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Researchers develop regenerative medicine breakthrough
Tissue Nano-Transfection (TNT) is a platform technology developed through a collaborative effort between Ohio State’s College of Engineering and College of Medicine, in response to the need for “virus-free” methods to genetically manipulate and reprogram tissues in vivo. Daniel Gallego-Perez, assistant professor of biomedical engineering and surgery, who co-led the study recently published in Nature Nanotechnology along with L. James Lee, professor of chemical and biomolecular engineering and Chandan K. Sen, director of Ohio State’s Center for Regenerative Medicine & Cell Based Therapies, explains that this technology creates nanometer-sized entry pathways into tissues through which novel or well-established “cocktails” of reprogramming factors can be delivered in order to instruct the cells to convert into a different cell type. Applications for this technology could include localized reprogramming of tissues for regenerative medicine, or gene editing to correct abnormalities among others.
To read the full article by Eileen Scahill, Wexner Medical Center, click here.