BME Seminar: Dr. David Hoelzle, OSU College of Engineering
"Two examples of integrated systems design for biomedical research: an application to tissue engineering and an application to mechanobiology research"
This seminar will provide two case examples of integrated systems design for biomedical research. The first example will demonstrate how advanced robotic systems may be used to further tissue engineering utility. Additive manufacturing (AM), a set of robotic tools most commonly referred to as 3D printing, has been applied to tissue engineering construct manufacture for over a decade, with multiple demonstrated successes in vitro and in vivo. However, construct fabrication is performed in the laboratory and therefore requires a highly invasive, open surgery for implantation. With the maturation of AM, robotic assisted surgery, and tissue engineering, we can now consider endoscopic AM robots to fabricate tissue engineered constructs in the human body through a ‘keyhole’ surgery. The talk will demonstrate a few preliminary developments in the design of such a system. The second example will demonstrate how microelectromechanical systems design and analysis can be used to study the mechanical properties of cells. Our lab is currently building microprobes in the sides of microfluidic channels with the purpose of creating a high-throughput mechanical flow cytometer. The talk will detail some of the unique challenges in designing such a system and preliminary results of the system applied to mechanically graded cell mimics.
Prof. David Hoelzle is an Assistant Professor in the Department of Mechanical and Aerospace Engineering at the Ohio State University. He received his MS and PhD from the University of Illinois at Urbana-Champaign in 2007 and 2011, respectively, in Mechanical Science and Engineering and his BS from the Ohio State University in 2005 in Mechanical Engineering. Between his PhD and current position, he completed a post-doc in the Department of Integrative Biology and Physiology at the University of California, Los Angeles and held the position of Assistant Professor in the Department of Aerospace and Mechanical Engineering at the University of Notre Dame. His research interests lie in applied control theory and dynamics for applications in additive manufacturing robotics and microsystems for mechanobiology research. Prof. Hoelzle is a recipient of the 2016 CAREER Award and the 2016 Society of Manufacturing Engineers Outstanding Young Manufacturing Engineer Award.