 17, 9880 - 4.
  • Zweier, J, L; Kuppusamy, P; Williams, R; Rayburn, B, K; Smith, D; Weisfeldt, M, L; Flaherty, J T, 1989, "Measurement and characterization of postischemic free radical generation in the isolated perfused heart.." The Journal of biological chemistry 264, no. 32, 18890 - 5.
  • Taffe, B, G; Zweier, J, L; Pannell, L, K; Kensler, T W, 1989, "Generation of reactive intermediates from the tumor promoter butylated hydroxytoluene hydroperoxide in isolated murine keratinocytes or by hematin.." Carcinogenesis 10, no. 7, 1261 - 8.

1988

  • Zweier, J, L; Kuppusamy, P; Lutty, G A, 1988, "Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.." Proceedings of the National Academy of Sciences of the United States of America 85, no. 11, 4046 - 50.
  • Zweier, J L, 1988, "Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.." The Journal of biological chemistry 263, no. 3, 1353 - 7.
  • Zweier, J, L; Kuppusamy, P, 1988, "Electron paramagnetic resonance measurements of free radicals in the intact beating heart: a technique for detection and characterization of free radicals in whole biological tissues.." Proceedings of the National Academy of Sciences of the United States of America 85, no. 15, 5703 - 7.

1987

  • Zweier, J, L; Flaherty, J, T; Weisfeldt, M L, 1987, "Direct measurement of free radical generation following reperfusion of ischemic myocardium.." Proceedings of the National Academy of Sciences of the United States of America 84, no. 5, 1404 - 7.
  • Zweier, J, L; Rayburn, B, K; Flaherty, J, T; Weisfeldt, M L, 1987, "Recombinant superoxide dismutase reduces oxygen free radical concentrations in reperfused myocardium.." The Journal of clinical investigation 80, no. 6, 1728 - 34.
  • Zweier, J, L; Jacobus, W E, 1987, "Substrate-induced alterations of high energy phosphate metabolism and contractile function in the perfused heart.." The Journal of biological chemistry 262, no. 17, 8015 - 21.
  • Ambrosio, G; Zweier, J, L; Jacobus, W, E; Weisfeldt, M, L; Flaherty, J T, 1987, "Improvement of postischemic myocardial function and metabolism induced by administration of deferoxamine at the time of reflow: the role of iron in the pathogenesis of reperfusion injury.." Circulation 76, no. 4, 906 - 15.

1986

  • Hilton, B, D; Misra, R; Zweier, J L, 1986, "Magnetic resonance studies of fredericamycin A: evidence for O2-dependent free-radical formation.." Biochemistry 25, no. 19, 5533 - 9.
  • Kusuoka, H; Weisfeldt, M, L; Zweier, J, L; Jacobus, W, E; Marban, E, 1986, "Mechanism of early contractile failure during hypoxia in intact ferret heart: evidence for modulation of maximal Ca2+-activated force by inorganic phosphate.." Circulation research 59, no. 3, 270 - 82.
  • Zweier, J, L; Gianni, L; Muindi, J; Myers, C E, 1986, "Differences in O2 reduction by the iron complexes of adriamycin and daunomycin: the importance of the sidechain hydroxyl group.." Biochimica et biophysica acta 884, no. 2, 326 - 36.

1985

  • Gianni, L; Zweier, J, L; Levy, A; Myers, C E, 1985, "Characterization of the cycle of iron-mediated electron transfer from Adriamycin to molecular oxygen.." The Journal of biological chemistry 260, no. 11, 6820 - 6.
  • Zweier, J L, 1985, "Iron-mediated formation of an oxidized adriamycin free radical.." Biochimica et biophysica acta 839, no. 2, 209 - 13.

1984

  • Zweier, J L, 1984, "Reduction of O2 by iron-adriamycin.." The Journal of biological chemistry 259, no. 10, 6056 - 8.

1983

  • Zweier, J L, 1983, "Electron paramagnetic resonance measurement of the distance between the metal binding sites of transferrin.." The Journal of biological chemistry 258, no. 22, 13759 - 60.

1982

  • Zweier, J, L; Peisach, J; Mims, W B, 1982, "Electron spin echo studies of the copper complexes of conalbumin.." The Journal of biological chemistry 257, no. 17, 10314 - 6.

1981

  • Zweier, J, L; Wooten, J, B; Cohen, J S, 1981, "Studies of anion binding by transferrin using carbon-13 nuclear magnetic resonance spectroscopy.." Biochemistry 20, no. 12, 3505 - 10.

1980

  • Zweier, J L, 1980, "Electron paramagnetic resonance studies of the binding of copper to conalbumin. Probes of the structure and properties of the metal and anion binding sites.." The Journal of biological chemistry 255, no. 7, 2782 - 9.
  • Atlas, S, A; Zweier, J, L; Nebert, D W, 1980, "Genetic differences in phenytoin pharmacokinetics. In vivo clearance and in vitro metabolism among inbred strains of mice.." Developmental pharmacology and therapeutics 1, no. 5, 281 - 304.

1978

  • Zweier, J L, 1978, "An electron paramagnetic resonance study of single site copper complexes of transferrin.." The Journal of biological chemistry 253, no. 21, 7616 - 21.